Prostatic carcinoma(PCa)has become one of the most common cancers among men worldwide,with both incidence and mortality rates steadily rising.Although current treatments are effective in the early stages of PCa,many c...Prostatic carcinoma(PCa)has become one of the most common cancers among men worldwide,with both incidence and mortality rates steadily rising.Although current treatments are effective in the early stages of PCa,many cases eventually progress to castration-resistant prostate cancer(CRPC),and led to treatment failure.To develop new therapeutic strategies to ameliorate the survival of PCa patients then has pressed the need on medicinal researchers.Of traditional Chinese medicinal herbs,Angelica gigas Naka(AGN),and its major pyranocoumarins were broadly reported on the effect of anti-PCa.However,existing reviews mainly focus on decursin(D),decursinol angelate(DA),and decursinol(DOH),without fully exploring other coumarins in AGN.Moreover,most reviews discuss general anticancer effects,with limited emphasis on PCa specifically.This review made a comprehensive summary of the coumarin components of AGN,and depicted the anti-PCa effects and mechanisms,giving a solid research support for drug discovery and development.This review also featured pharmacokinetic advantages and therapeutic potential of DOH,in order to suggest possibilities to overcome the in vivo transformation limitations of D and DA,and shed light on CRPC treatment.We also recommend future studies focus on more in vivo evidence,safety and toxicity evaluation,and clinical validation in humans.展开更多
A photocatalyst-free photoinduced radical difluoromethylation approach for the convenient synthesis of 3-CF_(2)H-coumarins from alkynoates by difluoromethyl phenoxathiinium salt(PT-CF_(2)H^(+)BF_(4)^(-))was developed....A photocatalyst-free photoinduced radical difluoromethylation approach for the convenient synthesis of 3-CF_(2)H-coumarins from alkynoates by difluoromethyl phenoxathiinium salt(PT-CF_(2)H^(+)BF_(4)^(-))was developed.This transformation in-volves radical difluoromethylation/5-exo spirocyclization/ester migration rearrangement cascade process and features mild reaction conditions,broad substrate scope and good functional groups tolerance.Using this method,a wide range of alkynoates was successfully converted to desired 3-CF_(2)H-coumarins in moderate to good yields.展开更多
Background Coumarins are toxic phytochemicals found in a variety of plants and are known to limit microbial degradation and interfere with nutrient cycling.While the degradation of coumarins by fungi has been studied ...Background Coumarins are toxic phytochemicals found in a variety of plants and are known to limit microbial degradation and interfere with nutrient cycling.While the degradation of coumarins by fungi has been studied in an environmental context,little is known about their degradation in the gastrointestinal system of herbivores after ingestion.Results In this study,we investigated in vitro fermentation by microbial enrichment,transcriptome sequencing,and high-resolution mass spectrometry to evaluate the ability of rumen anaerobic fungi to degrade coumarins.The results showed that despite the low abundance of anaerobic fungi in the rumen microbiota,they were able to effectively degrade coumarins.Specifically,Pecoramyces ruminantium F1 could tolerate coumarin concentrations up to 3 mmol/L and degrade it efficiently via metabolic pathways involving alpha/beta hydrolases and NAD(P)H oxidoreductases within the late growth phase.The fungus metabolized coumarin to less toxic compounds,including o-coumaric acid and melilotic acid,highlighting the detoxification potential of anaerobic fungi.Conclusions This study is the first to demonstrate the ability of rumen anaerobic fungi to degrade coumarin,providing new insights into the use of anaerobic fungi in sustainable agricultural practices and environmental detoxification strategies.展开更多
Objective:To evaluate the therapeutic potential of coumarin-loaded chitosan nanoparticles(CNNPs)in managing high-fructose diet-induced diabetes and associated complications.Methods:CNNPs were synthesized using an ioni...Objective:To evaluate the therapeutic potential of coumarin-loaded chitosan nanoparticles(CNNPs)in managing high-fructose diet-induced diabetes and associated complications.Methods:CNNPs were synthesized using an ionic gelation method with chitosan coating and characterized.Rats with a high-fructose diet-induced diabetes were treated with coumarin and CNNPs(30,70,and 100 mg/kg)for 6-12 weeks.Metabolic,inflammatory,oxidative stress,organ function,and cardiovascular parameters were assessed,and qRT-PCR studies were carried out for measuring the mRNA expression of glucose transporter-4(GLUT-4),sirtuin-1(SIRT1),pyrin domain containing-3(NLRP3),sterol regulatory element binding protein 1c(SREBP-1c),forkhead box O3(FOXO3),and endothelial nitric oxide synthase(eNOS)genes.Results:Nanoparticle characterization revealed a Z-average size of 510.8 nm with a+14 mV zeta potential.CNNP treatment was more effective than coumarin,normalizing glycemic markers(glycosylated hemoglobin,serum insulin,and fasting blood glucose),and lipid profiles(total cholesterol,low-density lipoprotein cholesterol,triglycerides,and high-density lipoprotein cholesterol).Significant improvements were also seen in adipokines(adiponectin,chemerin,and leptin),inflammatory cytokines(interleukin-6 and tumor necrosis factor-α),and oxidative stress markers(catalase,superoxide dismutase and malonaldehyde).In addition,both treatments significantly upregulated the gene expression of SIRT1,GLUT-4,and eNOS,and downregulated FOXO3,SREBP-1c,and NLRP3.Histopathological studies confirmed that CNNPs ameliorated diabetes-induced structural abnormalities in major organs.Conclusions:CNNPs demonstrate improved bioavailability and therapeutic efficacy,offering a promising strategy for managing high-fructose diet-induced metabolic dysfunction and its complications.展开更多
Two new O-terpenoidal coumarins named excavacoumarin A (2): B (3), and a known one 1 were isolated from the leaves of Clausena excavata Burm. f. (Rutaceae) collected in Xishuangbanna, Yunnan, Structure elucidation and...Two new O-terpenoidal coumarins named excavacoumarin A (2): B (3), and a known one 1 were isolated from the leaves of Clausena excavata Burm. f. (Rutaceae) collected in Xishuangbanna, Yunnan, Structure elucidation and unambiguous NMR assignments for the title compounds were carried out on the basis of 1D and 2D NMR experiments.展开更多
Species from Moraceae family stand out in popular medicine and phytotherapy, have been for example used as expectorants, bronchodilators, anthelmintics and treatment of skin diseases, such as vitiligo, due to the pres...Species from Moraceae family stand out in popular medicine and phytotherapy, have been for example used as expectorants, bronchodilators, anthelmintics and treatment of skin diseases, such as vitiligo, due to the presence of compounds with proven biological activity, as the coumarins. Coumarins are lactones with 1,2-benzopyrone basic structure, and are widely distributed in the plant kingdom, both in free form, and in glycosylated form. This work reports a literature review, describing the data of 13C NMR from 53 coumarins isolated from the family Moraceae, and data comparison between genera who presented photochemical studies, in order to contribute to the chemotaxonomy of this family.展开更多
A new angelol-type coumarin glucoside, 6-[（1R,2R）-1, 2-dihydroxy-3-β-D-glucosyloxy-3-methylbutyl]-7-methoxycoumarin, was isolated from the roots of Angelica pubescens. Its structure was elucidated on the basis of s...A new angelol-type coumarin glucoside, 6-[（1R,2R）-1, 2-dihydroxy-3-β-D-glucosyloxy-3-methylbutyl]-7-methoxycoumarin, was isolated from the roots of Angelica pubescens. Its structure was elucidated on the basis of spectral analysis.展开更多
TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes was performed using polystyrene-supported succini- midyl selenide as the selenium source. This catalytic process provides an efficient method for th...TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes was performed using polystyrene-supported succini- midyl selenide as the selenium source. This catalytic process provides an efficient method for the regioselective synthesis of dihydrocoumarins possessing a seleno-functionality, followed by traceless cleavage of selenium linker to provide dihydrocoumar- ins and coumarins in good yields and purifies.展开更多
Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings.They are commonly found in bioactive natural products and have a diverse range of biological ...Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings.They are commonly found in bioactive natural products and have a diverse range of biological and pharmaceutical properties,including cytotoxicity,photosensitivity,insecticidal,antibacterial,and antifungal activity,among others.The elegant linear/angular tricyclic skeleton and superior pharmacological properties,make them ideal for building and developing advanced biological scaffolds for biomedical applications.As a result,the family of furocoumarins has been the focus of intensive research,and lots of encouraging progress have been achieved in recent years.This review summarizes the most recent methods reported for the synthesis of the furocoumarin derivative family,along with their applications in medicinal chemistry covering from 2018 to 2022.展开更多
A facile procedure for the synthesis of 3-（2′-amino-3′-cyano-4′-arylpyrid-6′-yl） coumarins are being reported starting from 3- acetylcoumarin, aromatic aldehydes and malononitrile. The reactions were carried out...A facile procedure for the synthesis of 3-（2′-amino-3′-cyano-4′-arylpyrid-6′-yl） coumarins are being reported starting from 3- acetylcoumarin, aromatic aldehydes and malononitrile. The reactions were carried out on microwave irradiation in good yield with short time and easy work-up. The structures of all the compounds have been confirmed on the basis of their analytical, IR, ^1H NMR, and mass spectral data.展开更多
Two new coumarins, named marminal (13) and 7' O methylmarmin (15), along with nineteen known compounds: ( sitosteryl pentadecanoate (1), 4 methoxy 1 methyl 2 quinolone (2), aurapten (3), 4 sitosten 3 on...Two new coumarins, named marminal (13) and 7' O methylmarmin (15), along with nineteen known compounds: ( sitosteryl pentadecanoate (1), 4 methoxy 1 methyl 2 quinolone (2), aurapten (3), 4 sitosten 3 one (4), lupeol (5), imperatorin (6), xanthotoxin (7), dictamnine (8), (+) epoxyaurapten (9), ( sitosterol (10), ( fagarine (11), skimmianine (12), scoparone (14), umbelliferone (16), scopoletin (17), decursinol (18), marmesin (19), marmin (20), and integriquinolone (21) were isolated from the methanolic extract of the roots of Aegle marmelos Corr. (family Rutaceae).展开更多
Different hydroxy substituted coumarins were successfully phosphorylated with diisopropylphophite （DIPPH） by the Atherton-Todd reaction in 76-89% yields. Moreover, the reaction activities of different hydroxys of th...Different hydroxy substituted coumarins were successfully phosphorylated with diisopropylphophite （DIPPH） by the Atherton-Todd reaction in 76-89% yields. Moreover, the reaction activities of different hydroxys of the coumarins in the Atherton-Todd reaction were studied.展开更多
Three new coumarins,integmarins A–C(1–3),and a new coumarin glycoside,integmaside A(4)were isolated from the leaves and stems of Micromelum integerrimum.Their structures were elucidated on the basis of 1 D and 2 D N...Three new coumarins,integmarins A–C(1–3),and a new coumarin glycoside,integmaside A(4)were isolated from the leaves and stems of Micromelum integerrimum.Their structures were elucidated on the basis of 1 D and 2 D NMR and MS data,and their absolute configurations were assigned according to the ECD data of the in situ formed transition metal complexes and comparison of experimental and calculated ECD data.Compounds 1 and 2 are two rare coumarins with butyl and propyl moieties at the C-6 position;compound 3 is a novel coumarin with a highly oxidized prenyl group,and compound 4 is a rare bisdihydrofuranocoumarin glycoside.展开更多
A series of new N-substituted cyclic imides of coumarins and azacoumarins have been synthesized. All the compounds were screened for their antibacterial and antifungal activities. α-Amylase enzyme inhibition activiti...A series of new N-substituted cyclic imides of coumarins and azacoumarins have been synthesized. All the compounds were screened for their antibacterial and antifungal activities. α-Amylase enzyme inhibition activities of some N-substituted phthalimide derivatives have been explored. All the compounds were characterized by IR, 1H-NMR, and GC-MS.展开更多
Nine coumarin compounds were further isolated from Angelica pubescence. They were columbianedin (1), osthol (2), bergapten (3), isoimperaterin (4), meranzin hydrate (5), nodakenetin (6), marmesinin (7), columbianin (8...Nine coumarin compounds were further isolated from Angelica pubescence. They were columbianedin (1), osthol (2), bergapten (3), isoimperaterin (4), meranzin hydrate (5), nodakenetin (6), marmesinin (7), columbianin (8) and angelidiol (9). Among them, 5～8 were isolated for the first time from this plant, 9 is a new natural product.展开更多
Polyurethanes consisting of tri-functional homopolymer of hexamethylene diisocyanate （tri-HDI） and polyethylene glycol （PEG） are synthesized, in which photo-reversible coumarin moieties act as pendant groups. Acco...Polyurethanes consisting of tri-functional homopolymer of hexamethylene diisocyanate （tri-HDI） and polyethylene glycol （PEG） are synthesized, in which photo-reversible coumarin moieties act as pendant groups. Accordingly, the polyurethanes can be repeatedly self-healed under UV lights at room temperature by taking advantages of the photodimerization and photocleavage habits of coumarin. Molecular weight of the soft segment, PEG, is found to be closely related to the healing performance of the polyurethanes. Lower molecular weight PEG that corresponds to higher initial coumarin concentration in the polymer is critical for obtaining higher healing efficiency in the case of the first healing action. Nevertheless, it does not guarantee high reversibility of the photo-remendability during the repeated healing events. In contrast, the polyurethane with moderate molecular weight PEG has achieved balanced performance. Reaction kinetics is less important for the healing effect.展开更多
A novel dimeric coumarin (1), a dimeric of seselin named diseselin A, was isolated from the aerial part of Clausena lenis. The structure was elucidated based on the MS, 1D and 2D NMR data.
Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring...Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena(family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity. This review summarizes research progresses made in the anticancer properties of plants belonging to Clausena; in particular, compounds with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation effects are discussed. This review reveals the potential use of plants from Clausena in preventing and treating cancer and provides a basis for development of relevant therapeutic agents.展开更多
Oxalic acid was found to be an efficient catalyst for Pechmann condensation, which includes the reaction between phenols and β-keto esters leading to formation of coumarin derivatives. The advantages of present metho...Oxalic acid was found to be an efficient catalyst for Pechmann condensation, which includes the reaction between phenols and β-keto esters leading to formation of coumarin derivatives. The advantages of present methods are the use of cheap and easy available catalyst, solvent-free reaction conditions, better yields and shorter reaction time.展开更多
基金supported by the Natural Science Foundation of Guangdong Province(grant number 2021A1515011485)the Traditional Chinese Medicine Multidisciplinary Innovation Team Program of Liaoning Province(grant number LNZYYCXTD-JCCX-002)+1 种基金the Key Laboratory foundation of Ministry of Education for TCM Viscera State Theory and Applications of Liaoning University of Traditional Chinese Medicine(grant number.zyzx1807)“Three levels”Talent Construction Projects in Zhuhai College of Science and Technology.
文摘Prostatic carcinoma(PCa)has become one of the most common cancers among men worldwide,with both incidence and mortality rates steadily rising.Although current treatments are effective in the early stages of PCa,many cases eventually progress to castration-resistant prostate cancer(CRPC),and led to treatment failure.To develop new therapeutic strategies to ameliorate the survival of PCa patients then has pressed the need on medicinal researchers.Of traditional Chinese medicinal herbs,Angelica gigas Naka(AGN),and its major pyranocoumarins were broadly reported on the effect of anti-PCa.However,existing reviews mainly focus on decursin(D),decursinol angelate(DA),and decursinol(DOH),without fully exploring other coumarins in AGN.Moreover,most reviews discuss general anticancer effects,with limited emphasis on PCa specifically.This review made a comprehensive summary of the coumarin components of AGN,and depicted the anti-PCa effects and mechanisms,giving a solid research support for drug discovery and development.This review also featured pharmacokinetic advantages and therapeutic potential of DOH,in order to suggest possibilities to overcome the in vivo transformation limitations of D and DA,and shed light on CRPC treatment.We also recommend future studies focus on more in vivo evidence,safety and toxicity evaluation,and clinical validation in humans.
文摘A photocatalyst-free photoinduced radical difluoromethylation approach for the convenient synthesis of 3-CF_(2)H-coumarins from alkynoates by difluoromethyl phenoxathiinium salt(PT-CF_(2)H^(+)BF_(4)^(-))was developed.This transformation in-volves radical difluoromethylation/5-exo spirocyclization/ester migration rearrangement cascade process and features mild reaction conditions,broad substrate scope and good functional groups tolerance.Using this method,a wide range of alkynoates was successfully converted to desired 3-CF_(2)H-coumarins in moderate to good yields.
基金supported by National Key Research and Development Program of China(2021YFD1300302)the National Natural Science Foundation of China(U23A20216 and 32372905)。
文摘Background Coumarins are toxic phytochemicals found in a variety of plants and are known to limit microbial degradation and interfere with nutrient cycling.While the degradation of coumarins by fungi has been studied in an environmental context,little is known about their degradation in the gastrointestinal system of herbivores after ingestion.Results In this study,we investigated in vitro fermentation by microbial enrichment,transcriptome sequencing,and high-resolution mass spectrometry to evaluate the ability of rumen anaerobic fungi to degrade coumarins.The results showed that despite the low abundance of anaerobic fungi in the rumen microbiota,they were able to effectively degrade coumarins.Specifically,Pecoramyces ruminantium F1 could tolerate coumarin concentrations up to 3 mmol/L and degrade it efficiently via metabolic pathways involving alpha/beta hydrolases and NAD(P)H oxidoreductases within the late growth phase.The fungus metabolized coumarin to less toxic compounds,including o-coumaric acid and melilotic acid,highlighting the detoxification potential of anaerobic fungi.Conclusions This study is the first to demonstrate the ability of rumen anaerobic fungi to degrade coumarin,providing new insights into the use of anaerobic fungi in sustainable agricultural practices and environmental detoxification strategies.
基金This article is funded by HEC,520-163233-2AV6-09,Anam Iqbal.
文摘Objective:To evaluate the therapeutic potential of coumarin-loaded chitosan nanoparticles(CNNPs)in managing high-fructose diet-induced diabetes and associated complications.Methods:CNNPs were synthesized using an ionic gelation method with chitosan coating and characterized.Rats with a high-fructose diet-induced diabetes were treated with coumarin and CNNPs(30,70,and 100 mg/kg)for 6-12 weeks.Metabolic,inflammatory,oxidative stress,organ function,and cardiovascular parameters were assessed,and qRT-PCR studies were carried out for measuring the mRNA expression of glucose transporter-4(GLUT-4),sirtuin-1(SIRT1),pyrin domain containing-3(NLRP3),sterol regulatory element binding protein 1c(SREBP-1c),forkhead box O3(FOXO3),and endothelial nitric oxide synthase(eNOS)genes.Results:Nanoparticle characterization revealed a Z-average size of 510.8 nm with a+14 mV zeta potential.CNNP treatment was more effective than coumarin,normalizing glycemic markers(glycosylated hemoglobin,serum insulin,and fasting blood glucose),and lipid profiles(total cholesterol,low-density lipoprotein cholesterol,triglycerides,and high-density lipoprotein cholesterol).Significant improvements were also seen in adipokines(adiponectin,chemerin,and leptin),inflammatory cytokines(interleukin-6 and tumor necrosis factor-α),and oxidative stress markers(catalase,superoxide dismutase and malonaldehyde).In addition,both treatments significantly upregulated the gene expression of SIRT1,GLUT-4,and eNOS,and downregulated FOXO3,SREBP-1c,and NLRP3.Histopathological studies confirmed that CNNPs ameliorated diabetes-induced structural abnormalities in major organs.Conclusions:CNNPs demonstrate improved bioavailability and therapeutic efficacy,offering a promising strategy for managing high-fructose diet-induced metabolic dysfunction and its complications.
文摘Two new O-terpenoidal coumarins named excavacoumarin A (2): B (3), and a known one 1 were isolated from the leaves of Clausena excavata Burm. f. (Rutaceae) collected in Xishuangbanna, Yunnan, Structure elucidation and unambiguous NMR assignments for the title compounds were carried out on the basis of 1D and 2D NMR experiments.
文摘Species from Moraceae family stand out in popular medicine and phytotherapy, have been for example used as expectorants, bronchodilators, anthelmintics and treatment of skin diseases, such as vitiligo, due to the presence of compounds with proven biological activity, as the coumarins. Coumarins are lactones with 1,2-benzopyrone basic structure, and are widely distributed in the plant kingdom, both in free form, and in glycosylated form. This work reports a literature review, describing the data of 13C NMR from 53 coumarins isolated from the family Moraceae, and data comparison between genera who presented photochemical studies, in order to contribute to the chemotaxonomy of this family.
基金the Jiangsu Province Basic Facility Project(Nos.:BM2006104,BM2006507).
文摘A new angelol-type coumarin glucoside, 6-[（1R,2R）-1, 2-dihydroxy-3-β-D-glucosyloxy-3-methylbutyl]-7-methoxycoumarin, was isolated from the roots of Angelica pubescens. Its structure was elucidated on the basis of spectral analysis.
基金the National Natural Science Foundation of China(Nos.20802063,21162032)the Foundation of the Key Laboratory of Medicinal Chemistry of Natural Resource(Yunnan University),Ministry of Education,China
文摘TMSOTf-catalyzed intramolecular seleno-arylation of tethered alkenes was performed using polystyrene-supported succini- midyl selenide as the selenium source. This catalytic process provides an efficient method for the regioselective synthesis of dihydrocoumarins possessing a seleno-functionality, followed by traceless cleavage of selenium linker to provide dihydrocoumar- ins and coumarins in good yields and purifies.
基金financial support from the National Natural Science Foundation of China(Nos.21971211 and 22171232)the Natural Science Foundation of Zhejiang Province(No.2022XHSJJ007)+3 种基金the Qiantang River Talent Foundation(No.QJD1902029)Westlake Universitysupported by Instrumentation and Service Centers for Molecular Science and for Physical Science(ISCMS and ISCPS)by the Mass Spectrometry&Metabolomics Core Facility at the Center for Biomedical Research Core Facilities and Westlake University HPC Center。
文摘Furocoumarins are an important class of heterocyclic compounds with a fused tricyclic structure of coumarin and furan rings.They are commonly found in bioactive natural products and have a diverse range of biological and pharmaceutical properties,including cytotoxicity,photosensitivity,insecticidal,antibacterial,and antifungal activity,among others.The elegant linear/angular tricyclic skeleton and superior pharmacological properties,make them ideal for building and developing advanced biological scaffolds for biomedical applications.As a result,the family of furocoumarins has been the focus of intensive research,and lots of encouraging progress have been achieved in recent years.This review summarizes the most recent methods reported for the synthesis of the furocoumarin derivative family,along with their applications in medicinal chemistry covering from 2018 to 2022.
基金the Jiangsu Key Laboratory for Chemistry of Low-Dimensional Materials for financial support(No.JSKC07041).
文摘A facile procedure for the synthesis of 3-（2′-amino-3′-cyano-4′-arylpyrid-6′-yl） coumarins are being reported starting from 3- acetylcoumarin, aromatic aldehydes and malononitrile. The reactions were carried out on microwave irradiation in good yield with short time and easy work-up. The structures of all the compounds have been confirmed on the basis of their analytical, IR, ^1H NMR, and mass spectral data.
基金The authors thank the financial supports from the National Natural Science Foundation of China(No.20132020)the Ministry of Science and Technology,the Chinese Ministry of Education and Zhengzhou University.
文摘Different hydroxy substituted coumarins were successfully phosphorylated with diisopropylphophite （DIPPH） by the Atherton-Todd reaction in 76-89% yields. Moreover, the reaction activities of different hydroxys of the coumarins in the Atherton-Todd reaction were studied.
基金supported by the National Natural Sciences Foundation of China(Nos.81973199,81773864 and81473106)the Drug Innovation Major Project of China(No.2018ZX09711001-008-003)。
文摘Three new coumarins,integmarins A–C(1–3),and a new coumarin glycoside,integmaside A(4)were isolated from the leaves and stems of Micromelum integerrimum.Their structures were elucidated on the basis of 1 D and 2 D NMR and MS data,and their absolute configurations were assigned according to the ECD data of the in situ formed transition metal complexes and comparison of experimental and calculated ECD data.Compounds 1 and 2 are two rare coumarins with butyl and propyl moieties at the C-6 position;compound 3 is a novel coumarin with a highly oxidized prenyl group,and compound 4 is a rare bisdihydrofuranocoumarin glycoside.
文摘A series of new N-substituted cyclic imides of coumarins and azacoumarins have been synthesized. All the compounds were screened for their antibacterial and antifungal activities. α-Amylase enzyme inhibition activities of some N-substituted phthalimide derivatives have been explored. All the compounds were characterized by IR, 1H-NMR, and GC-MS.
文摘Nine coumarin compounds were further isolated from Angelica pubescence. They were columbianedin (1), osthol (2), bergapten (3), isoimperaterin (4), meranzin hydrate (5), nodakenetin (6), marmesinin (7), columbianin (8) and angelidiol (9). Among them, 5～8 were isolated for the first time from this plant, 9 is a new natural product.
基金financially supported by the National Natural Science Foundation of China(Nos.51333008,51273214 and 51073176)the project of key technological breakthrough for emerging industries of strategic importance(Nos.2011A091102001,and 2011A091102003)+2 种基金the Science and Technology Program of Guangdong Province(Nos.2010B010800021 and 2010A011300004)the Basic Scientific Research Foundation in Colleges and Universities of Ministry of Education of China(No.12lgjc08)the ST project of Hongyun Honghe Tobacco Group(No.HYHH2013YL06)
文摘Polyurethanes consisting of tri-functional homopolymer of hexamethylene diisocyanate （tri-HDI） and polyethylene glycol （PEG） are synthesized, in which photo-reversible coumarin moieties act as pendant groups. Accordingly, the polyurethanes can be repeatedly self-healed under UV lights at room temperature by taking advantages of the photodimerization and photocleavage habits of coumarin. Molecular weight of the soft segment, PEG, is found to be closely related to the healing performance of the polyurethanes. Lower molecular weight PEG that corresponds to higher initial coumarin concentration in the polymer is critical for obtaining higher healing efficiency in the case of the first healing action. Nevertheless, it does not guarantee high reversibility of the photo-remendability during the repeated healing events. In contrast, the polyurethane with moderate molecular weight PEG has achieved balanced performance. Reaction kinetics is less important for the healing effect.
基金supported by a grant from the National Natural Science Foundation of China(No.39525025 and No.30200350)
文摘A novel dimeric coumarin (1), a dimeric of seselin named diseselin A, was isolated from the aerial part of Clausena lenis. The structure was elucidated based on the MS, 1D and 2D NMR data.
基金supported by the Macao Science and Technology Development Fund(No.120/2013/A3)the Research Fund of University of Macao(Nos.MYRG2015-00153-ICMS-QRCM and MYRG2017-00109-ICMS)
文摘Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena(family Rutaceae) is a genus of flowering plants and includes several kinds of edible fruits and vegetables. Phytochemical and pharmacological studies show that carbazole alkaloids and coumarins from Clausena plants exhibit anticancer activity. This review summarizes research progresses made in the anticancer properties of plants belonging to Clausena; in particular, compounds with direct cytotoxicity, cell cycle arrest, apoptosis induction, and immune potentiation effects are discussed. This review reveals the potential use of plants from Clausena in preventing and treating cancer and provides a basis for development of relevant therapeutic agents.
文摘Oxalic acid was found to be an efficient catalyst for Pechmann condensation, which includes the reaction between phenols and β-keto esters leading to formation of coumarin derivatives. The advantages of present methods are the use of cheap and easy available catalyst, solvent-free reaction conditions, better yields and shorter reaction time.
