BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes tha...BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.展开更多
Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY o...Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.展开更多
This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for ...This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.展开更多
滚动轴承作为机械设备的重要部件,对其进行剩余使用寿命预测在企业的生产过程中变得越来越重要。目前,虽然主流的卷积神经网络(convolutional neural network, CNN)可以自动地从轴承的振动信号中提取特征,却不能给特征分配不同的权重来...滚动轴承作为机械设备的重要部件,对其进行剩余使用寿命预测在企业的生产过程中变得越来越重要。目前,虽然主流的卷积神经网络(convolutional neural network, CNN)可以自动地从轴承的振动信号中提取特征,却不能给特征分配不同的权重来提高模型对重要特征的关注程度,对于长时间序列容易丢失重要信息。另外,神经网络中隐藏层神经元个数、学习率以及正则化参数等超参数还需要依靠人工经验设置。为了解决上述问题,提出基于灰狼优化(grey wolf optimizer, GWO)算法、优化集合CNN、双向长短期记忆(bidirectional long short term memory, BiLSTM)网络和注意力机制(Attention)轴承剩余使用寿命预测方法。首先,从原始振动信号中提取时域、频域以及时频域特征指标构建可选特征集;然后,通过构建考虑特征相关性、鲁棒性和单调性的综合评价指标筛选出高于设定阈值的轴承退化敏感特征集,作为预测模型的输入;最后,将预测值和真实值的均方误差作为GWO算法的适应度函数,优化预测模型获得最优隐藏层神经元个数、学习率和正则化参数,利用优化后模型进行剩余使用寿命预测,并在公开数据集上进行验证。结果表明,所提方法可在非经验指导下获得最优的超参数组合,优化后的预测模型与未进行优化模型相比,平均绝对误差与均方根误差分别降低了28.8%和24.3%。展开更多
合理规划好集中供热一次网的供热负荷,对满足热用户的舒适度和减少能源消耗有着重要意义。为此提出一种改进金豺算法(improved golden jackal optimization,IGJO)优化的CNN-BiLSTM热负荷预测模型。综合考虑一次网各项参数和天气因素的影...合理规划好集中供热一次网的供热负荷,对满足热用户的舒适度和减少能源消耗有着重要意义。为此提出一种改进金豺算法(improved golden jackal optimization,IGJO)优化的CNN-BiLSTM热负荷预测模型。综合考虑一次网各项参数和天气因素的影响,将热负荷历史值和一次网供水温度、供水流量、供水压力、外界天气温度组成CNN-BiLSTM网络的输入,利用CNN-BiLSTM网络提取输入数据的空间特征和时间特征。同时,通过Circle混沌映射、螺旋波动搜索、自适应t变异策略改进GJO,得到的IGJO有效解决了GJO全局搜索能力弱和收敛精度不高的问题,具有高效的寻优效果,然后利用IGJO寻优CNN-BiLSTM网络的超参数,解决了因CNN-BiLSTM网络的超参数选取不当而影响热负荷预测结果的问题。最后利用吉林延边某换热站2021年1月到3月供热负荷数据进行模型测试。结果表明,所提IGJO-CNN-BiLSTM预测结果的MAE、MAPE、RMSE和NSE分别为0.005 MW、0.33%、0.008 MW和0.97,相比LSTM、CNN-LSTM等模型,具有更优的预测精度。展开更多
基金Supported by Key Research and Development Program of Shaanxi Province,China,No.2024SF-YBXM-078.
文摘BACKGROUND Non-suicidal self-injury(NSSI)is common among adolescents with depressive disorders and poses a major public health challenge.Rumination,a key cognitive feature of depression,includes different subtypes that may relate to NSSI through distinct psychological mechanisms.However,how these subtypes interact with specific NSSI behaviors remains unclear.AIM To examine associations between rumination subtypes and specific NSSI behaviors in adolescents.METHODS We conducted a cross-sectional study with 305 hospitalized adolescents diagnosed with depressive disorders.The subjects ranged from 12-18 years in age.Rumi-nation subtypes were assessed using the Ruminative Response Scale,and 12 NSSI behaviors were evaluated using a validated questionnaire.Network analysis was applied to explore symptom-level associations and identify central symptoms.RESULTS The network analysis revealed close connections between rumination subtypes and NSSI behaviors.Brooding was linked to behaviors such as hitting objects and burning.Scratching emerged as the most influential NSSI symptom.Symptomfocused rumination served as a key bridge connecting rumination and NSSI.CONCLUSION Symptom-focused rumination and scratching were identified as potential intervention targets.These findings highlight the psychological significance of specific cognitive-behavioral links in adolescent depression and suggest directions for tailored prevention and treatment.However,the cross-sectional,single-site design limits causal inference and generalizability.Future longitudinal and multi-center studies are needed to confirm causal pathways and verify the generalizability of the findings to broader adolescent populations.
基金supported by grants from the National Natural Science Foundation of China(82004252)the Project of Administration of Traditional Chinese Medicine of Guangdong Province(202405112017596500)the Basic and Applied Basic Research Foundation of Guangzhou Municipal Science and Technology Bureau(202102020533).
文摘Background:Wenqing Yin(WQY)is a classic prescription used to treat skin diseases like atopic dermatitis(AD)in China,and the aim of this study is to investigate the therapeutic effects and molecular mechanisms of WQY on AD.Methods:The DNFB-induced mouse models of AD were established to investigate the therapeutic effects of WQY on AD.The symptoms of AD in the ears and backs of the mice were assessed,while inflammatory factors in the ear were quantified using quantitative real-time-polymerase chain reaction(qRT-PCR),and the percentages of CD4^(+)and CD8^(+)cells in the spleen were analyzed through flow cytometry.The compounds in WQY were identified using ultra-performance liquid chromatography-tandem mass spectrometry(UPLC-MS/MS)analysis and the key targets and pathways of WQY to treat AD were predicted by network pharmacology.Subsequently,the key genes were tested and verified by qRT-PCR,and the potential active components and target proteins were verified by molecular docking.Results:WQY relieved the AD symptoms and histopathological injuries in the ear and back skin of mice with AD.Meanwhile,WQY significantly reduced the levels of inflammatory factors IL-6 and IL-1βin ear tissue,as well as the ratio of CD4^(+)/CD8^(+)cells in spleen.Additionally,a total of 142 compounds were identified from the water extract of WQY by UPLC-Orbitrap-MS/MS.39 key targets related to AD were screened out by network pharmacology methods.The KEGG analysis indicated that the effects of WQY were primarily mediated through pathways associated with Toll-like receptor signaling and T cell receptor signaling.Moreover,the results of qRT-PCR demonstrated that WQY significantly reduced the mRNA expressions of IL-4,IL-10,GATA3 and FOXP3,and molecular docking simulation verified that the active components of WQY had excellent binding abilities with IL-4,IL-10,GATA3 and FOXP3 proteins.Conclusion:The present study demonstrated that WQY effectively relieved AD symptoms in mice,decreased the inflammatory factors levels,regulated the balance of CD4^(+)and CD8^(+)cells,and the mechanism may be associated with the suppression of Th2 and Treg cell immune responses.
基金supported by Istanbul Technical University(Project No.45698)supported through the“Young Researchers’Career Development Project-training of doctoral students”of the Croatian Science Foundation.
文摘This paper investigates the reliability of internal marine combustion engines using an integrated approach that combines Fault Tree Analysis(FTA)and Bayesian Networks(BN).FTA provides a structured,top-down method for identifying critical failure modes and their root causes,while BN introduces flexibility in probabilistic reasoning,enabling dynamic updates based on new evidence.This dual methodology overcomes the limitations of static FTA models,offering a comprehensive framework for system reliability analysis.Critical failures,including External Leakage(ELU),Failure to Start(FTS),and Overheating(OHE),were identified as key risks.By incorporating redundancy into high-risk components such as pumps and batteries,the likelihood of these failures was significantly reduced.For instance,redundant pumps reduced the probability of ELU by 31.88%,while additional batteries decreased the occurrence of FTS by 36.45%.The results underscore the practical benefits of combining FTA and BN for enhancing system reliability,particularly in maritime applications where operational safety and efficiency are critical.This research provides valuable insights for maintenance planning and highlights the importance of redundancy in critical systems,especially as the industry transitions toward more autonomous vessels.
文摘滚动轴承作为机械设备的重要部件,对其进行剩余使用寿命预测在企业的生产过程中变得越来越重要。目前,虽然主流的卷积神经网络(convolutional neural network, CNN)可以自动地从轴承的振动信号中提取特征,却不能给特征分配不同的权重来提高模型对重要特征的关注程度,对于长时间序列容易丢失重要信息。另外,神经网络中隐藏层神经元个数、学习率以及正则化参数等超参数还需要依靠人工经验设置。为了解决上述问题,提出基于灰狼优化(grey wolf optimizer, GWO)算法、优化集合CNN、双向长短期记忆(bidirectional long short term memory, BiLSTM)网络和注意力机制(Attention)轴承剩余使用寿命预测方法。首先,从原始振动信号中提取时域、频域以及时频域特征指标构建可选特征集;然后,通过构建考虑特征相关性、鲁棒性和单调性的综合评价指标筛选出高于设定阈值的轴承退化敏感特征集,作为预测模型的输入;最后,将预测值和真实值的均方误差作为GWO算法的适应度函数,优化预测模型获得最优隐藏层神经元个数、学习率和正则化参数,利用优化后模型进行剩余使用寿命预测,并在公开数据集上进行验证。结果表明,所提方法可在非经验指导下获得最优的超参数组合,优化后的预测模型与未进行优化模型相比,平均绝对误差与均方根误差分别降低了28.8%和24.3%。
