The microstructure of 40Cr steel sample and its surface is ultra-fined through salt-bath cyclic quenching and high frequency hardening, then the superplasticity is studied under isothermal superplastic compressive def...The microstructure of 40Cr steel sample and its surface is ultra-fined through salt-bath cyclic quenching and high frequency hardening, then the superplasticity is studied under isothermal superplastic compressive deformation condition. The experimental results indicate that the stress-strain curves are shown to take place obvious superplastic flow characteristic at the temperature of 750-770℃ and at the initial strain rate of (1.7-5.0)×10-4 s-1. Its strain rate sensitivity is 0.30-0.38, the steady superplastic flow stress is 60-70MPa, the superplastic flow activation energy is 198-217kJ/mol, and it is close to α-Fe grain boundary self-diffusion activation energy. The super-plastic compressive constitute equations of this steel are correspondingly set up. Due to the finer microstructure of high frequency hardening, it appears bigger strain rate sensitivity value, smaller the steady superplastic flow stress and the superplastic flow activation energy, so it has better superplastic deformation capability.展开更多
The deformaton behavior of Ti - 6Al - 4V alloy under hot - working condition has been studied by compression testing in the temperature range 750 - 950℃ and strain rate range 0.05 - 15s -1. The flow stress decrease...The deformaton behavior of Ti - 6Al - 4V alloy under hot - working condition has been studied by compression testing in the temperature range 750 - 950℃ and strain rate range 0.05 - 15s -1. The flow stress decreases with the increase of temperature and with the decrease of strain rate. After a steep initial strain hardening, a flow softening occurs. This softening is mainly ascribed to the temperature rise and dynamic recmptallisation.By a simple extension, a classical sinushyperbolic constitutive equation can be used to describe the flow behavior of Ti - 6Al - 4V alloy. flow stress is described as a function of strain, strain rate and temperature. The parameters Q, n andaare the same at differ- ent deformation conditions, and A is a funciton of strain.展开更多
To investigate the influence of Al-Zn-Mg-Cu alloy with as-homogenized and as-rolled initial microstructures on the tensile flow behavior,isothermal tensile tests were conducted on a GLEEBLE-3500 isothermal simulator a...To investigate the influence of Al-Zn-Mg-Cu alloy with as-homogenized and as-rolled initial microstructures on the tensile flow behavior,isothermal tensile tests were conducted on a GLEEBLE-3500 isothermal simulator at temperatures of 380-440℃and strain rates of 0.05-1 s^(−1).The Johnson-Cook model,Hensel-Spittel model,strain-compensated Arrhenius model,and critical fracture strain model were established.Results show that through the evaluation of the models using the correlation coefficient(R)and the average absolute relative error,the strain-compensated Arrhenius model can represent the flow behavior of the alloy more accurately.Shear bands are more pronounced in the as-homogenized specimens,whereas dynamic recrystallization is predominantly observed in as-rolled specimens.Fracture morphology analysis reveals that a mixed fracture mechanism is prevalent in the as-homogenized specimen,whereas a ductile fracture mechanism is predominant in the as-rolled specimen.The processing maps indicate that the unstable region is reduced in the as-rolled specimens compared with that in the as-homogenized specimens.The optimal hot working windows for the as-homogenized and as-rolled specimens are determined as 410-440℃/0.14-1 s^(−1)and 380-400℃/0.05-0.29 s^(−1),respectively.展开更多
To the Editor,I read with interest the review by Zhang and Liu,[1]about the typical septic cardiomyopathy(SC)and sepsis-related Takotsubo syndrome(TTS)(S-TTS).The report rekindled some thoughts,which have occupied me ...To the Editor,I read with interest the review by Zhang and Liu,[1]about the typical septic cardiomyopathy(SC)and sepsis-related Takotsubo syndrome(TTS)(S-TTS).The report rekindled some thoughts,which have occupied me for the past few years,regarding the possibility that SC constitutes a phenotype of TTS,or whether it is an altogether different pathophysiological entity.展开更多
The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we condu...The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we conducted a series of triaxial tests on calcareous sand with varying Dri and stress paths,examining particle breakage and critical state behavior.Key findingsinclude:(1)At a constant stress ratio(η),B follows a hyperbolic relationship with mean effective stress(p'),and for a given p',B increases proportionally withη;(2)The critical state line(CSL)moves downward with increasing Dri,whereas the critical state friction angle(φcs)decreases with increasing B.Based on these findings,we propose a unifiedbreakage evolution model to quantify particle breakage in calcareous sand under various loading conditions.Integrating this model with the Normal Consolidation Line(NCL)and CSL equations,we successfully simulate the steepening of NCL and CSL slopes as B increases with the onset of particle breakage.Furthermore,we quantitatively evaluate the effect of B onφcs.Finally,within the framework of Critical State Soil Mechanics and Hypoplasticity theory,we develop a hypoplastic model incorporating B and Dri.The model is validated through strong agreement with experimental results across various initial relative densities,stress paths and drainage conditions.展开更多
To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests ...To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests were conducted,and a corresponding piecewise damage constitutive model(PDCM)was established.We found that both dry-wet cycling and precompression stress deteriorate the physical properties,alter the microscopic characteristics,and reduce the mechanical properties of the LHF.These degradations are particularly pronounced under the CEDWCPS,although the magnitude of these changes gradually diminishes with the progression of dry-wet cycling.Meanwhile,they also reduce the deformation degree,prolong the micropore compaction stage,shorten the unstable crack propagation stage,lower the frequency and intensity of AE events,decrease the high-amplitude and high-frequency AE signals,enlarge crack scales,and shorten the crack initiation time.Among the changes of these indicators,the dry-wet cycling plays a dominant role.The crack types of LHF under the CEDWCPS(LHFCEDWCPS)are predominantly tensile cracks,supplemented by shear cracks.The failure mode can be defined as tensileshear composite failure.Finally,the established PDCM effectively captures the nonlinear deformation of micropore and the linear deformation of the matrix in LHFCEDWCPS,with all corresponding R^(2) consistently exceeding 0.97.展开更多
Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening pa...Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.展开更多
With the support by the National Natural Science Foundation of China,the research team led by Prof.Yuan Peng(袁鹏)at the CAS Key Laboratory of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Aca...With the support by the National Natural Science Foundation of China,the research team led by Prof.Yuan Peng(袁鹏)at the CAS Key Laboratory of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences(CAS),unraveled the important role of lake sedimentary biogenic silica(BSi)from diatoms as a significant global sink for aluminium(Al),which was published in Nature Communications(2019,10:4829).展开更多
Objective:To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstruct...Objective:To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)based on TCM constitution theory.Methods:A total of 300 AECOPD patients in the high-risk window period(54-66 cases for each constitution)were randomly divided into two groups(150 cases each).The control group received fluticasone furoate/umeclidinium/vilanterol inhalation therapy,while the experimental group was additionally given constitution-specific TCM decoctions(e.g.,Erchen Decoction combined with Sanzi Yangqin Decoction for Phlegm-Dampness constitution).The treatment course was 8 weeks with a 6-month follow-up.CAT score,TCM syndrome score,pulmonary function,6-minute walking distance(6MWD),and levels of CRP and IL-6 were observed.Recurrence and safety indicators were recorded.Results:After treatment,all indicators improved significantly in both groups(p<0.05),with the experimental group showing superior improvements in CAT score,TCM syndrome score,FEV1,6MWD,and inflammatory indicators(p<0.01).The recurrence rate was lower in the experimental group during follow-up(p<0.05).No severe adverse reactions or abnormalities in liver/kidney function were observed in either group.Conclusion:TCM syndrome differentiation treatment guided by constitution theory can improve symptoms,quality of life,and pulmonary function,reduce inflammatory levels and recurrence rate in AECOPD patients during the high-risk window period,with good safety.展开更多
The rhizomes of Matteuccia orientalis(HOOK.)TREV(Dong Fang Jia Guo Jue)have been used as traditional folk remedies for rheumatalgia and traumatic hemorrhage in China.Our earlier work on the 50%EtOH eluate from the Dia...The rhizomes of Matteuccia orientalis(HOOK.)TREV(Dong Fang Jia Guo Jue)have been used as traditional folk remedies for rheumatalgia and traumatic hemorrhage in China.Our earlier work on the 50%EtOH eluate from the Diaion HP 20 macroporous adsorption resin column chromatography(CC)of the 60%EtOH extract of展开更多
The coronavirus disease 2019(COVID-19)outbreak affects the use of biologics for psoriatic patients,in the way that the consequential immunosuppression potentially alters a patient's susceptibility to the virus or ...The coronavirus disease 2019(COVID-19)outbreak affects the use of biologics for psoriatic patients,in the way that the consequential immunosuppression potentially alters a patient's susceptibility to the virus or deteriorate the condition if the patient is infected or even change the prognosis of infection.Therefore,authors reviewed currently available recommendations from international psoriasis academic organizations and specialists,and summarized them with the specific situation in China.We are trying to provide guidance to the use of biologics for psoriatic patients in the following contexts:patients on biologic therapy,patients being considered for biologic therapy initiation,patients with low-risk or high-risk of SARS-CoV-2 coronavirus infection,patients tested negative or positive for the nucleic acid testing of virus.展开更多
Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medi...Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).展开更多
Leng Changyan's watercolor paintings are like two carefully carved pieces of the puzzle.One depicts the natural scenery of Jiaodong area,and the other shows the local folk customs.The two pieces of the puzzle toge...Leng Changyan's watercolor paintings are like two carefully carved pieces of the puzzle.One depicts the natural scenery of Jiaodong area,and the other shows the local folk customs.The two pieces of the puzzle together constitute her artistic pursuit and emotional world.展开更多
Dear Editor,The true frogs classified under the genus Rana, with widespread distribution in Eurasia and North America,constitute a varied and intricate group (Yuan et al., 2016;Chen et al., 2022). In total, 52 species...Dear Editor,The true frogs classified under the genus Rana, with widespread distribution in Eurasia and North America,constitute a varied and intricate group (Yuan et al., 2016;Chen et al., 2022). In total, 52 species within this genus have been documented (IUCN, 2024), with 28 of those species found in China (Amphibia China, 2024).展开更多
Lactic acid bacteria constitute numerous unique but varied microorganisms,with general characteristics such as catalase negative,Gram-positive,similar end product which is lactic acid as a result of sugar fermentation...Lactic acid bacteria constitute numerous unique but varied microorganisms,with general characteristics such as catalase negative,Gram-positive,similar end product which is lactic acid as a result of sugar fermentation.The safe usage of lactic acid bacteria in fermented foods is as old as creation,but as technological advancement grows and new strains of lactic acid bacteria are discovered,and researchers have the responsibilities of testing the safety of the new strains along with the old ones.Lactic acid bacteria such as Bifidobacterium species,Streptococcus species and Lactobacillus species,Leuconostoc,Pediococcus have been used in fermented foods over the years without any associated health risks and many of the LAB strains have been granted the GRAS(generally regarded as safe)status by regulatory bodies.展开更多
Atomically precise coordination nanoclusters(NCs)constitute a pivotal and rapidly advancing domain in the realms of materials science and chemistry owing to their distinctive crystal structures and exceptional attribu...Atomically precise coordination nanoclusters(NCs)constitute a pivotal and rapidly advancing domain in the realms of materials science and chemistry owing to their distinctive crystal structures and exceptional attributes encompassing molecular magnetism[1],photoluminescence[2],and catalysis[3].Organic ligands play a crucial role in effectively shielding these NCs,serving two primary functions:firstly,vital in preventing NC aggregation,particularly for the formation of robust single-crystal structures;secondly,acting as either bridging or peripheral structural components of NCs[4].This characterization of organic-inorganic hybridization offers unique advantages for unraveling the intricate relationships between structure and properties[5].展开更多
OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which...OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.展开更多
The generalized rheological tests on sandstone were conducted under both dynamic stress and seepage fields.The results demonstrate that the rheological strain of the specimen under increased stress conditions is great...The generalized rheological tests on sandstone were conducted under both dynamic stress and seepage fields.The results demonstrate that the rheological strain of the specimen under increased stress conditions is greater than that under creep conditions,indicating that the dynamic stress field significantly influences the rheological behaviours of sandstone.Following the rheological tests,the number of small pores in the sandstone decreased,while the number of medium-sized pores increased,forming new seepage channels.The high initial rheological stress accelerated fracture compression and the closure of seepage channels,resulting in reduction in the permeability of sandstone.Based on the principles of generalized rheology and the experimental findings,a novel rock rheological constitutive model incorporating both the dynamic stress field and seepage properties has been developed.Numerical simulations of surrounding rock deformation in geotechnical engineering were carried out using a secondary development version of this model,which confirmed the applicability of the generalized rheological numerical simulation method.These results provide theoretical support for the long-term stability evaluation of engineering rock masses and for predicting the deformation of surrounding rock.展开更多
A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary ...A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary micro-variables evolution at different temperatures and their interaction.The dislocation density was incorporated into the model to capture the effect of creep deformation on precipitation.Quantitative transmission electron microscopy and experimental data obtained from a previous study were used to calibrate the model.Subsequently,the developed constitutive model was implemented in the finite element(FE)software ABAQUS via the user subroutines for TSCA process simulation and the springback prediction of an integral panel.A TSCA test was performed.The result shows that the maximum radius deviation between the formed plate and the simulation results is less than 0.4 mm,thus validating the effectiveness of the developed constitutive model and FE model.展开更多
基金supported by State Key Laboratory of New Nonferrous Metal Materials Natural Science Foundation of He'nan Province,China(No.984040900)Natural Science Foundation of the Education Department of He'nan Province,China(No.2003430211).
文摘The microstructure of 40Cr steel sample and its surface is ultra-fined through salt-bath cyclic quenching and high frequency hardening, then the superplasticity is studied under isothermal superplastic compressive deformation condition. The experimental results indicate that the stress-strain curves are shown to take place obvious superplastic flow characteristic at the temperature of 750-770℃ and at the initial strain rate of (1.7-5.0)×10-4 s-1. Its strain rate sensitivity is 0.30-0.38, the steady superplastic flow stress is 60-70MPa, the superplastic flow activation energy is 198-217kJ/mol, and it is close to α-Fe grain boundary self-diffusion activation energy. The super-plastic compressive constitute equations of this steel are correspondingly set up. Due to the finer microstructure of high frequency hardening, it appears bigger strain rate sensitivity value, smaller the steady superplastic flow stress and the superplastic flow activation energy, so it has better superplastic deformation capability.
文摘The deformaton behavior of Ti - 6Al - 4V alloy under hot - working condition has been studied by compression testing in the temperature range 750 - 950℃ and strain rate range 0.05 - 15s -1. The flow stress decreases with the increase of temperature and with the decrease of strain rate. After a steep initial strain hardening, a flow softening occurs. This softening is mainly ascribed to the temperature rise and dynamic recmptallisation.By a simple extension, a classical sinushyperbolic constitutive equation can be used to describe the flow behavior of Ti - 6Al - 4V alloy. flow stress is described as a function of strain, strain rate and temperature. The parameters Q, n andaare the same at differ- ent deformation conditions, and A is a funciton of strain.
文摘To investigate the influence of Al-Zn-Mg-Cu alloy with as-homogenized and as-rolled initial microstructures on the tensile flow behavior,isothermal tensile tests were conducted on a GLEEBLE-3500 isothermal simulator at temperatures of 380-440℃and strain rates of 0.05-1 s^(−1).The Johnson-Cook model,Hensel-Spittel model,strain-compensated Arrhenius model,and critical fracture strain model were established.Results show that through the evaluation of the models using the correlation coefficient(R)and the average absolute relative error,the strain-compensated Arrhenius model can represent the flow behavior of the alloy more accurately.Shear bands are more pronounced in the as-homogenized specimens,whereas dynamic recrystallization is predominantly observed in as-rolled specimens.Fracture morphology analysis reveals that a mixed fracture mechanism is prevalent in the as-homogenized specimen,whereas a ductile fracture mechanism is predominant in the as-rolled specimen.The processing maps indicate that the unstable region is reduced in the as-rolled specimens compared with that in the as-homogenized specimens.The optimal hot working windows for the as-homogenized and as-rolled specimens are determined as 410-440℃/0.14-1 s^(−1)and 380-400℃/0.05-0.29 s^(−1),respectively.
文摘To the Editor,I read with interest the review by Zhang and Liu,[1]about the typical septic cardiomyopathy(SC)and sepsis-related Takotsubo syndrome(TTS)(S-TTS).The report rekindled some thoughts,which have occupied me for the past few years,regarding the possibility that SC constitutes a phenotype of TTS,or whether it is an altogether different pathophysiological entity.
基金support to this study from the National Natural Science Foundation of China,NSFC(Grant No.52278367)The Belt and Road Special Foundation of the National Key Laboratory ofWater Disaster Prevention(Grant No.2024nkms08).
文摘The stress-strain behavior of calcareous sand is significantly influencedby particle breakage(B)and initial relative density(Dri),but few constitutive models consider their combined effects.To bridge this gap,we conducted a series of triaxial tests on calcareous sand with varying Dri and stress paths,examining particle breakage and critical state behavior.Key findingsinclude:(1)At a constant stress ratio(η),B follows a hyperbolic relationship with mean effective stress(p'),and for a given p',B increases proportionally withη;(2)The critical state line(CSL)moves downward with increasing Dri,whereas the critical state friction angle(φcs)decreases with increasing B.Based on these findings,we propose a unifiedbreakage evolution model to quantify particle breakage in calcareous sand under various loading conditions.Integrating this model with the Normal Consolidation Line(NCL)and CSL equations,we successfully simulate the steepening of NCL and CSL slopes as B increases with the onset of particle breakage.Furthermore,we quantitatively evaluate the effect of B onφcs.Finally,within the framework of Critical State Soil Mechanics and Hypoplasticity theory,we develop a hypoplastic model incorporating B and Dri.The model is validated through strong agreement with experimental results across various initial relative densities,stress paths and drainage conditions.
基金supported by the Yunnan Province Science and Technology Plan Project(No.202403AA080001-4)the Key Research and Development Project of Guangxi,China(No.guikeAB24010144)the National Key Research and Development Project of China(Nos.2021YFB3901402 and 2018YFC1504802)。
文摘To reveal the influence of coupled effects of dry-wet cycling and precompression stress(CEDWCPS)on the damage evolution of limestone with horizontal fissure(LHF),a series of degradation and uniaxial compression tests were conducted,and a corresponding piecewise damage constitutive model(PDCM)was established.We found that both dry-wet cycling and precompression stress deteriorate the physical properties,alter the microscopic characteristics,and reduce the mechanical properties of the LHF.These degradations are particularly pronounced under the CEDWCPS,although the magnitude of these changes gradually diminishes with the progression of dry-wet cycling.Meanwhile,they also reduce the deformation degree,prolong the micropore compaction stage,shorten the unstable crack propagation stage,lower the frequency and intensity of AE events,decrease the high-amplitude and high-frequency AE signals,enlarge crack scales,and shorten the crack initiation time.Among the changes of these indicators,the dry-wet cycling plays a dominant role.The crack types of LHF under the CEDWCPS(LHFCEDWCPS)are predominantly tensile cracks,supplemented by shear cracks.The failure mode can be defined as tensileshear composite failure.Finally,the established PDCM effectively captures the nonlinear deformation of micropore and the linear deformation of the matrix in LHFCEDWCPS,with all corresponding R^(2) consistently exceeding 0.97.
基金financial support of the National Natural Science Foundation of China(No.52371103)the Fundamental Research Funds for the Central Universities,China(No.2242023K40028)+1 种基金the Open Research Fund of Jiangsu Key Laboratory for Advanced Metallic Materials,China(No.AMM2023B01).financial support of the Research Fund of Shihezi Key Laboratory of AluminumBased Advanced Materials,China(No.2023PT02)financial support of Guangdong Province Science and Technology Major Project,China(No.2021B0301030005)。
文摘Oxide dispersion strengthened(ODS)alloys are extensively used owing to high thermostability and creep strength contributed from uniformly dispersed fine oxides particles.However,the existence of these strengthening particles also deteriorates the processability and it is of great importance to establish accurate processing maps to guide the thermomechanical processes to enhance the formability.In this study,we performed particle swarm optimization-based back propagation artificial neural network model to predict the high temperature flow behavior of 0.25wt%Al2O3 particle-reinforced Cu alloys,and compared the accuracy with that of derived by Arrhenius-type constitutive model and back propagation artificial neural network model.To train these models,we obtained the raw data by fabricating ODS Cu alloys using the internal oxidation and reduction method,and conducting systematic hot compression tests between 400 and800℃with strain rates of 10^(-2)-10 S^(-1).At last,processing maps for ODS Cu alloys were proposed by combining processing parameters,mechanical behavior,microstructure characterization,and the modeling results achieved a coefficient of determination higher than>99%.
文摘With the support by the National Natural Science Foundation of China,the research team led by Prof.Yuan Peng(袁鹏)at the CAS Key Laboratory of Mineralogy and Metallogeny,Guangzhou Institute of Geochemistry,Chinese Academy of Sciences(CAS),unraveled the important role of lake sedimentary biogenic silica(BSi)from diatoms as a significant global sink for aluminium(Al),which was published in Nature Communications(2019,10:4829).
基金Longquan Yi District Health Bureau Project(Project No.:WJKY2023009)。
文摘Objective:To observe the efficacy and safety of TCM syndrome differentiation-guided herbal intervention for patients with five constitutions during the high-risk window period of acute exacerbation of chronic obstructive pulmonary disease(AECOPD)based on TCM constitution theory.Methods:A total of 300 AECOPD patients in the high-risk window period(54-66 cases for each constitution)were randomly divided into two groups(150 cases each).The control group received fluticasone furoate/umeclidinium/vilanterol inhalation therapy,while the experimental group was additionally given constitution-specific TCM decoctions(e.g.,Erchen Decoction combined with Sanzi Yangqin Decoction for Phlegm-Dampness constitution).The treatment course was 8 weeks with a 6-month follow-up.CAT score,TCM syndrome score,pulmonary function,6-minute walking distance(6MWD),and levels of CRP and IL-6 were observed.Recurrence and safety indicators were recorded.Results:After treatment,all indicators improved significantly in both groups(p<0.05),with the experimental group showing superior improvements in CAT score,TCM syndrome score,FEV1,6MWD,and inflammatory indicators(p<0.01).The recurrence rate was lower in the experimental group during follow-up(p<0.05).No severe adverse reactions or abnormalities in liver/kidney function were observed in either group.Conclusion:TCM syndrome differentiation treatment guided by constitution theory can improve symptoms,quality of life,and pulmonary function,reduce inflammatory levels and recurrence rate in AECOPD patients during the high-risk window period,with good safety.
文摘The rhizomes of Matteuccia orientalis(HOOK.)TREV(Dong Fang Jia Guo Jue)have been used as traditional folk remedies for rheumatalgia and traumatic hemorrhage in China.Our earlier work on the 50%EtOH eluate from the Diaion HP 20 macroporous adsorption resin column chromatography(CC)of the 60%EtOH extract of
文摘The coronavirus disease 2019(COVID-19)outbreak affects the use of biologics for psoriatic patients,in the way that the consequential immunosuppression potentially alters a patient's susceptibility to the virus or deteriorate the condition if the patient is infected or even change the prognosis of infection.Therefore,authors reviewed currently available recommendations from international psoriasis academic organizations and specialists,and summarized them with the specific situation in China.We are trying to provide guidance to the use of biologics for psoriatic patients in the following contexts:patients on biologic therapy,patients being considered for biologic therapy initiation,patients with low-risk or high-risk of SARS-CoV-2 coronavirus infection,patients tested negative or positive for the nucleic acid testing of virus.
基金funded by the National Natural Science Foundation of China(Grant Nos.:82222068,82070423,82270348,and 82173779)the Innovation Team and Talents Cultivation Pro-gram of National Administration of Traditional Chinese Medicine,China(Grant No:ZYYCXTD-D-202206)+1 种基金Fujian Province Science and Technology Project,China(Grant Nos.:2021J01420479,2021J02058,2022J011374,and 2022J02057)Fundamental Research Funds for the Chinese Central Universities,China(Grant No.:20720230070).
文摘Insect-derived traditional Chinese medicine(TCM)constitutes an essential component of TCM,with the earliest records found in“52 Bingfang”(Prescriptions of fifty-two diseases,which is one of the earliest Chinese medical prescriptions).
文摘Leng Changyan's watercolor paintings are like two carefully carved pieces of the puzzle.One depicts the natural scenery of Jiaodong area,and the other shows the local folk customs.The two pieces of the puzzle together constitute her artistic pursuit and emotional world.
基金supported by the National Natural Science Foundation of China (No.31970499 to Liuwang NIE)。
文摘Dear Editor,The true frogs classified under the genus Rana, with widespread distribution in Eurasia and North America,constitute a varied and intricate group (Yuan et al., 2016;Chen et al., 2022). In total, 52 species within this genus have been documented (IUCN, 2024), with 28 of those species found in China (Amphibia China, 2024).
文摘Lactic acid bacteria constitute numerous unique but varied microorganisms,with general characteristics such as catalase negative,Gram-positive,similar end product which is lactic acid as a result of sugar fermentation.The safe usage of lactic acid bacteria in fermented foods is as old as creation,but as technological advancement grows and new strains of lactic acid bacteria are discovered,and researchers have the responsibilities of testing the safety of the new strains along with the old ones.Lactic acid bacteria such as Bifidobacterium species,Streptococcus species and Lactobacillus species,Leuconostoc,Pediococcus have been used in fermented foods over the years without any associated health risks and many of the LAB strains have been granted the GRAS(generally regarded as safe)status by regulatory bodies.
基金financial support from the National Natural Science Foundation of China(Nos.22171094,21925104,92261204,and 22431005)Hubei Provincial Science and Technology Innovation Team Project[2022]The National Key R&D Program of China(No.2022YFB3807700)。
文摘Atomically precise coordination nanoclusters(NCs)constitute a pivotal and rapidly advancing domain in the realms of materials science and chemistry owing to their distinctive crystal structures and exceptional attributes encompassing molecular magnetism[1],photoluminescence[2],and catalysis[3].Organic ligands play a crucial role in effectively shielding these NCs,serving two primary functions:firstly,vital in preventing NC aggregation,particularly for the formation of robust single-crystal structures;secondly,acting as either bridging or peripheral structural components of NCs[4].This characterization of organic-inorganic hybridization offers unique advantages for unraveling the intricate relationships between structure and properties[5].
基金National Nonprofit Institute Research Grant for the Institute of Basic Theory for Chinese Medicine,China Academy of Chinese Medical Sciences:Mechanism of Regulating Phlegm-Dampness Constitution to Prevent Metabolic Diseases based on Gut Microbiota-host DNA Methylation(No.YZ-202151)。
文摘OBJECTIVE:To investigate the difference in gut microbiota between population with damp-heat constitution(DHC)and balanced constitution(BC).METHODS:A multi-centered cross-sectional casecontrol study was conducted,which included 249 participants with damp-heat constitution or balanced constitution.Baseline information of participants was collected,and stool samples were collected for gut microbiota analysis.Principal coordinate analysis,linear discriminant analysis effect size analysis,receiver operating characteristic,random forest model,and phylogenetic investigation of communities by reconstruction of unobserved states methods were used to reveal the relationship between gut microbiota and the damp-heat constitution.RESULTS:Compared to those in the BC group,the richness and diversity of the microbiota,specifically those of several short-chain fatty acid producing genera such as Barnesiella,Coprobacter,and Butyricimonas,were significantly decreased in the DHC group.Regarding biological functions,flavonoid biosynthesis,propanoate metabolism,and nucleotide sugar metabolism were suppressed,while arachidonic acid metabolism and glutathione metabolism were enriched in the DHC group.Finally,a classifier based on the microbiota was constructed to discriminate between the DHC and BC populations.CONCLUSION:The gut microbiota of the DHC population exhibits significantly reduced diversity and is closely related to inflammation,metabolic disorders,and liver steatosis,which is consistent with clinical observations,thus serving as a potential diagnostic tool for traditional Chinese medicine constitution discrimination.
基金supported and financed by Scientific Research Foundation for High-level Talents of Anhui University of Science and Technology (No.2024yjrc96)Anhui Provincial University Excellent Research and Innovation Team Support Project (No.2022AH010053)+2 种基金National Key Research and Development Program of China (Nos.2023YFC2907602 and 2022YFF1303302)Anhui Provincial Major Science and Technology Project (No.202203a07020011)Open Foundation of Joint National-Local Engineering Research Centre for Safe and Precise Coal Mining (No.EC2023020)。
文摘The generalized rheological tests on sandstone were conducted under both dynamic stress and seepage fields.The results demonstrate that the rheological strain of the specimen under increased stress conditions is greater than that under creep conditions,indicating that the dynamic stress field significantly influences the rheological behaviours of sandstone.Following the rheological tests,the number of small pores in the sandstone decreased,while the number of medium-sized pores increased,forming new seepage channels.The high initial rheological stress accelerated fracture compression and the closure of seepage channels,resulting in reduction in the permeability of sandstone.Based on the principles of generalized rheology and the experimental findings,a novel rock rheological constitutive model incorporating both the dynamic stress field and seepage properties has been developed.Numerical simulations of surrounding rock deformation in geotechnical engineering were carried out using a secondary development version of this model,which confirmed the applicability of the generalized rheological numerical simulation method.These results provide theoretical support for the long-term stability evaluation of engineering rock masses and for predicting the deformation of surrounding rock.
基金supported by the National Key R&D Program of China(No.2021YFB3400900)the National Natural Science Foundation of China(Nos.52175373,52205435)+1 种基金Natural Science Foundation of Hunan Province,China(No.2022JJ40621)the Innovation Fund of National Commercial Aircraft Manufacturing Engineering Technology Center,China(No.COMACSFGS-2022-1875)。
文摘A new unified constitutive model was developed to predict the two-stage creep-aging(TSCA)behavior of Al-Zn-Mg-Cu alloys.The particular bimodal precipitation feature was analyzed and modeled by considering the primary micro-variables evolution at different temperatures and their interaction.The dislocation density was incorporated into the model to capture the effect of creep deformation on precipitation.Quantitative transmission electron microscopy and experimental data obtained from a previous study were used to calibrate the model.Subsequently,the developed constitutive model was implemented in the finite element(FE)software ABAQUS via the user subroutines for TSCA process simulation and the springback prediction of an integral panel.A TSCA test was performed.The result shows that the maximum radius deviation between the formed plate and the simulation results is less than 0.4 mm,thus validating the effectiveness of the developed constitutive model and FE model.
