Metabolic reprogramming frequently occurs in the majority of cancers,wherein fatty acid oxidation(FAO)is usually induced and serves as a compensatory mechanism to improve energy consumption.Carnitine palmitoyltransfer...Metabolic reprogramming frequently occurs in the majority of cancers,wherein fatty acid oxidation(FAO)is usually induced and serves as a compensatory mechanism to improve energy consumption.Carnitine palmitoyltransferase 1A(CPT1A)is the rate-limiting enzyme for FAO and is widely involved in tumor growth,metastasis,and chemo-/radio-resistance.This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis,including in proliferation and tumor growth,invasion and metastasis,and the tumor microenvironment.Importantly,CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,especially for the treatment of drug-and radiation-resistant tumors.In summary,CPT1A plays remarkable roles in promoting cancer progression and is a potential anticancer therapeutic target.展开更多
终末期肾脏病患者需要进行肾脏替代治疗维持生命,其中腹膜透析是一种可居家进行的肾脏替代治疗方式。PD的有效性取决于腹膜的结构和功能,然而腹膜长期暴露于生物不相容的高浓度葡萄糖透析液中,会发生纤维化改变,最终导致超滤失败。间皮...终末期肾脏病患者需要进行肾脏替代治疗维持生命,其中腹膜透析是一种可居家进行的肾脏替代治疗方式。PD的有效性取决于腹膜的结构和功能,然而腹膜长期暴露于生物不相容的高浓度葡萄糖透析液中,会发生纤维化改变,最终导致超滤失败。间皮细胞可在延长的PD反应中获得纤维化表型,促进腹膜纤维化的发展,最新的研究证明间皮细胞脂肪酸氧化的降低在PF发生发展中起到重要作用。该文章主要对间皮细胞脂肪酸氧化与腹膜纤维化的关系进行论述。Patients with end-stage kidney disease require renal replacement therapy to maintain their lives, among which peritoneal dialysis is a home-based kidney replacement therapy option. The effectiveness of PD depends on the structure and function of the peritoneum. However, long-term exposure of the peritoneum to biocompatible high concentration glucose dialysate can cause fibrosis changes, ultimately leading to ultrafiltration failure. Mesothelial cells can acquire fibrotic phenotype in prolonged PD response, promoting the development of peritoneal fibrosis. Recent studies have shown that the reduction of fatty acid oxidation in mesothelial cells plays an important role in the occurrence and development of PF. This article mainly discusses the relationship between mesothelial cell fatty acid oxidation and peritoneal fibrosis.展开更多
基金funded by the National Natural Science Foundation of China(Nos.82160585 and 81760526)the Yunnan Provincial Research Foundation for Basic Research,China(No.202001AT070028).
文摘Metabolic reprogramming frequently occurs in the majority of cancers,wherein fatty acid oxidation(FAO)is usually induced and serves as a compensatory mechanism to improve energy consumption.Carnitine palmitoyltransferase 1A(CPT1A)is the rate-limiting enzyme for FAO and is widely involved in tumor growth,metastasis,and chemo-/radio-resistance.This review summarizes the most recent advances in understanding the oncogenic roles and mechanisms of CPT1A in tumorigenesis,including in proliferation and tumor growth,invasion and metastasis,and the tumor microenvironment.Importantly,CPT1A has been shown to be a biomarker for diagnosis and prognosis prediction and proved to be a candidate therapeutic target,especially for the treatment of drug-and radiation-resistant tumors.In summary,CPT1A plays remarkable roles in promoting cancer progression and is a potential anticancer therapeutic target.
文摘终末期肾脏病患者需要进行肾脏替代治疗维持生命,其中腹膜透析是一种可居家进行的肾脏替代治疗方式。PD的有效性取决于腹膜的结构和功能,然而腹膜长期暴露于生物不相容的高浓度葡萄糖透析液中,会发生纤维化改变,最终导致超滤失败。间皮细胞可在延长的PD反应中获得纤维化表型,促进腹膜纤维化的发展,最新的研究证明间皮细胞脂肪酸氧化的降低在PF发生发展中起到重要作用。该文章主要对间皮细胞脂肪酸氧化与腹膜纤维化的关系进行论述。Patients with end-stage kidney disease require renal replacement therapy to maintain their lives, among which peritoneal dialysis is a home-based kidney replacement therapy option. The effectiveness of PD depends on the structure and function of the peritoneum. However, long-term exposure of the peritoneum to biocompatible high concentration glucose dialysate can cause fibrosis changes, ultimately leading to ultrafiltration failure. Mesothelial cells can acquire fibrotic phenotype in prolonged PD response, promoting the development of peritoneal fibrosis. Recent studies have shown that the reduction of fatty acid oxidation in mesothelial cells plays an important role in the occurrence and development of PF. This article mainly discusses the relationship between mesothelial cell fatty acid oxidation and peritoneal fibrosis.
