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The Efficacy of Explicit Instruction about Discourse Connectives in English Argumentative Writing on Second-Year Chinese University Students
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作者 袁勤 《海外英语》 2020年第12期83-85,94,共4页
This study investigated the effect of explicit instruction about DCs in argumentative writings by 15 Chinese learners of English. This study involved in a 4-week experiment. Pre-and post-writing tests were quantitativ... This study investigated the effect of explicit instruction about DCs in argumentative writings by 15 Chinese learners of English. This study involved in a 4-week experiment. Pre-and post-writing tests were quantitatively analyzed to examine whether the explicit instruction about DCs had a significant effect on the students'argumentative writing. The findings revealed that the ex-plicit instruction of the target DCs facilitated the improvement of the participants in their argumentative writing . 展开更多
关键词 explicit instruction discourse connectives argumentative writing quantitative analysis
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Rough Sets and Three Valued Connectives Extended Abstract
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作者 CIUCCI Davide DUBOIS Didier 《浙江海洋学院学报(自然科学版)》 CAS 2010年第5期411-415,共5页
1 Introduction In[5]we investigated the significance of some truth-functional three valued logics of ill-known sets described by pairs of disjoint(or pairs of nested) subsets.In particular,we referred to the case of r... 1 Introduction In[5]we investigated the significance of some truth-functional three valued logics of ill-known sets described by pairs of disjoint(or pairs of nested) subsets.In particular,we referred to the case of rough sets showing that if from a mathematical standpoint we obtain sound results,the interpretation with respect 展开更多
关键词 Rough sets Three valued connectives IMPLICATIONS
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The Explicitation and Implicitation of Connectives in E-C Literature Translation:A Corpus-based Case Study on Jane Eyre
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作者 茅慧 《海外英语》 2017年第22期148-149,162,共3页
This study is aimed to discover the explicitation and implicitation of connectives in literature translation. Based on parallel corpus, two Chinese versions of Jane Eyre are studied from three aspects, Intra-language ... This study is aimed to discover the explicitation and implicitation of connectives in literature translation. Based on parallel corpus, two Chinese versions of Jane Eyre are studied from three aspects, Intra-language comparison, inter-language comparison and case study. The findings in the study prove the reliability of Blum-Kulka's(1986) famous explicitation hypothesis, and its possible motivations are fully explored as well. 展开更多
关键词 EXPLICITATION Implicitation connectives CORPUS TRANSLATION
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A Pragmatic Analysis of Discourse Connectives in the Framework of Relevance Theory
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作者 ZHOU Da-jun REN Miao-miao MING Rui-long 《Sino-US English Teaching》 2018年第1期28-31,共4页
Discourse connectives can be dealt with in relevance-theoretic terms, as indicators of types of relevance. These connectives can be used to constrain the interpretation of an utterance. They are analyzed in a broad cl... Discourse connectives can be dealt with in relevance-theoretic terms, as indicators of types of relevance. These connectives can be used to constrain the interpretation of an utterance. They are analyzed in a broad classification outlined in discourse connectives which introduce contextual implications, which are concerned with strengthening and which introduce denials. A relevance based approach to discourse is a more adequate framework than a coherence based one for the analysis of discourse connectives. 展开更多
关键词 PRAGMATICS discourse connective relevance theory
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基于Connectivity Map的药物重定位评价维拉帕米作为治疗帕金森病的药物
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作者 新吉乐 刘晶 +6 位作者 张欣翼 郭家缘 韩文卓 孙怡馨 赵乐 冯卫生 郑晓珂 《中国临床药理学与治疗学》 北大核心 2026年第1期14-27,共14页
目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并... 目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并在6-羟基多巴胺(6-OHDA)诱导损伤的PC12细胞和PD小鼠模型评价其PD治疗作用。结果:维拉帕米(verapamil,Ver)为潜在的候选药物。Ver对6-OHDA损伤的PC12细胞具有保护作用,同时对6-OHDA诱导的PAX5、LEF1、MTF1、IKZF3和SP140等转录因子,以及ITGA6、CDH1、CD40、ESR1、SMAD3、CXCR4等PD发病基因的表达具有调控作用。PD模型小鼠中,Ver可对α-突触核蛋白(α-Syn)表达有一定抑制作用,但对上述PD发病基因及其转录因子和调控作用较弱。结论:Ver对PD的治疗作用部分依赖于对PD发病基因及其相关转录因子的调控作用。 展开更多
关键词 帕金森病 转录因子 Connectivity Map 维拉帕米 6-羟基多巴胺
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OpenID Connect协议的形式化分析与优化
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作者 陈琼 缪祥华 袁梅宇 《计算机技术与发展》 2026年第2期195-200,214,共7页
OpenID Connect协议作为实现身份认证与授权的重要机制,其安全性备受关注。利用Scyther模型检测工具,在CK强安全模型约束下对该协议进行形式化分析。分析结果表明,OpenID Connect协议存在明显的安全漏洞,其中包括跨站请求伪造攻击、重... OpenID Connect协议作为实现身份认证与授权的重要机制,其安全性备受关注。利用Scyther模型检测工具,在CK强安全模型约束下对该协议进行形式化分析。分析结果表明,OpenID Connect协议存在明显的安全漏洞,其中包括跨站请求伪造攻击、重放攻击以及中间人攻击等问题。这些安全漏洞严重威胁着协议运行的安全性和用户信息的保密性。针对跨站请求伪造攻击,对state参数实施加盐哈希处理;针对重放攻击,引入时间戳校验机制,客户端请求时服务端生成精确时间戳,通过网络时间协议确保时间同步,仅处理处于预设时间窗口期内的请求;针对中间人攻击,采用SM2数字签名算法,客户端用私钥签名请求,服务器用公钥验证,服务器转发时附加自身签名,确保请求来源可信。改进后的协议在抵御上述安全攻击方面表现出色,经检验具备良好的安全性,能够为用户提供更为可靠的身份验证和授权服务,对于提升OpenID Connect协议在实际应用中的安全性具有重要意义。 展开更多
关键词 OpenID Connect协议 形式化分析 CK安全模型 Scyther 协议分析 改进
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A Transformative Masterpiece--Chinese-built bridge in Tanzania boosts trade,connectivity
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作者 DERRICK SILIMINA 《ChinAfrica》 2026年第1期42-43,共2页
In the Kigongo area of Mwanza Region,northwest Tanzania,fishmonger Neema Aisha remembers how the morning’s fresh catch would sour while she queued for the ferry,putting her business at risk.
关键词 business risk FERRY BRIDGE CONNECTIVITY TRADE fishmonger transformative
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Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts
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作者 Shao-Chen Cheng Yong-Ming Wang +5 位作者 Yu-Tong Li Qian-Nan Yao Xin-Lin Huang Jian Ji Xiao-Bin Zhang Hong-Yan Sun 《World Journal of Psychiatry》 2026年第1期91-103,共13页
BACKGROUND Suicide constitutes the second leading cause of death among adolescents globally and represents a critical public health concern.The neural mechanisms underlying suicidal behavior in adolescents with major ... BACKGROUND Suicide constitutes the second leading cause of death among adolescents globally and represents a critical public health concern.The neural mechanisms underlying suicidal behavior in adolescents with major depressive disorder(MDD)remain poorly understood.Aberrant resting-state functional connectivity(rsFC)in the amygdala,a key region implicated in emotional regulation and threat detection,is strongly implicated in depression and suicidal behavior.AIM To investigate rsFC alterations between amygdala subregions and whole-brain networks in adolescent patients with depression and suicide attempts.METHODS Resting-state functional magnetic resonance imaging data were acquired from 32 adolescents with MDD and suicide attempts(sMDD)group,33 adolescents with MDD but without suicide attempts(nsMDD)group,and 34 demographically matched healthy control(HC)group,with the lateral and medial amygdala(MeA)defined as regions of interest.The rsFC patterns of amygdala subregions were compared across the three groups,and associations between aberrant rsFC values and clinical symptom severity scores were examined.RESULTS Compared with the nsMDD group,the sMDD group exhibited reduced rsFC between the right lateral amygdala(LA)and the right inferior occipital gyrus as well as the left middle occipital gyrus.Compared with the HC group,the abnormal brain regions of rsFC in the sMDD group and nsMDD group involve the parahippocampal gyrus(PHG)and fusiform gyrus.In the sMDD group,right MeA and right temporal pole:Superior temporal gyrus rsFC value negatively correlated with the Rosenberg Self-Esteem Scale scores(r=-0.409,P=0.025),while left LA and right PHG rsFC value positively correlated with the Adolescent Self-Rating Life Events Checklist interpersonal relationship scores(r=0.372,P=0.043).CONCLUSION Aberrant rsFC changes between amygdala subregions and these brain regions provide novel insights into the underlying neural mechanisms of suicide attempts in adolescents with MDD. 展开更多
关键词 Suicide attempt ADOLESCENT Major depressive disorder AMYGDALA Functional connectivity
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Parametric analyses on seismic performance of novel precast bridge columns with off-site post-tensioned tendons and on-site socket connection
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作者 Jia Junfeng Bian Jiachen +3 位作者 Cao Yanhui Xu Kun Song Chengzhe Deng Hedan 《Earthquake Engineering and Engineering Vibration》 2026年第1期203-218,共16页
This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avo... This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties. 展开更多
关键词 bridge column rocking self-centering PT tendons socket connection numerical simulation
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Social Value and Public Health:Exploring the Impact of Social Connection on the Community Mental Health
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作者 Jimin Chae Youngbin Lym Geiguen Shin 《International Journal of Mental Health Promotion》 2026年第1期92-107,共16页
Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social con... Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social connection and mental health,focusing on the mediating role of quality of life(QoL)and the moderating effect of regional differences.Methods:We analyzed data from the 2019 Korean Community Health Survey,comprising 229,099 adults.Mental health was assessed through validated measures of depressive symptoms and psychological well-being.Social connection was measured using indicators of interpersonal ties and community participation,and QoL was assessed via self-reported health-related satisfaction across major life domains.Analytical procedures included mediation modeling and subgroup analyses by region,with significance levels set at p<0.05.Results:The results indicate that social connections are significantly associated with lower stress levels and reduced depressive symptoms,with QoL playing a critical mediating role.Notably,the indirect effect of social connection on mental health via QoL is stronger in rural areas compared to urban regions,highlighting the importance of social cohesion and community support in mental well-being.Among 203,567 adults,greater social participation was associated with lower subjective stress(total effect=−0.052,p<0.001)and fewer depressive symptoms(PHQ-9 total effect=−0.308,p<0.001).QoL significantly mediated these associations,with the strongest indirect pathways observed through usual activities(19.2%for stress;27.6%for depression)and mobility(24.4%for depression).Regional analysis showed stronger mediation in rural areas(up to 26.8%for stress and 32.6%for depression)than in urban areas(8–16%and 14.9–23%).Direct effects remained significant,indicating partial mediation.These findings highlight that social participation enhances mental health directly and indirectly through QoL,particularly in rural contexts.Conclusions:Social connection contributes to better mental health both directly and indirectly through improved QoL,with stronger effects observed in rural communities.These findings highlight the importance of fostering social cohesion and enhancing life quality as strategies for improving population mental health.Policy interventions should adopt context-sensitive approaches that account for regional differences in social resources and service availability. 展开更多
关键词 Social connection mental health quality of life mediating effect regional disparities
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Measuring hydrological alterations and landscape patterns for sustainable development through ecosystem connectivity in Hastinapur Wildlife Sanctuary,India
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作者 Sonali Kundu Narendra Kumar Rana Barnali Kundu 《Journal of Environmental Sciences》 2026年第1期322-338,共17页
Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetland... Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being. 展开更多
关键词 Wetland monitoring Hastinapur wildlife sanctuary Landscape fragmentation Sustainable development goals Ecosystem connectivity
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An Optimal Right-Turn Coordination System for Connected and Automated Vehicles at Urban Intersections
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作者 Mahmudul Hasan Shuji Doman +2 位作者 A.S.M.Bakibillah Md Abdus Samad Kamal Kou Yamada 《Computers, Materials & Continua》 2026年第1期430-446,共17页
Traffic at urban intersections frequently encounters unexpected obstructions,resulting in congestion due to uncooperative and priority-based driving behavior.This paper presents an optimal right-turn coordination syst... Traffic at urban intersections frequently encounters unexpected obstructions,resulting in congestion due to uncooperative and priority-based driving behavior.This paper presents an optimal right-turn coordination system for Connected and Automated Vehicles(CAVs)at single-lane intersections,particularly in the context of left-hand side driving on roads.The goal is to facilitate smooth right turns for certain vehicles without creating bottlenecks.We consider that all approaching vehicles share relevant information through vehicular communications.The Intersection Coordination Unit(ICU)processes this information and communicates the optimal crossing or turning times to the vehicles.The primary objective of this coordination is to minimize overall traffic delays,which also helps improve the fuel consumption of vehicles.By considering information from upcoming vehicles at the intersection,the coordination system solves an optimization problem to determine the best timing for executing right turns,ultimately minimizing the total delay for all vehicles.The proposed coordination system is evaluated at a typical urban intersection,and its performance is compared to traditional traffic systems.Numerical simulation results indicate that the proposed coordination system significantly enhances the average traffic speed and fuel consumption compared to the traditional traffic system in various scenarios. 展开更多
关键词 Right-turn coordination connected and automated vehicles vehicular communication edge processing urban intersection
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Noradrenergic excitation of astrocytes supports cognitive reserve
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作者 Robert Zorec Alexei Verkhratsky 《Neural Regeneration Research》 2026年第4期1546-1547,共2页
The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It ha... The concept of the brain cognitive reserve is derived from the well-acknowledged notion that the degree of brain damage does not always match the severity of clinical symptoms and neurological/cognitive outcomes.It has been suggested that the size of the brain(brain reserve) and the extent of neural connections acquired through life(neural reserve) set a threshold beyond which noticeable impairments occur.In contrast,cognitive reserve refers to the brain's ability to adapt and reo rganize stru cturally and functionally to resist damage and maintain function,including neural reserve and brain maintenance,resilience,and compensation(Verkhratsky and Zorec,2024). 展开更多
关键词 ASTROCYTES brain reserve cognitive reserve clinical symptoms noradrenergic excitation neural reserve neural connections brain cognitive reserve
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Artificial Intelligence (AI)-Enabled Unmanned Aerial Vehicle (UAV) Systems for Optimizing User Connectivity in Sixth-Generation (6G) Ubiquitous Networks
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作者 Zeeshan Ali Haider Inam Ullah +2 位作者 Ahmad Abu Shareha Rashid Nasimov Sufyan Ali Memon 《Computers, Materials & Continua》 2026年第1期534-549,共16页
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener... The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment. 展开更多
关键词 6G networks UAV-based communication cooperative reinforcement learning network optimization user connectivity energy efficiency
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Conservation priority for protected areas in Fuzhou,southeast China:An integrated inside-out approach based on ecological network
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作者 CAI Xinyu XU Zesong +2 位作者 YOU Weibin KATTEL Giri WANG Yingzi 《Journal of Mountain Science》 2026年第1期327-342,共16页
Addressing the widespread issues of internal fragmentation within protected areas and the neglect of surrounding critical habitat networks,this study aims to develop an assessment framework for the precise identificat... Addressing the widespread issues of internal fragmentation within protected areas and the neglect of surrounding critical habitat networks,this study aims to develop an assessment framework for the precise identification and remediation of regional conservation gaps.To this end,we introduce the Framework for Conservation Priority Identification(FCPI).The framework integrates Morphological Spatial Pattern Analysis(MSPA),the Remote Sensing Ecological Index(RSEI),Circuit Theory,and the Minimum Cumulative Resistance(MCR)model to formulate a multidimensional conservation priority index.This index facilitates the identification of critical ecological network components and enables the dynamic prioritization of conservation efforts.A case study of Fuzhou City from 2014 to 2020 reveals that despite an overall improvement in regional environmental quality,the functionality of core ecological sources has markedly declined.Between 2014 and 2020,the number of ecological sources grew by 76.9%,yet their total area shrank by 13.9%.Concurrently,the number of ecological corridors rose from 27 to 53,extending their total length by 380.23 km,which indicates an intensifying trend of habitat fragmentation.Furthermore,a significant number of crucial ecological network nodes,particularly within Minhou County,lie explicitly outside the existing protected area system.This confirms the presence of conservation gaps and unveils the spatiotemporal dynamics of shifting conservation priorities.The research validates that the proposed FCPI can effectively diagnose the dynamic deficiencies within conservation systems.It offers scientific decisionsupport for local governments,facilitating a transition from isolated conservation efforts towards systematic and comprehensive ecological network governance. 展开更多
关键词 Conservation prioritization Ecological corridors Protected areas Remote sensing ecological index Landscape connectivity
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Non-right-handedness and psychiatric disorders:A synthesis of epidemiological,genetic,and neurobiological evidence
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作者 Qing-Qing Wang Zhong-Sheng Sun Jie-Si Wang 《World Journal of Psychiatry》 2026年第1期20-31,共12页
Non-right-handedness(NRH),encompassing left-handedness and mixed-handedness,has been frequently reported at elevated rates in individuals with various psychiatric disorders.The consistency of this association across m... Non-right-handedness(NRH),encompassing left-handedness and mixed-handedness,has been frequently reported at elevated rates in individuals with various psychiatric disorders.The consistency of this association across multiple conditions and its underlying mechanisms is the subject of ongoing investigation.This review synthesized current evidence to explore the association between NRH and psychiatric disorders from epidemiological,genetic,and neurobiological perspectives.We systematically identified and appraised relevant literature investigating NRH prevalence in psychiatric populations and potential explanatory mechanisms.Epidemiological evidence indicates an elevated prevalence of NRH,particularly within neurodevelopmental disorders.Potential contributing mechanisms identified include early developmental disruptions,shared genetic predispositions,and atypical patterns of brain lateralization.While the association between NRH and psychiatric conditions,especially neurodevelopmental disorders,is evident,the causal pathways and relative contributions of identified mechanisms are complex and debated.This review highlighted key areas requiring further research to elucidate these relationships. 展开更多
关键词 HANDEDNESS Psychiatric disorder Neurodevelopmental disorders Brain lateralization/asymmetry Interhemispheric connectivity Early developmental disruption
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Clinical information prompt-driven retinal fundus image for brain health evaluation
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作者 Nuo Tong Ying Hui +10 位作者 Shui-Ping Gou Ling-Xi Chen Xiang-Hong Wang Shuo-Hua Chen Jing Li Xiao-Shuai Li Yun-Tao Wu Shou-Ling Wu Zhen-Chang Wang Jing Sun Han Lv 《Military Medical Research》 2026年第1期43-57,共15页
Background:Brain volume measurement serves as a critical approach for assessing brain health status.Considering the close biological connection between the eyes and brain,this study aims to investigate the feasibility... Background:Brain volume measurement serves as a critical approach for assessing brain health status.Considering the close biological connection between the eyes and brain,this study aims to investigate the feasibility of estimating brain volume through retinal fundus imaging integrated with clinical metadata,and to offer a cost-effective approach for assessing brain health.Methods:Based on clinical information,retinal fundus images,and neuroimaging data derived from a multicenter,population-based cohort study,the Kai Luan Study,we proposed a cross-modal correlation representation(CMCR)network to elucidate the intricate co-degenerative relationships between the eyes and brain for 755 subjects.Specifically,individual clinical information,which has been followed up for as long as 12 years,was encoded as a prompt to enhance the accuracy of brain volume estimation.Independent internal validation and external validation were performed to assess the robustness of the proposed model.Root mean square error(RMSE),peak signal-tonoise ratio(PSNR),and structural similarity index measure(SSIM)metrics were employed to quantitatively evaluate the quality of synthetic brain images derived from retinal imaging data.Results:The proposed framework yielded average RMSE,PSNR,and SSIM values of 98.23,35.78 d B,and 0.64,respectively,which significantly outperformed 5 other methods:multi-channel Variational Autoencoder(mcVAE),Pixelto-Pixel(Pixel2pixel),transformer-based U-Net(Trans UNet),multi-scale transformer network(MT-Net),and residual vision transformer(ResViT).The two-(2D)and three-dimensional(3D)visualization results showed that the shape and texture of the synthetic brain images generated by the proposed method most closely resembled those of actual brain images.Thus,the CMCR framework accurately captured the latent structural correlations between the fundus and the brain.The average difference between predicted and actual brain volumes was 61.36 cm~3,with a relative error of 4.54%.When all of the clinical information(including age and sex,daily habits,cardiovascular factors,metabolic factors,and inflammatory factors)was encoded,the difference was decreased to 53.89 cm~3,with a relative error of 3.98%.Based on the synthesized brain magnetic resonance images from retinal fundus images,the volumes of brain tissues could be estimated with high accuracy.Conclusion:This study provides an innovative,accurate,and cost-effective approach to characterize brain health status through readily accessible retinal fundus images. 展开更多
关键词 Retinal fundus image Brain volume Brain health Magnetic resonance imaging Deep learning Eye and brain connection
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Classification Method of Lower Limbs Motor Imagery Based on Functional Connectivity and Graph Convolutional Network
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作者 Yang Liu Qi Lu +2 位作者 Junjie Wu Huaichang Yin Shiwei Cheng 《Computers, Materials & Continua》 2026年第3期1674-1689,共16页
The development of brain-computer interfaces(BCI)based on motor imagery(MI)has greatly improved patients’quality of life with movement disorders.The classification of upper limb MI has been widely studied and applied... The development of brain-computer interfaces(BCI)based on motor imagery(MI)has greatly improved patients’quality of life with movement disorders.The classification of upper limb MI has been widely studied and applied in many fields,including rehabilitation.However,the physiological representations of left and right lower limb movements are too close and activated deep in the cerebral cortex,making it difficult to distinguish their features.Therefore,classifying lower limbs motor imagery is more challenging.In this study,we propose a feature extraction method based on functional connectivity,which utilizes phase-locked values to construct a functional connectivity matrix as the features of the left and right legs,which can effectively avoid the problem of physiological representations of the left and right lower limbs being too close to each other during movement.In addition,considering the topology and the temporal characteristics of the electroencephalogram(EEG),we designed a temporal-spatial convolutional network(TSGCN)to capture the spatiotemporal information for classification.Experimental results show that the accuracy of the proposed method is higher than that of existing methods,achieving an average classification accuracy of 73.58%on the internal dataset.Finally,this study explains the network mechanism of left and right foot MI from the perspective of graph theoretic features and demonstrates the feasibility of decoding lower limb MI. 展开更多
关键词 Brain-computer interface lower limb motor imagery functional connectivity temporal-spatial convolutional network
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Carved Connections:Merging artisanal skill,advanced manufacturing and cultural storytelling,Yunhe turns wooden toys into carriers of Chinese culture across the globe
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作者 LIU YOUMENG 《ChinAfrica》 2026年第2期46-48,共3页
Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent ... Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions. 展开更多
关键词 yunhe county advanced manufacturing carved connections artisanal skill wooden toy wooden toys accounting cultural storytelling lishui city
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The characteristics of cerebral cortical oxygenation levels and functional connectivity under upper and lower limb exercise-induced fatigue
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作者 Feng Li Yajie Wang +3 位作者 Xinyi Wang Jiawei Bi Ye Luo Lingyan Huang 《Sports Medicine and Health Science》 2026年第1期61-69,共9页
This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fati... This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fatigue was induced using an upper limb ergometer or a lower limb ergometer,with the load increasing gradually each minute.fNIRS covering the prefrontal cortex and motor cortex were used to collect data during the resting state,both before and after fatigue induction.A two-way ANOVA was conducted to examine differences in oxyhemoglobin(HbO_(2))and functional connectivity before and after fatigue induction in both groups,with the significance level set at 0.05.Exercise-induced fatigue in both the upper and lower limbs leads to a significant decrease in cerebral cortical oxygenation levels.Upper limb fatigue leads to a significant reduction in functional connectivity,there were significant decreases in connectivity within the motor cortex,between the motor cortex and frontal regions,and between the right ventrolateral prefrontal cortex and other frontal regions.Conversely,no significant changes were observed before and after lower limb fatigue.Future studies should focus on examining the extent to which how changes in the cerebral cortex,induced by exercise fatigue,are linked to exercise-and/or performance-related outcomes. 展开更多
关键词 Brain functional connectivity Cerebral oxygenation level Exercise-induced fatigue Functional near-infrared spectroscopy
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