In the present work, new kinetics to describe the creaming stability of oil-in-water emulsions determined by backscattering measurements （BS） is proposed. The emulsions assayed exhibited a different backscattering p...In the present work, new kinetics to describe the creaming stability of oil-in-water emulsions determined by backscattering measurements （BS） is proposed. The emulsions assayed exhibited a different backscattering profiles regarding creaming destabilization hyperbolic and sigmoid one. Hyperbolic behavior can be described by a second order kinetics, where k_h could be equaled to a rate constant that describes the creaming process and its values would indicate the stability of emulsions. While for the sigmoid BS pattern, kinetics with two terms, is adequate to describe the creaming process in contrast to kinetics previously reported in the literature. The kh value has the same meaning as before, and ks indicates the delaying effect on the creaming rate.展开更多
Tom:Hi,Lily!What's the weather like today?Lily:It's sunny and warm.The sky is blue.Tom:That's great!I like sunny days.We can play outside.Lily:Yes!Let's go to the park after school.Tom:Good idea!What&#...Tom:Hi,Lily!What's the weather like today?Lily:It's sunny and warm.The sky is blue.Tom:That's great!I like sunny days.We can play outside.Lily:Yes!Let's go to the park after school.Tom:Good idea!What's your favourite season?Lily:I like winter.I can play in the snow and make a snowman.Tom:I like spring.The flowers are beautiful,and the weather is nice.Lily:Do you like summer?Tom:It's too hot,but I like eating ice cream!Lily:Haha!Me too.Ice cream is the best in summer!展开更多
This study aimed to develop and evaluate antimicrobial herbal creams formulated with fresh and dried banana peel(FBP and DBP)extracts for cosmetic applications.Given the abundance of lignocellulosic and bioactive comp...This study aimed to develop and evaluate antimicrobial herbal creams formulated with fresh and dried banana peel(FBP and DBP)extracts for cosmetic applications.Given the abundance of lignocellulosic and bioactive compounds in banana peels,their use in skincare products may provide a natural alternative to synthetic antimicrobial agents.Creams were prepared using standardized formulations containing either fresh or dried banana peel extract.Antimicrobial activity was tested against Staphylococcus aureus,Pseudomonas aeruginosa,Aspergillus niger,and Candida albicans using the agar well diffusion method.Physical properties,including spreadability,pH,homogeneity,and stability,were also evaluated and compared to a commercial cream.The FBP-based cream exhibited strong antibacterial activity,particularly against S.aureus and P.aeruginosa,with inhibition zones up to 40.73 mm.In contrast,the DBP-based cream showed superior antifungal activity against C.albicans and A.niger,with zones up to 49.63 mm.FBP creams also demonstrated better spreadability(34.0 g·cm/s)and uniformity compared to DBP.The results suggest that banana peel extracts possess significant antimicrobial properties and are suitable for use in topical formulations.FBP is more effective for antibacterial applications,while DBP shows stronger antifungal activity.Combining both may offer broad-spectrum protection.Further work should include compound characterization and formulation controls to optimize efficacy.展开更多
Background: The effects of radiation therapy can impact patients’ quality of life, leading to treatment interruptions and therefore sub-optimal outcomes. The main aim was to evaluate the preliminary effects of Ocoxin...Background: The effects of radiation therapy can impact patients’ quality of life, leading to treatment interruptions and therefore sub-optimal outcomes. The main aim was to evaluate the preliminary effects of Ocoxin cream® in the prevention of radiation therapy. Methods: Fifty patients were enrolled in an observational, longitudinal, prospective, single-centre clinical trial in the Department of Radiation Therapy at the National Institute of Oncology and Radiobiology in Havana, Cuba. The Radiation Therapy Oncology Group (RTOG) toxicity criteria were used to classify the radiation therapy, and the Dermatology Life Quality Index (DLQI) instrument was used to assess quality of life. Results: Patients who met the inclusion criteria were enrolled consecutively and were treated with teletherapy using a 60Co source with 1.25 MeV energy. 70.0% of the patients were head and neck cancer patients. No grade 3 - 4 radiation therapy was reported, nor were there any interruptions in radiation treatment due to skin toxicity. Radiation therapy was observed in only 14.0% of patients, and of these, only two patients developed grade 2 toxicity. The perception of quality of life before vs. after radiation therapy remained within an average range of “no effect” (at the start of radiation therapy) to “small effect” (at the end of radiation therapy). Conclusions: This clinical study is the first report of the use of Ocoxin cream® in cancer patients and demonstrates that it is able to prevent radiation therapy and reduce the severity of toxicity of treatment with ionising radiation.展开更多
“This durian smells amazing!What variety is it?”“Do you offer any discounts for buying ice cream in bulk?”“One durian pizza and one portion of fresh durian,please!”At a tropical-themed shop in Nanning East Stati...“This durian smells amazing!What variety is it?”“Do you offer any discounts for buying ice cream in bulk?”“One durian pizza and one portion of fresh durian,please!”At a tropical-themed shop in Nanning East Station,a chorus of customer questions filled the air.Student clerks smiled as they answered inquiries,swiftly packing each order.展开更多
Using the back skin of the mice as the test object,UPLC was used to determine the retention rate of Glabridin(GLA)in the skin and subcutaneous fat pf mice with different dosage forms and different administration times...Using the back skin of the mice as the test object,UPLC was used to determine the retention rate of Glabridin(GLA)in the skin and subcutaneous fat pf mice with different dosage forms and different administration times,and to investigate the transdermal absorption effect of liquid crystal cream.The experimental results showed that the 0.5,1,2,4,6 and 8h skin retention rates of GLA in the liquid crystal cream group were 1.67,0.79,1.73,1.47,1.17 and 1.15 times higher than those of the ordinary cream group under the same dosage of administration,respectively.The 0.5,1,2,4,6 and 8 h fat retention rates of GLA in the normal cream group were 0.86,1.87,1.37,1.20,1.35 and 1.19 times higher than those in the liquid crystal group,respectively.Liquid crystal cream can significantly improve the skin retention of GLA,with certain slow and controlled release,and possesses certain skin targeting properties.展开更多
Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer sur...Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery.Methods:Ninety patients with breast cancer who received postoperative radiotherapy between July 2018 and July 2021 were randomly divided into the Bergmann treatment(experimental)group and the triethanolamine cream treatment(control)group,with 45 patients in each group.Radiodermatitis severity was assessed using the RTOG radiodermatitis grading standards.Results:The radiation dose required to develop grade I radiodermatitis was significantly higher in the experimental group compared to the control group,at(36.13±1.17 Gy)and(25.38±0.63 Gy),respectively.At a radiation dose of 30 Gy,the proportion of grade I radiodermatitis cases in the experimental group was significantly lower than in the control group(P=0.002).At radiation doses of 40 Gy and 50 Gy,the proportion of grade II radiodermatitis cases in the experimental group was also significantly lower than in the control group(P<0.001).No cases of grade III or higher radiodermatitis were observed in the experimental group,while three cases of grade III radiodermatitis occurred in the control group,although the difference was not statistically significant.No patients in the experimental group discontinued treatment due to radiodermatitis or mucosal reactions,whereas two patients in the control group interrupted treatment due to these reactions but eventually completed therapy.Conclusion:Bergmann spray effectively prevents radiodermatitis in patients undergoing radiotherapy after breast cancer surgery and is more effective than triethanolamine cream in treating skin lesions.Its ease of use improves the quality of life for patients undergoing radiotherapy and ensures successful treatment completion.Bergmann is suitable for clinical promotion and application.展开更多
BACKGROUND Ultrasound-guided peripherally inserted central catheter(PICC)placement is vital for cancer therapy,but lidocaine infiltration faces limitations like puncture pain and vasospasm.AIM To assess the clinical e...BACKGROUND Ultrasound-guided peripherally inserted central catheter(PICC)placement is vital for cancer therapy,but lidocaine infiltration faces limitations like puncture pain and vasospasm.AIM To assess the clinical efficacy of a no-pain intervention-combining compound lidocaine cream with warm compress-in reducing pain during ultrasound-guided PICC placement in cancer patients.METHODS A retrospective cohort study analyzed 88 cancer patients undergoing PICC placement(Shanghai Fourth People’s Hospital,2024).Patients were divided into control(lidocaine infiltration,n=44)and intervention(cream+warm compress,n=44)groups.Primary outcomes:Pain scores(numerical rating scale),procedural time,complications;secondary outcome:Satisfaction.RESULTS The intervention group showed significantly lower pain scores(1.2±0.4 vs 3.8±1.2,P=0.012)with comparable first-attempt success(95.5%vs 90.9%)and safety(P=0.672).Thermal activation of transient receptor potential vanilloid 1 channel enhanced drug penetration,achieving anesthesia within 8-10 minutes.Patient satisfaction reached 97.7%.CONCLUSION The combination of compound lidocaine cream with warm compress significantly alleviates procedural pain and enhances patient satisfaction during ultrasound-guided PICC placement in cancer patients,supporting its clinical application.展开更多
文摘In the present work, new kinetics to describe the creaming stability of oil-in-water emulsions determined by backscattering measurements （BS） is proposed. The emulsions assayed exhibited a different backscattering profiles regarding creaming destabilization hyperbolic and sigmoid one. Hyperbolic behavior can be described by a second order kinetics, where k_h could be equaled to a rate constant that describes the creaming process and its values would indicate the stability of emulsions. While for the sigmoid BS pattern, kinetics with two terms, is adequate to describe the creaming process in contrast to kinetics previously reported in the literature. The kh value has the same meaning as before, and ks indicates the delaying effect on the creaming rate.
文摘Tom:Hi,Lily!What's the weather like today?Lily:It's sunny and warm.The sky is blue.Tom:That's great!I like sunny days.We can play outside.Lily:Yes!Let's go to the park after school.Tom:Good idea!What's your favourite season?Lily:I like winter.I can play in the snow and make a snowman.Tom:I like spring.The flowers are beautiful,and the weather is nice.Lily:Do you like summer?Tom:It's too hot,but I like eating ice cream!Lily:Haha!Me too.Ice cream is the best in summer!
文摘This study aimed to develop and evaluate antimicrobial herbal creams formulated with fresh and dried banana peel(FBP and DBP)extracts for cosmetic applications.Given the abundance of lignocellulosic and bioactive compounds in banana peels,their use in skincare products may provide a natural alternative to synthetic antimicrobial agents.Creams were prepared using standardized formulations containing either fresh or dried banana peel extract.Antimicrobial activity was tested against Staphylococcus aureus,Pseudomonas aeruginosa,Aspergillus niger,and Candida albicans using the agar well diffusion method.Physical properties,including spreadability,pH,homogeneity,and stability,were also evaluated and compared to a commercial cream.The FBP-based cream exhibited strong antibacterial activity,particularly against S.aureus and P.aeruginosa,with inhibition zones up to 40.73 mm.In contrast,the DBP-based cream showed superior antifungal activity against C.albicans and A.niger,with zones up to 49.63 mm.FBP creams also demonstrated better spreadability(34.0 g·cm/s)and uniformity compared to DBP.The results suggest that banana peel extracts possess significant antimicrobial properties and are suitable for use in topical formulations.FBP is more effective for antibacterial applications,while DBP shows stronger antifungal activity.Combining both may offer broad-spectrum protection.Further work should include compound characterization and formulation controls to optimize efficacy.
文摘Background: The effects of radiation therapy can impact patients’ quality of life, leading to treatment interruptions and therefore sub-optimal outcomes. The main aim was to evaluate the preliminary effects of Ocoxin cream® in the prevention of radiation therapy. Methods: Fifty patients were enrolled in an observational, longitudinal, prospective, single-centre clinical trial in the Department of Radiation Therapy at the National Institute of Oncology and Radiobiology in Havana, Cuba. The Radiation Therapy Oncology Group (RTOG) toxicity criteria were used to classify the radiation therapy, and the Dermatology Life Quality Index (DLQI) instrument was used to assess quality of life. Results: Patients who met the inclusion criteria were enrolled consecutively and were treated with teletherapy using a 60Co source with 1.25 MeV energy. 70.0% of the patients were head and neck cancer patients. No grade 3 - 4 radiation therapy was reported, nor were there any interruptions in radiation treatment due to skin toxicity. Radiation therapy was observed in only 14.0% of patients, and of these, only two patients developed grade 2 toxicity. The perception of quality of life before vs. after radiation therapy remained within an average range of “no effect” (at the start of radiation therapy) to “small effect” (at the end of radiation therapy). Conclusions: This clinical study is the first report of the use of Ocoxin cream® in cancer patients and demonstrates that it is able to prevent radiation therapy and reduce the severity of toxicity of treatment with ionising radiation.
文摘“This durian smells amazing!What variety is it?”“Do you offer any discounts for buying ice cream in bulk?”“One durian pizza and one portion of fresh durian,please!”At a tropical-themed shop in Nanning East Station,a chorus of customer questions filled the air.Student clerks smiled as they answered inquiries,swiftly packing each order.
文摘Using the back skin of the mice as the test object,UPLC was used to determine the retention rate of Glabridin(GLA)in the skin and subcutaneous fat pf mice with different dosage forms and different administration times,and to investigate the transdermal absorption effect of liquid crystal cream.The experimental results showed that the 0.5,1,2,4,6 and 8h skin retention rates of GLA in the liquid crystal cream group were 1.67,0.79,1.73,1.47,1.17 and 1.15 times higher than those of the ordinary cream group under the same dosage of administration,respectively.The 0.5,1,2,4,6 and 8 h fat retention rates of GLA in the normal cream group were 0.86,1.87,1.37,1.20,1.35 and 1.19 times higher than those in the liquid crystal group,respectively.Liquid crystal cream can significantly improve the skin retention of GLA,with certain slow and controlled release,and possesses certain skin targeting properties.
基金supported by the Baoding City Self-Financed Fund Project(Project No.2241ZF339).
文摘Objective:This study investigates the preventive and therapeutic effects of medical radiation protection spray(Bergmann)compared to triethanolamine cream in patients undergoing radiotherapy following breast cancer surgery.Methods:Ninety patients with breast cancer who received postoperative radiotherapy between July 2018 and July 2021 were randomly divided into the Bergmann treatment(experimental)group and the triethanolamine cream treatment(control)group,with 45 patients in each group.Radiodermatitis severity was assessed using the RTOG radiodermatitis grading standards.Results:The radiation dose required to develop grade I radiodermatitis was significantly higher in the experimental group compared to the control group,at(36.13±1.17 Gy)and(25.38±0.63 Gy),respectively.At a radiation dose of 30 Gy,the proportion of grade I radiodermatitis cases in the experimental group was significantly lower than in the control group(P=0.002).At radiation doses of 40 Gy and 50 Gy,the proportion of grade II radiodermatitis cases in the experimental group was also significantly lower than in the control group(P<0.001).No cases of grade III or higher radiodermatitis were observed in the experimental group,while three cases of grade III radiodermatitis occurred in the control group,although the difference was not statistically significant.No patients in the experimental group discontinued treatment due to radiodermatitis or mucosal reactions,whereas two patients in the control group interrupted treatment due to these reactions but eventually completed therapy.Conclusion:Bergmann spray effectively prevents radiodermatitis in patients undergoing radiotherapy after breast cancer surgery and is more effective than triethanolamine cream in treating skin lesions.Its ease of use improves the quality of life for patients undergoing radiotherapy and ensures successful treatment completion.Bergmann is suitable for clinical promotion and application.
基金Supported by the Discipline Promotion Program of Shanghai Fourth People’s Hospital,No.SY-XKZT-2021-2006.
文摘BACKGROUND Ultrasound-guided peripherally inserted central catheter(PICC)placement is vital for cancer therapy,but lidocaine infiltration faces limitations like puncture pain and vasospasm.AIM To assess the clinical efficacy of a no-pain intervention-combining compound lidocaine cream with warm compress-in reducing pain during ultrasound-guided PICC placement in cancer patients.METHODS A retrospective cohort study analyzed 88 cancer patients undergoing PICC placement(Shanghai Fourth People’s Hospital,2024).Patients were divided into control(lidocaine infiltration,n=44)and intervention(cream+warm compress,n=44)groups.Primary outcomes:Pain scores(numerical rating scale),procedural time,complications;secondary outcome:Satisfaction.RESULTS The intervention group showed significantly lower pain scores(1.2±0.4 vs 3.8±1.2,P=0.012)with comparable first-attempt success(95.5%vs 90.9%)and safety(P=0.672).Thermal activation of transient receptor potential vanilloid 1 channel enhanced drug penetration,achieving anesthesia within 8-10 minutes.Patient satisfaction reached 97.7%.CONCLUSION The combination of compound lidocaine cream with warm compress significantly alleviates procedural pain and enhances patient satisfaction during ultrasound-guided PICC placement in cancer patients,supporting its clinical application.
