Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multip...Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multiple-Output(MIMO)Orthogonal Frequency Division Multiplexing(OFDM)signals as integrated signals and investigate the estimation performance of MIMO-OFDM signals.First,we analyze the Cramer-Rao Lower Bound(CRLB)of parameter estimation.Then,the transmit powers over different subcarriers are optimized to achieve the best tradeoff between the transmission rate and the estimation performance.Finally,we propose a more accurate estimation method that uses Canonical Polyadic Decomposition(CPD)of the third-order tensor to obtain the parameter matrices.Due to the characteristic of the column structure of the parameter matrices,we only need to use DFT/IDFT to recover the parameters of multiple targets.The simulation results show that tensor-based estimation method can achieve a performance close to CRLB,and the estimation performance can be improved by optimizing the transmit powers.展开更多
Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yu...Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yuan et al demonstrated that CPD4,an ATP-binding pocket inhibitor of MLKL,significantly reduces liver inflammation and improves liver function by inhibiting NF-κB signaling,suggesting its use as a potential therapeutic candidate for alcoholic liver disease.However,the pharmacokinetic properties and long-term toxicity of CPD4 require further evaluation.Moreover,a single therapeutic strategy targeting MLKL may not be sufficient.Future studies should focus on the precise regulation of MLKL and develop combination therapies to achieve dual intervention of inflammatory and cell death pathways.This paper provides an important theoretical foundation for translational research on MLKL-targeted therapy.However,its clinical translation requires overcoming existing limitations and further elucidating the regulatory network of MLKL in complex microenvironments.展开更多
激光点云匹配是影响激光SLAM系统精度和效率的关键因素.传统激光SLAM算法无法区分场景结构,且在非结构化场景下由于特征提取不佳而出现性能退化.为此,提出一种联合CPD(coherent point drift)面向复杂场景的自适应激光SLAM算法CPD-LOAM....激光点云匹配是影响激光SLAM系统精度和效率的关键因素.传统激光SLAM算法无法区分场景结构,且在非结构化场景下由于特征提取不佳而出现性能退化.为此,提出一种联合CPD(coherent point drift)面向复杂场景的自适应激光SLAM算法CPD-LOAM.该算法提出一种基于预判和验证相结合的场景结构辨识方法,首先引入场景特征变量对场景结构进行初步判断,然后从几何特征角度通过表面曲率对其进行验证,增强对场景结构辨识的准确性.此外,在非结构化场景下添加CPD算法进行点云预配准,进而利用ICP算法进行再配准,解决该场景下的特征退化问题,从而提高点云配准的精度和效率.实验结果表明,提出的场景特征变量以及表面曲率可以根据设置的阈值有效地区分场景结构,在公开数据集KITTI上的验证结果显示,CPD-LOAM较LOAM算法定位误差降低了84.47%,相较于LeGO-LOAM与LIO-SAM算法定位精度也分别提升了55.88%和30.52%,且具有更高的效率和鲁棒性.展开更多
基金supported by the National Natural Science Foundation of China under grants 62072229,U1936201,62071220,61976113joint project of China Mobile Research Institute&X-NET。
文摘Dual-function communication radar systems use common Radio Frequency(RF)signals are used for both communication and detection.For better compatibility with existing communication systems,we adopt Multiple-Input Multiple-Output(MIMO)Orthogonal Frequency Division Multiplexing(OFDM)signals as integrated signals and investigate the estimation performance of MIMO-OFDM signals.First,we analyze the Cramer-Rao Lower Bound(CRLB)of parameter estimation.Then,the transmit powers over different subcarriers are optimized to achieve the best tradeoff between the transmission rate and the estimation performance.Finally,we propose a more accurate estimation method that uses Canonical Polyadic Decomposition(CPD)of the third-order tensor to obtain the parameter matrices.Due to the characteristic of the column structure of the parameter matrices,we only need to use DFT/IDFT to recover the parameters of multiple targets.The simulation results show that tensor-based estimation method can achieve a performance close to CRLB,and the estimation performance can be improved by optimizing the transmit powers.
文摘Although mixed lineage kinase domain-like protein(MLKL)is widely recognized as a critical effector in the necroptotic signaling pathway,MLKL plays broader regulatory roles beyond programmed necroptosis.Notably,Xuan Yuan et al demonstrated that CPD4,an ATP-binding pocket inhibitor of MLKL,significantly reduces liver inflammation and improves liver function by inhibiting NF-κB signaling,suggesting its use as a potential therapeutic candidate for alcoholic liver disease.However,the pharmacokinetic properties and long-term toxicity of CPD4 require further evaluation.Moreover,a single therapeutic strategy targeting MLKL may not be sufficient.Future studies should focus on the precise regulation of MLKL and develop combination therapies to achieve dual intervention of inflammatory and cell death pathways.This paper provides an important theoretical foundation for translational research on MLKL-targeted therapy.However,its clinical translation requires overcoming existing limitations and further elucidating the regulatory network of MLKL in complex microenvironments.
文摘激光点云匹配是影响激光SLAM系统精度和效率的关键因素.传统激光SLAM算法无法区分场景结构,且在非结构化场景下由于特征提取不佳而出现性能退化.为此,提出一种联合CPD(coherent point drift)面向复杂场景的自适应激光SLAM算法CPD-LOAM.该算法提出一种基于预判和验证相结合的场景结构辨识方法,首先引入场景特征变量对场景结构进行初步判断,然后从几何特征角度通过表面曲率对其进行验证,增强对场景结构辨识的准确性.此外,在非结构化场景下添加CPD算法进行点云预配准,进而利用ICP算法进行再配准,解决该场景下的特征退化问题,从而提高点云配准的精度和效率.实验结果表明,提出的场景特征变量以及表面曲率可以根据设置的阈值有效地区分场景结构,在公开数据集KITTI上的验证结果显示,CPD-LOAM较LOAM算法定位误差降低了84.47%,相较于LeGO-LOAM与LIO-SAM算法定位精度也分别提升了55.88%和30.52%,且具有更高的效率和鲁棒性.
