Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medi...Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells. We detected a fast and significant (P <0.001) release of transforming growth factor-β1 (TGF-β1) from autologous bone within 10 min versus a delayed bone morphogenetic protein-2 (BMP-2) release from 40 min onwards. BCMs harvested within short time periods (10, 20, or 40 min), corresponding to the time of a typical surgical procedure, significantly increased the proliferative activity and collagen matrix production of BCM-treated cells. Long-term (1, 3, or 6 days)-extracted BCMs promoted the later stages of osteoblast differentiation and maturation. Short-term-extracted BCMs, in which TGF-β1 but no BMP-2was detected, reduced the expression of the late differentiation marker osteocalcin. However, when both growth factors were present simultaneously in the BCM, no inhibitory effects on osteoblast differentiation were observed, suggesting a synergistic TGF-β1/BMP-2 activity. Consequently, in cells that were co-stimulated with recombinant TGF-β1 and BMP-2, we showed a significant stimulatory and dose-dependent effect of TGF-β1 on BMP-2-induced osteoblast differentiation due to prolonged BMP signaling and reduced expression of the BMP-2 antagonist noggin. Altogether, our data provide new insights into the molecular mechanisms underlying the favorable outcome from GBR procedures using BCM, derived from autologous bone grafts.展开更多
In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of O...In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of OsABA8ox2 in root growth and development and drought response. GUS staining results showed that OsABA8ox2 was expressed mainly in roots at seedling stage and was strongly expressed in the meristematic zone of the radicle. OsABA8ox2 expression in roots was markedly decreased after 0.5 h polyethylene glycol(PEG) treatment and increased after 0.5 h rehydration, implying that OsABA8ox2 is a drought-responsive gene.OsABA8ox2 knockout mediated by the CRISPR-Cas9 system increased drought-induced ABA and indole-3-acetic acid accumulation in roots, conferred increased ABA sensitivity, and promoted a more vertically oriented root system architecture(RSA) beneficial to drought tolerance.OsABA8ox2 overexpression suppressed root elongation and increased stomatal conductance and transpiration rate. Consequently, OsABA8ox2 knockout dramatically improved rice drought tolerance, whereas OsABA8ox2 overexpression seedlings were hypersensitive to drought stress,suggesting that OsABA8ox2 contributes to drought response in rice. Compared with wild type,functional leaves of OsABA8ox2 knockout seedlings showed higher ABA levels, whereas overexpression lines showed lower ABA levels, suggesting that OsABA8ox2, as an ABA catabolic gene, modulates ABA concentration through ABA catabolism. OsABA8ox2 and OsABA8ox3 were both localized in the endoplasmic reticulum. Together, these results indicate that OsABA8ox2 suppresses root elongation of rice seedlings, increases water transpiration, and contributes to drought response through ABA catabolism, and that OsABA8ox2 knockout dramatically improves rice drought tolerance. They highlight the key role of ABA catabolism mediated by OsABA8ox2 on root growth and development. OsABA8ox2, as a novel RSA gene, would be a potential genetic target for the improvement of rice drought tolerance.展开更多
SAMR Vice-Minister and SAC Administrator Tian Shihong as the Leader of the Chinese delegation attended the 109th ISO Council Meeting in Costa Rica and subsequently the fourth meeting of the China-UK Standardization Co...SAMR Vice-Minister and SAC Administrator Tian Shihong as the Leader of the Chinese delegation attended the 109th ISO Council Meeting in Costa Rica and subsequently the fourth meeting of the China-UK Standardization Cooperati on Commissi on in the UK from June 10 to 17.展开更多
MicroRNAs(miRNAs) are endogenous 20 -23 -nucleotide (nt) -containing small non-coding RNAs that negatively regulate gene expression in diverse biological and pathological processes,including cell differentiation,proli...MicroRNAs(miRNAs) are endogenous 20 -23 -nucleotide (nt) -containing small non-coding RNAs that negatively regulate gene expression in diverse biological and pathological processes,including cell differentiation,proliferation, apoptosis,heart disease and human cancers.We investigated miR-133 expression and its potential role in a high glucose-induced myocardium in Streptozotocin(STZ)-induced C57bl6 mouse model of diabetes.miR-133 expression was significantly increased in myocardium in a time-dependent manner after STZ treatment.IGF1 receptor(IGF1R) protein was dramatically decreased without obvious up-regulation of its mRNA level post hyperglycemia.IGF1R protein level was decreaed with increase of its transcript level in neonatal mouse ventricular cardiomyocytes induced by high D-glucose concentration. Dual luciferase assay revealed that miR133 could interact with specific sites in the 3’UTR of IGF1R gene.p-ERK and p-Akt levels were reduced in neonatal mouse cardiomyocytes over-expressed with miR133 after IGF treatment.Introduction of functional miR-133,IGF1R siRNA into neonatal mouse cardiomyocytes could enhance cardiomyocyte apoptosis.These results implicate that miR-133 is involved in contributing to high glucose-induced cardiomyocyte apoptosis via regulating IGF1R expression post-transcriptionally.展开更多
Over the past 40 years of reform and opening up,the Party and the State have gained a richer and deeper understanding of human rights.In 1997,the 15;Communist Party of China National Congress Report put forward"r...Over the past 40 years of reform and opening up,the Party and the State have gained a richer and deeper understanding of human rights.In 1997,the 15;Communist Party of China National Congress Report put forward"respect for human rights".In 2004,the idea that"the State respects and protects human rights"was written into展开更多
The writer makes a survey among her students to know their opinions on the relation between outside class reading in English and English learning. After the analysis of the results, this paper points out that outside ...The writer makes a survey among her students to know their opinions on the relation between outside class reading in English and English learning. After the analysis of the results, this paper points out that outside class reading plays a positive role in English learning. Furthermore, some suggestions are made in the end.展开更多
Based on the Olsson-Turn’s Lagrangian, contribution to DCX reaction from the contact term has been discussed, The result shows that althought there are some cancellations between the pole-and contact-term contributio...Based on the Olsson-Turn’s Lagrangian, contribution to DCX reaction from the contact term has been discussed, The result shows that althought there are some cancellations between the pole-and contact-term contributions the contact term must be carefully included in any assessment of DCX reaction and can not be discarded a priori.展开更多
Dear Editor,Chemotherapy is one of major means for cancer treatments, and many of chemotherapeutic drugs are DNA damaging agents that reduce tumor growth through triggering cancer cell apoptosis or necrosis. Following...Dear Editor,Chemotherapy is one of major means for cancer treatments, and many of chemotherapeutic drugs are DNA damaging agents that reduce tumor growth through triggering cancer cell apoptosis or necrosis. Following DNA damage, ataxia telangiectasia mutated （ATM）, a protein kinase, was acti- vated and a cytosolic complex containing ATM, NEMO, RIP1 were formed （Biton and Ashkenazi, 2011）.展开更多
Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LM...Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LMRB's terrestrial water storage anomaly(TWSA)and its spatio-temporal dynamics during 2002–2020.Considering the effects of natural factors and human activities,the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC)were separated.Results showed that:(1)LMRB's TWSA decreased by 0.3158 cm/a.(2)TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB.TWSA positively changed in Myanmar while slightly changed in Laos and China.It negatively changed in Vietnam,Thailand and Cambodia.(3)TWSA components decreased in a descending order of soil moisture,groundwater and precipitation.(4)Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5)Climate variability contributed 79%of TWSC in the LMRB while human activities contributed 21%with an increasing impact after 2008.The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.展开更多
Dear Editor,Infectious bursal disease virus （IBDV） causes an economically significant disease of chickens worldwide （Berg,2000）. The molecular basis for the virulence of very virulent IBDV （vvIBDV） is not fully ...Dear Editor,Infectious bursal disease virus （IBDV） causes an economically significant disease of chickens worldwide （Berg,2000）. The molecular basis for the virulence of very virulent IBDV （vvIBDV） is not fully understood. Previous studies have shown that genome segment A, especically VP2 protein, plays the most important role in the tropism and pathogenicity of serotype 1 IBDV （Brandt et al., 2001）. VP2 is,however, unlikely to be the only factor for the virulence of vvIBDV （Boot et al., 2000）.展开更多
Introduction Types of paper Contributions falling into the following categories will be considered for publication:Reviews article(>10000 words),Short review(~5000 words),Feature article(>8000 words),Research pa...Introduction Types of paper Contributions falling into the following categories will be considered for publication:Reviews article(>10000 words),Short review(~5000 words),Feature article(>8000 words),Research paper,Short communication(~3000 words),Commentary(~1000 words),and Viewpiont(~3000 words).Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.展开更多
Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking ...Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking EGFR has shown limited efficacy in a proportion of patients with HNSCC in clinical trials. Sok et al. in a recent paper (Clin Cancer Res, 2006, 12:5064-5073 ) attempted to ascertain whether it is due to mutation of EGFR. As the most common form of mutation of EGFR seen in several other types of cancer is a truncation mutation,展开更多
The arsenic(As)release from sediments in great lakes is affected by various factors.In this study,the characteristics of As release fromsediments was investigated,and the As sources and sinks with the strengths in sed...The arsenic(As)release from sediments in great lakes is affected by various factors.In this study,the characteristics of As release fromsediments was investigated,and the As sources and sinks with the strengths in sediments from different areas(grass-type,algae-type,and grass-algae alternation areas)in great shallow lakes(Taihu Lake,China)were analyzed,and the influence of P competition in the process of As release was also studied.The results showed that changing trend of the values of equilibrium As concentration in sediments were consistent with the regional changes(0 to 28.12μg/L),and the sediments from algaetype areas had the higher values.The sediments from western lake and northwest lake bay were a strong As and a weak P source,and the north lake bay had the opposite trend of these two regions.Intense P source competition with As from the sediments occurred in algae-type areas.The grass-type areas had strong As and P retention capacities,indicating a sink role of sediment with high As and P sorption capacities.The degree of As and P saturation had similar trend in sediments,and the grass-type areas had the higher values,18.3%-21.4%and 15.31%-20.34%,respectively.Contribution analysis results showed that most of As release contribution was from the bottom(30-50 cm)sediments,and the surface(0-10 cm)sediments from algae-type areas contributed more to the overlying water than other region.展开更多
During high-temperature periods in summer,formaldehyde(HCHO)levels increase due to secondary production.However,recent studies have also shown a rise in the HCHO concentration in winter,but the underlying cause remain...During high-temperature periods in summer,formaldehyde(HCHO)levels increase due to secondary production.However,recent studies have also shown a rise in the HCHO concentration in winter,but the underlying cause remains unclear.Here,HCHO observations in urban Beijing were conducted,the impact of meteorological differences between warm and cold seasons to HCHO concentrations was investigated.Additionally,the positive matrix factorization model was applied to the source apportionment of HCHO,with a focus on changes during pollution events.The results indicated that,during warm seasons,the secondary production of HCHO was driven by high temperature influenced by the low-pressure front,with the contribution of secondary production+background peaking at 85.9% in the afternoon,exhibiting a unimodal diurnal variation.Conversely,during cold seasons,the influence of a uniform pressure field,coupled with weak winds,low boundary layers and high humidity,led to HCHO accumulation from primary emissions,resulting in multiday highconcentration pollution.During the most severe pollution periods,anthropogenic primary emissions contributed up to 91.7%.Therefore,while the contribution of volatile organic compounds to HCHO levels through secondary production has been recognized,the significant impact of primary emissions during cold seasons cannot be overlooked.展开更多
Introduction Types of paper Contributions falling into the following categories will be considered for publication:Original research papers,reviews,perspectives,news and views,case reports,letters.Please ensure that y...Introduction Types of paper Contributions falling into the following categories will be considered for publication:Original research papers,reviews,perspectives,news and views,case reports,letters.Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.展开更多
Introduction Types of paper Contributions falling into the following categories will be considered for publication:Reviews article(>10000 words),Short review(~5000 words),Feature article(>8000 words),Research pa...Introduction Types of paper Contributions falling into the following categories will be considered for publication:Reviews article(>10000 words),Short review(~5000 words),Feature article(>8000 words),Research paper,Short communication(~3000 words),Commentary(~1000 words),and Viewpiont(~3000 words).Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.展开更多
Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attack...Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attacks on smart contracts often cause huge economic losses.Since it is difficult to repair and update smart contracts,it is necessary to find the vulnerabilities before they are deployed.However,code analysis,which requires traversal paths,and learning methods,which require many features to be trained,are too time-consuming to detect large-scale on-chain contracts.Learning-based methods will obtain detection models from a feature space compared to code analysis methods such as symbol execution.But the existing features lack the interpretability of the detection results and training model,even worse,the large-scale feature space also affects the efficiency of detection.This paper focuses on improving the detection efficiency by reducing the dimension of the features,combined with expert knowledge.In this paper,a feature extraction model Block-gram is proposed to form low-dimensional knowledge-based features from bytecode.First,the metadata is separated and the runtime code is converted into a sequence of opcodes,which are divided into segments based on some instructions(jumps,etc.).Then,scalable Block-gram features,including 4-dimensional block features and 8-dimensional attribute features,are mined for the learning-based model training.Finally,feature contributions are calculated from SHAP values to measure the relationship between our features and the results of the detection model.In addition,six types of vulnerability labels are made on a dataset containing 33,885 contracts,and these knowledge-based features are evaluated using seven state-of-the-art learning algorithms,which show that the average detection latency speeds up 25×to 650×,compared with the features extracted by N-gram,and also can enhance the interpretability of the detection model.展开更多
The Editorial Office of Water Science and Engineering would like to express their sincere appreciation to the academic editors including Prof.Carlo Gualtieri from University of Napoli Federico Ⅱ,Italy,Prof.Guo-qing W...The Editorial Office of Water Science and Engineering would like to express their sincere appreciation to the academic editors including Prof.Carlo Gualtieri from University of Napoli Federico Ⅱ,Italy,Prof.Guo-qing Wang and Prof.Zhong-zhi Fu from Nanjing Hydraulic Research Institute,China,and Prof.Yan-hui Ao,Prof.Ching-sheng Huang,Prof.Guang-qiu Jin,Prof.Bin Xu,Prof.Sai-yu Yuan,Prof.Zeng Zhou,Prof.Bo Chen,and Prof.Da-wei Guan from Hohai Uiversity,China,for their great effort and contribution to WSE in the year 2024.展开更多
INTRODUCTION Types of paper Contributions falling into the following categories will be considered for publication:Original research papers,reviews and short communications.Please ensure that you select the appropriat...INTRODUCTION Types of paper Contributions falling into the following categories will be considered for publication:Original research papers,reviews and short communications.Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.展开更多
基金supported by a grant from the ITI International Team for Implantology Foundation 1235_2017 to M.B.A
文摘Guided bone regeneration (GBR) often utilizes a combination of autologous bone grafts, deproteinized bovine bone mineral(DBBM), and collagen membranes. DBBM and collagen membranes pre-coated with bone-conditioned medium (BCM) extracted from locally harvested autologous bone chips have shown great regenerative potential in GBR. However, the underlying molecular mechanism remains largely unknown. Here, we investigated the composition of BCM and its activity on the osteogenic potential of mesenchymal stromal cells. We detected a fast and significant (P <0.001) release of transforming growth factor-β1 (TGF-β1) from autologous bone within 10 min versus a delayed bone morphogenetic protein-2 (BMP-2) release from 40 min onwards. BCMs harvested within short time periods (10, 20, or 40 min), corresponding to the time of a typical surgical procedure, significantly increased the proliferative activity and collagen matrix production of BCM-treated cells. Long-term (1, 3, or 6 days)-extracted BCMs promoted the later stages of osteoblast differentiation and maturation. Short-term-extracted BCMs, in which TGF-β1 but no BMP-2was detected, reduced the expression of the late differentiation marker osteocalcin. However, when both growth factors were present simultaneously in the BCM, no inhibitory effects on osteoblast differentiation were observed, suggesting a synergistic TGF-β1/BMP-2 activity. Consequently, in cells that were co-stimulated with recombinant TGF-β1 and BMP-2, we showed a significant stimulatory and dose-dependent effect of TGF-β1 on BMP-2-induced osteoblast differentiation due to prolonged BMP signaling and reduced expression of the BMP-2 antagonist noggin. Altogether, our data provide new insights into the molecular mechanisms underlying the favorable outcome from GBR procedures using BCM, derived from autologous bone grafts.
基金supported by the National Natural Science Foundation of China(31501244)Chinese Academy of Agricultural Sciences Elite Youth Program Grant to Yubin Lithe Fundamental Research Funds for Central Non-profit Scientific Institution(1610392019001)。
文摘In rice, OsABA8ox encodes abscisic acid(ABA) 8′-hydroxylase, which catalyzes the committed step of ABA catabolism. The contribution of ABA catabolism in root development remains unclear. We investigated the role of OsABA8ox2 in root growth and development and drought response. GUS staining results showed that OsABA8ox2 was expressed mainly in roots at seedling stage and was strongly expressed in the meristematic zone of the radicle. OsABA8ox2 expression in roots was markedly decreased after 0.5 h polyethylene glycol(PEG) treatment and increased after 0.5 h rehydration, implying that OsABA8ox2 is a drought-responsive gene.OsABA8ox2 knockout mediated by the CRISPR-Cas9 system increased drought-induced ABA and indole-3-acetic acid accumulation in roots, conferred increased ABA sensitivity, and promoted a more vertically oriented root system architecture(RSA) beneficial to drought tolerance.OsABA8ox2 overexpression suppressed root elongation and increased stomatal conductance and transpiration rate. Consequently, OsABA8ox2 knockout dramatically improved rice drought tolerance, whereas OsABA8ox2 overexpression seedlings were hypersensitive to drought stress,suggesting that OsABA8ox2 contributes to drought response in rice. Compared with wild type,functional leaves of OsABA8ox2 knockout seedlings showed higher ABA levels, whereas overexpression lines showed lower ABA levels, suggesting that OsABA8ox2, as an ABA catabolic gene, modulates ABA concentration through ABA catabolism. OsABA8ox2 and OsABA8ox3 were both localized in the endoplasmic reticulum. Together, these results indicate that OsABA8ox2 suppresses root elongation of rice seedlings, increases water transpiration, and contributes to drought response through ABA catabolism, and that OsABA8ox2 knockout dramatically improves rice drought tolerance. They highlight the key role of ABA catabolism mediated by OsABA8ox2 on root growth and development. OsABA8ox2, as a novel RSA gene, would be a potential genetic target for the improvement of rice drought tolerance.
文摘SAMR Vice-Minister and SAC Administrator Tian Shihong as the Leader of the Chinese delegation attended the 109th ISO Council Meeting in Costa Rica and subsequently the fourth meeting of the China-UK Standardization Cooperati on Commissi on in the UK from June 10 to 17.
文摘MicroRNAs(miRNAs) are endogenous 20 -23 -nucleotide (nt) -containing small non-coding RNAs that negatively regulate gene expression in diverse biological and pathological processes,including cell differentiation,proliferation, apoptosis,heart disease and human cancers.We investigated miR-133 expression and its potential role in a high glucose-induced myocardium in Streptozotocin(STZ)-induced C57bl6 mouse model of diabetes.miR-133 expression was significantly increased in myocardium in a time-dependent manner after STZ treatment.IGF1 receptor(IGF1R) protein was dramatically decreased without obvious up-regulation of its mRNA level post hyperglycemia.IGF1R protein level was decreaed with increase of its transcript level in neonatal mouse ventricular cardiomyocytes induced by high D-glucose concentration. Dual luciferase assay revealed that miR133 could interact with specific sites in the 3’UTR of IGF1R gene.p-ERK and p-Akt levels were reduced in neonatal mouse cardiomyocytes over-expressed with miR133 after IGF treatment.Introduction of functional miR-133,IGF1R siRNA into neonatal mouse cardiomyocytes could enhance cardiomyocyte apoptosis.These results implicate that miR-133 is involved in contributing to high glucose-induced cardiomyocyte apoptosis via regulating IGF1R expression post-transcriptionally.
文摘Over the past 40 years of reform and opening up,the Party and the State have gained a richer and deeper understanding of human rights.In 1997,the 15;Communist Party of China National Congress Report put forward"respect for human rights".In 2004,the idea that"the State respects and protects human rights"was written into
文摘The writer makes a survey among her students to know their opinions on the relation between outside class reading in English and English learning. After the analysis of the results, this paper points out that outside class reading plays a positive role in English learning. Furthermore, some suggestions are made in the end.
文摘Based on the Olsson-Turn’s Lagrangian, contribution to DCX reaction from the contact term has been discussed, The result shows that althought there are some cancellations between the pole-and contact-term contributions the contact term must be carefully included in any assessment of DCX reaction and can not be discarded a priori.
文摘Dear Editor,Chemotherapy is one of major means for cancer treatments, and many of chemotherapeutic drugs are DNA damaging agents that reduce tumor growth through triggering cancer cell apoptosis or necrosis. Following DNA damage, ataxia telangiectasia mutated （ATM）, a protein kinase, was acti- vated and a cytosolic complex containing ATM, NEMO, RIP1 were formed （Biton and Ashkenazi, 2011）.
基金National Natural Science Foundation of China,No.42161006Yunnan Fundamental Research Projects No.202201AT070094,No.202301BF070001-004+1 种基金Special Project for High-level Talents of Yunnan Province for Young Top Talents,No.C6213001159European Research Council(ERC)Starting-Grant STORIES,No.101040939。
文摘Due to water conflicts and allocation in the Lancang-Mekong River Basin(LMRB),the spatio-temporal differentiation of total water resources and the natural-human influence need to be clarified.This work investigated LMRB's terrestrial water storage anomaly(TWSA)and its spatio-temporal dynamics during 2002–2020.Considering the effects of natural factors and human activities,the respective contributions of climate variability and human activities to terrestrial water storage change(TWSC)were separated.Results showed that:(1)LMRB's TWSA decreased by 0.3158 cm/a.(2)TWSA showed a gradual increase in distribution from southwest of MRB to middle LMRB and from northeast of LRB to middle LMRB.TWSA positively changed in Myanmar while slightly changed in Laos and China.It negatively changed in Vietnam,Thailand and Cambodia.(3)TWSA components decreased in a descending order of soil moisture,groundwater and precipitation.(4)Natural factors had a substantial and spatial differentiated influence on TWSA over the LMRB.(5)Climate variability contributed 79%of TWSC in the LMRB while human activities contributed 21%with an increasing impact after 2008.The TWSC of upstream basin countries was found to be controlled by climate variability while Vietnam and Cambodia's TWSC has been controlled by human activities since 2012.
基金supported by the National Natural Science Foundation of China (31500129, 31430087)
文摘Dear Editor,Infectious bursal disease virus （IBDV） causes an economically significant disease of chickens worldwide （Berg,2000）. The molecular basis for the virulence of very virulent IBDV （vvIBDV） is not fully understood. Previous studies have shown that genome segment A, especically VP2 protein, plays the most important role in the tropism and pathogenicity of serotype 1 IBDV （Brandt et al., 2001）. VP2 is,however, unlikely to be the only factor for the virulence of vvIBDV （Boot et al., 2000）.
文摘Introduction Types of paper Contributions falling into the following categories will be considered for publication:Reviews article(>10000 words),Short review(~5000 words),Feature article(>8000 words),Research paper,Short communication(~3000 words),Commentary(~1000 words),and Viewpiont(~3000 words).Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.
文摘Epidermal growth factor receptor (EGFR) is overexpressed in head and neck squamous-cell carcinoma (HNSCC) and its expression levels correlate with decreased patient survival. Nonetheless, therapies aiming at blocking EGFR has shown limited efficacy in a proportion of patients with HNSCC in clinical trials. Sok et al. in a recent paper (Clin Cancer Res, 2006, 12:5064-5073 ) attempted to ascertain whether it is due to mutation of EGFR. As the most common form of mutation of EGFR seen in several other types of cancer is a truncation mutation,
基金supported by the National Natural Science Foundation(Nos.52000024 and 41907335)the Natural Science Foundation of Shanghai(No.23ZR1400700).
文摘The arsenic(As)release from sediments in great lakes is affected by various factors.In this study,the characteristics of As release fromsediments was investigated,and the As sources and sinks with the strengths in sediments from different areas(grass-type,algae-type,and grass-algae alternation areas)in great shallow lakes(Taihu Lake,China)were analyzed,and the influence of P competition in the process of As release was also studied.The results showed that changing trend of the values of equilibrium As concentration in sediments were consistent with the regional changes(0 to 28.12μg/L),and the sediments from algaetype areas had the higher values.The sediments from western lake and northwest lake bay were a strong As and a weak P source,and the north lake bay had the opposite trend of these two regions.Intense P source competition with As from the sediments occurred in algae-type areas.The grass-type areas had strong As and P retention capacities,indicating a sink role of sediment with high As and P sorption capacities.The degree of As and P saturation had similar trend in sediments,and the grass-type areas had the higher values,18.3%-21.4%and 15.31%-20.34%,respectively.Contribution analysis results showed that most of As release contribution was from the bottom(30-50 cm)sediments,and the surface(0-10 cm)sediments from algae-type areas contributed more to the overlying water than other region.
基金supported by the National Natural Science Foundation of China(Nos.42075097 and 42177081)the National Key R&D Program of China(No.2023YFC3706103)+2 种基金the Strategic Priority Research Program of the Chinese Academy of Sciences(No.XDB0760200)Beijing Municipal Natural Science Foundation(No.8222075)the Youth Cross Team Scientific Research Project of the Chinese Academy of Sciences(No.JCTD-2021-10)。
文摘During high-temperature periods in summer,formaldehyde(HCHO)levels increase due to secondary production.However,recent studies have also shown a rise in the HCHO concentration in winter,but the underlying cause remains unclear.Here,HCHO observations in urban Beijing were conducted,the impact of meteorological differences between warm and cold seasons to HCHO concentrations was investigated.Additionally,the positive matrix factorization model was applied to the source apportionment of HCHO,with a focus on changes during pollution events.The results indicated that,during warm seasons,the secondary production of HCHO was driven by high temperature influenced by the low-pressure front,with the contribution of secondary production+background peaking at 85.9% in the afternoon,exhibiting a unimodal diurnal variation.Conversely,during cold seasons,the influence of a uniform pressure field,coupled with weak winds,low boundary layers and high humidity,led to HCHO accumulation from primary emissions,resulting in multiday highconcentration pollution.During the most severe pollution periods,anthropogenic primary emissions contributed up to 91.7%.Therefore,while the contribution of volatile organic compounds to HCHO levels through secondary production has been recognized,the significant impact of primary emissions during cold seasons cannot be overlooked.
文摘Introduction Types of paper Contributions falling into the following categories will be considered for publication:Original research papers,reviews,perspectives,news and views,case reports,letters.Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.
文摘Introduction Types of paper Contributions falling into the following categories will be considered for publication:Reviews article(>10000 words),Short review(~5000 words),Feature article(>8000 words),Research paper,Short communication(~3000 words),Commentary(~1000 words),and Viewpiont(~3000 words).Please ensure that you select the appropriate article type from the list of options when making your submission.Authors contributing to special issues should ensure that they select the special issue article type from this list.
基金partially supported by the National Natural Science Foundation (62272248)the Open Project Fund of State Key Laboratory of Computer Architecture,Institute of Computing Technology,Chinese Academy of Sciences (CARCHA202108,CARCH201905)+1 种基金the Natural Science Foundation of Tianjin (20JCZDJC00610)Sponsored by Zhejiang Lab (2021KF0AB04)。
文摘Smart contracts are widely used on the blockchain to implement complex transactions,such as decentralized applications on Ethereum.Effective vulnerability detection of large-scale smart contracts is critical,as attacks on smart contracts often cause huge economic losses.Since it is difficult to repair and update smart contracts,it is necessary to find the vulnerabilities before they are deployed.However,code analysis,which requires traversal paths,and learning methods,which require many features to be trained,are too time-consuming to detect large-scale on-chain contracts.Learning-based methods will obtain detection models from a feature space compared to code analysis methods such as symbol execution.But the existing features lack the interpretability of the detection results and training model,even worse,the large-scale feature space also affects the efficiency of detection.This paper focuses on improving the detection efficiency by reducing the dimension of the features,combined with expert knowledge.In this paper,a feature extraction model Block-gram is proposed to form low-dimensional knowledge-based features from bytecode.First,the metadata is separated and the runtime code is converted into a sequence of opcodes,which are divided into segments based on some instructions(jumps,etc.).Then,scalable Block-gram features,including 4-dimensional block features and 8-dimensional attribute features,are mined for the learning-based model training.Finally,feature contributions are calculated from SHAP values to measure the relationship between our features and the results of the detection model.In addition,six types of vulnerability labels are made on a dataset containing 33,885 contracts,and these knowledge-based features are evaluated using seven state-of-the-art learning algorithms,which show that the average detection latency speeds up 25×to 650×,compared with the features extracted by N-gram,and also can enhance the interpretability of the detection model.
文摘The Editorial Office of Water Science and Engineering would like to express their sincere appreciation to the academic editors including Prof.Carlo Gualtieri from University of Napoli Federico Ⅱ,Italy,Prof.Guo-qing Wang and Prof.Zhong-zhi Fu from Nanjing Hydraulic Research Institute,China,and Prof.Yan-hui Ao,Prof.Ching-sheng Huang,Prof.Guang-qiu Jin,Prof.Bin Xu,Prof.Sai-yu Yuan,Prof.Zeng Zhou,Prof.Bo Chen,and Prof.Da-wei Guan from Hohai Uiversity,China,for their great effort and contribution to WSE in the year 2024.
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