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基于Connectivity Map的药物重定位评价维拉帕米作为治疗帕金森病的药物
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作者 新吉乐 刘晶 +6 位作者 张欣翼 郭家缘 韩文卓 孙怡馨 赵乐 冯卫生 郑晓珂 《中国临床药理学与治疗学》 北大核心 2026年第1期14-27,共14页
目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并... 目的:筛选调控帕金森病(Parkinson's disease,PD)发病关键基因及相关转录因子表达的小分子化合物。方法:分析PD患者的基因表达谱数据,筛选PD发病关键基因及转录因子。Connectivity Map(CMap)筛选可调控转录因子表达的小分子药物,并在6-羟基多巴胺(6-OHDA)诱导损伤的PC12细胞和PD小鼠模型评价其PD治疗作用。结果:维拉帕米(verapamil,Ver)为潜在的候选药物。Ver对6-OHDA损伤的PC12细胞具有保护作用,同时对6-OHDA诱导的PAX5、LEF1、MTF1、IKZF3和SP140等转录因子,以及ITGA6、CDH1、CD40、ESR1、SMAD3、CXCR4等PD发病基因的表达具有调控作用。PD模型小鼠中,Ver可对α-突触核蛋白(α-Syn)表达有一定抑制作用,但对上述PD发病基因及其转录因子和调控作用较弱。结论:Ver对PD的治疗作用部分依赖于对PD发病基因及其相关转录因子的调控作用。 展开更多
关键词 帕金森病 转录因子 connectivity Map 维拉帕米 6-羟基多巴胺
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OpenID Connect协议的形式化分析与优化
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作者 陈琼 缪祥华 袁梅宇 《计算机技术与发展》 2026年第2期195-200,214,共7页
OpenID Connect协议作为实现身份认证与授权的重要机制,其安全性备受关注。利用Scyther模型检测工具,在CK强安全模型约束下对该协议进行形式化分析。分析结果表明,OpenID Connect协议存在明显的安全漏洞,其中包括跨站请求伪造攻击、重... OpenID Connect协议作为实现身份认证与授权的重要机制,其安全性备受关注。利用Scyther模型检测工具,在CK强安全模型约束下对该协议进行形式化分析。分析结果表明,OpenID Connect协议存在明显的安全漏洞,其中包括跨站请求伪造攻击、重放攻击以及中间人攻击等问题。这些安全漏洞严重威胁着协议运行的安全性和用户信息的保密性。针对跨站请求伪造攻击,对state参数实施加盐哈希处理;针对重放攻击,引入时间戳校验机制,客户端请求时服务端生成精确时间戳,通过网络时间协议确保时间同步,仅处理处于预设时间窗口期内的请求;针对中间人攻击,采用SM2数字签名算法,客户端用私钥签名请求,服务器用公钥验证,服务器转发时附加自身签名,确保请求来源可信。改进后的协议在抵御上述安全攻击方面表现出色,经检验具备良好的安全性,能够为用户提供更为可靠的身份验证和授权服务,对于提升OpenID Connect协议在实际应用中的安全性具有重要意义。 展开更多
关键词 OpenID connect协议 形式化分析 CK安全模型 Scyther 协议分析 改进
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融合骨架约束域的RRT-Connect路径规划算法
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作者 聂铭杰 向贤宝 +3 位作者 蔡芸 蒋林 汤勃 潘艳桥 《重庆理工大学学报(自然科学)》 北大核心 2026年第1期123-131,共9页
针对RRT-Connect路径规划算法存在采样随机性强、路径点冗余及搜索效率低等问题,提出了一种融合骨架约束域的RRT-Connect路径规划算法。首先,对栅格地图进行预处理,提取骨架并生成全局骨架地图,基于给定的起始点和目标点在骨架上搜索初... 针对RRT-Connect路径规划算法存在采样随机性强、路径点冗余及搜索效率低等问题,提出了一种融合骨架约束域的RRT-Connect路径规划算法。首先,对栅格地图进行预处理,提取骨架并生成全局骨架地图,基于给定的起始点和目标点在骨架上搜索初始路径,并扩展该路径生成的骨架约束区域;其次,为降低RRT-Connect算法的采样随机性,将采样点限制在生成的骨架约束域内,并引入目标节点偏置策略;然后,为减少路径冗余点,引入启发式代价函数,选取代价值最低的节点作为扩展节点;最后,通过路径裁剪结合二次贝塞尔曲线进行路径平滑优化,通过构建不同复杂度的仿真场景和实际环境进行对比实验。实验结果表明,所提算法可以高效地生成一条无碰撞且包含初始节点与目标节点的最优路径,提升路径生成效率。 展开更多
关键词 RRT-connect算法 骨架约束域 目标偏置 启发式代价函数 路径裁剪
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A Transformative Masterpiece--Chinese-built bridge in Tanzania boosts trade,connectivity
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作者 DERRICK SILIMINA 《ChinAfrica》 2026年第1期42-43,共2页
In the Kigongo area of Mwanza Region,northwest Tanzania,fishmonger Neema Aisha remembers how the morning’s fresh catch would sour while she queued for the ferry,putting her business at risk.
关键词 business risk FERRY BRIDGE connectIVITY TRADE fishmonger transformative
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Aberrant resting-state functional connectivity in amygdala subregions among adolescents with depression and suicide attempts
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作者 Shao-Chen Cheng Yong-Ming Wang +5 位作者 Yu-Tong Li Qian-Nan Yao Xin-Lin Huang Jian Ji Xiao-Bin Zhang Hong-Yan Sun 《World Journal of Psychiatry》 2026年第1期91-103,共13页
BACKGROUND Suicide constitutes the second leading cause of death among adolescents globally and represents a critical public health concern.The neural mechanisms underlying suicidal behavior in adolescents with major ... BACKGROUND Suicide constitutes the second leading cause of death among adolescents globally and represents a critical public health concern.The neural mechanisms underlying suicidal behavior in adolescents with major depressive disorder(MDD)remain poorly understood.Aberrant resting-state functional connectivity(rsFC)in the amygdala,a key region implicated in emotional regulation and threat detection,is strongly implicated in depression and suicidal behavior.AIM To investigate rsFC alterations between amygdala subregions and whole-brain networks in adolescent patients with depression and suicide attempts.METHODS Resting-state functional magnetic resonance imaging data were acquired from 32 adolescents with MDD and suicide attempts(sMDD)group,33 adolescents with MDD but without suicide attempts(nsMDD)group,and 34 demographically matched healthy control(HC)group,with the lateral and medial amygdala(MeA)defined as regions of interest.The rsFC patterns of amygdala subregions were compared across the three groups,and associations between aberrant rsFC values and clinical symptom severity scores were examined.RESULTS Compared with the nsMDD group,the sMDD group exhibited reduced rsFC between the right lateral amygdala(LA)and the right inferior occipital gyrus as well as the left middle occipital gyrus.Compared with the HC group,the abnormal brain regions of rsFC in the sMDD group and nsMDD group involve the parahippocampal gyrus(PHG)and fusiform gyrus.In the sMDD group,right MeA and right temporal pole:Superior temporal gyrus rsFC value negatively correlated with the Rosenberg Self-Esteem Scale scores(r=-0.409,P=0.025),while left LA and right PHG rsFC value positively correlated with the Adolescent Self-Rating Life Events Checklist interpersonal relationship scores(r=0.372,P=0.043).CONCLUSION Aberrant rsFC changes between amygdala subregions and these brain regions provide novel insights into the underlying neural mechanisms of suicide attempts in adolescents with MDD. 展开更多
关键词 Suicide attempt ADOLESCENT Major depressive disorder AMYGDALA Functional connectivity
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Parametric analyses on seismic performance of novel precast bridge columns with off-site post-tensioned tendons and on-site socket connection
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作者 Jia Junfeng Bian Jiachen +3 位作者 Cao Yanhui Xu Kun Song Chengzhe Deng Hedan 《Earthquake Engineering and Engineering Vibration》 2026年第1期203-218,共16页
This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avo... This study proposes a new post-tensioned precast bridge column(PT-PBC)with a socket connection.Compared to conventional PBCs connected by PT tendons,the combination of the PT tendons with the socket connection can avoid tensioning the PT tendons on site,which further accelerates construction speed while improving construction quality and safety.In addition,compared to conventional PBCs with a socket connection,a rocking interface can avoid the formation of a plastic hinge in a column,which greatly alleviates seismic damage to that area.One specimen for quasi-static testing is used to validate the feasibility of this connection type.Subsequently,finite element models(FEM)are established to systematically predict the responses of the proposed columns under lateral cyclic loading.The accuracy of the FEM is verified through quasistatic testing.Next,the influences of the key design parameters of the PT-PBC,including the area ratio and prestress level of the PT tendons,the area ratio of energy dissipation(ED)steel rebars,and the total axial compression ratio on the seismic performances of PT-PBC are systematically investigated.The use of shape memory alloy(SMA)rods as energy dissipation devices and their performances also are investigated.The results show that increasing the area ratio and prestress level of PT tendons has an overall positive impact on the self-centering capacity of the column.The prestress level of PT tendons should be kept between 35%and 55%,depending on different conditions.The total compression axial ratio of the columns should be maintained between 0.3 and 0.4.Both ED steel rebars and SMA rods can boost the column’s energy dissipation capacity,while SMA rods can reduce residual deformation due to their inherent mechanical properties. 展开更多
关键词 bridge column rocking self-centering PT tendons socket connection numerical simulation
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Social Value and Public Health:Exploring the Impact of Social Connection on the Community Mental Health
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作者 Jimin Chae Youngbin Lym Geiguen Shin 《International Journal of Mental Health Promotion》 2026年第1期92-107,共16页
Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social con... Background:Social connection is widely recognized as a protective determinant of health,yet its direct and indirect effects on mental health remain underexplored.This study examines the relationship between social connection and mental health,focusing on the mediating role of quality of life(QoL)and the moderating effect of regional differences.Methods:We analyzed data from the 2019 Korean Community Health Survey,comprising 229,099 adults.Mental health was assessed through validated measures of depressive symptoms and psychological well-being.Social connection was measured using indicators of interpersonal ties and community participation,and QoL was assessed via self-reported health-related satisfaction across major life domains.Analytical procedures included mediation modeling and subgroup analyses by region,with significance levels set at p<0.05.Results:The results indicate that social connections are significantly associated with lower stress levels and reduced depressive symptoms,with QoL playing a critical mediating role.Notably,the indirect effect of social connection on mental health via QoL is stronger in rural areas compared to urban regions,highlighting the importance of social cohesion and community support in mental well-being.Among 203,567 adults,greater social participation was associated with lower subjective stress(total effect=−0.052,p<0.001)and fewer depressive symptoms(PHQ-9 total effect=−0.308,p<0.001).QoL significantly mediated these associations,with the strongest indirect pathways observed through usual activities(19.2%for stress;27.6%for depression)and mobility(24.4%for depression).Regional analysis showed stronger mediation in rural areas(up to 26.8%for stress and 32.6%for depression)than in urban areas(8–16%and 14.9–23%).Direct effects remained significant,indicating partial mediation.These findings highlight that social participation enhances mental health directly and indirectly through QoL,particularly in rural contexts.Conclusions:Social connection contributes to better mental health both directly and indirectly through improved QoL,with stronger effects observed in rural communities.These findings highlight the importance of fostering social cohesion and enhancing life quality as strategies for improving population mental health.Policy interventions should adopt context-sensitive approaches that account for regional differences in social resources and service availability. 展开更多
关键词 Social connection mental health quality of life mediating effect regional disparities
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Measuring hydrological alterations and landscape patterns for sustainable development through ecosystem connectivity in Hastinapur Wildlife Sanctuary,India
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作者 Sonali Kundu Narendra Kumar Rana Barnali Kundu 《Journal of Environmental Sciences》 2026年第1期322-338,共17页
Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetland... Floodplain wetlands are invaluable ecosystems providing numerous ecological benefits,yet they face a global crisis necessitating sustainable preservation efforts.This study examines the depletion of floodplain wetlands within the Hastinapur Wildlife Sanctuary(HWLS)in Uttar Pradesh.Encroachment activities such as grazing,agriculture,and human settlements have fragmented and degraded critical wetland ecosystems.Additionally,irrigation projects,dam construction,and water diversion have disrupted natural water flow and availability.To assess wetland inundation in 2023,five classification techniques were employed:Random Forest(RF),Support Vector Machine(SVM),artificial neural network(ANN),Spectral Information Divergence(SID),and Maximum Likelihood Classifier(MLC).SVM emerged as the most precise method,as determined by kappa coefficient and index-based validation.Consequently,the SVM classifier was used to model wetland inundation areas from 1983 to 2023 and analyze spatiotemporal changes and fragmentation patterns.The findings revealed that the SVM clas-sifier accurately mapped 2023 wetland areas.The modeled time-series data demonstrated a 62.55%and 38.12%reduction in inundated wetland areas over the past 40 years in the pre-and post-monsoon periods,respectively.Fragmentation analysis indicated an 86.27%decrease in large core wetland areas in the pre-monsoon period,signifying severe habitat degradation.This rapid decline in wetlands within protected areas raises concerns about their ecological impacts.By linking wetland loss to global sustainability objectives,this study underscores the global urgency for strengthened wetland protection measures and highlights the need for integrating wetland conservation into broader sustainable development goals.Effective policies and adaptive management strategies are crucial for preserving these ecosystems and their vital services,which are essential for biodiversity,climate regulation,and human well-being. 展开更多
关键词 Wetland monitoring Hastinapur wildlife sanctuary Landscape fragmentation Sustainable development goals Ecosystem connectivity
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An Optimal Right-Turn Coordination System for Connected and Automated Vehicles at Urban Intersections
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作者 Mahmudul Hasan Shuji Doman +2 位作者 A.S.M.Bakibillah Md Abdus Samad Kamal Kou Yamada 《Computers, Materials & Continua》 2026年第1期430-446,共17页
Traffic at urban intersections frequently encounters unexpected obstructions,resulting in congestion due to uncooperative and priority-based driving behavior.This paper presents an optimal right-turn coordination syst... Traffic at urban intersections frequently encounters unexpected obstructions,resulting in congestion due to uncooperative and priority-based driving behavior.This paper presents an optimal right-turn coordination system for Connected and Automated Vehicles(CAVs)at single-lane intersections,particularly in the context of left-hand side driving on roads.The goal is to facilitate smooth right turns for certain vehicles without creating bottlenecks.We consider that all approaching vehicles share relevant information through vehicular communications.The Intersection Coordination Unit(ICU)processes this information and communicates the optimal crossing or turning times to the vehicles.The primary objective of this coordination is to minimize overall traffic delays,which also helps improve the fuel consumption of vehicles.By considering information from upcoming vehicles at the intersection,the coordination system solves an optimization problem to determine the best timing for executing right turns,ultimately minimizing the total delay for all vehicles.The proposed coordination system is evaluated at a typical urban intersection,and its performance is compared to traditional traffic systems.Numerical simulation results indicate that the proposed coordination system significantly enhances the average traffic speed and fuel consumption compared to the traditional traffic system in various scenarios. 展开更多
关键词 Right-turn coordination connected and automated vehicles vehicular communication edge processing urban intersection
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Artificial Intelligence (AI)-Enabled Unmanned Aerial Vehicle (UAV) Systems for Optimizing User Connectivity in Sixth-Generation (6G) Ubiquitous Networks
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作者 Zeeshan Ali Haider Inam Ullah +2 位作者 Ahmad Abu Shareha Rashid Nasimov Sufyan Ali Memon 《Computers, Materials & Continua》 2026年第1期534-549,共16页
The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-gener... The advent of sixth-generation(6G)networks introduces unprecedented challenges in achieving seamless connectivity,ultra-low latency,and efficient resource management in highly dynamic environments.Although fifth-generation(5G)networks transformed mobile broadband and machine-type communications at massive scales,their properties of scaling,interference management,and latency remain a limitation in dense high mobility settings.To overcome these limitations,artificial intelligence(AI)and unmanned aerial vehicles(UAVs)have emerged as potential solutions to develop versatile,dynamic,and energy-efficient communication systems.The study proposes an AI-based UAV architecture that utilizes cooperative reinforcement learning(CoRL)to manage an autonomous network.The UAVs collaborate by sharing local observations and real-time state exchanges to optimize user connectivity,movement directions,allocate power,and resource distribution.Unlike conventional centralized or autonomous methods,CoRL involves joint state sharing and conflict-sensitive reward shaping,which ensures fair coverage,less interference,and enhanced adaptability in a dynamic urban environment.Simulations conducted in smart city scenarios with 10 UAVs and 50 ground users demonstrate that the proposed CoRL-based UAV system increases user coverage by up to 10%,achieves convergence 40%faster,and reduces latency and energy consumption by 30%compared with centralized and decentralized baselines.Furthermore,the distributed nature of the algorithm ensures scalability and flexibility,making it well-suited for future large-scale 6G deployments.The results highlighted that AI-enabled UAV systems enhance connectivity,support ultra-reliable low-latency communications(URLLC),and improve 6G network efficiency.Future work will extend the framework with adaptive modulation,beamforming-aware positioning,and real-world testbed deployment. 展开更多
关键词 6G networks UAV-based communication cooperative reinforcement learning network optimization user connectivity energy efficiency
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Classification Method of Lower Limbs Motor Imagery Based on Functional Connectivity and Graph Convolutional Network
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作者 Yang Liu Qi Lu +2 位作者 Junjie Wu Huaichang Yin Shiwei Cheng 《Computers, Materials & Continua》 2026年第3期1674-1689,共16页
The development of brain-computer interfaces(BCI)based on motor imagery(MI)has greatly improved patients’quality of life with movement disorders.The classification of upper limb MI has been widely studied and applied... The development of brain-computer interfaces(BCI)based on motor imagery(MI)has greatly improved patients’quality of life with movement disorders.The classification of upper limb MI has been widely studied and applied in many fields,including rehabilitation.However,the physiological representations of left and right lower limb movements are too close and activated deep in the cerebral cortex,making it difficult to distinguish their features.Therefore,classifying lower limbs motor imagery is more challenging.In this study,we propose a feature extraction method based on functional connectivity,which utilizes phase-locked values to construct a functional connectivity matrix as the features of the left and right legs,which can effectively avoid the problem of physiological representations of the left and right lower limbs being too close to each other during movement.In addition,considering the topology and the temporal characteristics of the electroencephalogram(EEG),we designed a temporal-spatial convolutional network(TSGCN)to capture the spatiotemporal information for classification.Experimental results show that the accuracy of the proposed method is higher than that of existing methods,achieving an average classification accuracy of 73.58%on the internal dataset.Finally,this study explains the network mechanism of left and right foot MI from the perspective of graph theoretic features and demonstrates the feasibility of decoding lower limb MI. 展开更多
关键词 Brain-computer interface lower limb motor imagery functional connectivity temporal-spatial convolutional network
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Carved Connections:Merging artisanal skill,advanced manufacturing and cultural storytelling,Yunhe turns wooden toys into carriers of Chinese culture across the globe
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作者 LIU YOUMENG 《ChinAfrica》 2026年第2期46-48,共3页
Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent ... Yunhe County in Lishui City,southwestern Zhejiang Province,doesn’t have any Disney castles.Instead,it has built bridges to the world with wood.Known as“China’s town of wooden toys,”accounting for about 40 percent of the global wooden toy market,Yunhe’s story began with a small factory established in 1970.Today,it has grown into a distinctive industrial cluster with an annual output value exceeding 8 billion yuan($1.15 billion),exporting products to 82 countries and regions. 展开更多
关键词 yunhe county advanced manufacturing carved connections artisanal skill wooden toy wooden toys accounting cultural storytelling lishui city
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The characteristics of cerebral cortical oxygenation levels and functional connectivity under upper and lower limb exercise-induced fatigue
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作者 Feng Li Yajie Wang +3 位作者 Xinyi Wang Jiawei Bi Ye Luo Lingyan Huang 《Sports Medicine and Health Science》 2026年第1期61-69,共9页
This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fati... This study aims to explore the impact of fatigue induced by different limb exercises on cerebral cortical oxygenation levels and functional connectivity strength using functional near-infrared spectroscopy(fNIRS).Fatigue was induced using an upper limb ergometer or a lower limb ergometer,with the load increasing gradually each minute.fNIRS covering the prefrontal cortex and motor cortex were used to collect data during the resting state,both before and after fatigue induction.A two-way ANOVA was conducted to examine differences in oxyhemoglobin(HbO_(2))and functional connectivity before and after fatigue induction in both groups,with the significance level set at 0.05.Exercise-induced fatigue in both the upper and lower limbs leads to a significant decrease in cerebral cortical oxygenation levels.Upper limb fatigue leads to a significant reduction in functional connectivity,there were significant decreases in connectivity within the motor cortex,between the motor cortex and frontal regions,and between the right ventrolateral prefrontal cortex and other frontal regions.Conversely,no significant changes were observed before and after lower limb fatigue.Future studies should focus on examining the extent to which how changes in the cerebral cortex,induced by exercise fatigue,are linked to exercise-and/or performance-related outcomes. 展开更多
关键词 Brain functional connectivity Cerebral oxygenation level Exercise-induced fatigue Functional near-infrared spectroscopy
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Double Wilczek–Zee connection and mixed-state quantum geometric tensor
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作者 Xiaoguang Wang Xiao-Ming Lu +2 位作者 Jing Liu Wenkui Ding Libin Fu 《Chinese Physics B》 2026年第2期300-305,共6页
The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor... The Wilczek–Zee connection(WZC)is a key concept in the study of topology of quantum systems.Here,we introduce the double Wilczek–Zee connection(DWZC)which naturally appears in the pure-state quantum geometric tensor(QGT),another important concept in the field of quantum geometry.The DWZC is Hermitian with respect to the two integer indices,just like the original Hermitian WZC.Based on the symmetric logarithmic derivative operator,we propose a mixed-state quantum geometric tensor.Using the symmetric properties of the DWZC,we find that the real part of the QGT is connected to the real part of the DWZC and the square of eigenvalue differences of the density matrix,whereas the imaginary part can be given in terms of the imaginary part of the DWZC and the cube of the eigenvalue differences.For density matrices with full rank or no full rank,the QGT can be given in terms of real and imaginary parts of the DWZC. 展开更多
关键词 quantum geometry Wilczek–Zee connection quantum geometric tensor
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The intelligent leap of wireless short-range connection
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作者 Wan Lei 《China Standardization》 2026年第1期47-47,共1页
Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSL... Founded in September 2020,the International SparkLink Alliance(iSLA)now has approximately 1,200 members in diverse sectors including terminals,homes,vehicles,manufacturing,transportation,finance and healthcare.The iSLA has established a technical standards system for wireless short-range communication covering full-stack standards such as the end-to-end protocol system. 展开更多
关键词 wireless short range communication end end protocol system technical standards system full stack standards international sparklink alliance isla now wireless short range connection standards system ISLA
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A Multi-Block Material Balance Framework for Connectivity Evaluation and Optimization of Water-Drive Gas Reservoirs
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作者 Fankun Meng Yuyang Liu +2 位作者 Xiaohua Liu Chenlong Duan Yuhui Zhou 《Fluid Dynamics & Materials Processing》 2026年第1期45-65,共21页
Carbonate gas reservoirs are often characterized by strong heterogeneity,complex inter-well connectivity,extensive edge or bottom water,and unbalanced production,challenges that are also common in many heterogeneous g... Carbonate gas reservoirs are often characterized by strong heterogeneity,complex inter-well connectivity,extensive edge or bottom water,and unbalanced production,challenges that are also common in many heterogeneous gas reservoirs with intricate storage and flow behavior.To address these issues within a unified,data-driven framework,this study develops a multi-block material balance model that accounts for inter-block flow and aquifer influx,and is applicable to a wide range of reservoir types.The model incorporates inter-well and well-group conductive connectivity together with pseudo–steady-state aquifer support.The governing equations are solved using a Newton–Raphson scheme,while particle swarm optimization is employed to estimate formation pressures,inter-well connectivity,and effective aquifer volumes.An unbalanced exploitation factor,UEF,is introduced to quantify production imbalance and to guide development optimization.Validation using a synthetic reservoir model demonstrates that the approach accurately reproduces pressure evolution,crossflow behavior,and water influx.Application to a representative case(the Longwangmiao)field further confirms its robustness under highly heterogeneous conditions,achieving a 12.9%reduction in UEF through optimized production allocation. 展开更多
关键词 Heterogeneous gas reservoir with bottom/edge water material balance equation connective conductivity unbalanced exploitation factor aquifer volume Evaluation production optimization
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Photoinduced skeletal editing of oxetanes:light-driven pathway connecting four-membered heterocycles and beyond
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作者 Ha Eun Kim Yoonsu Park 《Science Bulletin》 2026年第3期469-471,共3页
Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has... Organic and pharmaceutical synthesis have traditionally relied on the stepwise transformation ofactivated functional groups to synthesize cyclic molecules.The design of valuable heterocyclic compounds,for instance,has depended on multi-step routes such as polar or radical cyclization,cycloadditions,and the manipulation of various functional groups to achieve ring formation or connection[1,2]. 展开更多
关键词 organic pharmaceutical synthesis cyclic moleculesthe design valuable heterocyclic compoundsfor OXETANES polar radical cyclizationcycloadditionsand ring formation connection stepwise transformation ofactivated functional groups photoinduced skeletal editing
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Early Postnatal Pharmacological Intervention Rescues the Disruption of Developmental Connectivity in MAO-A KO Mice
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作者 Qian Xue Hanpeng Xu +6 位作者 Muye Zhu Bin Qian Lei Gao Lin Gou Houri Hintiryan Jean C.Shih Hong-Wei Dong 《Neuroscience Bulletin》 2025年第2期339-343,共5页
Dear Editors,The term“developmental disconnection syndromes”(DDSs)was first coined by Geshwind and Levitt in 2007[1]to describe the weakening of already formed connections or an absence of certain connections to est... Dear Editors,The term“developmental disconnection syndromes”(DDSs)was first coined by Geshwind and Levitt in 2007[1]to describe the weakening of already formed connections or an absence of certain connections to establish correct organization de novo in early developmental stages.DDSs include a number of neuropsychiatric diseases,such as autistic spectrum disorder(ASD)[1,2],which is characterized by impaired social communication and repetitive and stereotyped behaviors.Nevertheless,the exact etiology underlying these“disconnections”and their abnormal developmental trajectory remains largely unclear.Even less known is whether developmental disconnections relevant to autism can be rescued by early intervention thereby preventing neuropsychiatric and repetitive symptoms in later stages.This study addresses these important questions. 展开更多
关键词 impaired social communication Developmental Disconnection Syndromes Neuropsychiatric Diseases Early Postnatal disconnection syndromes ddss Pharmacological Intervention MAOA KO Mice weakening already formed connections
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基于H1 Connect的多元化评价标签相关分析及综合评价指标体系建立研究 被引量:1
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作者 许丹 罗祥东 +1 位作者 王雯霞 徐爽 《江苏科技信息》 2025年第5期93-98,共6页
文章基于H1 Connect对生物医学科技论文各类同行评议标签进行相关性分析研究,结合多元化指标尝试构建更为全面、科学的论文评价指标体系。从H1 Connect、Altmetric、WoS(Web of Science)平台获取同行评议、社会影响力、学术影响力代表... 文章基于H1 Connect对生物医学科技论文各类同行评议标签进行相关性分析研究,结合多元化指标尝试构建更为全面、科学的论文评价指标体系。从H1 Connect、Altmetric、WoS(Web of Science)平台获取同行评议、社会影响力、学术影响力代表性指标和评价标签,根据规则计算出综合评分,运用SPSS软件进行斯皮尔曼相关性比较分析。H1 Connect中同行评议各指标与不同评价标签之间大多呈低相关或不相关关系。相对引用率与同行评级之间也呈低相关或不相关关系,而星级权重与同行评级“Very Good”和“Exceptional”呈中度相关。文章提出综合评分指标CS,该指标与同行评议结果呈中度相关性,与社会影响力和学术影响力评价结果也高度一致,可为生物医学领域的学术评价提供新视角。 展开更多
关键词 H1 connect 综合评分 评价标签 对比分析
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基于改进RRT-Connect与DWA融合的移动机器人路径规划 被引量:2
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作者 罗毅 邓嘉 《系统仿真学报》 北大核心 2025年第10期2545-2556,共12页
为提高复杂环境中移动机器人动态路径规划效率和质量,提出了一种改进RRT-connect与DWA融合的路径规划算法。引入两棵扩展随机树交替扩展,设置动态限制采样区域,降低采样过程随机性并保证算法的概率完备性,采用目标偏向自适应步长策略,... 为提高复杂环境中移动机器人动态路径规划效率和质量,提出了一种改进RRT-connect与DWA融合的路径规划算法。引入两棵扩展随机树交替扩展,设置动态限制采样区域,降低采样过程随机性并保证算法的概率完备性,采用目标偏向自适应步长策略,以增强随机树扩展过程的目标导向性;采用贪心策略裁剪路径冗余节点并对全局路径进行平滑处理,得到全局优化路径;利用DWA跟踪全局路径,对评价函数进行改进,引入路径跟踪评价函数并采用自适应权重策略,同时引入路径校正机制,去除无效局部目标点,避免回绕现象。仿真结果表明:相比改进前,所提算法在不同静态环境中的运行时间分别下降36.18%、68.61%和89.33%,路径长度缩短17.61%、17.48%和12.33%,在动态环境中运行时间下降31.46%,路径长度缩短9.21%,并始终保证了路径的安全性。 展开更多
关键词 移动机器人 自适应 RRT-connect 动态采样区域 DWA 路径规划
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