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A Hierarchical Short Microneedle-Cupping Dual-Amplified Patch Enables Accelerated,Uniform,Pain-Free Transdermal Delivery of Extracellular Vesicles 被引量:1
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作者 Minwoo Song Minji Ha +8 位作者 Sol Shin Minjin Kim Soyoung Son Jihyun Lee Gui Won Hwang Jeongyun Kim Van Hieu Duong Jae Hyung Park Changhyun Pang 《Nano-Micro Letters》 2026年第1期268-289,共22页
Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,con... Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort. 展开更多
关键词 Biomimetics cupping MICRONEEDLE Transdermal patch Extracellular vesicles
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Clinical Efficacy of Mongolian Medicine Silver Needle Combined with Cupping and Bloodletting Therapy in the Treatment of Cervical Spondylotic Radiculopathy(CSR)
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作者 Mei SHUANG Wentong BAI +1 位作者 Sarula WANG Galiba 《Medicinal Plant》 2025年第3期62-65,68,共5页
[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patie... [Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patients diagnosed with CSR who received treatment at the International Mongolian Hospital of Inner Mongolia between October 2021 and October 2022 were selected and randomly divided into two groups:A test group and a control group,with 60 patients in each group.The patients in the test group received Mongolian medicine silver needle combined with cupping and bloodletting therapy,following the principles of syndrome differentiation in Mongolian medicine.In contrast,the patients in the control group received only the Mongolian medicine silver needle therapy.After treatment,the Mongolian medicine syndrome scores,visual analogue scale(VAS)scores,and total clinical therapeutic effects in the two groups of patients were compared both prior to and following the treatment.[Results]The improvement in VAS and Mongolian medicine syndrome scores in the test group was greater than that in the control group,with a statistically significant difference(P<0.05).The scores of the test group surpassed those of the control group,and this difference was also statistically significant(P<0.05).Furthermore,the overall therapeutic effect in the test group was 93.33%,which was markedly higher than 76.67%observed in the control group(P<0.05).[Conclusions]The therapeutic effect of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of CSR is remarkable.This approach has demonstrated efficacy in alleviating patient pain and improving the functionality of the cervical vertebrae,thereby warranting clinical promotion and application. 展开更多
关键词 Cervical spondylotic RADICULOPATHY (CSR) MONGOLIAN medicine silver needle THERAPY cupping and BLOODLETTING THERAPY Clinical efficacy
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Update evidence of effectiveness on pain relieving of cupping therapy:a systematic review and Meta-analysis of randomized controlled trials
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作者 WANG Yiying DONG Shuai +2 位作者 LI Bo HAN Mei CAO Huijuan 《Journal of Traditional Chinese Medicine》 2025年第2期234-253,共20页
OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated ... OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated literature searching in 7 databases was conducted from January 2014 to January 2023.Two authors extracted data and assessed the risk of bias independently.Statistical analysis was performed using RevMan 5.4.1 software(Cochrane Collaboration,London,UK).Meta-analysis with a random effect model was conducted when there was no serious statistical heterogeneity among trials(I^(2) ≤ 75%).Grading of Recommendations Assessment,Development,and Evaluation was also conducted to assess the quality of evidence.RESULTS:Seventy-two trials with 5720 participants were included.All included trials were assessed as having high risk of bias.The majority of the included trials reported the benefit of cupping plus other therapy or cupping alone on improving cure rate(average risk ratio more than 1.15) and reducing visual analogue scale [average mean difference(MD) reduction 0.16 to 7.0 cm],improving quality of life,quality of sleep or other symptoms related to pain condition.And there was low/very low quality evidence that the incidence of adverse events in the cupping groups were lower than that in the control groups.Although the heterogeneity between studies and the methodological quality of the study itself lead to the low evidence strength of the current conclusions,the results of this study are a valuable supplement to the founding of previous review.CONCLUSION:Cupping therapy alone or combined with other therapy was considered benefit in relieving pain,improving the quality of life,and increasing the cure rate of patients with pain conditions,though supported by the low quality of evidence.According to the limited evidence,cupping therapy seems to have less harm than drugs when treating pain conditions. 展开更多
关键词 cupping therapy PAIN systematic review Metaanalysis
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Effect of kinetic needling combined with blood-letting puncturing and cupping on functions of upper limbs of patients with shoulder-hand syndrome after apoplexy 被引量:3
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作者 刘未艾 吴清明 +2 位作者 付磊 李向荣 李丹丹 《World Journal of Acupuncture-Moxibustion》 2010年第1期7-12,23,共7页
Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation g... Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation group (45 cases) and a control group (45 cases). Basic treatments selected according to corresponding stroke units were applied to both groups. Besides, scalp acupuncture at Dingnie Qianxiexian (MS 6, 顶颞前斜线), Dingnie Houxiexian (MS 6, 顶颞前斜线) and Dingzhongxian (NS 5, 顶中线), was applied in the treatment group. In the observation group, active and passive movement was carried out during the process of scalp acupuncture, and then needling plus bloodletting puncturing and cupping was applied. In the control group, only needling plus blood-letting puncturing and cupping was given. Therapeutic effects, pain scoring obtained by visual analogue scales (VAS), FugI-Meyer and FugI-Meyer's scoring reflecting moving functions of upper limbs were made after 4 courses of treatments in both groups. Results The total effective rate was 95.5% and 91.1% in the observation group and control group, respectively, showing superiority of the former to the latter (P〈0.05). After treatment, VAS scores were all obviously reduced in both groups (P〈0.01), and the reduction in the former was significantly more than that in the latter (P〈0.01). Moving functions of upper limbs shown by Fugl-Meyer's scoring were improved after 2 courses of treatment in both groups (P〈0.01). The improvement was more obvious after 4 courses of treatment than that after 2 courses of treatment in both groups (P〈0.05). After 4 courses of treatment, moving functions shown by FugI-Meyer's scoring were more remarkably improved in the observation group than those in the control group(t=3.9, P〈0.01). Conclusion Both kinetic needling combined with needling plus blood-letting puncturing and cupping and simple needling plus blood-letting puncturing and cupping are effective in treating shoulder-hand syndrome after apoplexy, and the former is better than the latter. 展开更多
关键词 APOPLEXY Shoulder-hand Syndrome Kinetic Needling Blood-letting Puncturing and cupping (B-IPC)
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Effects of cupping on blood flow under skin of back in healthy human 被引量:5
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作者 刘葳 朴盛爱 +2 位作者 孟向文 魏连海 LIU Zhao 《World Journal of Acupuncture-Moxibustion》 2013年第3期50-52,共3页
Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at D... Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at Dhzhui (大椎 GV 14) and bilateral Dazhu (大杼 BL 11) for 10 min in healthy subject. Blood flow monitoring video system of laser speckle was used to record blood flow of GV 14, Shenzhu (身柱 GV 12), bilateral Feishu (肺俞 BL 13) and Xinshu (心俞 BL 15) before cupping therapy, immediate time of cupping removal and 5 min, 10 rain, 15 min, 20 min, 25 rain and 30 rain after cupping removal. Results Compared before cupping therapy, the blood flow of GV 14, GV 12 and bilateral BL 13 was obviously increased at immediate time of cupping removal (all P〈0.05). Compared with immediate time of cupping removal, the blood flow of GV 14 at each time point after 20 rain of cupping removal, GV 12 at 10 min and 15 min after cupping removal, bilateral BL 13 at each time point after cupping removal was all obviously decreased (all P〈0.05). The difference of blood flow of Shendao (神道 GV 11) and bilateral BL 15 before and after cupping therapy was not significantly different (all P〉0.05). Conclusion The cupping therapy could adjust skin blood flow, which is more obvious near the cupping area. 展开更多
关键词 cupping healthy human blood flow
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Preliminary observation on effect of cupping on the skin surface temperature of patients with back pain 被引量:8
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作者 许培昌 崔淑丽 +2 位作者 胡政伟 许晟 李达良 《World Journal of Acupuncture-Moxibustion》 2014年第4期59-61,共3页
Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with mediu... Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with medium-sized cups with a volume of 260 mL The randomly selected Xinshu(心俞 BL 15)on one side(37 cases) was given cupping treatment while that on the other side as the control.And Shenshu(肾俞 BL 23)(6 cases) was treated in the same way.The thermal infrared imager was used to record the changes in localized skin temperature before and after cupping(for 10 minutes),and then comparison was made with that of the control side.Results After cupping,the localized skin temperature fell and then rose.When the cup was removed after retaining for 10 minutes,the localized skin temperature was(0.4±0.9) ℃(P=0.004) lower than that before cupping;10 minutes after cupping off,the localized skin temperature was(0.4±1.1) ℃(P=0.016) higher than that before cupping while(0.8±0.9) ℃ higher than that when cupping off.The skin surface temperature on the control side declined steadily.Conclusion After cupping treatment,the localized skin temperature fell and then rose while that of the control side declined steadily.It might be related to therapeutic effects. 展开更多
关键词 ACUPUNCTURE cupping therapy skin temperature infrared ray thermal imagine
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Observation on therapeutic effects of simple obesity treated with needling and quick cupping therapy at the selected eight points around umbilicus 被引量:2
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作者 李湘力 蔡敬宙 江海玲 《World Journal of Acupuncture-Moxibustion》 2010年第1期13-18,共6页
Objective To observe the clinical effects of simple obesity treated with needling and quick cupping therapy at the selected eight points around umbilicus. Methods Ninety-five cases were randomly allocated into an obse... Objective To observe the clinical effects of simple obesity treated with needling and quick cupping therapy at the selected eight points around umbilicus. Methods Ninety-five cases were randomly allocated into an observation group and a control group. In observation group (n=50) patients were treated with acupuncture and quick cupping therapy at the selected eight points around umbilicus, namely Huaroumen (滑肉门 ST 24), Tianshu (天枢 ST 25),Wailing (外陵 ST 26),Shuifen (水分 CV 9), and Yinjiao(阴交 CV 7).In control group (n=45) patients were advised to take Sibutramine, an oral administration to suppress appetite. Relevant data concerning one's weight, body mass index (BMI), waist hip ratio (WHR) and distribution rate of body fat (F%) before treatment and after eight weeks' of treatment were collected to observe the effects. Results The total effective rate was 98.0%(49/50) in the observation group and 97.8%(44/45) in the control group. There was no significant difference on body weight and BMI between the two groups (P〉0.05), however the therapeutic effects on WHR and F% in the observation group were more satisfactory than those of the control group (P〈0.05). Conclusion Acupuncture and quick cupping therapy at the selected eight points around umbilicus have a good therapeutic effect on simple obesity, moreover acupuncture and quick cupping therapy can greatly improve the condition of WHR and F% for obesity patients, which is also safe and without any side effect. 展开更多
关键词 Simple Obesity ACUPUNCTURE cupping Eight Points Around Umbilicus
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Acupuncture combined with medicated cupping for temporomandibular disorders 被引量:2
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作者 韩燕 郭立华 肖京 《World Journal of Acupuncture-Moxibustion》 CSCD 2015年第3期31-34,共4页
Objective To observe the application of acupuncture at distal points combined with medicated cupping on the affected parts in the treatment of temporomandibular disorders(TMD) and to evaluate its effectiveness. Meth... Objective To observe the application of acupuncture at distal points combined with medicated cupping on the affected parts in the treatment of temporomandibular disorders(TMD) and to evaluate its effectiveness. Methods A total of 120 patients with TMD were randomly divided into two groups according to the random number table and random number remainder method. Sixty-two patients in acupuncture combined with cupping group(group A) were treated with acupuncture at Hég(合谷 LI 4) and Tàichōng(太冲 LR 3) combined with medicated cupping on the affected parts with Sānqī(三七 Radix et Rhizoma Notoginseng) and Báizh(白芷 Radix Angelicae Dahuricae). Fifty-eight patients in cupping group(group B) were just treated with medicated cupping. Patients were treated for 30 min each time, once daily, and 10 times were considered as one course of treatment. After one course of treatment, the therapeutic effect was evaluated. Before and after treatment, craniomandihular index(CMI), dysfunction index(DI), palpation index(Pl) and changes in pain degree(VAS score) were compared. Results Before and after treatment, CMI in group A were 0.27±0.02 and 0.04±0.01, respectively, and in group B were 0.29±0.02 and 0.06±0.01, respectively; PI in group A were 0.19±0.01 and 0.05±0.03, respectively, and in group B were 0.18±0.02 and 0.11±0.02, respectively; DI in group A were 0.33±0.04 and 0.06±0.02, respectively, and in group B were 0.34±0.05 and 0.11±0.04, respectively; VAS in group A were 5.39±0.24 and 2.13±0.47, respectively, and in group B were 5.70±0.31 and 3.97±0.26, respectively. After treatment, CMI, DI, PI and VAS in both groups significantly decreased when compared with those before treatment(all P0.01), and the indices in group A were significantly lower than that in group B after treatment(all P0.05), indicating that the difference was significant. Conclusion The therapeutic effect of acupuncture at distal points combined with cupping at adjacent points in treatment of TMD is superior to that of single medicated cupping therapy. 展开更多
关键词 temporomandibular disorders acupuncture therapy medicated cupping
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Observation on therapeutic effect of chronic fatigue syndrome treated with Panlongci (coiling dragon needling) and moving cupping on back 被引量:1
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作者 徐纬 周日花 +2 位作者 李磊 姜鸣炜 ZHANG Yi 《World Journal of Acupuncture-Moxibustion》 2012年第4期27-31,共5页
Objective To compare the differences of therapeutic effect of chronic fatigue syndrome (CFS) treated with the combined therapy of Panlongci (coiling dragon needling) and cupping on back and the western medicine th... Objective To compare the differences of therapeutic effect of chronic fatigue syndrome (CFS) treated with the combined therapy of Panlongci (coiling dragon needling) and cupping on back and the western medicine therapy with prednisone. Methods Seventy-two cases were randomly divided into 2 groups of acupuncture-cupping group (37 cases) and prednisone group (35 cases). In acupuncture-cupping group, Jiaji points (夹脊 EX-B 2) of the level of T1–L5 were applied with coiling dragon needling once a day, combining with moving cupping on back once every two days. In prednisone group, prednisone tablets of 10 mg were orally taken at 8:00 am everyday. Seven days were counted as one treatment course, and 2 courses were carried on totally. FS-14 scale and BELL’s CFS integral table were applied to evaluate the fatigue degree of patients before and after the treatment, and the therapeutic effects of both groups were compared. Results After one course of treatment, the BELL’s scores of both groups were obviously improved (both P0.01), but there was no significant difference between the 2 groups (P0.05); after 2 courses of treatment, the BELL’s score in acupuncture-cupping group improved more obviously than that of the prednisone group (P0.05), and the total effective rate of 91.9% (34/37) in acupuncture-cupping group was superior to that of 71.4% (25/35) in prednisone group (P0.05). Conclusion The therapeutic effect of chronic fatigue syndrome treated with coiling dragon needling and moving cupping on back is positive, which is superior to that of prednisone with oral administration. 展开更多
关键词 chronic fatigue syndrome coiling dragon needling moving cupping PREDNISONE
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Clinical research on postherpetic neuralgia treated by floating-acupuncture combined with collateral-bloodletting puncture and cupping 被引量:5
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作者 刘敏娟 《World Journal of Acupuncture-Moxibustion》 2014年第3期35-39,共5页
Objective To observe the clinical efficacy of treating postherpetic neuralgia (PHN) by combining floating-acupuncture laser with cupping following collateral bloodletting, and to analyze its mechanism. Method One hu... Objective To observe the clinical efficacy of treating postherpetic neuralgia (PHN) by combining floating-acupuncture laser with cupping following collateral bloodletting, and to analyze its mechanism. Method One hundred and thirty cases of PHN were randomly divided into a floating-acupuncture laser with cupping following collateral bloodletting group (group A) and an electroacupuncture group (group B) based on the treatment sequence and according to the random number table, with 65 cases in each group. In the group B, G-6805 electroacupuncture apparatus was adopted after the arrival of qi through even reinforcing and reducing (even method) in such acupoints as Hegu (合俗 LI 4), Taihong (太冲 LR 3), Zhigou (支沟 TE 6), Quchi ( 曲池 LI 11) and Zusanli (足三里 ST 36); in the group A, the treatment combining floatingacupuncture laser with cupping following collateral bloodletting was adopted, and the score of VAS and clinical efficacy before and after treatment in the two groups were compared. Result The differences of VAS scores of the two groups between the time points of after one course of treatment, after the entire treatment, follow up visit three months after the treatment and before treatment were statistically significant (all P〈0.05). The rate of significant efficiency and total effective rate in the group A were respectively 37.8% and 98.5% (64/65), and 11.2% and 78.5% (52/65) in the group B. The difference between the two groups was statistically significant after Ridit analysis (P〈0.05). Conclusion The efficacy of treating PHN by combining floating-acupuncture laser with cupping following collateral bloodletting was significant. 展开更多
关键词 floating-acupuncture laser cupping following collatera bloodletting postherpetic neuralgia (PHN)
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Acupuncture combined with vesiculating cupping for 110 patients with rheumatoid arthritis 被引量:4
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作者 刘一儒 乔圣茜 《World Journal of Acupuncture-Moxibustion》 CSCD 2015年第4期38-42,共5页
Objective To explore the clinical efficacy of acupuncture combined with vesiculating cupping in treatment of rheumatoid arthritis(RA). Methods A total of 110 patients with RA were randomly divided into an acupunctur... Objective To explore the clinical efficacy of acupuncture combined with vesiculating cupping in treatment of rheumatoid arthritis(RA). Methods A total of 110 patients with RA were randomly divided into an acupuncture combined with vesiculating cupping group(group A) and an acupuncture combined with non-vesiculating cupping group(group B). Treatment was conducted once a day in two groups, and ten days were considered as one course of treatment. The total effective rate was observed after treatment for three courses. Results The difference in cured and markable effective rate of group A and group B was obviously significant [81.82%(45/55) vs 18.18%(10/55), P〈0.01], the difference in total effective rate of group A and group B was significant [96.36%(53/55) vs 69.09%(38/55), P〈0.05], indicating that the efficacy in group A was significantly superior to that of group B. Conclusion Acupurcture combined with vesiculating cupping therapy achieves more satisfactory efficacy on RA compared with acupuncture combined with nonvesiculating cupping therapy. 展开更多
关键词 Rheumatoid arthritis ACUPUNCTURE cupping vesiculating therapy
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Blood-letting puncture and cupping at Dong's unique extra points for 65 cases of neck type of cervical spondylosis 被引量:3
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作者 闫晓瑞 《World Journal of Acupuncture-Moxibustion》 2012年第3期60-62,共3页
Objective To observe the clinical effect of blood-letting puncture and cupping at Chōngxiāo(冲霄 Extra) point of Dong's unique Extra-ordinary points in the treatment of neck type of cervical spondylosis.Methods S... Objective To observe the clinical effect of blood-letting puncture and cupping at Chōngxiāo(冲霄 Extra) point of Dong's unique Extra-ordinary points in the treatment of neck type of cervical spondylosis.Methods Sixty-five patients of neck type of cervical spondylosis were selected and treated with blood-letting puncture and cupping at Chōngxiāo(冲霄 Extra) point once every two or three days,three times constituted one course and two successive courses were given,then the clinical effect was evaluated.Results The curative rate was 69.2%(45/65),and the total effective rate was 92.3%(60/65).Conclusion Blood-letting puncture and cupping at Dong's Chōngxiāo(冲霄 Extra) point can be used to treat neck type of cervical spondylosis with simple manipulation and obvious efficacy. 展开更多
关键词 cervical spondylosis neck type blood-letting puncture and cupping Dong's unique extra-ordinary points
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Extreme venous letting and cupping resulting in life-threatening anemia and acute myocardial infarction:A case report
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作者 Albert Youngwoo Jang Soon Yong Suh 《World Journal of Clinical Cases》 SCIE 2020年第24期6432-6436,共5页
BACKGROUND Wet cupping (WC) is a traditional therapy of skin suction-assisted bloodlettingthat is widely used in modern alternative medicine in Asia and the Middle East.Herein, we report the case of a male who present... BACKGROUND Wet cupping (WC) is a traditional therapy of skin suction-assisted bloodlettingthat is widely used in modern alternative medicine in Asia and the Middle East.Herein, we report the case of a male who presented with ST-elevation myocardialinfarction (STEMI) and life-threatening anemia and underwent excessive WC.CASE SUMMARY A 55-year-old male presented with chest pain (30 min) and dyspnea (3 wk). Hisinitial electrocardiogram suggested STEMI in the anterior wall. Furthermore, hislaboratory results showed severe anemia with a hemoglobin level of 4.1 g/dL. Ofnote, the patient underwent regular WC therapy for chronic back pain, which hehad recently intensified. His WC practice resulted in life-threatening anemia andeventually STEMI. Percutaneous coronary intervention in the left anteriordescending artery was performed to treat the STEMI. His dyspnea dramaticallyimproved after the transfusion, and his hemoglobin level returned to 14.8 g/dLwithin 2 mo after discharge. He has been uneventful for the last seven years offollow-up.CONCLUSION The current case demonstrates that excessive WC without adequate medicalmonitoring can result in severe anemia, which can further develop into STEMI. 展开更多
关键词 BLOODLETTING ST-elevation myocardial infarction ANEMIA cupping Wet cupping Case report
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Technical operation specification for pricking-cupping therapy
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作者 Jiaji LI Jingjin XU +3 位作者 Jing ZHANG Ling TANG Hong CHEN Ye LI 《Journal of Integrative Nursing》 2023年第3期223-227,共5页
Pricking-cupping therapy is a Traditional Chinese Medicine(TCM)nursing technology that can adjust the viscera of the human body,make the meridians smooth,and Yin and Yang balanced mainly by means of relieving heat and... Pricking-cupping therapy is a Traditional Chinese Medicine(TCM)nursing technology that can adjust the viscera of the human body,make the meridians smooth,and Yin and Yang balanced mainly by means of relieving heat and detoxification,harmonizing Qi and blood,promoting blood circulation and removing blood stasis,dredging meridians and activating collaterals,reducing swelling and pain,purging heat and calming shock,clearing heat,and opening orifices.Pricking-cupping therapy has a long history and wide application.After thousands of years of development,it has made great progress.They are widely used to treat lumbar disc herniation,herpes zoster,acute arthritis,migraine,and other diseases in China.Through the clinical practice and theoretical exploration of physicians of past dynasties,the therapeutic mechanism and application scope of pricking-cupping therapy have been greatly enriched.Modern TCM practitioners have conducted in-depth researches on the operation norms of the therapy on the basis of the ancients,hoping to grasp the essence of the disease more accurately and make the rational use of the operation technology of the therapy. 展开更多
关键词 Bloodletting puncture cupping external treatment of traditional Chinese medicine operating procedures pricking-cupping therapy Traditional Chinese Medicine nursing technology
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Preliminary studies on the mechanism of blistering cupping therapy
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作者 Xiang-Hong Chen Bo Chen +2 位作者 Ze-Lin Chen Meng-dan Li Qin Long 《TMR Non-Drug Therapy》 2018年第2期26-31,共6页
Blistering cupping therapy, as a new type of cupping therapy, has attracted more and more attention of clinical doctor and scholars in home and abroad. Blistering cupping therapy achieves better effects through the fo... Blistering cupping therapy, as a new type of cupping therapy, has attracted more and more attention of clinical doctor and scholars in home and abroad. Blistering cupping therapy achieves better effects through the formation of blistering fluid after suction. However, it is still controversial whether cupping induced blisters are beneficial to recovery of diseases, and the mechanism is still not completely clear. Here on the basis of the traditional cupping method, we aimed to identify the mechanism of blistering cupping from the levels of biomechanics and molecular biology. The negative pressure attraction induced by cupping suck should be of value in increasing pain threshold and relieving pain as well as improving the blood circulation and metabolism. Furthermore, the blistering fluid induced by cupping was the inflammatory substance actually that discharged through the superficial lymphatic vessels, including immunoglobulin, lysozyme, erythrocytes, etc. which could cause the autogenetic inflammatory reaction of selected cupping area, and further activated certain immune pathways including anti-oxidation, anti-apoptosis, tissue repairing and metabolic regulation. Besides, the formation of scar induced by blistering cupping was not only the result of excessive inflammatory response, but also involved in mobilizing the immune response. 展开更多
关键词 cupping Blistering cupping MECHANISM BIOMECHANICS Molecular biology Inflammation Immunity.
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Subconjunctival hemorrhage after wet cupping therapy: a case report
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作者 Zainab AlMusleh Ahmad Alrawashdeh Tamer Aboushanab 《Clinical Research Communications》 2024年第2期27-29,共3页
Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of years.Cupping therapy is reported to be a relatively safe practice e... Introduction:Cupping therapy is an integrative and complementary medicine therapy that practiced worldwide by several civilizations for thousands of years.Cupping therapy is reported to be a relatively safe practice especially if performed by qualified therapists.Subconjunctival hemorrhage(SCH)is a common cause of eye redness and can be classified into traumatic and spontaneous.Case presentation:This case report discussed an adverse event related to wet cupping therapy.The patient developed SCH one day after performing cupping therapy.He was completely recovered after 2 weeks.This case report should increase the knowledge of cupping therapists regarding increasing safety of patient when performing wet cupping therapy on specific body parts especially,head,neck and cervical areas.Furthermore,it highlighted the importance of conducting research regarding the mechanical and physiological effects of cupping therapy.Conclusion:Adverse events related to cupping therapy should be reported with every patient.Cupping therapists should be aware of this possible mild adverse event.To the best of our knowledge,this is the first published adult case of SCH related to wet cupping therapy session.More studies are critically needed for evaluation of cupping therapy effects and adverse events especially when performed on head and neck. 展开更多
关键词 cupping therapy wet cupping Hijama subconjunctival hemorrhage adverse event
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Effects of wet-cupping on blood pressure in hypertensive patients:a randomized controlled trial 被引量:6
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作者 Nouran A.Aleyeidi Khaled S.Aseri +2 位作者 Shadia M.Matbouli Albaraa A.Sulaiamani Sumayyah A.Kobeisy 《Journal of Integrative Medicine》 SCIE CAS CSCD 2015年第6期391-399,共9页
BACKGROUND: Although cupping remains a popular treatment modality worldwide, its efficacy for most diseases, including hypertension, has not been scientifically evaluated. OBJECTIVE: We aimed to determine the effica... BACKGROUND: Although cupping remains a popular treatment modality worldwide, its efficacy for most diseases, including hypertension, has not been scientifically evaluated. OBJECTIVE: We aimed to determine the efficacy of wet-cupping for high blood pressure, and the incidence of the procedure's side effects in the intervention group. DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This is a randomized controlled trial conducted in the General Practice Department at King Abdulaziz University Hospital, Jeddah, Saudi Arabia, between May 2013 and February 2014. There were two groups (40 participants each): intervention group undergoing wet-cupping (hijama) in addition to conventional hypertension treatment, and a control group undergoing only conventional hypertension treatment. Three wet-cupping sessions were performed every other day. MAIN OUTCOME MEASURE: The mean systolic and diastolic blood pressures were measured using a validated automatic sphygmomanometer. The follow-up period was 8 weeks. RESULTS: Wet-cupping provided an immediate reduction of systolic blood pressure. After 4 weeks of follow-up, the mean systolic blood pressure in the intervention group was 8.4 mmHg less than in the control group (P = 0.046). After 8 weeks, there were no significant differences in blood pressures between the intervention and control groups. In this study, wet-cupping did not result in any serious side effects. CONCLUSION: Wet-cupping therapy is effective for reducing systolic blood pressure in hypertensive patients for up to 4 weeks, without serious side effects. Wet-cupping should be considered as a complementary hypertension treatment, and further studies are needed. 展开更多
关键词 blood pressure HYPERTENSION cupping therapy randomized controlled trials
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Cupping therapy for patients with chronic urticaria: A systematic review and meta-analysis 被引量:5
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作者 Xian-jun Xiao Lei-xiao Zhang +9 位作者 Yun-zhou Shi Jun-peng Yao Wei Cao Ying Liu Zi-hao Zou Si-yuan Zhou Ming-ling Chen Chun-xiao Li Qian-hua Zheng Ying Li 《Journal of Integrative Medicine》 SCIE CAS CSCD 2020年第4期303-312,共10页
Background:Chronic urticaria(CU)is a common skin disease,which has a negative effect on quality of life.Current treatments do not fully control the symptoms of urticaria for many CU patients,thus effective and safe tr... Background:Chronic urticaria(CU)is a common skin disease,which has a negative effect on quality of life.Current treatments do not fully control the symptoms of urticaria for many CU patients,thus effective and safe treatments for CU are still needed.Objective:This review aims to evaluate the effectiveness and safety of cupping therapy in patients with CU.Search strategy:The search strategy looked for the presence of related keywords,such as‘‘chronic urticaria"and‘‘cupping therapy,"in the title and abstract of research articles indexed in major databases.Randomized controlled trials(RCTs)were selected after querying nine electronic databases from their inception to May 2019 with the above search terms.Inclusion criteria:RCTs were included if they recruited patients with CU who were intervened with dry or wet cupping.Publications could be written in Chinese or English.Data extraction and analysis:Data were extracted,and the studies were assessed for the quality of their methodological design and risk of bias.Meta-analyses of the RCT data were conducted to assess the total effective rate of the treatment as the primary outcome.Skin disease quality of life index score,recurrence rate,and adverse events were assessed as secondary outcomes.Subgroup analyses were conducted based on different interventions.Results:Thirteen comparisons from 12 RCTs involving 842 participants were included.There were no significant differences between wet cupping and medications in total effective rate(n=372;risk ratio[RR]=1.10,95%confidence interval[CI]0.97 to 1.25;P=0.14)or recurrence rate(n=240;RR=0.56,95%CI 0.23 to 1.36;P=0.20).Cupping therapy,in combination with antihistamine treatment was more efficacious than antihistamines alone,with a greater total effective rate(n=342;RR=1.18,95%CI 1.01 to1.39;P=0.03)and lower recurrence rate(n=342;RR=0.52,95%CI 0.32 to 0.84;P=0.007).Cupping therapy combined with acupuncture was more effective than acupuncture alone(n=156;RR=1.25,95%CI 1.07 to 1.46;P=0.006).No serious adverse events were reported.Conclusion:Wet cupping may be as effective as treatment with antihistamines.When cupping therapy is used as an adjuvant therapy to antihistamines or acupuncture,it may enhance the efficacy.Results drawn from these studies should be interpreted with caution and applied with care to clinical practice,because of the poor quality among the studies that were reviewed.Systematic review registration:PROSPERO,CRD42019137451. 展开更多
关键词 cupping Chronic urticaria Systematic review META-ANALYSIS ANTIHISTAMINES ACUPUNCTURE
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Repeated cupping manipulation temporary decreases natural killer lymphocyte frequency, activity and cytotoxicity 被引量:6
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作者 Boris V.Dons' koi Viktor P.C hernyshov +1 位作者 Dariia V.Osypchuk Sergiy M.Baksheev 《Journal of Integrative Medicine》 SCIE CAS CSCD 2016年第3期197-202,共6页
OBJECTIVE: Elevated natural killer lymphocyte cytotoxicity(NKc) has been linked with reproductive problems in women. Here we evaluate the potential benefit of cupping therapy(CT) in reproductionrelated immune res... OBJECTIVE: Elevated natural killer lymphocyte cytotoxicity(NKc) has been linked with reproductive problems in women. Here we evaluate the potential benefit of cupping therapy(CT) in reproductionrelated immune responses.METHODS: This was a pilot clinical study. Participants were he althy fe male volunteers(n = 23) with elevated NKc, and received repeated CT 3 times over 5 d(inner pressure 40–50 kPa, 40 min; 12–1 5 cups). Lymphocyte subsets, NKc and NK lymphocyte activity(NKa) were measured in blood on day 0(initial levels, before the first treatment) and days 3, 10 and 17 after the last CT treatment, using the K562-stimulated CD69 expression assay.RESULTS: As a result of CT manipulations NKa was reduced on days 3 and 10, and NK percentage was reduced on day 10. NKc was most sensitive to CT treatment, resulting in their decreased counts at 3, 10 and 17 d post CT. CT treatment decreased NKc in the majority of individuals(87%), but the magnitude of the effect was variable. Out of 23 subjects 9(39.1%) had a 2–3 fold decrease of NKc on days 3, 10 and 17; 11(47.8%) started to show a decrease in NKc later, or more quickly returned to base levels; and only 3(13%) subjects displayed no effect of CT on NKc. Expectedly, no changes in T-cell subsets(CD3CD4, CD3CD8, HLADR, CD158a) were observed after CT.CONCLUSION: CT decreased NK cell numbers, their activity and cytotoxicity. Low cost, safety, noninvasive nature and ease of administration make CT a promising approach for NKc down-regulation. 展开更多
关键词 killer cells natural CYTOTOXICITY cupping therapy
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Ninety cases of simple obesity treated with the combined therapy of penetration needling, flash-fire cupping method and auricular acupuncture 被引量:5
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作者 Juan WANG Yan LI +5 位作者 Xuan ZHANG Mei-na WANG Long CAO Na NU Yuan LI Gui-lan LI 《World Journal of Acupuncture-Moxibustion》 CSCD 2018年第4期287-290,313-314,共5页
Objective: To observe the clinical effects on simple obesity treated with the combined therapy of penetration needling, flash-fire cupping method and auricular acupuncture.Methods: In 90 patients of simple obesity, th... Objective: To observe the clinical effects on simple obesity treated with the combined therapy of penetration needling, flash-fire cupping method and auricular acupuncture.Methods: In 90 patients of simple obesity, the Bo’s abdominal acupuncture therapy was adopted. Taking Shénquè(神阙 CV 8), the points 2 cun directly below CV 8 and 2 cun directly above CV 8 as the landmarks, 3 cun bilateral to each of the above three points, and penetrated through to the conception vessel. Then the electroacupuncture apparatus was connected, with the disperse-dense wave for 30 min.After acupuncture, the glass cup of the middle size was used to stimulate the selected points with the flash-fire cupping method. The cupping stimulation stopped when the skin turned to be slightly red. One treatment was given each day and every other day after 5 days. The 10 treatments made one course. In the auricular acupuncture therapy, Jīdiǎn(饥点), Shénm6 n(神门TF4), NèiFēnmì(内分泌CO18) and S5 njiāo(三焦 CO17) were selected. The auricular acupuncture therapy was given once every two days and 10 treatments made one course. After 3 courses of treatment, the waist circumference, hip circumference,body weight and body mass index(BMI) were observed.Results: Compared to before treatment, after 3 courses of treatment, the waist circumference of patients was(92.3 ±2.4 vs 80.4 ±2.3) cm, hip circumference(110.6 士 2.3 vs 99.2 ±2.5) cm, body weight(74.2 ±3.1 vs 68.2 ±2.4) kg and BMI(29.8 士 3.1 vs 25.2 士 2.1), they were all reduced obviously, indicating the significant differences(all P<0.05). Seventy-nine patients lost three to five kilograms, accounting for 87.8%.Conclusion: The combined therapy of penetration needling at abdomen, flash-fire cupping method and auricular acupuncture achieves the significant therapeutic effects on simple obesity. 展开更多
关键词 Simple obesity Penetration needling Abdominal needle therapy cupping Auricular acupuncture therapy
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