Background Computed tomography(CT) and cone-beam computed tomography(CBCT) image registration play pivotal roles in computer-assisted navigation for orthopedic surgery. Traditional methods often apply uniform deformat...Background Computed tomography(CT) and cone-beam computed tomography(CBCT) image registration play pivotal roles in computer-assisted navigation for orthopedic surgery. Traditional methods often apply uniform deformation models, neglecting the biomechanical differences between rigid structures and soft tissues, which compromises registration accuracy, especially during significant bone displacements. Method To address this issue, we introduce RE-Reg, a rigid-elastic CT-CBCT image registration framework that jointly learns rigid bone motion and soft tissue deformation. RE-Reg incorporates a rigid alignment(RA) module to estimate global bone motion and an elastic deformation(ED) module to model soft tissue deformation, preserving bony structures through bone shape preservation(BSP) loss. Result Our comprehensive evaluation on publicly available datasets demonstrates that RE-Reg significantly outperforms existing methods in terms of registration accuracy and rigid bone structure preservation, achieving a 1.3% improvement in Dice similarity coefficient(DSC) and a 23% reduction in rigid bone deformation(%Δvol) compared with the best baseline. Conclusion This framework not only enhances anatomical fidelity but also ensures biomechanical plausibility and provides a valuable tool for image-guided orthopedic surgery. This code is available athttps://github.com/Zq-Huang/RE-Reg.展开更多
目的探讨替牙期单侧非综合征唇腭裂男性患者经上颌前方牵引治疗前后其软硬组织的三维变化。方法选择于南京医科大学附属口腔医院正畸科就诊并经上颌前方牵引治疗替牙期单侧非综合征唇腭裂男性患者20例(平均年龄(10.6±1.23)岁),拍...目的探讨替牙期单侧非综合征唇腭裂男性患者经上颌前方牵引治疗前后其软硬组织的三维变化。方法选择于南京医科大学附属口腔医院正畸科就诊并经上颌前方牵引治疗替牙期单侧非综合征唇腭裂男性患者20例(平均年龄(10.6±1.23)岁),拍摄治疗前后的锥形束CT,应用Dolphin 3D 11.95软件进行三维测量分析,采用SPSS 25.0软件包进行统计学分析,采用自身对照配对t检验对单侧唇腭裂男性患者治疗前后的软硬组织变化进行比较,其中ANS点前移量、A点前移量及B点后移量变化采用单样本t检验。结果矢状向骨性变化:∠SNA(P<0.01)、∠ANB(P<0.01)、Y轴角(P<0.05)、ANS点前移量(P<0.01)、A点前移量(P<0.01)和B点后移量(P<0.01)均显著增大,而∠SNB(P<0.05)则显著减小;垂直向骨性变化:∠MP-FH(P<0.01)、∠MP-SN(P<0.05)和ANS-Me线距(P<0.05)显著增加,而∠SN-PP(P<0.01)则显著减小;牙性变化:∠U1-NA(P<0.01)、U1-NA线距(P<0.01)、∠U1-SN(P<0.01)、前牙覆盖(P<0.01)和Wits值(P<0.01)均显著增加;而∠L1-NB(P<0.01)、L1-NB线距(P<0.01)和∠L1-MP(P<0.01)均显著减小;软组织变化:∠S-Ns-Sn(P<0.01)、∠Sn-Ns-Bs(P<0.01)、UL-EP线距(P<0.01)和LL-UL线距(P<0.01)均显著增加。结论对于生长发育期的唇腭裂患者,上颌前方牵引治疗可促进上颌骨向前生长,改善颌间关系及软组织侧貌,但需注意其不良反应。展开更多
基金Supported by the National Natural Science Foundation of China(Grant Nos.62025104,62331005,and U22A2052)the Beijing Natural Science Foundation(Grant No.L242100).
文摘Background Computed tomography(CT) and cone-beam computed tomography(CBCT) image registration play pivotal roles in computer-assisted navigation for orthopedic surgery. Traditional methods often apply uniform deformation models, neglecting the biomechanical differences between rigid structures and soft tissues, which compromises registration accuracy, especially during significant bone displacements. Method To address this issue, we introduce RE-Reg, a rigid-elastic CT-CBCT image registration framework that jointly learns rigid bone motion and soft tissue deformation. RE-Reg incorporates a rigid alignment(RA) module to estimate global bone motion and an elastic deformation(ED) module to model soft tissue deformation, preserving bony structures through bone shape preservation(BSP) loss. Result Our comprehensive evaluation on publicly available datasets demonstrates that RE-Reg significantly outperforms existing methods in terms of registration accuracy and rigid bone structure preservation, achieving a 1.3% improvement in Dice similarity coefficient(DSC) and a 23% reduction in rigid bone deformation(%Δvol) compared with the best baseline. Conclusion This framework not only enhances anatomical fidelity but also ensures biomechanical plausibility and provides a valuable tool for image-guided orthopedic surgery. This code is available athttps://github.com/Zq-Huang/RE-Reg.
文摘目的探讨替牙期单侧非综合征唇腭裂男性患者经上颌前方牵引治疗前后其软硬组织的三维变化。方法选择于南京医科大学附属口腔医院正畸科就诊并经上颌前方牵引治疗替牙期单侧非综合征唇腭裂男性患者20例(平均年龄(10.6±1.23)岁),拍摄治疗前后的锥形束CT,应用Dolphin 3D 11.95软件进行三维测量分析,采用SPSS 25.0软件包进行统计学分析,采用自身对照配对t检验对单侧唇腭裂男性患者治疗前后的软硬组织变化进行比较,其中ANS点前移量、A点前移量及B点后移量变化采用单样本t检验。结果矢状向骨性变化:∠SNA(P<0.01)、∠ANB(P<0.01)、Y轴角(P<0.05)、ANS点前移量(P<0.01)、A点前移量(P<0.01)和B点后移量(P<0.01)均显著增大,而∠SNB(P<0.05)则显著减小;垂直向骨性变化:∠MP-FH(P<0.01)、∠MP-SN(P<0.05)和ANS-Me线距(P<0.05)显著增加,而∠SN-PP(P<0.01)则显著减小;牙性变化:∠U1-NA(P<0.01)、U1-NA线距(P<0.01)、∠U1-SN(P<0.01)、前牙覆盖(P<0.01)和Wits值(P<0.01)均显著增加;而∠L1-NB(P<0.01)、L1-NB线距(P<0.01)和∠L1-MP(P<0.01)均显著减小;软组织变化:∠S-Ns-Sn(P<0.01)、∠Sn-Ns-Bs(P<0.01)、UL-EP线距(P<0.01)和LL-UL线距(P<0.01)均显著增加。结论对于生长发育期的唇腭裂患者,上颌前方牵引治疗可促进上颌骨向前生长,改善颌间关系及软组织侧貌,但需注意其不良反应。
