作为一种具有高发病率、高死亡率特点的呼吸系统疾病,慢阻肺不仅给患者带来巨大负担,对全球卫生系统而言也是一个巨大挑战。在多种机制的参与下的反复急性加重是慢阻肺患者死亡的原因之一。据统计,约50%的急性加重事件并未报告。频繁的...作为一种具有高发病率、高死亡率特点的呼吸系统疾病,慢阻肺不仅给患者带来巨大负担,对全球卫生系统而言也是一个巨大挑战。在多种机制的参与下的反复急性加重是慢阻肺患者死亡的原因之一。据统计,约50%的急性加重事件并未报告。频繁的急性加重是慢阻肺全因死亡的独立危险因素,慢阻肺患者一次急性加重入院其5年死亡率为55.2%,两次中重度急性加重,其死亡风险增加至80%。目前慢阻肺急性加重期的诊断及其严重程度的判定缺乏具体的量化性指标,主要依据患者的症状、体征和医生的判断,故感染性炎性标志物对于AECOPD的诊断和治疗至关重要。该文对近年来关于COPD生物标志物的研究进行了综述。As a respiratory disease with high incidence rate and mortality, COPD not only brings huge burden to patients, but also poses a huge challenge to the global health system. Repeated acute exacerbations involving multiple mechanisms are one of the causes of death in patients with chronic obstructive pulmonary disease. According to statistics, about 50% of acute exacerbations are not reported. Frequent acute exacerbations are an independent risk factor for all-cause mortality in patients with chronic obstructive pulmonary disease (COPD). A 5-year mortality rate of 55.2% for COPD patients admitted to the hospital with one acute exacerbation, and an increased risk of death of 80% for patients with two moderate to severe acute exacerbations. At present, there is a lack of specific quantitative indicators for the diagnosis and severity assessment of acute exacerbation of chronic obstructive pulmonary disease (COPD), mainly based on the patient’s symptoms, signs, and the doctor’s judgment. Therefore, infectious inflammatory markers are crucial for the diagnosis and treatment of AECOPD. This article provides a review of recent research on biomarkers for COPD.展开更多
We present the physics program of the open charm and heavy cc states above the DD production energy threshold, which will be studied with the BES-Ⅲ detector at the BEPC- Ⅱ collider in the coming years. Based on some...We present the physics program of the open charm and heavy cc states above the DD production energy threshold, which will be studied with the BES-Ⅲ detector at the BEPC- Ⅱ collider in the coming years. Based on some full Monte Carlo simulations with the BES-Ⅲ detector, we predict the accuracy levels on measuring some physical quantities related to D^0, D^＋ and Ds^＋ decays as well as some non-charmed decays of the heavy cc states.展开更多
I give a brief overview of D^0-D^0 mixing and CP violation in the framework of the standard model. I focus on the theoretical estimate of the D^0-D^0 mixing parameters and the phenomenological description of several t...I give a brief overview of D^0-D^0 mixing and CP violation in the framework of the standard model. I focus on the theoretical estimate of the D^0-D^0 mixing parameters and the phenomenological description of several types of CP violation in neutral D-meson decays.展开更多
The D^0-D^0 mixing at Belle in different modes with corresponding methods is reported in this paper, there is a clear evidence for non-zero y D^0 mixing parameter, and the measurement of D^0 mixing parameter x is stil...The D^0-D^0 mixing at Belle in different modes with corresponding methods is reported in this paper, there is a clear evidence for non-zero y D^0 mixing parameter, and the measurement of D^0 mixing parameter x is still a challenge. CP violation in the decays is not observed. Branching fractions of other charm decays are presented.展开更多
Recently, both BaBar and Belle experiments found evidences of neutral D mixing. In this paper, we discuss the sensitivities of the measurements of D mixing parameters at BES-Ⅲ. With CP tag technique at ψ（3770） pea...Recently, both BaBar and Belle experiments found evidences of neutral D mixing. In this paper, we discuss the sensitivities of the measurements of D mixing parameters at BES-Ⅲ. With CP tag technique at ψ（3770） peak, the extraction of the strong phase difference in D^0 → Kπ decay at BES-Ⅲ are discussed. We also make an estimate on the measurements of the mixing rate RM by using the coherent data at ψ（3770） peak. The CP violation in D system is predicted with an unobserved level in the Standard Model. Any significant CP violation in the D system indicates the existence of new physics. The sensitivity of the measurements of CP violation in the D system is estimated in the coherent D decays. Finally, the search for the rare D decays are discussed, in which some of the forbidden decays are smoking gun of new physics.展开更多
文摘作为一种具有高发病率、高死亡率特点的呼吸系统疾病,慢阻肺不仅给患者带来巨大负担,对全球卫生系统而言也是一个巨大挑战。在多种机制的参与下的反复急性加重是慢阻肺患者死亡的原因之一。据统计,约50%的急性加重事件并未报告。频繁的急性加重是慢阻肺全因死亡的独立危险因素,慢阻肺患者一次急性加重入院其5年死亡率为55.2%,两次中重度急性加重,其死亡风险增加至80%。目前慢阻肺急性加重期的诊断及其严重程度的判定缺乏具体的量化性指标,主要依据患者的症状、体征和医生的判断,故感染性炎性标志物对于AECOPD的诊断和治疗至关重要。该文对近年来关于COPD生物标志物的研究进行了综述。As a respiratory disease with high incidence rate and mortality, COPD not only brings huge burden to patients, but also poses a huge challenge to the global health system. Repeated acute exacerbations involving multiple mechanisms are one of the causes of death in patients with chronic obstructive pulmonary disease. According to statistics, about 50% of acute exacerbations are not reported. Frequent acute exacerbations are an independent risk factor for all-cause mortality in patients with chronic obstructive pulmonary disease (COPD). A 5-year mortality rate of 55.2% for COPD patients admitted to the hospital with one acute exacerbation, and an increased risk of death of 80% for patients with two moderate to severe acute exacerbations. At present, there is a lack of specific quantitative indicators for the diagnosis and severity assessment of acute exacerbation of chronic obstructive pulmonary disease (COPD), mainly based on the patient’s symptoms, signs, and the doctor’s judgment. Therefore, infectious inflammatory markers are crucial for the diagnosis and treatment of AECOPD. This article provides a review of recent research on biomarkers for COPD.
基金Supported by National Natural Science Foundation of China (10935007)National Key Basic Research Program (973 by MOST) (2009CB825200XX)
文摘We present the physics program of the open charm and heavy cc states above the DD production energy threshold, which will be studied with the BES-Ⅲ detector at the BEPC- Ⅱ collider in the coming years. Based on some full Monte Carlo simulations with the BES-Ⅲ detector, we predict the accuracy levels on measuring some physical quantities related to D^0, D^＋ and Ds^＋ decays as well as some non-charmed decays of the heavy cc states.
基金National Natural Science Foundation of China(10425522)
文摘I give a brief overview of D^0-D^0 mixing and CP violation in the framework of the standard model. I focus on the theoretical estimate of the D^0-D^0 mixing parameters and the phenomenological description of several types of CP violation in neutral D-meson decays.
基金Supported by National Natural Science Foundation of China (10935008,10875115)
文摘The D^0-D^0 mixing at Belle in different modes with corresponding methods is reported in this paper, there is a clear evidence for non-zero y D^0 mixing parameter, and the measurement of D^0 mixing parameter x is still a challenge. CP violation in the decays is not observed. Branching fractions of other charm decays are presented.
基金Knowledge Innovation Project of CAS(U-612, U-530(IHEP))100 Talents Program of CAS
文摘Recently, both BaBar and Belle experiments found evidences of neutral D mixing. In this paper, we discuss the sensitivities of the measurements of D mixing parameters at BES-Ⅲ. With CP tag technique at ψ（3770） peak, the extraction of the strong phase difference in D^0 → Kπ decay at BES-Ⅲ are discussed. We also make an estimate on the measurements of the mixing rate RM by using the coherent data at ψ（3770） peak. The CP violation in D system is predicted with an unobserved level in the Standard Model. Any significant CP violation in the D system indicates the existence of new physics. The sensitivity of the measurements of CP violation in the D system is estimated in the coherent D decays. Finally, the search for the rare D decays are discussed, in which some of the forbidden decays are smoking gun of new physics.
