With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most i...With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most important component of high-precision ADC,is widely used in high-quality audio,high-precision instrument measurement,and other fields due to its advantages of high precision,strong noise resistance,and low hardware cost.This article designs a discrete structure third-order four-bit high-precision Sigma-Delta modulator through modeling,with an oversampling rate set to 512.Under ideal conditions,the simulation results show that the SDNR reaches 152.7db and the ENOB is 25.24bits.After introducing non-ideal noise,the system performance has decreased.The simulation results show that the SDNR is as high as 124.5db and the ENOB is 20.39bits.This indicates that the design can achieve high-precision conversion and provide assistance for further research in the future.展开更多
This paper investigates the design of digital Sigma-Delta Modulator (SDM) for fractional-N frequency synthesizer. Characteristics of SDMs are compared through theory analysis and simulation. The curve of maximum-loop-...This paper investigates the design of digital Sigma-Delta Modulator (SDM) for fractional-N frequency synthesizer. Characteristics of SDMs are compared through theory analysis and simulation. The curve of maximum-loop-bandwidth vs. maximum-phase-noise is suggested to be a new criterion to the performance of SDM,which greatly helps designers to select an appropriate SDM structure to meet their real application requirements and to reduce the cost as low as possible. A low-spur 3-order Mul-tistage Noise Shaping (MASH)-1-1-1 SDM using three 2-bit first-order cascaded modulators is proposed,which balances the requirements of tone-free and maximum operation frequency.展开更多
This paper presents the design and experimental results of a continuous-time (CT) sigma-delta (ΣΔ) modulator with data-weighted average (DWA) technology for WiMAX applications. The proposed modulator comprises a thi...This paper presents the design and experimental results of a continuous-time (CT) sigma-delta (ΣΔ) modulator with data-weighted average (DWA) technology for WiMAX applications. The proposed modulator comprises a third-order active RC loop filter, internal quantizer operating at 160 MHz and three DAC circuits. A multi-bit quantizer is used to increase resolution and multi-bit non-return-to-zero (NRZ) DACs are adopted to reduce clock jitter sensitivity. The NRZ DAC circuits with quantizer excess loop delay compensation are set to be half the sampling period of the quantizer for increasing modulator stability. A dynamic element matching (DEM) technique is applied to multi-bit ΣΔ modulators to improve the nonlinearity of the internal DAC. This approach translates the harmonic distortion components of a nonideal DAC in the feedback loop of a ΣΔ modulator to high-frequency components. Capacitor tuning is utilized to overcome loop coefficient shifts due to process variations. The DWA technique is used for reducing DAC noise due to component mismatches. The prototype is implemented in TSMC 0.18 um CMOS process. Experimental results show that the ΣΔ modulator achieves 54-dB dynamic range, 51-dB SNR, and 48-dB SNDR over a 10-MHz signal bandwidth with an oversampling ratio (OSR) of 8, while dissipating 19.8 mW from a 1.2-V supply. Including pads, the chip area is 1.156 mm2.展开更多
In this paper,in order to reduce power consumption and chip area,as well as to improve the performance of the bandpass sigma-delta modulator,a novel full differential feedforward fourth-order bandpass sigma-delta modu...In this paper,in order to reduce power consumption and chip area,as well as to improve the performance of the bandpass sigma-delta modulator,a novel full differential feedforward fourth-order bandpass sigma-delta modulator was proposed. It used a resonator based on Salo architecture,which employed doublesampling and double-delay technique. The results show that the proposed modulator can achieve lower power consumption and a lower capacitive load than the conventional bandpass modulators on the platform of Simulink. The circuit is implemented with TSMC0. 18 μm CMOS process and operates at a sampling frequency of 20 MHz, 80 MHz effective sampling frequency. Furthermore,it consumes 21. 2 mW from a 1. 8 V supply. The simulated peak signal-to-noise ratio( SNR) is 85. 9 dB and the dynamic range( DR) is 91 dB with 200 kHz bandwidth.展开更多
A novel method to partially compensate sigma-delta shaped noise is proposed. By injecting the compensation current into the passive loop filter during the delay time of the phase frequency detector（PFD）,a maximum re...A novel method to partially compensate sigma-delta shaped noise is proposed. By injecting the compensation current into the passive loop filter during the delay time of the phase frequency detector（PFD）,a maximum reduction of the phase noise by about 16dB can be achieved. Compared to other compensation methods,the technique proposed here is relatively simple and easy to implement. Key building blocks for realizing the noise cancellation,including the delay variable PFD and compensation current source, are specially designed. Both the behavior level and circuit level simulation results are presented.展开更多
A high-resolution,200kHz signal bandwidth,third-order single-loop single-bit ε△ modulator used in low-IF GSM receivers is presented. The modulator is implemented with fully differential switched capacitor circuits i...A high-resolution,200kHz signal bandwidth,third-order single-loop single-bit ε△ modulator used in low-IF GSM receivers is presented. The modulator is implemented with fully differential switched capacitor circuits in standard 0. 6μm 2P2M CMOS technology. The modulator uses two balanced reference voltages of ±1V,and is driven by a single 26MHz clock signal. The measurement results show that,with an oversampling ratio of 64, the modulator achieves an 80.6dB dynamic range,a 71.8dB peak SNDR,and a 73.9dB peak SNR in the signal bandwidth of 200kHz. The modulator dissipates 15mW static power from a single 5V supply.展开更多
Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emiss...Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.展开更多
Objective The aim of this study was to compare the long-term local control, overall survival, and late toxicities of positron emission tomography/computed tomography （PET/CT）-guided dose escalation radio- therapy ve...Objective The aim of this study was to compare the long-term local control, overall survival, and late toxicities of positron emission tomography/computed tomography （PET/CT）-guided dose escalation radio- therapy versus conventional radiotherapy in the concurrent chemoradiotherapy treatment of locally ad- vanced nasopharyngeal carcinoma （NPC）. Methods Atotal of 48 patients with stage IIl-IVa NPC were recruited and randomly administered PET/CT- guided dose escalation chemoradiotherapy （group A） or conventional chemoradiotherapy （group B）. The dose-escalation radiotherapy was performed using the simultaneous modulated accelerated radiotherapy technique at prescribed doses of 77 gray （Gy） in 32 fractions （f） to the gross target volume （GTV）： planning target volume （PTV） 1 received 64 Gy/32 f, while PTV2 received 54.4 Gy/32 f. Patients in group B received uniform-dose intensity-modulated radiotherapy, PTV1 received 70 Gy/35 f and PTV2 received 58 Gy/29 f. Concurrent chemotherapy consisted of cisplatin [20 mg/m2 intravenous （IV） on days 1-4] and docetaxel （75 mg/m2 IV on days 1 and 8） administered during treatment weeks 1 and 4. All patients received 2-4 cycles of adjuvant chemotherapy of the same dose and drug regimen. Results The use of fluorine-18-fluorodeoxyglucose （18F-FDG） PET/CT significantly reduced the treat- ment volume delineation of the GTV in 83.3% （20/24） of patients. The 5-year local recurrence-free survival rates of the two groups were 100% and 79.2%, respectively （P = 0.019）. The 5-year disease free survival （DFS） rates were 95.8% and 75.0%, respectively （P = 0.018）. The 5-year local progression-free survival and DFS rates were significantly different. The 5-year overall survival （OS） rates were 95.8% and 79.2%, re- spectively. Differences in OS improvement were insignificant （P = 0.079）. Late toxicities were similar in the two groups. The most common late toxicities of the two arms were grade 1-2 skin dystrophy, xerostomia, subcutaneous fibrosis, and hearing loss. There were no cases of grade 4 late toxicity. Conclusion The use of 18F-FDG PET/CT-guided dose escalation radiotherapy is well tolerated and can reduce local recurrence rates for patients with locally advanced NPC compared to conventional chemora- diotherapy.展开更多
Objective:to study the effect of automatic tube current modulation on abdominal CT image quality and radiation dose. Methods: a total of 70 patients who underwent abdominal CT examination in our hospital from August 2...Objective:to study the effect of automatic tube current modulation on abdominal CT image quality and radiation dose. Methods: a total of 70 patients who underwent abdominal CT examination in our hospital from August 2019 to August 2020 were collected and divided into control group (35 cases) and study group (35 cases) according to the random number table. CT scan was performed in the control group according to the conventional parameters, while CT scan was performed in the research group using automatic tube current modulation technology. The CT image quality and radiation dose of patients in the two groups were compared. Results: the image quality of the study group was better than that of the control group (P < 0.05). When NI ≥8, the radiation dose in the study group was lower than that in the control group (P < 0.05). Conclusion Automatic tube current modulation technique can obtain better image quality in CT detection, and has significant significance in reducing radiation dose. It is worthy of affirmation, praise and application.展开更多
文摘With the continuous improvement of signal processing accuracy requirements in modern electronic systems,the demand for high-precision analog-to-digital converters(ADCs)is increasing.Sigma-Delta modulator,as the most important component of high-precision ADC,is widely used in high-quality audio,high-precision instrument measurement,and other fields due to its advantages of high precision,strong noise resistance,and low hardware cost.This article designs a discrete structure third-order four-bit high-precision Sigma-Delta modulator through modeling,with an oversampling rate set to 512.Under ideal conditions,the simulation results show that the SDNR reaches 152.7db and the ENOB is 25.24bits.After introducing non-ideal noise,the system performance has decreased.The simulation results show that the SDNR is as high as 124.5db and the ENOB is 20.39bits.This indicates that the design can achieve high-precision conversion and provide assistance for further research in the future.
基金the National Natural Science Foundation of China (No. 60025101, No.90207001, and No. 90307016).
文摘This paper investigates the design of digital Sigma-Delta Modulator (SDM) for fractional-N frequency synthesizer. Characteristics of SDMs are compared through theory analysis and simulation. The curve of maximum-loop-bandwidth vs. maximum-phase-noise is suggested to be a new criterion to the performance of SDM,which greatly helps designers to select an appropriate SDM structure to meet their real application requirements and to reduce the cost as low as possible. A low-spur 3-order Mul-tistage Noise Shaping (MASH)-1-1-1 SDM using three 2-bit first-order cascaded modulators is proposed,which balances the requirements of tone-free and maximum operation frequency.
文摘This paper presents the design and experimental results of a continuous-time (CT) sigma-delta (ΣΔ) modulator with data-weighted average (DWA) technology for WiMAX applications. The proposed modulator comprises a third-order active RC loop filter, internal quantizer operating at 160 MHz and three DAC circuits. A multi-bit quantizer is used to increase resolution and multi-bit non-return-to-zero (NRZ) DACs are adopted to reduce clock jitter sensitivity. The NRZ DAC circuits with quantizer excess loop delay compensation are set to be half the sampling period of the quantizer for increasing modulator stability. A dynamic element matching (DEM) technique is applied to multi-bit ΣΔ modulators to improve the nonlinearity of the internal DAC. This approach translates the harmonic distortion components of a nonideal DAC in the feedback loop of a ΣΔ modulator to high-frequency components. Capacitor tuning is utilized to overcome loop coefficient shifts due to process variations. The DWA technique is used for reducing DAC noise due to component mismatches. The prototype is implemented in TSMC 0.18 um CMOS process. Experimental results show that the ΣΔ modulator achieves 54-dB dynamic range, 51-dB SNR, and 48-dB SNDR over a 10-MHz signal bandwidth with an oversampling ratio (OSR) of 8, while dissipating 19.8 mW from a 1.2-V supply. Including pads, the chip area is 1.156 mm2.
基金Sponsored by the National Basic Research Program of China(Grant No.2012CB934104)
文摘In this paper,in order to reduce power consumption and chip area,as well as to improve the performance of the bandpass sigma-delta modulator,a novel full differential feedforward fourth-order bandpass sigma-delta modulator was proposed. It used a resonator based on Salo architecture,which employed doublesampling and double-delay technique. The results show that the proposed modulator can achieve lower power consumption and a lower capacitive load than the conventional bandpass modulators on the platform of Simulink. The circuit is implemented with TSMC0. 18 μm CMOS process and operates at a sampling frequency of 20 MHz, 80 MHz effective sampling frequency. Furthermore,it consumes 21. 2 mW from a 1. 8 V supply. The simulated peak signal-to-noise ratio( SNR) is 85. 9 dB and the dynamic range( DR) is 91 dB with 200 kHz bandwidth.
文摘A novel method to partially compensate sigma-delta shaped noise is proposed. By injecting the compensation current into the passive loop filter during the delay time of the phase frequency detector（PFD）,a maximum reduction of the phase noise by about 16dB can be achieved. Compared to other compensation methods,the technique proposed here is relatively simple and easy to implement. Key building blocks for realizing the noise cancellation,including the delay variable PFD and compensation current source, are specially designed. Both the behavior level and circuit level simulation results are presented.
文摘A high-resolution,200kHz signal bandwidth,third-order single-loop single-bit ε△ modulator used in low-IF GSM receivers is presented. The modulator is implemented with fully differential switched capacitor circuits in standard 0. 6μm 2P2M CMOS technology. The modulator uses two balanced reference voltages of ±1V,and is driven by a single 26MHz clock signal. The measurement results show that,with an oversampling ratio of 64, the modulator achieves an 80.6dB dynamic range,a 71.8dB peak SNDR,and a 73.9dB peak SNR in the signal bandwidth of 200kHz. The modulator dissipates 15mW static power from a single 5V supply.
基金supported by grants from the Science and Technology Project of Guangzhou City,China(No.14570006)the Planned Science and Technology Project of Guangdong Province,China(No.2013B020400004)
文摘Background: Little is known about the nature of metaistasis to small cervical lymph nodes(SCLNS) in the patients with nasopharyngeal carcinoma(NPC)examined by using 18-fluoro-2-deoxy-glucose(^(18)F-FDG) positron emission tomography/computed tomography(PET/CT).The present study aimed to evaluate the diagnostic values of PET/CT in identifying metastasis in SCLNs in NPC patients.Methods: Magnetic resonance images(MRI) and PET/CT scans for 470 patients with newly diagnosed, non-distant metastatic NPC were analyzed. Metastatic rates of SCLNs were defined by the positive number of SCLNs on PET/CT scans and total number of SCLNs on MRI scans. Receiver operating characteristic curve was applied to compare PET/CT-determined stage with MRI-determined stage.Results: In total, 2082 SCLNs were identified, with 808(38.8%) ≥ 5 and < 6 mm in diameter(group A), 526(25.3%)≥ 6 and < 7 mm in diameter(group B),374(18.0%)≥ 7 and < 8 mm in diameter(group C), 237(11.4%) ≥8 and<9 mm in diameter(group D),and 137(6.5%) ≥ 9 and <10 mm in diameter(group E).The overall metastatic rates examined by using PET/CT for groups A, B,C,D, and E were 3.5%, 8.0%, 31.3%, 60.0%, and 83.9%, respectively(P< 0.001). In level IV/Vb, the metastatic rate for nodes ≥ 8 mm was 84.6%. PET/CT examination resulted in modification of N category and overall stage for 135(28.7%) and 46(9.8%) patients, respectively. The areas under curve of MRIdetermined and PET/CT-determined overall stage were 0.659 and 0.704 for predicting overall survival, 0.661 and 0.711 for predicting distant metastasis-free survival, and 0.636 and 0.663 for predicting disease-free survival.Conclusions: PET/CT was more effective than MRI in identifying metastatic SCLNs, and the radiologic diagnostic criteria for metastatic lymph nodes in level IV/Vb should be re-defined.
基金Supported by grants from the National Natural Science Foundation of China(No.81071831)Jiangsu Provincial Health Bureau issues(No.H201021)+1 种基金Xuzhou City Science and Technology Bureau issues(No.XF10C082)Jiangsu Province Natural Science Foundation of China(No.BK20131131)
文摘Objective The aim of this study was to compare the long-term local control, overall survival, and late toxicities of positron emission tomography/computed tomography （PET/CT）-guided dose escalation radio- therapy versus conventional radiotherapy in the concurrent chemoradiotherapy treatment of locally ad- vanced nasopharyngeal carcinoma （NPC）. Methods Atotal of 48 patients with stage IIl-IVa NPC were recruited and randomly administered PET/CT- guided dose escalation chemoradiotherapy （group A） or conventional chemoradiotherapy （group B）. The dose-escalation radiotherapy was performed using the simultaneous modulated accelerated radiotherapy technique at prescribed doses of 77 gray （Gy） in 32 fractions （f） to the gross target volume （GTV）： planning target volume （PTV） 1 received 64 Gy/32 f, while PTV2 received 54.4 Gy/32 f. Patients in group B received uniform-dose intensity-modulated radiotherapy, PTV1 received 70 Gy/35 f and PTV2 received 58 Gy/29 f. Concurrent chemotherapy consisted of cisplatin [20 mg/m2 intravenous （IV） on days 1-4] and docetaxel （75 mg/m2 IV on days 1 and 8） administered during treatment weeks 1 and 4. All patients received 2-4 cycles of adjuvant chemotherapy of the same dose and drug regimen. Results The use of fluorine-18-fluorodeoxyglucose （18F-FDG） PET/CT significantly reduced the treat- ment volume delineation of the GTV in 83.3% （20/24） of patients. The 5-year local recurrence-free survival rates of the two groups were 100% and 79.2%, respectively （P = 0.019）. The 5-year disease free survival （DFS） rates were 95.8% and 75.0%, respectively （P = 0.018）. The 5-year local progression-free survival and DFS rates were significantly different. The 5-year overall survival （OS） rates were 95.8% and 79.2%, re- spectively. Differences in OS improvement were insignificant （P = 0.079）. Late toxicities were similar in the two groups. The most common late toxicities of the two arms were grade 1-2 skin dystrophy, xerostomia, subcutaneous fibrosis, and hearing loss. There were no cases of grade 4 late toxicity. Conclusion The use of 18F-FDG PET/CT-guided dose escalation radiotherapy is well tolerated and can reduce local recurrence rates for patients with locally advanced NPC compared to conventional chemora- diotherapy.
文摘Objective:to study the effect of automatic tube current modulation on abdominal CT image quality and radiation dose. Methods: a total of 70 patients who underwent abdominal CT examination in our hospital from August 2019 to August 2020 were collected and divided into control group (35 cases) and study group (35 cases) according to the random number table. CT scan was performed in the control group according to the conventional parameters, while CT scan was performed in the research group using automatic tube current modulation technology. The CT image quality and radiation dose of patients in the two groups were compared. Results: the image quality of the study group was better than that of the control group (P < 0.05). When NI ≥8, the radiation dose in the study group was lower than that in the control group (P < 0.05). Conclusion Automatic tube current modulation technique can obtain better image quality in CT detection, and has significant significance in reducing radiation dose. It is worthy of affirmation, praise and application.
