In this study, 16 combinations of the ECMWF (European Centre for Medium Range Weather Forecast) reanalyzed daily rainfall and the pentad CMAP in China for the period 1980-1993(1 May-31 Dec.) were calculated. Correlati...In this study, 16 combinations of the ECMWF (European Centre for Medium Range Weather Forecast) reanalyzed daily rainfall and the pentad CMAP in China for the period 1980-1993(1 May-31 Dec.) were calculated. Correlation analysis was used to roughly evaluate daily rainfall for the whole of China and a combination of RPC (rotated principal component) and wavelet analyses was applied to data on observed and combined daily rainfall to obtain a detailed evaluation of the quality of these combined datasets in 6 selected major rainfall regions of eastern China. The results showed that except for intraweekly fluctuation, the best combination was roughly similar to or accorded well with observation in the aspects of space variation patterns and long period rainfall fluctuations related to monsoon onset and serious meteorologic disasters, indicating that this combination yielded better values of long term daily mean and standard deviation through the pentad CMAP (CPC Merged Analysis of Precipitation), and can also represent rainfall fluctuations through the reanalyzed daily rainfall.展开更多
This study compares the boreal summer monsoon （BSM） precipitation between the GPCP and CMAP products during 1979-2014. The authors apply temporal, spatial correlation and error evaluation methods to evaluate their d...This study compares the boreal summer monsoon （BSM） precipitation between the GPCP and CMAP products during 1979-2014. The authors apply temporal, spatial correlation and error evaluation methods to evaluate their discrepancies in terms of BSM distribution and summer rainfall interannual variability over the five BSM regions. The results suggest that the climatology of the seasonal evolution of BSM rainfall is reflected well in both datasets, and the summer rainfall anomalies of the two products are highly correlated. However, major diversity is found in the rainfall pattern and the magnitude in climatology over the oceanic monsoon areas, especially the western North Pacific monsoon region, as well as in the interannual variability of summer rainfall anomalies over the North Africa and India monsoon regions. Although inconsistency between the two datasets is evident before the 1990s, the use of their arithmetic mean is demonstrated to be an efficient way to reduce the uncertainty between them.展开更多
This study presents a novel compound muscle action potential(CMAP)examination of motor unit changes in paretic muscle post stroke.CMAP scan of the first dorsal interosseous(FDI)muscle was performed bilaterally in 16 c...This study presents a novel compound muscle action potential(CMAP)examination of motor unit changes in paretic muscle post stroke.CMAP scan of the first dorsal interosseous(FDI)muscle was performed bilaterally in 16 chronic stroke subjects.Various parameters were derived from the CMAP scan to examine paretic muscle changes,including CMAP amplitude,D50,step index(STEPIX)and amplitude index(AMPIX).A significant decrease in CMAP amplitude and STEPIX was observed in paretic muscles compared with contralateral muscles(CMAP amplitude:paretic(9.0±0.5)mV,contralateral(11.3±0.9)mV,P=0.024;STEPIX:paretic 101.2±7.6,contralateral 121.9±6.5,P=0.020).No significant difference in D50 and AMPIX was observed between the paretic and contralateral sides(P>0.05).The findings revealed complex paretic muscle changes including motor unit degeneration,muscle fiber denervation,reinnervation and atrophy,providing useful insights to help understand neuromuscular mechanisms associated with weakness and other functional deterioration post stroke.The CMAP scan experimental protocols and the applied processing methods are noninvasive,convenient,and automated,offering practical benefits for clinical application.展开更多
Objective:To investigate the molecular mechanism and identify potential drugs for subthreshold depression(SD),and elucidate the detalied mechanism of Danzhi Xiaoyao powder(DZXY)in SD.Methods:Using RNA-sequencing,we id...Objective:To investigate the molecular mechanism and identify potential drugs for subthreshold depression(SD),and elucidate the detalied mechanism of Danzhi Xiaoyao powder(DZXY)in SD.Methods:Using RNA-sequencing,we identified differentially expressed genes(DEGs)in leukocytes of SD compared to healthy controls,deciphered their functions and pathways,and identified the hub genes of SD.We also assessed changes in leukocyte transcription factor activity in patients with SD using the TELis platform.The Connectivity Map database was retrieved to screen candidate drugs for SD.Based on network pharmacology,we elucidated the"multi-component,multi-target,and multi-pathway"mechanism of DZXY in the treatment of SD.Results:We identified 1080 DEGs(padj<0.05 and|log2(fold change)l≥1&protein coding)in the leukocytes of patients with SD.These DEGs,including hub genes,were primarily involved in immune and inflammatory response-related processes.Transcription factor activity analysis revealed similarities between the leukocyte transcriptome profile in SD and the conserved transcriptional response to adversities in immune cells.Connectivity Map analysis identified 28 potential drugs for SD treatment,particularly SB-202190 and TWS-119.Constructing the"Direct Compounds-Direct Targets-Pathways"network for DZXY and SD revealed the curative mechanisms of DZXY in SD,primarily including inflammatory response,lipid metabolism,immune response,and other processes.Conclusion:These results provide new insights into the characteristics and functional changes of leukocytes in SD,partially illustrate the pathogenesis of SD,and suggest potential drugs for SD.The curative mechanisms of DZXY in SD are also partially elucidated.展开更多
文摘In this study, 16 combinations of the ECMWF (European Centre for Medium Range Weather Forecast) reanalyzed daily rainfall and the pentad CMAP in China for the period 1980-1993(1 May-31 Dec.) were calculated. Correlation analysis was used to roughly evaluate daily rainfall for the whole of China and a combination of RPC (rotated principal component) and wavelet analyses was applied to data on observed and combined daily rainfall to obtain a detailed evaluation of the quality of these combined datasets in 6 selected major rainfall regions of eastern China. The results showed that except for intraweekly fluctuation, the best combination was roughly similar to or accorded well with observation in the aspects of space variation patterns and long period rainfall fluctuations related to monsoon onset and serious meteorologic disasters, indicating that this combination yielded better values of long term daily mean and standard deviation through the pentad CMAP (CPC Merged Analysis of Precipitation), and can also represent rainfall fluctuations through the reanalyzed daily rainfall.
基金jointly supported by the National Natural Science Foundation of China[grant number 41475057],[grant number 41221064],[grant number 91437218],[grant number41505049]the Key Program of Chinese Academy of Meteorological Sciences[grant number 2015Z001]
文摘This study compares the boreal summer monsoon （BSM） precipitation between the GPCP and CMAP products during 1979-2014. The authors apply temporal, spatial correlation and error evaluation methods to evaluate their discrepancies in terms of BSM distribution and summer rainfall interannual variability over the five BSM regions. The results suggest that the climatology of the seasonal evolution of BSM rainfall is reflected well in both datasets, and the summer rainfall anomalies of the two products are highly correlated. However, major diversity is found in the rainfall pattern and the magnitude in climatology over the oceanic monsoon areas, especially the western North Pacific monsoon region, as well as in the interannual variability of summer rainfall anomalies over the North Africa and India monsoon regions. Although inconsistency between the two datasets is evident before the 1990s, the use of their arithmetic mean is demonstrated to be an efficient way to reduce the uncertainty between them.
基金supported by the National Natural Science Foundation of China(82102179)the Shandong Provincial Natural Science Foundation(ZR2020KF012,ZR2021QH267,ZR2021QH053)+2 种基金the Shanghai Municipal Key Clinical Specialty(shslczdzk02701)the National Institutes of Health(7 R21 NS113716-02)the National Institute on Disability and Rehabilitation Research(90REMM0001-01-00).
文摘This study presents a novel compound muscle action potential(CMAP)examination of motor unit changes in paretic muscle post stroke.CMAP scan of the first dorsal interosseous(FDI)muscle was performed bilaterally in 16 chronic stroke subjects.Various parameters were derived from the CMAP scan to examine paretic muscle changes,including CMAP amplitude,D50,step index(STEPIX)and amplitude index(AMPIX).A significant decrease in CMAP amplitude and STEPIX was observed in paretic muscles compared with contralateral muscles(CMAP amplitude:paretic(9.0±0.5)mV,contralateral(11.3±0.9)mV,P=0.024;STEPIX:paretic 101.2±7.6,contralateral 121.9±6.5,P=0.020).No significant difference in D50 and AMPIX was observed between the paretic and contralateral sides(P>0.05).The findings revealed complex paretic muscle changes including motor unit degeneration,muscle fiber denervation,reinnervation and atrophy,providing useful insights to help understand neuromuscular mechanisms associated with weakness and other functional deterioration post stroke.The CMAP scan experimental protocols and the applied processing methods are noninvasive,convenient,and automated,offering practical benefits for clinical application.
基金supported by the National Key Research and Development Program of China(SQ2019YFC170218).
文摘Objective:To investigate the molecular mechanism and identify potential drugs for subthreshold depression(SD),and elucidate the detalied mechanism of Danzhi Xiaoyao powder(DZXY)in SD.Methods:Using RNA-sequencing,we identified differentially expressed genes(DEGs)in leukocytes of SD compared to healthy controls,deciphered their functions and pathways,and identified the hub genes of SD.We also assessed changes in leukocyte transcription factor activity in patients with SD using the TELis platform.The Connectivity Map database was retrieved to screen candidate drugs for SD.Based on network pharmacology,we elucidated the"multi-component,multi-target,and multi-pathway"mechanism of DZXY in the treatment of SD.Results:We identified 1080 DEGs(padj<0.05 and|log2(fold change)l≥1&protein coding)in the leukocytes of patients with SD.These DEGs,including hub genes,were primarily involved in immune and inflammatory response-related processes.Transcription factor activity analysis revealed similarities between the leukocyte transcriptome profile in SD and the conserved transcriptional response to adversities in immune cells.Connectivity Map analysis identified 28 potential drugs for SD treatment,particularly SB-202190 and TWS-119.Constructing the"Direct Compounds-Direct Targets-Pathways"network for DZXY and SD revealed the curative mechanisms of DZXY in SD,primarily including inflammatory response,lipid metabolism,immune response,and other processes.Conclusion:These results provide new insights into the characteristics and functional changes of leukocytes in SD,partially illustrate the pathogenesis of SD,and suggest potential drugs for SD.The curative mechanisms of DZXY in SD are also partially elucidated.
