Objective Although dietary preferences influence chronic diseases,few studies have linked dietary preferences to mortality risk,particularly in large cohorts.To investigate the relationship between dietary preferences...Objective Although dietary preferences influence chronic diseases,few studies have linked dietary preferences to mortality risk,particularly in large cohorts.To investigate the relationship between dietary preferences and mortality risk(all-cause,cancer,and cardiovascular disease[CVD])in a large adult cohort.Methods A cohort of 1,160,312 adults(mean age 62.48±9.55)from the Shenzhen Healthcare Big Data Cohort(SHBDC)was analyzed.Hazard ratios(HRs)for mortality were estimated using the Cox proportional hazards model.Results The study identified 12,308 all-cause deaths,of which 3,865(31.4%)were cancer-related and 3,576(29.1%)were attributed to CVD.Compared with a mixed diet of meat and vegetables,a mainly meat-based diet(hazard ratio[HR]=1.13;95%confidence interval[CI]:1.02,1.27)associated with a higher risk of all-cause mortality,while mainly vegetarian(HR=0.87;95%CI:0.78,0.97)was linked to a reduced risk.Furthermore,there was a stronger correlation between mortality risk and dietary preference in the>65 age range.Conclusion A meat-based diet was associated with an increased risk of all-cause mortality,whereas a mainly vegetarian diet was linked to a reduced risk.展开更多
Objectives:There is a debate on the association between the circulating manganese(Mn)levels and mortality.The aim of this study was to explore the nonlinear association between the serum Mn levels and all-cause or cau...Objectives:There is a debate on the association between the circulating manganese(Mn)levels and mortality.The aim of this study was to explore the nonlinear association between the serum Mn levels and all-cause or cause-specific mortality.Methods:We included 8,145 adults from the United States(US)and their serum Mn concentrations obtained from the National Health and Nutrition Examination Survey(NHANES 2011–2014).We retrieved their survival information from baseline until 2019 using the national death index.Multivariable Cox proportional hazards models were used to show the risk of all-cause or cause-specific mortality according to the baseline serum Mn concentrations.Smooth curve fitting and threshold effect analyses were used to clarify the potential nonlinearity.Results:During a median follow-up of 6.2 years,there were 716 deaths from all causes,224 of which were due to cardiovascular dis-ease(CVD)and 165 due to cancer.The serum Mn levels exhibited a U-shaped relationship with all-cause or CVD-associated mortality.Serum Mn levels lower than the threshold value(7.32μg/L)were negatively associated with all-cause(fully adjusted HR:0.86,95%CI:0.80–0.94)and CVD(fully adjusted HR:0.82,95%CI:0.71–0.94)mortality.In contrast,serum Mn levels higher than the threshold value(7.32μg/L)were positively associated with all-cause(fully adjusted HR:1.04,95%CI:1.02–1.06)and CVD(fully adjusted HR:1.05,95%CI:1.02–1.08)mortality.Conclusions:The serum Mn concentrations showed a U-shaped relationship with all-cause and CVD-associated mortality among NHANES participants.展开更多
基金supported by the National Natural Science Foundation of China(No.82425052).
文摘Objective Although dietary preferences influence chronic diseases,few studies have linked dietary preferences to mortality risk,particularly in large cohorts.To investigate the relationship between dietary preferences and mortality risk(all-cause,cancer,and cardiovascular disease[CVD])in a large adult cohort.Methods A cohort of 1,160,312 adults(mean age 62.48±9.55)from the Shenzhen Healthcare Big Data Cohort(SHBDC)was analyzed.Hazard ratios(HRs)for mortality were estimated using the Cox proportional hazards model.Results The study identified 12,308 all-cause deaths,of which 3,865(31.4%)were cancer-related and 3,576(29.1%)were attributed to CVD.Compared with a mixed diet of meat and vegetables,a mainly meat-based diet(hazard ratio[HR]=1.13;95%confidence interval[CI]:1.02,1.27)associated with a higher risk of all-cause mortality,while mainly vegetarian(HR=0.87;95%CI:0.78,0.97)was linked to a reduced risk.Furthermore,there was a stronger correlation between mortality risk and dietary preference in the>65 age range.Conclusion A meat-based diet was associated with an increased risk of all-cause mortality,whereas a mainly vegetarian diet was linked to a reduced risk.
基金supported by the Young Talent Development Plan of Changzhou Health Commission(No.CZQM2021023)Medical Education Collaborative Innovation Fund of Jiangsu University(No.JDYY2023156)the Changzhou Municipal 14th Five-Year Plan for High-level Health Care Talent Training Program.
文摘Objectives:There is a debate on the association between the circulating manganese(Mn)levels and mortality.The aim of this study was to explore the nonlinear association between the serum Mn levels and all-cause or cause-specific mortality.Methods:We included 8,145 adults from the United States(US)and their serum Mn concentrations obtained from the National Health and Nutrition Examination Survey(NHANES 2011–2014).We retrieved their survival information from baseline until 2019 using the national death index.Multivariable Cox proportional hazards models were used to show the risk of all-cause or cause-specific mortality according to the baseline serum Mn concentrations.Smooth curve fitting and threshold effect analyses were used to clarify the potential nonlinearity.Results:During a median follow-up of 6.2 years,there were 716 deaths from all causes,224 of which were due to cardiovascular dis-ease(CVD)and 165 due to cancer.The serum Mn levels exhibited a U-shaped relationship with all-cause or CVD-associated mortality.Serum Mn levels lower than the threshold value(7.32μg/L)were negatively associated with all-cause(fully adjusted HR:0.86,95%CI:0.80–0.94)and CVD(fully adjusted HR:0.82,95%CI:0.71–0.94)mortality.In contrast,serum Mn levels higher than the threshold value(7.32μg/L)were positively associated with all-cause(fully adjusted HR:1.04,95%CI:1.02–1.06)and CVD(fully adjusted HR:1.05,95%CI:1.02–1.08)mortality.Conclusions:The serum Mn concentrations showed a U-shaped relationship with all-cause and CVD-associated mortality among NHANES participants.
