Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,con...Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.展开更多
In June 2026,the FIFA World Cup will be jointly hosted by three countries for the first time,featur ing 48 teams and 104 matches across 16 cities in North Amer ica.For the United States,Canada,and Mexico,this is not o...In June 2026,the FIFA World Cup will be jointly hosted by three countries for the first time,featur ing 48 teams and 104 matches across 16 cities in North Amer ica.For the United States,Canada,and Mexico,this is not only a sporting event but also a well-planned“economic feast.”展开更多
Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with mediu...Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with medium-sized cups with a volume of 260 mL The randomly selected Xinshu（心俞 BL 15）on one side（37 cases） was given cupping treatment while that on the other side as the control.And Shenshu（肾俞 BL 23）（6 cases） was treated in the same way.The thermal infrared imager was used to record the changes in localized skin temperature before and after cupping（for 10 minutes）,and then comparison was made with that of the control side.Results After cupping,the localized skin temperature fell and then rose.When the cup was removed after retaining for 10 minutes,the localized skin temperature was（0.4±0.9） ℃（P=0.004） lower than that before cupping;10 minutes after cupping off,the localized skin temperature was（0.4±1.1） ℃（P=0.016） higher than that before cupping while（0.8±0.9） ℃ higher than that when cupping off.The skin surface temperature on the control side declined steadily.Conclusion After cupping treatment,the localized skin temperature fell and then rose while that of the control side declined steadily.It might be related to therapeutic effects.展开更多
[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patie...[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patients diagnosed with CSR who received treatment at the International Mongolian Hospital of Inner Mongolia between October 2021 and October 2022 were selected and randomly divided into two groups:A test group and a control group,with 60 patients in each group.The patients in the test group received Mongolian medicine silver needle combined with cupping and bloodletting therapy,following the principles of syndrome differentiation in Mongolian medicine.In contrast,the patients in the control group received only the Mongolian medicine silver needle therapy.After treatment,the Mongolian medicine syndrome scores,visual analogue scale(VAS)scores,and total clinical therapeutic effects in the two groups of patients were compared both prior to and following the treatment.[Results]The improvement in VAS and Mongolian medicine syndrome scores in the test group was greater than that in the control group,with a statistically significant difference(P<0.05).The scores of the test group surpassed those of the control group,and this difference was also statistically significant(P<0.05).Furthermore,the overall therapeutic effect in the test group was 93.33%,which was markedly higher than 76.67%observed in the control group(P<0.05).[Conclusions]The therapeutic effect of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of CSR is remarkable.This approach has demonstrated efficacy in alleviating patient pain and improving the functionality of the cervical vertebrae,thereby warranting clinical promotion and application.展开更多
OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated ...OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated literature searching in 7 databases was conducted from January 2014 to January 2023.Two authors extracted data and assessed the risk of bias independently.Statistical analysis was performed using RevMan 5.4.1 software(Cochrane Collaboration,London,UK).Meta-analysis with a random effect model was conducted when there was no serious statistical heterogeneity among trials(I^(2) ≤ 75%).Grading of Recommendations Assessment,Development,and Evaluation was also conducted to assess the quality of evidence.RESULTS:Seventy-two trials with 5720 participants were included.All included trials were assessed as having high risk of bias.The majority of the included trials reported the benefit of cupping plus other therapy or cupping alone on improving cure rate(average risk ratio more than 1.15) and reducing visual analogue scale [average mean difference(MD) reduction 0.16 to 7.0 cm],improving quality of life,quality of sleep or other symptoms related to pain condition.And there was low/very low quality evidence that the incidence of adverse events in the cupping groups were lower than that in the control groups.Although the heterogeneity between studies and the methodological quality of the study itself lead to the low evidence strength of the current conclusions,the results of this study are a valuable supplement to the founding of previous review.CONCLUSION:Cupping therapy alone or combined with other therapy was considered benefit in relieving pain,improving the quality of life,and increasing the cure rate of patients with pain conditions,though supported by the low quality of evidence.According to the limited evidence,cupping therapy seems to have less harm than drugs when treating pain conditions.展开更多
BACKGROUND Clinical studies using Trabecular Titanium™acetabular cups have shown promising short and medium-term results.This material,due to its macro and micro surface roughness,provides a substrate for osseointegra...BACKGROUND Clinical studies using Trabecular Titanium™acetabular cups have shown promising short and medium-term results.This material,due to its macro and micro surface roughness,provides a substrate for osseointegration and enhances implant stability.However,there is a lack of evidence in the literature on the use of this material in patients with femoral neck fracture.AIM To evaluate the short-term clinical-functional and radiographic outcomes in patients with femoral neck fractures undergoing total hip arthroplasty(THA)with Trabecular Titanium™acetabular cup implants.METHODS The study included 104 patients with medial femoral neck fractures who underwent THA between January 2020 and December 2020 with the Delta TT acetabular cup(Lima Corporate,Villanova di San Daniele del Friuli,Italy).The mean age of the patients was 69.57±10.16 years(range:36-85 years).The followup period ranged from a minimum of 3 to a maximum of 4 years.Three questionnaires(Harris Hip Score,Oxford Hip Score,and EQ5D)were administered along with radiographic evaluations.Statistical methods included the Student's t-test and one-way analysis of variance for comparisons(with significance set at 0.05),and the Kaplan-Meier curve for prosthetic implant survival.RESULTS The mean follow-up was 41.5 months.The Harris Hip Score(HHS)showed a mean increase of 2.74 points(mean HHS 88.52 at 6 months postoperatively and mean HHS 91.26 at the last follow-up)with statistical significance.Similarly,the Oxford Hip Score demonstrated a statistically significant difference between follow-up groups.However,the EQ5D did not show statistically significant differences among the three groups(preoperative,6-month follow-up,and last follow-up).Revision surgery was required in 6 patients.According to Moore's criteria,96%of the acetabular components were radiographically stable and well-integrated at the last follow-up.The Kaplan-Meier curve showed a 96%survival rate.CONCLUSION The clinical and radiographic results obtained in the short to medium term confirm the excellent performance of the Delta TT acetabular cup in terms of osseointegration,providing an optimal solution both for young patients with high functional recovery demands and for fragile patients requiring optimal stability of the acetabular component to reduce the risk of implant failure.展开更多
AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were i...AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were isolated from optic cups of rats on embryonic day 12.5,and high-purity OC-RSCs were obtained by conditioned culture and passage.Differentiation of OC-RSCs into RGCs under different serum concentrations was examined using flow cytometry,and the serum concentration with high interference with differentiation ratio was selected.Furthermore,the effect of blocking IGF-1Rαon the differentiation of OC-RSCs into RGCs was analyzed through immunocytochemistry and Western blotting.RESULTS:Immunohistochemical analysis revealed IGF-1Rαwas highly expressed in rat embryos at day 12.5.OC-RSCs were isolated and purified,and high-purity OCRSCs were obtained.When 2.5%serum was administered,the ratio of differentiated RGCs(Thy-1.1 positive)decreased significantly,and the results of immunoblotting also confirmed the blockade of IGF-1Rαreduced Thy-1.1 protein expression.CONCLUSION:IGF-1Rαblocking can reduce the differentiation of OC-RSCs into RGCs.展开更多
Objective To observe the clinical effects of simple obesity treated with needling and quick cupping therapy at the selected eight points around umbilicus. Methods Ninety-five cases were randomly allocated into an obse...Objective To observe the clinical effects of simple obesity treated with needling and quick cupping therapy at the selected eight points around umbilicus. Methods Ninety-five cases were randomly allocated into an observation group and a control group. In observation group （n=50） patients were treated with acupuncture and quick cupping therapy at the selected eight points around umbilicus, namely Huaroumen （滑肉门 ST 24）, Tianshu （天枢 ST 25）,Wailing （外陵 ST 26）,Shuifen （水分 CV 9）, and Yinjiao（阴交 CV 7）.In control group （n=45） patients were advised to take Sibutramine, an oral administration to suppress appetite. Relevant data concerning one＇s weight, body mass index （BMI）, waist hip ratio （WHR） and distribution rate of body fat （F%） before treatment and after eight weeks＇ of treatment were collected to observe the effects. Results The total effective rate was 98.0%（49/50） in the observation group and 97.8%（44/45） in the control group. There was no significant difference on body weight and BMI between the two groups （P〉0.05）, however the therapeutic effects on WHR and F% in the observation group were more satisfactory than those of the control group （P〈0.05）. Conclusion Acupuncture and quick cupping therapy at the selected eight points around umbilicus have a good therapeutic effect on simple obesity, moreover acupuncture and quick cupping therapy can greatly improve the condition of WHR and F% for obesity patients, which is also safe and without any side effect.展开更多
Objective To observe the application of acupuncture at distal points combined with medicated cupping on the affected parts in the treatment of temporomandibular disorders（TMD） and to evaluate its effectiveness. Meth...Objective To observe the application of acupuncture at distal points combined with medicated cupping on the affected parts in the treatment of temporomandibular disorders（TMD） and to evaluate its effectiveness. Methods A total of 120 patients with TMD were randomly divided into two groups according to the random number table and random number remainder method. Sixty-two patients in acupuncture combined with cupping group（group A） were treated with acupuncture at Hég（合谷 LI 4） and Tàichōng（太冲 LR 3） combined with medicated cupping on the affected parts with Sānqī（三七 Radix et Rhizoma Notoginseng） and Báizh（白芷 Radix Angelicae Dahuricae）. Fifty-eight patients in cupping group（group B） were just treated with medicated cupping. Patients were treated for 30 min each time, once daily, and 10 times were considered as one course of treatment. After one course of treatment, the therapeutic effect was evaluated. Before and after treatment, craniomandihular index（CMI）, dysfunction index（DI）, palpation index（Pl） and changes in pain degree（VAS score） were compared. Results Before and after treatment, CMI in group A were 0.27±0.02 and 0.04±0.01, respectively, and in group B were 0.29±0.02 and 0.06±0.01, respectively; PI in group A were 0.19±0.01 and 0.05±0.03, respectively, and in group B were 0.18±0.02 and 0.11±0.02, respectively; DI in group A were 0.33±0.04 and 0.06±0.02, respectively, and in group B were 0.34±0.05 and 0.11±0.04, respectively; VAS in group A were 5.39±0.24 and 2.13±0.47, respectively, and in group B were 5.70±0.31 and 3.97±0.26, respectively. After treatment, CMI, DI, PI and VAS in both groups significantly decreased when compared with those before treatment（all P0.01）, and the indices in group A were significantly lower than that in group B after treatment（all P0.05）, indicating that the difference was significant. Conclusion The therapeutic effect of acupuncture at distal points combined with cupping at adjacent points in treatment of TMD is superior to that of single medicated cupping therapy.展开更多
Objective To observe clinical efficacy of acupuncture-moxibustion combined with cupping on postsurgical gastroparesis of abdominal cancer. Methods Thirty-six cases of postsurgical gastroparesis of abdominal cancer wer...Objective To observe clinical efficacy of acupuncture-moxibustion combined with cupping on postsurgical gastroparesis of abdominal cancer. Methods Thirty-six cases of postsurgical gastroparesis of abdominal cancer were treated with （1） acupuncture at Weishiu （胃俞 BL 21）, Shangwan （上脘 CV 13）, Zhangwan （中脘CV 12）, Xiawan （下脘 CV 10） and Tianshu （天枢 ST 25） to dredging the meridians, （2） quick cupping on local area to promote gastrointestinal motility and （3） mild moxibustion at CV 12, Shanque （神阙 CV 8） and Zusanli （足三里 ST 36）. The treatment was given once a day, 5 times made a course. The clinical efficacy was assessed after two courses of treatment. Results After the treatment, 27 cases were cured, 6 cases were effective and 3 cases were failed, and the total effective rate was 91.7% （33/36）. Conclusion The acupuncture-moxibustion combined with cupping has remarkable clinical efficacy on postsurgical gastroparesis of abdominal cancer.展开更多
Objective To observe the clinical efficacy of treating postherpetic neuralgia （PHN） by combining floating-acupuncture laser with cupping following collateral bloodletting, and to analyze its mechanism. Method One hu...Objective To observe the clinical efficacy of treating postherpetic neuralgia （PHN） by combining floating-acupuncture laser with cupping following collateral bloodletting, and to analyze its mechanism. Method One hundred and thirty cases of PHN were randomly divided into a floating-acupuncture laser with cupping following collateral bloodletting group （group A） and an electroacupuncture group （group B） based on the treatment sequence and according to the random number table, with 65 cases in each group. In the group B, G-6805 electroacupuncture apparatus was adopted after the arrival of qi through even reinforcing and reducing （even method） in such acupoints as Hegu （合俗 LI 4）, Taihong （太冲 LR 3）, Zhigou （支沟 TE 6）, Quchi （ 曲池 LI 11） and Zusanli （足三里 ST 36）; in the group A, the treatment combining floatingacupuncture laser with cupping following collateral bloodletting was adopted, and the score of VAS and clinical efficacy before and after treatment in the two groups were compared. Result The differences of VAS scores of the two groups between the time points of after one course of treatment, after the entire treatment, follow up visit three months after the treatment and before treatment were statistically significant （all P〈0.05）. The rate of significant efficiency and total effective rate in the group A were respectively 37.8% and 98.5% （64/65）, and 11.2% and 78.5% （52/65） in the group B. The difference between the two groups was statistically significant after Ridit analysis （P〈0.05）. Conclusion The efficacy of treating PHN by combining floating-acupuncture laser with cupping following collateral bloodletting was significant.展开更多
Objective To explore the clinical efficacy of acupuncture combined with vesiculating cupping in treatment of rheumatoid arthritis（RA）. Methods A total of 110 patients with RA were randomly divided into an acupunctur...Objective To explore the clinical efficacy of acupuncture combined with vesiculating cupping in treatment of rheumatoid arthritis（RA）. Methods A total of 110 patients with RA were randomly divided into an acupuncture combined with vesiculating cupping group（group A） and an acupuncture combined with non-vesiculating cupping group（group B）. Treatment was conducted once a day in two groups, and ten days were considered as one course of treatment. The total effective rate was observed after treatment for three courses. Results The difference in cured and markable effective rate of group A and group B was obviously significant [81.82%（45/55） vs 18.18%（10/55）, P〈0.01], the difference in total effective rate of group A and group B was significant [96.36%（53/55） vs 69.09%（38/55）, P〈0.05], indicating that the efficacy in group A was significantly superior to that of group B. Conclusion Acupurcture combined with vesiculating cupping therapy achieves more satisfactory efficacy on RA compared with acupuncture combined with nonvesiculating cupping therapy.展开更多
Objective:To observe the clinical effect of electroacupuncture(EA)at Zhouling(Extra)and Ashi points in combination with blood-letting cupping for the treatment of external humeral epicondylitis(EHE).Methods:Thirty EHE...Objective:To observe the clinical effect of electroacupuncture(EA)at Zhouling(Extra)and Ashi points in combination with blood-letting cupping for the treatment of external humeral epicondylitis(EHE).Methods:Thirty EHE patients were treated with EA at Zhouling(Extra)and Ashi points in combination with blood-letting cupping,once every 2 days,twice a week,4 times as one course of treatment,and2 successive courses of treatment were given.Before treatment,after 1 course of treatment,and after 2 courses of treatment,the visual analogue scale(VAS)score and Mayo elbow performance score(MEPS)were adopted to evaluate the curative effect.Results:Before treatment,the VAS score of patients was 7.81±1.39.After 1 course of treatment and after 2 courses of treatment,it was 4.77±1.56 and 2.95±1.23 respectively,lowered than before treatment,and the difference was statistically significant(both P<0.01).Before treatment,the Mayo score of patients was 32.17±19.31.After 1 course of treatment and after 2 courses of treatment,it was 47.39±19.85 and85.21±20.47 respectively,increased than before treatment,and the difference was statistically significant(both P<0.01).Of the 30 patients,5 were cured,accounting for 16.67%;14 cases obviously effective,accounting for 46.67%;8 cases effective,accounting for 26.67%;3 cases ineffective,accounting for 10.00%,and the total effective rate was 90.00%.Conclusion:EA at Zhouling(Extra)and Ashi points and blood-letting cupping used in combination are remarkably effective in the treatment of EHE,being worthy for popularization.展开更多
233 cases of arthralgia-syndrome were randomly divided into five treatment groupswith double blind method:1)acupuncture pills cupping;2)acupoint medicinal injection;3)acupointmedicinal injection plus laser radiation;4...233 cases of arthralgia-syndrome were randomly divided into five treatment groupswith double blind method:1)acupuncture pills cupping;2)acupoint medicinal injection;3)acupointmedicinal injection plus laser radiation;4)acupoint medicinal injection plus field effect,and 5)electroacupuncture(EA)plus cupping for observation of the therapeutic effect.The total effective ratewas 89.2％.No significant differences were found among the five groups in the total effective rate.But,the markedly effective rate was highest in the acupoint medicinal injection plus field effect group.And the therapeutic effect in patients with pain arthralgia and migratory arthralgia and shorter courseof disease was best.展开更多
High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the diffe...High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the difference in grinding style between the cup wheel and the conventional external wheel. So the grit grinding process of the cup wheel is studied, and a new concept of the effective grinding width of the cup wheel is presented. Then the grinding force in grinding WC-Co coating materials by cup wheel is analyzed and a theoretical formula is deduced. Finally, experimental results of the grinding force verify the correctness and the precision of the theoretical formula.展开更多
Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at D...Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at Dhzhui （大椎 GV 14） and bilateral Dazhu （大杼 BL 11） for 10 min in healthy subject. Blood flow monitoring video system of laser speckle was used to record blood flow of GV 14, Shenzhu （身柱 GV 12）, bilateral Feishu （肺俞 BL 13） and Xinshu （心俞 BL 15） before cupping therapy, immediate time of cupping removal and 5 min, 10 rain, 15 min, 20 min, 25 rain and 30 rain after cupping removal. Results Compared before cupping therapy, the blood flow of GV 14, GV 12 and bilateral BL 13 was obviously increased at immediate time of cupping removal （all P〈0.05）. Compared with immediate time of cupping removal, the blood flow of GV 14 at each time point after 20 rain of cupping removal, GV 12 at 10 min and 15 min after cupping removal, bilateral BL 13 at each time point after cupping removal was all obviously decreased （all P〈0.05）. The difference of blood flow of Shendao （神道 GV 11） and bilateral BL 15 before and after cupping therapy was not significantly different （all P〉0.05）. Conclusion The cupping therapy could adjust skin blood flow, which is more obvious near the cupping area.展开更多
Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation g...Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation group （45 cases） and a control group （45 cases）. Basic treatments selected according to corresponding stroke units were applied to both groups. Besides, scalp acupuncture at Dingnie Qianxiexian （MS 6, 顶颞前斜线）, Dingnie Houxiexian （MS 6, 顶颞前斜线） and Dingzhongxian （NS 5, 顶中线）, was applied in the treatment group. In the observation group, active and passive movement was carried out during the process of scalp acupuncture, and then needling plus bloodletting puncturing and cupping was applied. In the control group, only needling plus blood-letting puncturing and cupping was given. Therapeutic effects, pain scoring obtained by visual analogue scales （VAS）, FugI-Meyer and FugI-Meyer＇s scoring reflecting moving functions of upper limbs were made after 4 courses of treatments in both groups. Results The total effective rate was 95.5% and 91.1% in the observation group and control group, respectively, showing superiority of the former to the latter （P〈0.05）. After treatment, VAS scores were all obviously reduced in both groups （P〈0.01）, and the reduction in the former was significantly more than that in the latter （P〈0.01）. Moving functions of upper limbs shown by Fugl-Meyer＇s scoring were improved after 2 courses of treatment in both groups （P〈0.01）. The improvement was more obvious after 4 courses of treatment than that after 2 courses of treatment in both groups （P〈0.05）. After 4 courses of treatment, moving functions shown by FugI-Meyer＇s scoring were more remarkably improved in the observation group than those in the control group（t=3.9, P〈0.01）. Conclusion Both kinetic needling combined with needling plus blood-letting puncturing and cupping and simple needling plus blood-letting puncturing and cupping are effective in treating shoulder-hand syndrome after apoplexy, and the former is better than the latter.展开更多
基金supported by National Research Foundation of Korea(NRF)grants funded by the Korean government(MSIT)(No.RS-2023-00256265,RS-2024-00352352,RS-2024-00405818)the Korean Fund for Regenerative Medicine(KFRM)grant funded by the Korea government(the Ministry of Science and ICT,the Ministry of Health&Welfare).(No.25A0102L1)support from the Market-led K-sensor technology program(RS-2022-00154781,Development of large-area wafer-level flexible/stretchable hybrid sensor platform technology for form factor-free highly integrated convergence sensor),funded By the Ministry of Trade,Industry&Energy(MOTIE,Korea).
文摘Microneedles(MNs)have been extensively investigated for transdermal delivery of large-sized drugs,including proteins,nucleic acids,and even extracellular vesicles(EVs).However,for their sufficient skin penetration,conventional MNs employ long needles(≥600μm),leading to pain and skin irritation.Moreover,it is critical to stably apply MNs against complex skin surfaces for uniform nanoscale drug delivery.Herein,a dually amplified transdermal patch(MN@EV/SC)is developed as the stem cell-derived EV delivery platform by hierarchically integrating an octopusinspired suction cup(SC)with short MNs(≤300μm).While leveraging the suction effect to induce nanoscale deformation of the stratum corneum,MN@EV/SC minimizes skin damage and enhances the adhesion of MNs,allowing EV to penetrate deeper into the dermis.When MNs of various lengths are applied to mouse skin,the short MNs can elicit comparable corticosterone release to chemical adhesives,whereas long MNs induce a prompt stress response.MN@EV/SC can achieve a remarkable penetration depth(290μm)for EV,compared to that of MN alone(111μm).Consequently,MN@EV/SC facilitates the revitalization of fibroblasts and enhances collagen synthesis in middle-aged mice.Overall,MN@EV/SC exhibits the potential for skin regeneration by modulating the dermal microenvironment and ensuring patient comfort.
文摘In June 2026,the FIFA World Cup will be jointly hosted by three countries for the first time,featur ing 48 teams and 104 matches across 16 cities in North Amer ica.For the United States,Canada,and Mexico,this is not only a sporting event but also a well-planned“economic feast.”
文摘Objective To preliminarily observe the effects of cupping on localized skin temperature of patients with back pain.Methods A total of 43 patients with back pain were included in this study.They were treated with medium-sized cups with a volume of 260 mL The randomly selected Xinshu（心俞 BL 15）on one side（37 cases） was given cupping treatment while that on the other side as the control.And Shenshu（肾俞 BL 23）（6 cases） was treated in the same way.The thermal infrared imager was used to record the changes in localized skin temperature before and after cupping（for 10 minutes）,and then comparison was made with that of the control side.Results After cupping,the localized skin temperature fell and then rose.When the cup was removed after retaining for 10 minutes,the localized skin temperature was（0.4±0.9） ℃（P=0.004） lower than that before cupping;10 minutes after cupping off,the localized skin temperature was（0.4±1.1） ℃（P=0.016） higher than that before cupping while（0.8±0.9） ℃ higher than that when cupping off.The skin surface temperature on the control side declined steadily.Conclusion After cupping treatment,the localized skin temperature fell and then rose while that of the control side declined steadily.It might be related to therapeutic effects.
基金Supported by Project of Science and Technology Department of Inner Mongolia Autonomous Region(2019GG125).
文摘[Objectives]To observe the clinical efficacy of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of cervical spondylotic radiculopathy(CSR).[Methods]A total of 120 patients diagnosed with CSR who received treatment at the International Mongolian Hospital of Inner Mongolia between October 2021 and October 2022 were selected and randomly divided into two groups:A test group and a control group,with 60 patients in each group.The patients in the test group received Mongolian medicine silver needle combined with cupping and bloodletting therapy,following the principles of syndrome differentiation in Mongolian medicine.In contrast,the patients in the control group received only the Mongolian medicine silver needle therapy.After treatment,the Mongolian medicine syndrome scores,visual analogue scale(VAS)scores,and total clinical therapeutic effects in the two groups of patients were compared both prior to and following the treatment.[Results]The improvement in VAS and Mongolian medicine syndrome scores in the test group was greater than that in the control group,with a statistically significant difference(P<0.05).The scores of the test group surpassed those of the control group,and this difference was also statistically significant(P<0.05).Furthermore,the overall therapeutic effect in the test group was 93.33%,which was markedly higher than 76.67%observed in the control group(P<0.05).[Conclusions]The therapeutic effect of Mongolian medicine silver needle combined with cupping and bloodletting therapy in the treatment of CSR is remarkable.This approach has demonstrated efficacy in alleviating patient pain and improving the functionality of the cervical vertebrae,thereby warranting clinical promotion and application.
基金National Natural Science Foundation of China Project:Research on the Correlation between Traditional Chinese Medicine Constitution,Cupping Marks Color,and Clinical Efficacy Based on Regression Models (No.81804000)。
文摘OBJECTIVE:To update the current best evidence on the effectiveness and safety of cupping therapy in pain management.METHODS:The protocol of this systematic review was registered at PROSPERO(CRD42021261308).An updated literature searching in 7 databases was conducted from January 2014 to January 2023.Two authors extracted data and assessed the risk of bias independently.Statistical analysis was performed using RevMan 5.4.1 software(Cochrane Collaboration,London,UK).Meta-analysis with a random effect model was conducted when there was no serious statistical heterogeneity among trials(I^(2) ≤ 75%).Grading of Recommendations Assessment,Development,and Evaluation was also conducted to assess the quality of evidence.RESULTS:Seventy-two trials with 5720 participants were included.All included trials were assessed as having high risk of bias.The majority of the included trials reported the benefit of cupping plus other therapy or cupping alone on improving cure rate(average risk ratio more than 1.15) and reducing visual analogue scale [average mean difference(MD) reduction 0.16 to 7.0 cm],improving quality of life,quality of sleep or other symptoms related to pain condition.And there was low/very low quality evidence that the incidence of adverse events in the cupping groups were lower than that in the control groups.Although the heterogeneity between studies and the methodological quality of the study itself lead to the low evidence strength of the current conclusions,the results of this study are a valuable supplement to the founding of previous review.CONCLUSION:Cupping therapy alone or combined with other therapy was considered benefit in relieving pain,improving the quality of life,and increasing the cure rate of patients with pain conditions,though supported by the low quality of evidence.According to the limited evidence,cupping therapy seems to have less harm than drugs when treating pain conditions.
文摘BACKGROUND Clinical studies using Trabecular Titanium™acetabular cups have shown promising short and medium-term results.This material,due to its macro and micro surface roughness,provides a substrate for osseointegration and enhances implant stability.However,there is a lack of evidence in the literature on the use of this material in patients with femoral neck fracture.AIM To evaluate the short-term clinical-functional and radiographic outcomes in patients with femoral neck fractures undergoing total hip arthroplasty(THA)with Trabecular Titanium™acetabular cup implants.METHODS The study included 104 patients with medial femoral neck fractures who underwent THA between January 2020 and December 2020 with the Delta TT acetabular cup(Lima Corporate,Villanova di San Daniele del Friuli,Italy).The mean age of the patients was 69.57±10.16 years(range:36-85 years).The followup period ranged from a minimum of 3 to a maximum of 4 years.Three questionnaires(Harris Hip Score,Oxford Hip Score,and EQ5D)were administered along with radiographic evaluations.Statistical methods included the Student's t-test and one-way analysis of variance for comparisons(with significance set at 0.05),and the Kaplan-Meier curve for prosthetic implant survival.RESULTS The mean follow-up was 41.5 months.The Harris Hip Score(HHS)showed a mean increase of 2.74 points(mean HHS 88.52 at 6 months postoperatively and mean HHS 91.26 at the last follow-up)with statistical significance.Similarly,the Oxford Hip Score demonstrated a statistically significant difference between follow-up groups.However,the EQ5D did not show statistically significant differences among the three groups(preoperative,6-month follow-up,and last follow-up).Revision surgery was required in 6 patients.According to Moore's criteria,96%of the acetabular components were radiographically stable and well-integrated at the last follow-up.The Kaplan-Meier curve showed a 96%survival rate.CONCLUSION The clinical and radiographic results obtained in the short to medium term confirm the excellent performance of the Delta TT acetabular cup in terms of osseointegration,providing an optimal solution both for young patients with high functional recovery demands and for fragile patients requiring optimal stability of the acetabular component to reduce the risk of implant failure.
文摘AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were isolated from optic cups of rats on embryonic day 12.5,and high-purity OC-RSCs were obtained by conditioned culture and passage.Differentiation of OC-RSCs into RGCs under different serum concentrations was examined using flow cytometry,and the serum concentration with high interference with differentiation ratio was selected.Furthermore,the effect of blocking IGF-1Rαon the differentiation of OC-RSCs into RGCs was analyzed through immunocytochemistry and Western blotting.RESULTS:Immunohistochemical analysis revealed IGF-1Rαwas highly expressed in rat embryos at day 12.5.OC-RSCs were isolated and purified,and high-purity OCRSCs were obtained.When 2.5%serum was administered,the ratio of differentiated RGCs(Thy-1.1 positive)decreased significantly,and the results of immunoblotting also confirmed the blockade of IGF-1Rαreduced Thy-1.1 protein expression.CONCLUSION:IGF-1Rαblocking can reduce the differentiation of OC-RSCs into RGCs.
文摘Objective To observe the clinical effects of simple obesity treated with needling and quick cupping therapy at the selected eight points around umbilicus. Methods Ninety-five cases were randomly allocated into an observation group and a control group. In observation group （n=50） patients were treated with acupuncture and quick cupping therapy at the selected eight points around umbilicus, namely Huaroumen （滑肉门 ST 24）, Tianshu （天枢 ST 25）,Wailing （外陵 ST 26）,Shuifen （水分 CV 9）, and Yinjiao（阴交 CV 7）.In control group （n=45） patients were advised to take Sibutramine, an oral administration to suppress appetite. Relevant data concerning one＇s weight, body mass index （BMI）, waist hip ratio （WHR） and distribution rate of body fat （F%） before treatment and after eight weeks＇ of treatment were collected to observe the effects. Results The total effective rate was 98.0%（49/50） in the observation group and 97.8%（44/45） in the control group. There was no significant difference on body weight and BMI between the two groups （P〉0.05）, however the therapeutic effects on WHR and F% in the observation group were more satisfactory than those of the control group （P〈0.05）. Conclusion Acupuncture and quick cupping therapy at the selected eight points around umbilicus have a good therapeutic effect on simple obesity, moreover acupuncture and quick cupping therapy can greatly improve the condition of WHR and F% for obesity patients, which is also safe and without any side effect.
文摘Objective To observe the application of acupuncture at distal points combined with medicated cupping on the affected parts in the treatment of temporomandibular disorders（TMD） and to evaluate its effectiveness. Methods A total of 120 patients with TMD were randomly divided into two groups according to the random number table and random number remainder method. Sixty-two patients in acupuncture combined with cupping group（group A） were treated with acupuncture at Hég（合谷 LI 4） and Tàichōng（太冲 LR 3） combined with medicated cupping on the affected parts with Sānqī（三七 Radix et Rhizoma Notoginseng） and Báizh（白芷 Radix Angelicae Dahuricae）. Fifty-eight patients in cupping group（group B） were just treated with medicated cupping. Patients were treated for 30 min each time, once daily, and 10 times were considered as one course of treatment. After one course of treatment, the therapeutic effect was evaluated. Before and after treatment, craniomandihular index（CMI）, dysfunction index（DI）, palpation index（Pl） and changes in pain degree（VAS score） were compared. Results Before and after treatment, CMI in group A were 0.27±0.02 and 0.04±0.01, respectively, and in group B were 0.29±0.02 and 0.06±0.01, respectively; PI in group A were 0.19±0.01 and 0.05±0.03, respectively, and in group B were 0.18±0.02 and 0.11±0.02, respectively; DI in group A were 0.33±0.04 and 0.06±0.02, respectively, and in group B were 0.34±0.05 and 0.11±0.04, respectively; VAS in group A were 5.39±0.24 and 2.13±0.47, respectively, and in group B were 5.70±0.31 and 3.97±0.26, respectively. After treatment, CMI, DI, PI and VAS in both groups significantly decreased when compared with those before treatment（all P0.01）, and the indices in group A were significantly lower than that in group B after treatment（all P0.05）, indicating that the difference was significant. Conclusion The therapeutic effect of acupuncture at distal points combined with cupping at adjacent points in treatment of TMD is superior to that of single medicated cupping therapy.
文摘Objective To observe clinical efficacy of acupuncture-moxibustion combined with cupping on postsurgical gastroparesis of abdominal cancer. Methods Thirty-six cases of postsurgical gastroparesis of abdominal cancer were treated with （1） acupuncture at Weishiu （胃俞 BL 21）, Shangwan （上脘 CV 13）, Zhangwan （中脘CV 12）, Xiawan （下脘 CV 10） and Tianshu （天枢 ST 25） to dredging the meridians, （2） quick cupping on local area to promote gastrointestinal motility and （3） mild moxibustion at CV 12, Shanque （神阙 CV 8） and Zusanli （足三里 ST 36）. The treatment was given once a day, 5 times made a course. The clinical efficacy was assessed after two courses of treatment. Results After the treatment, 27 cases were cured, 6 cases were effective and 3 cases were failed, and the total effective rate was 91.7% （33/36）. Conclusion The acupuncture-moxibustion combined with cupping has remarkable clinical efficacy on postsurgical gastroparesis of abdominal cancer.
文摘Objective To observe the clinical efficacy of treating postherpetic neuralgia （PHN） by combining floating-acupuncture laser with cupping following collateral bloodletting, and to analyze its mechanism. Method One hundred and thirty cases of PHN were randomly divided into a floating-acupuncture laser with cupping following collateral bloodletting group （group A） and an electroacupuncture group （group B） based on the treatment sequence and according to the random number table, with 65 cases in each group. In the group B, G-6805 electroacupuncture apparatus was adopted after the arrival of qi through even reinforcing and reducing （even method） in such acupoints as Hegu （合俗 LI 4）, Taihong （太冲 LR 3）, Zhigou （支沟 TE 6）, Quchi （ 曲池 LI 11） and Zusanli （足三里 ST 36）; in the group A, the treatment combining floatingacupuncture laser with cupping following collateral bloodletting was adopted, and the score of VAS and clinical efficacy before and after treatment in the two groups were compared. Result The differences of VAS scores of the two groups between the time points of after one course of treatment, after the entire treatment, follow up visit three months after the treatment and before treatment were statistically significant （all P〈0.05）. The rate of significant efficiency and total effective rate in the group A were respectively 37.8% and 98.5% （64/65）, and 11.2% and 78.5% （52/65） in the group B. The difference between the two groups was statistically significant after Ridit analysis （P〈0.05）. Conclusion The efficacy of treating PHN by combining floating-acupuncture laser with cupping following collateral bloodletting was significant.
文摘Objective To explore the clinical efficacy of acupuncture combined with vesiculating cupping in treatment of rheumatoid arthritis（RA）. Methods A total of 110 patients with RA were randomly divided into an acupuncture combined with vesiculating cupping group（group A） and an acupuncture combined with non-vesiculating cupping group（group B）. Treatment was conducted once a day in two groups, and ten days were considered as one course of treatment. The total effective rate was observed after treatment for three courses. Results The difference in cured and markable effective rate of group A and group B was obviously significant [81.82%（45/55） vs 18.18%（10/55）, P〈0.01], the difference in total effective rate of group A and group B was significant [96.36%（53/55） vs 69.09%（38/55）, P〈0.05], indicating that the efficacy in group A was significantly superior to that of group B. Conclusion Acupurcture combined with vesiculating cupping therapy achieves more satisfactory efficacy on RA compared with acupuncture combined with nonvesiculating cupping therapy.
基金National Natural Science Foundation of China:81774402。
文摘Objective:To observe the clinical effect of electroacupuncture(EA)at Zhouling(Extra)and Ashi points in combination with blood-letting cupping for the treatment of external humeral epicondylitis(EHE).Methods:Thirty EHE patients were treated with EA at Zhouling(Extra)and Ashi points in combination with blood-letting cupping,once every 2 days,twice a week,4 times as one course of treatment,and2 successive courses of treatment were given.Before treatment,after 1 course of treatment,and after 2 courses of treatment,the visual analogue scale(VAS)score and Mayo elbow performance score(MEPS)were adopted to evaluate the curative effect.Results:Before treatment,the VAS score of patients was 7.81±1.39.After 1 course of treatment and after 2 courses of treatment,it was 4.77±1.56 and 2.95±1.23 respectively,lowered than before treatment,and the difference was statistically significant(both P<0.01).Before treatment,the Mayo score of patients was 32.17±19.31.After 1 course of treatment and after 2 courses of treatment,it was 47.39±19.85 and85.21±20.47 respectively,increased than before treatment,and the difference was statistically significant(both P<0.01).Of the 30 patients,5 were cured,accounting for 16.67%;14 cases obviously effective,accounting for 46.67%;8 cases effective,accounting for 26.67%;3 cases ineffective,accounting for 10.00%,and the total effective rate was 90.00%.Conclusion:EA at Zhouling(Extra)and Ashi points and blood-letting cupping used in combination are remarkably effective in the treatment of EHE,being worthy for popularization.
文摘233 cases of arthralgia-syndrome were randomly divided into five treatment groupswith double blind method:1)acupuncture pills cupping;2)acupoint medicinal injection;3)acupointmedicinal injection plus laser radiation;4)acupoint medicinal injection plus field effect,and 5)electroacupuncture(EA)plus cupping for observation of the therapeutic effect.The total effective ratewas 89.2％.No significant differences were found among the five groups in the total effective rate.But,the markedly effective rate was highest in the acupoint medicinal injection plus field effect group.And the therapeutic effect in patients with pain arthralgia and migratory arthralgia and shorter courseof disease was best.
文摘High machining precision and machining efficiency can be obtained in grinding WC-Co coating by cup wheel. The conventional model of the grinding force is not suitable for the grinding of the cup wheel due to the difference in grinding style between the cup wheel and the conventional external wheel. So the grit grinding process of the cup wheel is studied, and a new concept of the effective grinding width of the cup wheel is presented. Then the grinding force in grinding WC-Co coating materials by cup wheel is analyzed and a theoretical formula is deduced. Finally, experimental results of the grinding force verify the correctness and the precision of the theoretical formula.
基金Supported by Natural Science Foundaion of China in 2012(No.81273673)
文摘Objective To observe the effects of cupping on blood flow under different skins of back in healthy human. Methods With meridian-cupping dredging apparatus to set cupping pressure at -0.04 MPa, cupping was applied at Dhzhui （大椎 GV 14） and bilateral Dazhu （大杼 BL 11） for 10 min in healthy subject. Blood flow monitoring video system of laser speckle was used to record blood flow of GV 14, Shenzhu （身柱 GV 12）, bilateral Feishu （肺俞 BL 13） and Xinshu （心俞 BL 15） before cupping therapy, immediate time of cupping removal and 5 min, 10 rain, 15 min, 20 min, 25 rain and 30 rain after cupping removal. Results Compared before cupping therapy, the blood flow of GV 14, GV 12 and bilateral BL 13 was obviously increased at immediate time of cupping removal （all P〈0.05）. Compared with immediate time of cupping removal, the blood flow of GV 14 at each time point after 20 rain of cupping removal, GV 12 at 10 min and 15 min after cupping removal, bilateral BL 13 at each time point after cupping removal was all obviously decreased （all P〈0.05）. The difference of blood flow of Shendao （神道 GV 11） and bilateral BL 15 before and after cupping therapy was not significantly different （all P〉0.05）. Conclusion The cupping therapy could adjust skin blood flow, which is more obvious near the cupping area.
文摘Objective To observe influence of kinetic needling on functional restoration of upper limbs of patients with apoplexy-induced shoulder-hand syndrome. Methods Ninety patients were randomly divided into an observation group （45 cases） and a control group （45 cases）. Basic treatments selected according to corresponding stroke units were applied to both groups. Besides, scalp acupuncture at Dingnie Qianxiexian （MS 6, 顶颞前斜线）, Dingnie Houxiexian （MS 6, 顶颞前斜线） and Dingzhongxian （NS 5, 顶中线）, was applied in the treatment group. In the observation group, active and passive movement was carried out during the process of scalp acupuncture, and then needling plus bloodletting puncturing and cupping was applied. In the control group, only needling plus blood-letting puncturing and cupping was given. Therapeutic effects, pain scoring obtained by visual analogue scales （VAS）, FugI-Meyer and FugI-Meyer＇s scoring reflecting moving functions of upper limbs were made after 4 courses of treatments in both groups. Results The total effective rate was 95.5% and 91.1% in the observation group and control group, respectively, showing superiority of the former to the latter （P〈0.05）. After treatment, VAS scores were all obviously reduced in both groups （P〈0.01）, and the reduction in the former was significantly more than that in the latter （P〈0.01）. Moving functions of upper limbs shown by Fugl-Meyer＇s scoring were improved after 2 courses of treatment in both groups （P〈0.01）. The improvement was more obvious after 4 courses of treatment than that after 2 courses of treatment in both groups （P〈0.05）. After 4 courses of treatment, moving functions shown by FugI-Meyer＇s scoring were more remarkably improved in the observation group than those in the control group（t=3.9, P〈0.01）. Conclusion Both kinetic needling combined with needling plus blood-letting puncturing and cupping and simple needling plus blood-letting puncturing and cupping are effective in treating shoulder-hand syndrome after apoplexy, and the former is better than the latter.
