More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents.Among them,Cordia dichotoma F...More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents.Among them,Cordia dichotoma Forst.,a small to moderate size plant of family Boragenaceae.commonly called bhokar,lasura,gonda,Indian cherry and shlesmataka.Plant parts such as leaves,fruit,bark and seed have been reported for possessing antidiabetic,antiulcer,anti-inflammatory,immune-modulator and analgesic activity.Screening of fruit,leaves and seed shows the presence of pyrrolizidine alkaloids,coumarins,flavonoids,saponins,lerpenes and sterols.Present review focuses on details of geographical distribution,physicochemical parameters,phytoconstituents and pharmacological properties of Cordia dichotoma reported so far.展开更多
Plants of the genus Cordia(Boraginaceae family)are widely distributed in the tropical regions of America,Africa,and Asia.They are extensively used in folk medicine due to their rich medicinal properties.This review pr...Plants of the genus Cordia(Boraginaceae family)are widely distributed in the tropical regions of America,Africa,and Asia.They are extensively used in folk medicine due to their rich medicinal properties.This review presents a comprehensive analysis of the isolation,structure,biogenesis,and biological properties of quinones from Cordia species reported from 1972 to 2023.Meroterpenoids were identified as the major quinones in most Cordia species and are reported as a chemotaxonomic markers of the Cordia.In addition to this property,quinones are reported to display a wider and broader spectrum of activities,are efficient scaffold in biological activity,compared to other classes of compounds reported in Cordia,hence our focus on the study of quinones reported from Cordia species.About 70 types of quinones have been isolated,while others have been identified by phytochemical screening or gas chromatography.Although the biosynthesis of quinones from Cordia species is not yet fully understood,previous reports suggest that they may be derived from geranyl pyrophosphate and an aromatic precursor unit,followed by oxidative cyclization of the allylic methyl group.Studies have demonstrated that quinones from this genus exhibit antifungal,larvicidal,antileishmanial,anti-inflammatory,antibiofilm,antimycobacterial,antioxidant,antimalarial,neuroinhibitory,and hemolytic activities.In addition,they have been shown to exhibit remarkable cytotoxic effects against several cancer cell lines which is likely related to their ability to inhibit electron transport as well as oxidative phosphorylation,and generate reactive oxygen species(ROS).Their biological activities indicate potential utility in the development of new drugs,especially as active components in drug-carrier systems,against a broad spectrum of pathogens and ailments.展开更多
文摘More than half of the world's population relies on the traditional medicine and major role of the traditional medicine including the use of plant extract and their active constituents.Among them,Cordia dichotoma Forst.,a small to moderate size plant of family Boragenaceae.commonly called bhokar,lasura,gonda,Indian cherry and shlesmataka.Plant parts such as leaves,fruit,bark and seed have been reported for possessing antidiabetic,antiulcer,anti-inflammatory,immune-modulator and analgesic activity.Screening of fruit,leaves and seed shows the presence of pyrrolizidine alkaloids,coumarins,flavonoids,saponins,lerpenes and sterols.Present review focuses on details of geographical distribution,physicochemical parameters,phytoconstituents and pharmacological properties of Cordia dichotoma reported so far.
基金XS-N kindly acknowledges a National Research Foundation(NRF)Competitive Support for Unrated Researchers(CSUR)grant,Reference Number:SRUG2203291031.
文摘Plants of the genus Cordia(Boraginaceae family)are widely distributed in the tropical regions of America,Africa,and Asia.They are extensively used in folk medicine due to their rich medicinal properties.This review presents a comprehensive analysis of the isolation,structure,biogenesis,and biological properties of quinones from Cordia species reported from 1972 to 2023.Meroterpenoids were identified as the major quinones in most Cordia species and are reported as a chemotaxonomic markers of the Cordia.In addition to this property,quinones are reported to display a wider and broader spectrum of activities,are efficient scaffold in biological activity,compared to other classes of compounds reported in Cordia,hence our focus on the study of quinones reported from Cordia species.About 70 types of quinones have been isolated,while others have been identified by phytochemical screening or gas chromatography.Although the biosynthesis of quinones from Cordia species is not yet fully understood,previous reports suggest that they may be derived from geranyl pyrophosphate and an aromatic precursor unit,followed by oxidative cyclization of the allylic methyl group.Studies have demonstrated that quinones from this genus exhibit antifungal,larvicidal,antileishmanial,anti-inflammatory,antibiofilm,antimycobacterial,antioxidant,antimalarial,neuroinhibitory,and hemolytic activities.In addition,they have been shown to exhibit remarkable cytotoxic effects against several cancer cell lines which is likely related to their ability to inhibit electron transport as well as oxidative phosphorylation,and generate reactive oxygen species(ROS).Their biological activities indicate potential utility in the development of new drugs,especially as active components in drug-carrier systems,against a broad spectrum of pathogens and ailments.
