On December 31,2019,the Wuhan Health Commission reported the discovery of an“unexplained”pneumonia for the first time;the pathogen was confirmed as novel coronavirus pneumonia(2019-nCoV)on January 7,2020.As one of t...On December 31,2019,the Wuhan Health Commission reported the discovery of an“unexplained”pneumonia for the first time;the pathogen was confirmed as novel coronavirus pneumonia(2019-nCoV)on January 7,2020.As one of the important examination methods for the coronavirus diseases 2019(COVID-19),Computed Tomography(CT)examination plays an important role in the clinical discovery of suspected cases,diagnosis,and treatment review.This paper reviews the published papers in order to offer help in early clinical screening,disease diagnosis,disease severity determination and post-treatment review.展开更多
<strong>Object:</strong> To evaluate CT Features on serial thin-section computed tomographic (CT) scans in patients with conventional Novel Coronavirus Pneumonia (COVID-19) for the period during which they...<strong>Object:</strong> To evaluate CT Features on serial thin-section computed tomographic (CT) scans in patients with conventional Novel Coronavirus Pneumonia (COVID-19) for the period during which they remained hospitalized. <strong>Methods:</strong> In this Retrospective study, we collected clinical information including Laboratory investigations and more importantly we focused on collecting imaging data of these 15 selected patients (8 men and 7 women, 22 - 70 years old, average age (45 <span style="white-space:nowrap;">±</span> 15)) with COVID-19 disease. The mean time between the initial and repeat thin-section CT scans was 3.3 <span style="white-space:nowrap;">±</span> 2.1 days, 7.9 <span style="white-space:nowrap;">±</span> 2.1 days, 14.2 <span style="white-space:nowrap;">±</span> 1.3 days after onset of symptoms in these 15 patients. Three experienced Radiologists reviewed the CT images independently and also in collaboration with each other for complicated or unique cases, for the Imaging characteristics like number and site of lesions, distribution of lesions whether it is lobular, lobar, unilateral or bilateral, and comparing the severity of disease in relation to the CT findings. The CT features were compared using the χ<sup>2</sup> test and <em>Fisher’s </em>exact probability.<strong> Results:</strong> All of 15 patients had a history of visit to the endemic center <em>i.e.</em> Wuhan city or came in direct contact with an infected individual. Fever (93.3%) was the most common symptom. Majority of patients had a normal white blood cell count, and normal lymphocyte count although there were patients with leucopenia and lymphocytopenia. CT images showed predominate Ground-Glass opacities in the initial and repeat CT scans with a percentage of 90.6%, 53.9%, 44.2% respectively during the three spaced CT examinations;most patients had bilateral lung involvement (60%, 93.3%, 93.3%), the lesions predominantly involved the posterior (87.5%, 71.9%, 76.6%) and peripheral (90.6%, 84.3%, 85.7%) part of the lungs. There were more consolidation and mixed patterns in repeat CT scan Versus initial CT scan, the difference was statistically significant (P-values were < 0.001). The total lung severity score in the three aforementioned timely spaced CT scans were 36 (3.3 <span style="white-space:nowrap;">±</span> 2.1 days) 63 (7.9 <span style="white-space:nowrap;">±</span> 2.1 days), and 57 (14.2 <span style="white-space:nowrap;">±</span> 1.3 days) respectively. The median percentage of pneumonia lesions of the whole lung volume in three times CT scan was 1.69% (4.59), 3.47% (5.46), 2.33% (4.75) respectively. Besides, “Tree-in-bud” sign, lung cavitation, and lymphadenopathy were absent. <strong>Conclusion:</strong> The Thin-slice Section CT Imaging features show uniquely different characteristics, each time the scans are taken. The most common findings in our study were bilateral multiple peripheral and mostly posterior ground-glass opacities (GGO), however the CT scan images that were taken in a timely manner to follow up demonstrated some remarkable changes, which undoubtedly play an important role in the diagnosis and management of the patient with COVID-19 disease.展开更多
Objective:To investigate in the CT manifestations of severe and critical coronavirus disease 2019(COVID-19)patients.Methods:Medical data was collected for 2 severe patients and 4 critical COVID-19 patients from onset ...Objective:To investigate in the CT manifestations of severe and critical coronavirus disease 2019(COVID-19)patients.Methods:Medical data was collected for 2 severe patients and 4 critical COVID-19 patients from onset to their recovery.Three or four CT scans for each patient were taken.The semi-quantitative analysis method was introduced for lesion and its distribution area.Results:The ground-glass opacities(GGO)and mixed GGO with consolidation were found as the most frequent features.Consolidation followed,and the appearance of stripes which showed an increasing trend before the patient was discharged.Consolidation was associated with clinical severity and disease progression,and the rapid change of the lesion in a short period of time was also a notable feature within 2e3 weeks.After being discharged,the efficacy of treatment could be demonstrated by a follow up CT scan.The distribution of lesion also showed dynamic progress in the follow up CT scan.Conclusion:CT scans in the whole course provided the entire inflammation information to assess clinical severity,disease progression and the treatment efficacy for COVID-19.展开更多
Objective:To discuss the early imaging features of novel coronary pneumonia(NCP)and its differential diagnosis with common pneumonia for the clinical Provide relatively correct imaging diagnosis.Methods:A review of 10...Objective:To discuss the early imaging features of novel coronary pneumonia(NCP)and its differential diagnosis with common pneumonia for the clinical Provide relatively correct imaging diagnosis.Methods:A review of 10 cases of novel coronavirus pneumonia diagnosed in our hospital and surrounding counties was collected,and our hospital's 2019-2020 Common pneumonia such as influenza A and B virus pneumonia,lobar pneumonia and adenovirus confirmed by laboratory tests and abnormal chest radiographs Ten patients each with pneumonia,a total of 40 patients,were collected and their imaging features were analyzed.Results:In 10 patients with neo-coronary pneumonia,there were 30 lesions on chest CT,with typical characteristic lesions containing bronchograms within their Angiographic thickening;located in the subpleura,with grinding glass-like or combined solid changes,referred to as"extratubular halo",with multifocal and multifocal distribution.Morphology or unilobular large lamellar foci without lymph node enlargement and pleural effusion;10 cases of influenza A and B virus pneumonia in chest CT performance In nine patients,the lesions were distributed in the subpleural or along the perimeter of the bronchial vessels in the form of an analogous circular ground-glass shadow,some of which was a small piece of solid shadow,1 The case involved a single lobe of the lung and showed a large mixed ground glass image,and the CT in 10 cases of lobar pneumonia showed that they all had a single large solid lobe The variegated shadow or patchy cloud with blurred margins was triangularly altered with the tip pointing to the lung portal,and there were five cases of air-containing bronchograms.Adenoviral pneumonia is more common in infants and young children,and CT showed single or multiple grinded glass images in both lungs with patchy solid variegated shadows and lobar distribution.Conclusion:NCP and common pneumonia have certain imaging features that,in combination with laboratory tests and epidemiologic history,allow a preliminary diagnosis to be made.It has certain directions and help for clinical diagnosis.展开更多
Purpose:To analyze the clinical and radiological characteristics of AIDS related pneumocystis jiroveci infection,pneumocystis pneumonia(AIDS-PCP).Methods:A total of 15 patients with AIDS-PCP was recruited,14 males and...Purpose:To analyze the clinical and radiological characteristics of AIDS related pneumocystis jiroveci infection,pneumocystis pneumonia(AIDS-PCP).Methods:A total of 15 patients with AIDS-PCP was recruited,14 males and 1 female.All clinical and CT data were collected with all CT images retrospectively analyzed by two senior radiologists who are blind to patients'clinical diagnosis.Results:The radiological findings were categorized into 4 types:(1)Ground-glass opacities in 14 cases(93%),with diffuse distributed in bilateral lungs;(2)Interstitial infiltrations in 11 cases(73%),which mainly distributed in lower lobes close to pleura;(3)Irregular patchy densities distributed along the bronchus in 3 cases(20%).(4)Irregular patchy densities with cavity in one case of AIDS-PCP coinfected with Aspergillus infection.Other cases also presented with enlarged mediastinal and axillary lymph nodes,pneumothorax,and pericardial effusion.Conclusion:The radiological findings of AIDS-PCP varies from ground-glass opacifications to interstitial changes,and the definitive diagnosis should be made by combination of clinical data.展开更多
文摘On December 31,2019,the Wuhan Health Commission reported the discovery of an“unexplained”pneumonia for the first time;the pathogen was confirmed as novel coronavirus pneumonia(2019-nCoV)on January 7,2020.As one of the important examination methods for the coronavirus diseases 2019(COVID-19),Computed Tomography(CT)examination plays an important role in the clinical discovery of suspected cases,diagnosis,and treatment review.This paper reviews the published papers in order to offer help in early clinical screening,disease diagnosis,disease severity determination and post-treatment review.
文摘<strong>Object:</strong> To evaluate CT Features on serial thin-section computed tomographic (CT) scans in patients with conventional Novel Coronavirus Pneumonia (COVID-19) for the period during which they remained hospitalized. <strong>Methods:</strong> In this Retrospective study, we collected clinical information including Laboratory investigations and more importantly we focused on collecting imaging data of these 15 selected patients (8 men and 7 women, 22 - 70 years old, average age (45 <span style="white-space:nowrap;">±</span> 15)) with COVID-19 disease. The mean time between the initial and repeat thin-section CT scans was 3.3 <span style="white-space:nowrap;">±</span> 2.1 days, 7.9 <span style="white-space:nowrap;">±</span> 2.1 days, 14.2 <span style="white-space:nowrap;">±</span> 1.3 days after onset of symptoms in these 15 patients. Three experienced Radiologists reviewed the CT images independently and also in collaboration with each other for complicated or unique cases, for the Imaging characteristics like number and site of lesions, distribution of lesions whether it is lobular, lobar, unilateral or bilateral, and comparing the severity of disease in relation to the CT findings. The CT features were compared using the χ<sup>2</sup> test and <em>Fisher’s </em>exact probability.<strong> Results:</strong> All of 15 patients had a history of visit to the endemic center <em>i.e.</em> Wuhan city or came in direct contact with an infected individual. Fever (93.3%) was the most common symptom. Majority of patients had a normal white blood cell count, and normal lymphocyte count although there were patients with leucopenia and lymphocytopenia. CT images showed predominate Ground-Glass opacities in the initial and repeat CT scans with a percentage of 90.6%, 53.9%, 44.2% respectively during the three spaced CT examinations;most patients had bilateral lung involvement (60%, 93.3%, 93.3%), the lesions predominantly involved the posterior (87.5%, 71.9%, 76.6%) and peripheral (90.6%, 84.3%, 85.7%) part of the lungs. There were more consolidation and mixed patterns in repeat CT scan Versus initial CT scan, the difference was statistically significant (P-values were < 0.001). The total lung severity score in the three aforementioned timely spaced CT scans were 36 (3.3 <span style="white-space:nowrap;">±</span> 2.1 days) 63 (7.9 <span style="white-space:nowrap;">±</span> 2.1 days), and 57 (14.2 <span style="white-space:nowrap;">±</span> 1.3 days) respectively. The median percentage of pneumonia lesions of the whole lung volume in three times CT scan was 1.69% (4.59), 3.47% (5.46), 2.33% (4.75) respectively. Besides, “Tree-in-bud” sign, lung cavitation, and lymphadenopathy were absent. <strong>Conclusion:</strong> The Thin-slice Section CT Imaging features show uniquely different characteristics, each time the scans are taken. The most common findings in our study were bilateral multiple peripheral and mostly posterior ground-glass opacities (GGO), however the CT scan images that were taken in a timely manner to follow up demonstrated some remarkable changes, which undoubtedly play an important role in the diagnosis and management of the patient with COVID-19 disease.
基金supported by the following grants the Capital Characteristic Clinical Application Research Foundation key funding(RXL:No.Z181100001718184)the Beijing Fire Inheritance 3+3 Project(RXL:No.830104)+1 种基金the National Natural Science Foundation of China(RXL:81873293,JLF:81774433)the National Key R&D Program of China(JLF:2018YFC1705802).
文摘Objective:To investigate in the CT manifestations of severe and critical coronavirus disease 2019(COVID-19)patients.Methods:Medical data was collected for 2 severe patients and 4 critical COVID-19 patients from onset to their recovery.Three or four CT scans for each patient were taken.The semi-quantitative analysis method was introduced for lesion and its distribution area.Results:The ground-glass opacities(GGO)and mixed GGO with consolidation were found as the most frequent features.Consolidation followed,and the appearance of stripes which showed an increasing trend before the patient was discharged.Consolidation was associated with clinical severity and disease progression,and the rapid change of the lesion in a short period of time was also a notable feature within 2e3 weeks.After being discharged,the efficacy of treatment could be demonstrated by a follow up CT scan.The distribution of lesion also showed dynamic progress in the follow up CT scan.Conclusion:CT scans in the whole course provided the entire inflammation information to assess clinical severity,disease progression and the treatment efficacy for COVID-19.
文摘Objective:To discuss the early imaging features of novel coronary pneumonia(NCP)and its differential diagnosis with common pneumonia for the clinical Provide relatively correct imaging diagnosis.Methods:A review of 10 cases of novel coronavirus pneumonia diagnosed in our hospital and surrounding counties was collected,and our hospital's 2019-2020 Common pneumonia such as influenza A and B virus pneumonia,lobar pneumonia and adenovirus confirmed by laboratory tests and abnormal chest radiographs Ten patients each with pneumonia,a total of 40 patients,were collected and their imaging features were analyzed.Results:In 10 patients with neo-coronary pneumonia,there were 30 lesions on chest CT,with typical characteristic lesions containing bronchograms within their Angiographic thickening;located in the subpleura,with grinding glass-like or combined solid changes,referred to as"extratubular halo",with multifocal and multifocal distribution.Morphology or unilobular large lamellar foci without lymph node enlargement and pleural effusion;10 cases of influenza A and B virus pneumonia in chest CT performance In nine patients,the lesions were distributed in the subpleural or along the perimeter of the bronchial vessels in the form of an analogous circular ground-glass shadow,some of which was a small piece of solid shadow,1 The case involved a single lobe of the lung and showed a large mixed ground glass image,and the CT in 10 cases of lobar pneumonia showed that they all had a single large solid lobe The variegated shadow or patchy cloud with blurred margins was triangularly altered with the tip pointing to the lung portal,and there were five cases of air-containing bronchograms.Adenoviral pneumonia is more common in infants and young children,and CT showed single or multiple grinded glass images in both lungs with patchy solid variegated shadows and lobar distribution.Conclusion:NCP and common pneumonia have certain imaging features that,in combination with laboratory tests and epidemiologic history,allow a preliminary diagnosis to be made.It has certain directions and help for clinical diagnosis.
文摘Purpose:To analyze the clinical and radiological characteristics of AIDS related pneumocystis jiroveci infection,pneumocystis pneumonia(AIDS-PCP).Methods:A total of 15 patients with AIDS-PCP was recruited,14 males and 1 female.All clinical and CT data were collected with all CT images retrospectively analyzed by two senior radiologists who are blind to patients'clinical diagnosis.Results:The radiological findings were categorized into 4 types:(1)Ground-glass opacities in 14 cases(93%),with diffuse distributed in bilateral lungs;(2)Interstitial infiltrations in 11 cases(73%),which mainly distributed in lower lobes close to pleura;(3)Irregular patchy densities distributed along the bronchus in 3 cases(20%).(4)Irregular patchy densities with cavity in one case of AIDS-PCP coinfected with Aspergillus infection.Other cases also presented with enlarged mediastinal and axillary lymph nodes,pneumothorax,and pericardial effusion.Conclusion:The radiological findings of AIDS-PCP varies from ground-glass opacifications to interstitial changes,and the definitive diagnosis should be made by combination of clinical data.
