This research uses a theoretical conceptual method based on Chantal Mouffe＇s Radical Democracy which blended with Derrida＇s deconstruction thesis about ＂democracy to come＂ to reach findings on the state of South A...This research uses a theoretical conceptual method based on Chantal Mouffe＇s Radical Democracy which blended with Derrida＇s deconstruction thesis about ＂democracy to come＂ to reach findings on the state of South Africa＇s media freedom landscape. The method is contained in the conceptual framework. The article provides the constitutional legal landscape--or the overarching laws of the land--and the co-regulatory framework within which journalists work. There are four research explications： the Protection of State Information Bill （dubbed the Secrecy Bill）, a painting of the president and Freedom of Expression, an arson attack on a community radio station and finally, the death of a photojournalist at the hands of police. The argument here is that the death, the arson attack, the Secrecy Bill, and the shut-down of dissent during the exhibition of the painting of the president all undermine democracy and signify significant closures for the media in the now 20-year-old post-apartheid South Africa. The analysis and reflections will be framed within theories of radical democracy, which argue for more fights and contestations and more voices from the margins in order to deepen democracy, rather than rational consensus which closes the spaces for greater plurality.展开更多
In this paper,finite p-groups G with G/HGbeing cyclic for every minimal nonnormal subgroup H are classified up to isomorphism,where HGdenotes the normal closure of H.
In this paper we study the structure of k-transitive closures of directed paths and formulate several properties. Concept of k-transitive orientation generalizes the traditional concept of transitive orientation of a ...In this paper we study the structure of k-transitive closures of directed paths and formulate several properties. Concept of k-transitive orientation generalizes the traditional concept of transitive orientation of a graph.展开更多
Shell-model studies on the N =14 and 16 shell closures in neutron-rich Be, C, O and Ne isotopes are presented. We calculate, with the WBT interaction, the excited states in these nuclei. The calculations agree with re...Shell-model studies on the N =14 and 16 shell closures in neutron-rich Be, C, O and Ne isotopes are presented. We calculate, with the WBT interaction, the excited states in these nuclei. The calculations agree with recent experiment data. Excited energies and B(E2) values are displayed to discuss the shell closures. Our results support the N =16 shell closure in these isotopes, while indicating a disappearance of N =14 shell closure in Be and C isotopes.展开更多
As underground mining advances to greater depths,cemented paste backfill(CPB)is increasingly subjected to complex thermo-mechanical loading conditions,including multiaxial stress states and elevated temperatures.This ...As underground mining advances to greater depths,cemented paste backfill(CPB)is increasingly subjected to complex thermo-mechanical loading conditions,including multiaxial stress states and elevated temperatures.This study investigates the coupled effects of field-representative vertical self-weight and horizontal rockwall closure stresses,along with in-situ temperatures,on the mechanical behavior and pore water pressure(PWP)evolution of CPB.Experiments were conducted using a novel apparatus capable of controlling multiaxial stress and temperature during curing,replicating in-situ stress paths and thermal profiles typical of deep mine environments.Results show that multiaxial stress enhances CPB strength and stiffness by promoting denser particle packing,reducing porosity,and increasing frictional resistance.Elevated temperatures independently accelerate early-age cement hydration,further improving bond strength and stiffness.When combined,multiaxial stress and elevated temperature produce a synergistic enhancement in unconfined compressive strength(UCS)and elastic modulus,as confirmed by two-way ANOVA and synergy index analysis.PWP responses were also highly sensitive to thermo-mechanical conditions.The evolution of positive and negative PWP was governed by the interplay of thermal expansion,hydration-induced desaturation,and mechanical compaction.Multiaxial stress amplified early positive PWP and delayed its dissipation,whereas elevated temperature accelerated hydration and reduced pore pressure,leading to enhanced suction at later ages.A transient“stress-induced resaturation”effect was observed under late-stage excessive horizontal stress but was mitigated by elevated temperatures.These findings provide critical insights into the coupled mechanical and hydraulic behavior of CPB under realistic field conditions and offer guidance for optimizing backfill design,binder content,and barricade stability in deep mining applications.展开更多
AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longit...AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longitudinal observational study,detailed medical histories of APAC patients and comprehensive ophthalmic examinations at final followup were collected.Logistic regression analysis was performed to identify predictors of blindness.Univariate and multivariate linear regression analyses were conducted to determine risk factors associated with visual outcomes.RESULTS:This study included 39 affected eyes of 31 subjects(26 females)with an average age of 74.1±8.0y.At 6.7±4.2y after APAC attack,2(5.7%)eyes had bestcorrected visual acuity(VA)worse than 3/60.Advanced glaucomatous visual field loss was observed in 15(39.5%)affected eyes and 5(25.0%)fellow eyes.Nine affected eyes(23.7%)had GON,and 11(28.9%)were blind.Six(15.4%)affected eyes and 2(9.1%)fellow eyes had suspicious progression.A significantly higher blindness rate in factory workers compared to office workers.Logistic regression identified that worse VA at attack(OR 10.568,95%CI 1.288-86.695;P=0.028)and worse early postoperative VA(OR 13.214,95%CI 1.157-150.881;P=0.038)were risk factors for blindness.Multivariate regression showed that longer duration of elevated intraocular pressure(P=0.004)and worse early postoperative VA(P=0.009)were associated with worse visual outcomes.CONCLUSION:Despite LE surgery,some APAC patients experience continued visual function deterioration.Lifelong monitoring is necessary.Target pressure and progression rates should be re-evaluated during follow-up.展开更多
Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 Dec...Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 December 2025,Hainan officially launched island-wide special customs operations,commonly referred to as“customs closure.”From that date,goods entering or leaving the island,except those traded with the Chinese mainland,are subject to simplified customs procedures and potentially reduced or zero tariffs.展开更多
Dear Editor,We reported a Chinese family carrying a novel Crumbs homologue 1(CRB1)variant(c.1737_1755del).Consanguineous marriage resulted in a homozygous mutation,leading to the onset of Leber congenital amaurosis(LC...Dear Editor,We reported a Chinese family carrying a novel Crumbs homologue 1(CRB1)variant(c.1737_1755del).Consanguineous marriage resulted in a homozygous mutation,leading to the onset of Leber congenital amaurosis(LCA)in their offspring.展开更多
Background:School closure is a common mitigation strategy during severe infuenza epidemics and pandemics.However,the efectiveness of this strategy remains controversial.In this study,we aimed to explore the efectivene...Background:School closure is a common mitigation strategy during severe infuenza epidemics and pandemics.However,the efectiveness of this strategy remains controversial.In this study,we aimed to explore the efectiveness of school closure on seasonal infuenza epidemics in provincial-level administrative divisions(PLADs)with varying urbanization rates in China.Methods:This study analyzed infuenza surveillance data between 2010 and 2019 provided by the Chinese National Infuenza Center.Taking into consideration the climate,this study included a region with 3 adjacent PLADs in Northern China and another region with 4 adjacent PLADs in Southern China.The efect of school closure on infuenza transmission was evaluated by the reduction of the efective reproductive number of seasonal infuenza during school winter breaks compared with that before school winter breaks.An age-structured Susceptible-Infected-Recovered-Susceptible(SIRS)model was built to model infuenza transmission in diferent levels of urbanization.Parameters were determined using the surveillance data via robust Bayesian method.Results:Between 2010 and 2019,in the less urbanized provinces:Hebei,Zhejiang,Jiangsu and Anhui,during school winter breaks,the efective reproductive number of seasonal infuenza epidemics reduced 14.6%[95%confdential interval(CI):6.2–22.9%],9.6%(95%CI:2.5–16.6%),7.3%(95%CI:0.1–14.4%)and 8.2%(95%CI:1.1–15.3%)respectively.However,in the highly urbanized cities:Beijing,Tianjin and Shanghai,it reduced only 5.2%(95%CI:-0.7–11.2%),4.1%(95%CI:-0.9–9.1%)and 3.9%(95%CI:-1.6–9.4%)respectively.In China,urbanization is associated with decreased proportion of children and increased social contact.According to the SIRS model,both factors could reduce the impact of school closure on seasonal infuenza epidemics,and the proportion of children in the population is thought to be the dominant infuencing factor.Conclusions:Efectiveness of school closure on the epidemics varies with the age structure in the population and social contact patterns.School closure should be recommended in the low urbanized regions in China in the infuenza seasons.展开更多
Introduction:Low energy balance closure(EBC)at a particular eddy-covariance flux site has increased the uncertainties of carbon,water,and energy measurements and has thus hampered the urgent research of scaling up and...Introduction:Low energy balance closure(EBC)at a particular eddy-covariance flux site has increased the uncertainties of carbon,water,and energy measurements and has thus hampered the urgent research of scaling up and modeling analyses through site combinations in regional or global flux networks.Methods:A series of manipulative experiments were conducted in this study to explore the role of net radiation(Rn)in the EBC in relation to spatial variability of vegetation characteristics,source area,and sensor type in three sites of the Inner Mongolian grassland of northern China.Results:At all three sites,the residual fluxes of EBC peaked consistently at 110 W m^(-2).The spatial variability in net radiation was 19 W m^(-2)(5%of R_(n))during the day and 7 W m^(-2)(16%)at night,with an average of 13 W m^(-2)(11%)from eight plot measurements across the three sites.Large area measurements of Rn significantly increased by 9 W m^(-2)during the day and decreased by 4 W m^(-2)at night in the unclipped treatments.Net radiation decreased by 25 W m^(-2)(6%of Rn)at midday and 81 MJ m^(-2)(6%)during a growing season with heavier regular clipping than that in unclipped treatments.The Rn was lower by 11–21 W m^(-2)(~20–40%of Rn)measured by CNR1 than by Q7.1 at night,while there was only 6 W m^(-2)(~1–2%of Rn)difference during the daytime between these two types of commonly used net radiometers.Conclusions:Overall,the inclusion of the uncertainty in available energy accounted for 65%of the~110 W m^(-2)shortfalls in the lack of closure.Clearly,the unclosed energy balance at these three grassland sites remains significant,with unexplored mechanisms for future research.展开更多
Let D be an integral domain with quotient field K,D be the integral closure of D in K,and D^[w] be the ω-integral closure of D in K;so D ■ D^[w],and equality holds when D is Noetherian or dim(D)=1.The Mori-Nagata th...Let D be an integral domain with quotient field K,D be the integral closure of D in K,and D^[w] be the ω-integral closure of D in K;so D ■ D^[w],and equality holds when D is Noetherian or dim(D)=1.The Mori-Nagata theorem states that if D is Noetherian,then D is a Krull domain;it has also been investigated when D is a Dedekind domain.We study integral domains D such that D^[w] is a Krull domain.We also provide an example of an integral domain D such that D ■ D ■ D^[w],t-dim(D)=1,D is a Priifer multiplication domain with v-dim(D)=2,and D^[w] is a UFD.展开更多
In this study,we systematically investigate theαdecay preformation factors,Pα,and theαdecay half-lives of 152 nuclei around Z=82,N=126 closed shells based on the generalized liquid drop model(GLDM)with Pαbeing ext...In this study,we systematically investigate theαdecay preformation factors,Pα,and theαdecay half-lives of 152 nuclei around Z=82,N=126 closed shells based on the generalized liquid drop model(GLDM)with Pαbeing extracted from the ratio of the calculatedαdecay half-life to the experimental one.The results show that there is a remarkable linear relationship between Pαand the product of valance protons(holes)Np and valance neutrons(holes)Nn.At the same time,we extract theαdecay preformation factor values of the even–even nuclei around the Z=82,N=126 closed shells from the study of Sun et al.[J.Phys.G:Nucl.Part.Phys.,45:075106(2018)],in which theαdecay was calculated by two different microscopic formulas.We find that theαdecay preformation factors are also related to NpNn.Combining with our previous studies[Sun et al.,Phys.Rev.C,94:024338(2016);Deng et al.,ibid.96:024318(2017);Deng et al.,ibid.97:044322(2018)]and that of Seif et al.,[Phys.Rev.C,84:064608(2011)],we suspect that this phenomenon of linear relationship for the nuclei around the above closed shells is model-independent.This may be caused by the effect of the valence protons(holes)and valence neutrons(holes)around the shell closures.Finally,using the formula obtained by fitting theαdecay preformation factor data calculated by the GLDM,we calculate theαdecay half-lives of these nuclei.The calculated results agree with the experimental data well.展开更多
In the first half of 2025,practitioners in the beauty industry are barely feeling at ease.The industry is in the throes of intense pressure.Several international giants continue to face operational performance challen...In the first half of 2025,practitioners in the beauty industry are barely feeling at ease.The industry is in the throes of intense pressure.Several international giants continue to face operational performance challenges;domestic beauty enterprises are trapped in“business wars”;several listed companies have delisted either voluntarily or passively;news of brand store closures and bankruptcies is spreading...展开更多
The excellent irradiation resistance,high strength and plasticity exhibited by high-entropy alloys(HEAs)make it candidate for engin-eering applications.Diffusion bonding of Al_(0.3)CoCrFeNi single-phase HEAs was carri...The excellent irradiation resistance,high strength and plasticity exhibited by high-entropy alloys(HEAs)make it candidate for engin-eering applications.Diffusion bonding of Al_(0.3)CoCrFeNi single-phase HEAs was carried out using electric-assisted diffusion bonding(EADB),and the effect of bonding temperature on the evolution of the interfacial microstructure and the mechanical properties was investigated.The results indicate that as the bonding temperature increases,the pores at the interface gradually decrease in size and undergo closure.The electric current significantly promotes the pore closure mechanism dominated by plastic deformation at the diffusion interface and promotes the recrystallisation behavior at the interface,and the fracture mode changes from intergranular fracture at the interface to jagged fracture along the grains spanning the weld parent material.Due to the activation effect of EADB,higher-strength diffusion bonding of high-entropy alloys can be achieved at the same temperature compared with the conventional hot-pressure diffusion bonding(HPDB)process.展开更多
The models constructed by particle flow simulation method can effectively simulate the heterogeneous substance characteristics and failure behaviors of rocks.However,existing contact models overlook the rock cracks,an...The models constructed by particle flow simulation method can effectively simulate the heterogeneous substance characteristics and failure behaviors of rocks.However,existing contact models overlook the rock cracks,and the various simulation methods that do consider cracks still exhibit certain limitations.In this paper,based on Flat-Joint model and Linear Parallel Bond model,a crack contact model considering linked substance in the crack is proposed by splitting the crack contact into two portions:linked portion and unlinked portion for calculation.The new contact model considers the influence of crack closure on the contact force-displacement law.And a better compressive tensile strength ratio(UCS/T)was obtained by limiting the failure of the contact bond to be solely controlled by the contact force and moment of the linked portion.Then,by employing the FISH Model tool within the Particle Flow Code,the contact model was constructed and verified through contact force–displacement experiments and loading-unloading tests with cracked model.Finally,the contact model was tested through simulations of rock mechanics experiments.The results indicate that the contact model can effectively simulate the axial and lateral strain laws of rocks simultaneously and has a relatively good reproduction of the bi-modularity of rocks.展开更多
Understanding the diffusion mechanisms of indium(In)in ZnS minerals can clarify the kinetic processes governing its migration,enrichment,or depletion in these typical In-host minerals,thereby establishing a theoretica...Understanding the diffusion mechanisms of indium(In)in ZnS minerals can clarify the kinetic processes governing its migration,enrichment,or depletion in these typical In-host minerals,thereby establishing a theoretical foundation for the exploration of high-grade In deposits.This study investigates sphalerite and wurtzite to identify stable In incorporation sites and diffusion pathways,and systematically calculates In transport properties in two types of ZnS minerals using first-principles calculations combined with the climbing image-nudged elastic band(CI-NEB)method.The results demonstrate that structural anisotropy significantly governs In diffusion characteristics,with wurtzite exhibiting stronger directiondependent diffusion behavior and superior In retention capacity compared to sphalerite.Across the 0−10 GPa pressure range,In diffusion in wurtzite shows markedly higher anisotropy(2−3 orders of magnitude greater than in sphalerite)and consistently lower diffusion rates.Furthermore,closure temperature calculations reveal spatial heterogeneity,with the[111]direction in sphalerite(about 65 K higher than[110]direction)and the[001]direction in wurtzite(about 100 K higher than[100]direction)displaying elevated closure thresholds.Overall,wurtzite achieves higher closure temperatures than sphalerite.These computational findings indicate that wurtzite exhibits stronger In retention capabilities than sphalerite,suggesting its potential as a critical host mineral for In.These insights provide valuable implications for understanding In geochemical cycling and offer some guidance for mineral exploration and ore genesis studies.展开更多
Global warming and climate change are accelerating,and drought has become a major threat to global agriculture,severely affecting crop yields and food security.To survive water scarcity,plants have developed various s...Global warming and climate change are accelerating,and drought has become a major threat to global agriculture,severely affecting crop yields and food security.To survive water scarcity,plants have developed various strategies.One important mechanism is stomatal closure(气孔关闭).Stomata,the tiny holes on leaf surfaces,regulate gas exchange and water loss.展开更多
Recently,the continuous advancement of endoscopic technology has led to the widespread application of endoscopic full-thickness resection(EFTR)in clinical practice.The crucial aspect of EFTR is the successful closure ...Recently,the continuous advancement of endoscopic technology has led to the widespread application of endoscopic full-thickness resection(EFTR)in clinical practice.The crucial aspect of EFTR is the successful closure of the wound.Initially,endoscopic clip and nylon thread suturing was employed;subsequently,a variety of innovative suturing techniques based on that have been developed,driving ongoing technological innovation in this field.Given the unique characteristics of EFTR,an increasing number of specialized endoscopic suturing devices are being explored.This article aims to systematically evaluate the efficacy,limitations,and clinical applicability of current endoscopic closure techniques for EFTR-induced defects.展开更多
AIM:To study the relationship between ultrasound biomicroscopy(UBM)and Lenstar when measuring anterior chamber depth(ACD)in eyes with shallow anterior chamber,and the necessity of conducting both examinations.METHODS:...AIM:To study the relationship between ultrasound biomicroscopy(UBM)and Lenstar when measuring anterior chamber depth(ACD)in eyes with shallow anterior chamber,and the necessity of conducting both examinations.METHODS:This is a retrospective observational study including 56 acute primary angle closure(APAC)eyes and 47 primary angle closure suspect(PACS)eyes with shallow ACD.ACD value measured by Lenstar and UBM were documented.The Bland-Altman plots were examined separately in all included eyes,APAC eyes and PACS eyes,for the assessment of agreement between two measurements.The agreement was compared across different population by evaluating mean difference,width of 95%limit of agreement(LoA)and the presence of proportional bias or outliers in Bland-Altman plots.R E S U LT S:The average ACD in APAC eyes(1.71±0.23 mm)was significantly smaller than that in PACS eyes(1.79±0.25 mm,P=0.038).Bland-Altman plots of both APAC eyes and PACS eyes showed small mean difference without the presence of proportional bias.However,compared with PACS eyes,the Bland-Altman plot of APAC eyes had wider 95%LoA and more outliers outside the 95%LoA.CONCLUSION:Despite the small ACD values,the two methods in measuring ACD,Lenstar and UBM,demonstrate substantial consistency when measuring PACS eyes.However,for the APAC population,the agreement might be limited,and thus the measured values should be interpreted with caution.展开更多
Dear Editor,X-linked retinoschisis(XLRS)is a rare X-linked recessive disorder predominantly afflicting young males.The schisis of the retinal layers is a result of deleterious mutations in the RS1 gene.Insufficient ep...Dear Editor,X-linked retinoschisis(XLRS)is a rare X-linked recessive disorder predominantly afflicting young males.The schisis of the retinal layers is a result of deleterious mutations in the RS1 gene.Insufficient epidemiological data has caused significant variation in reported global prevalence,with estimates fluctuating between 1 in 5000 and 1 in 30000 individuals[1].A large follow-up multicenter study recently published has yielded noteworthy findings concerning the phenotypic spectrum,long-term natural history,and genotype of XLRS.The investigation revealed a significant variability in visual function and disease progression,with particular variants of the RS1 gene displaying diverse phenotypic expressions,suggesting the intricate genetic basis underlying this disorder[2].The range of visual impairments associated with XLRS is extensive,varying from minor to severe.This condition is also characterized by specific retinal abnormalities,including radial streaks emanating from a divided central fovea,schisis affecting the inner layers of the retina in peripheral areas,and a diminished amplitude ratio of b-to a-wave,or even an electronegative electroretinography(ERG)[3].At their initial consultation,the majority of individuals with XLRS exhibit visual acuity(VA)levels between 20/60 and 20/120.However,there is a significant diversity in the condition’s presentation and progression,even among relatives,with VA levels spanning from near-normal to complete loss of sight[4-5].While vision tends to be reasonably consistent over several years for those with XLRS,there is documentation of a more rapid decline in later adulthood,specifically during the fourth and fifth decades,due to central retinal degeneration[5-7].Moreover,those with XLRS face an elevated risk for serious visual issues,such as retinal detachment,vitreous hemorrhages,and neovascular glaucoma[4].Female carriers could be found with slightly abnormal retinal changes without clinical symptoms[5].Even within the same family,the manifestation and progression of the condition can vary greatly,with individuals experiencing anything from nearly normal vision to complete loss of sight[8-9].Earlier investigations have revealed that retinoschisisrelated cystoid degeneration can impact multiple layers of the retina,beginning at the retinal nerve fiber zone and continuing to the nuclear stratum,with considerable fluctuation in the severity of the schisis[10-13].展开更多
文摘This research uses a theoretical conceptual method based on Chantal Mouffe＇s Radical Democracy which blended with Derrida＇s deconstruction thesis about ＂democracy to come＂ to reach findings on the state of South Africa＇s media freedom landscape. The method is contained in the conceptual framework. The article provides the constitutional legal landscape--or the overarching laws of the land--and the co-regulatory framework within which journalists work. There are four research explications： the Protection of State Information Bill （dubbed the Secrecy Bill）, a painting of the president and Freedom of Expression, an arson attack on a community radio station and finally, the death of a photojournalist at the hands of police. The argument here is that the death, the arson attack, the Secrecy Bill, and the shut-down of dissent during the exhibition of the painting of the president all undermine democracy and signify significant closures for the media in the now 20-year-old post-apartheid South Africa. The analysis and reflections will be framed within theories of radical democracy, which argue for more fights and contestations and more voices from the margins in order to deepen democracy, rather than rational consensus which closes the spaces for greater plurality.
基金Supported by the National Natural Science Foundation of China(Grant Nos.1137123211226048+1 种基金11401355)the Natural Science Foundation of Shanxi Province(Grant No.2013011001-1)
文摘In this paper,finite p-groups G with G/HGbeing cyclic for every minimal nonnormal subgroup H are classified up to isomorphism,where HGdenotes the normal closure of H.
文摘In this paper we study the structure of k-transitive closures of directed paths and formulate several properties. Concept of k-transitive orientation generalizes the traditional concept of transitive orientation of a graph.
基金Supported by National Natural Science Foundation of China (10735010, 10525520)Chinese Major State Basic Research Development Program (2007CB815000)
文摘Shell-model studies on the N =14 and 16 shell closures in neutron-rich Be, C, O and Ne isotopes are presented. We calculate, with the WBT interaction, the excited states in these nuclei. The calculations agree with recent experiment data. Excited energies and B(E2) values are displayed to discuss the shell closures. Our results support the N =16 shell closure in these isotopes, while indicating a disappearance of N =14 shell closure in Be and C isotopes.
基金the University of Ottawa, the China Scholarship Council and the Natural Sciences and Engineering Research Council of Canada (NSERC) for their financial support.
文摘As underground mining advances to greater depths,cemented paste backfill(CPB)is increasingly subjected to complex thermo-mechanical loading conditions,including multiaxial stress states and elevated temperatures.This study investigates the coupled effects of field-representative vertical self-weight and horizontal rockwall closure stresses,along with in-situ temperatures,on the mechanical behavior and pore water pressure(PWP)evolution of CPB.Experiments were conducted using a novel apparatus capable of controlling multiaxial stress and temperature during curing,replicating in-situ stress paths and thermal profiles typical of deep mine environments.Results show that multiaxial stress enhances CPB strength and stiffness by promoting denser particle packing,reducing porosity,and increasing frictional resistance.Elevated temperatures independently accelerate early-age cement hydration,further improving bond strength and stiffness.When combined,multiaxial stress and elevated temperature produce a synergistic enhancement in unconfined compressive strength(UCS)and elastic modulus,as confirmed by two-way ANOVA and synergy index analysis.PWP responses were also highly sensitive to thermo-mechanical conditions.The evolution of positive and negative PWP was governed by the interplay of thermal expansion,hydration-induced desaturation,and mechanical compaction.Multiaxial stress amplified early positive PWP and delayed its dissipation,whereas elevated temperature accelerated hydration and reduced pore pressure,leading to enhanced suction at later ages.A transient“stress-induced resaturation”effect was observed under late-stage excessive horizontal stress but was mitigated by elevated temperatures.These findings provide critical insights into the coupled mechanical and hydraulic behavior of CPB under realistic field conditions and offer guidance for optimizing backfill design,binder content,and barricade stability in deep mining applications.
文摘AIM:To investigate the long-term outcomes in acute primary angle closure(APAC)patients treated with lens extraction(LE)surgery and to identify risk factors for glaucomatous optic neuropathy(GON).METHODS:In this longitudinal observational study,detailed medical histories of APAC patients and comprehensive ophthalmic examinations at final followup were collected.Logistic regression analysis was performed to identify predictors of blindness.Univariate and multivariate linear regression analyses were conducted to determine risk factors associated with visual outcomes.RESULTS:This study included 39 affected eyes of 31 subjects(26 females)with an average age of 74.1±8.0y.At 6.7±4.2y after APAC attack,2(5.7%)eyes had bestcorrected visual acuity(VA)worse than 3/60.Advanced glaucomatous visual field loss was observed in 15(39.5%)affected eyes and 5(25.0%)fellow eyes.Nine affected eyes(23.7%)had GON,and 11(28.9%)were blind.Six(15.4%)affected eyes and 2(9.1%)fellow eyes had suspicious progression.A significantly higher blindness rate in factory workers compared to office workers.Logistic regression identified that worse VA at attack(OR 10.568,95%CI 1.288-86.695;P=0.028)and worse early postoperative VA(OR 13.214,95%CI 1.157-150.881;P=0.038)were risk factors for blindness.Multivariate regression showed that longer duration of elevated intraocular pressure(P=0.004)and worse early postoperative VA(P=0.009)were associated with worse visual outcomes.CONCLUSION:Despite LE surgery,some APAC patients experience continued visual function deterioration.Lifelong monitoring is necessary.Target pressure and progression rates should be re-evaluated during follow-up.
文摘Hainan Province in south China is the country’s second-largest island and the largest free trade port by area.It has entered a historic phase in China’s drive to promote high-level institutional opening up.On 18 December 2025,Hainan officially launched island-wide special customs operations,commonly referred to as“customs closure.”From that date,goods entering or leaving the island,except those traded with the Chinese mainland,are subject to simplified customs procedures and potentially reduced or zero tariffs.
基金Supported by the National Natural Science Foundation of China(No.81970804)Natural Science Foundation of Hunan Province(No.2021JJ30949).
文摘Dear Editor,We reported a Chinese family carrying a novel Crumbs homologue 1(CRB1)variant(c.1737_1755del).Consanguineous marriage resulted in a homozygous mutation,leading to the onset of Leber congenital amaurosis(LCA)in their offspring.
基金funded by grants from the Shenzhen Science and Technology Program(Grant No.KQTD20180411143323605)the National Natural Science Foundation of China(Grant No.82003509)+1 种基金the Natural Science Foundation of Zhejiang Province(Grant No.LQ20H260009)Fundamental Research Funds for the Central Universities.
文摘Background:School closure is a common mitigation strategy during severe infuenza epidemics and pandemics.However,the efectiveness of this strategy remains controversial.In this study,we aimed to explore the efectiveness of school closure on seasonal infuenza epidemics in provincial-level administrative divisions(PLADs)with varying urbanization rates in China.Methods:This study analyzed infuenza surveillance data between 2010 and 2019 provided by the Chinese National Infuenza Center.Taking into consideration the climate,this study included a region with 3 adjacent PLADs in Northern China and another region with 4 adjacent PLADs in Southern China.The efect of school closure on infuenza transmission was evaluated by the reduction of the efective reproductive number of seasonal infuenza during school winter breaks compared with that before school winter breaks.An age-structured Susceptible-Infected-Recovered-Susceptible(SIRS)model was built to model infuenza transmission in diferent levels of urbanization.Parameters were determined using the surveillance data via robust Bayesian method.Results:Between 2010 and 2019,in the less urbanized provinces:Hebei,Zhejiang,Jiangsu and Anhui,during school winter breaks,the efective reproductive number of seasonal infuenza epidemics reduced 14.6%[95%confdential interval(CI):6.2–22.9%],9.6%(95%CI:2.5–16.6%),7.3%(95%CI:0.1–14.4%)and 8.2%(95%CI:1.1–15.3%)respectively.However,in the highly urbanized cities:Beijing,Tianjin and Shanghai,it reduced only 5.2%(95%CI:-0.7–11.2%),4.1%(95%CI:-0.9–9.1%)and 3.9%(95%CI:-1.6–9.4%)respectively.In China,urbanization is associated with decreased proportion of children and increased social contact.According to the SIRS model,both factors could reduce the impact of school closure on seasonal infuenza epidemics,and the proportion of children in the population is thought to be the dominant infuencing factor.Conclusions:Efectiveness of school closure on the epidemics varies with the age structure in the population and social contact patterns.School closure should be recommended in the low urbanized regions in China in the infuenza seasons.
基金This study was supported by the Natural Science Foundation of China(31170454,31229001,31130202)the State Key Basic Research Development Program of China(2013CB956600)the NASA-NEWS Program(NN-H-04-Z-YS-005-N),and the USCCC。
文摘Introduction:Low energy balance closure(EBC)at a particular eddy-covariance flux site has increased the uncertainties of carbon,water,and energy measurements and has thus hampered the urgent research of scaling up and modeling analyses through site combinations in regional or global flux networks.Methods:A series of manipulative experiments were conducted in this study to explore the role of net radiation(Rn)in the EBC in relation to spatial variability of vegetation characteristics,source area,and sensor type in three sites of the Inner Mongolian grassland of northern China.Results:At all three sites,the residual fluxes of EBC peaked consistently at 110 W m^(-2).The spatial variability in net radiation was 19 W m^(-2)(5%of R_(n))during the day and 7 W m^(-2)(16%)at night,with an average of 13 W m^(-2)(11%)from eight plot measurements across the three sites.Large area measurements of Rn significantly increased by 9 W m^(-2)during the day and decreased by 4 W m^(-2)at night in the unclipped treatments.Net radiation decreased by 25 W m^(-2)(6%of Rn)at midday and 81 MJ m^(-2)(6%)during a growing season with heavier regular clipping than that in unclipped treatments.The Rn was lower by 11–21 W m^(-2)(~20–40%of Rn)measured by CNR1 than by Q7.1 at night,while there was only 6 W m^(-2)(~1–2%of Rn)difference during the daytime between these two types of commonly used net radiometers.Conclusions:Overall,the inclusion of the uncertainty in available energy accounted for 65%of the~110 W m^(-2)shortfalls in the lack of closure.Clearly,the unclosed energy balance at these three grassland sites remains significant,with unexplored mechanisms for future research.
基金supported by the Academic Research Fund of Hoseo University in 2017(no.2017-0047).
文摘Let D be an integral domain with quotient field K,D be the integral closure of D in K,and D^[w] be the ω-integral closure of D in K;so D ■ D^[w],and equality holds when D is Noetherian or dim(D)=1.The Mori-Nagata theorem states that if D is Noetherian,then D is a Krull domain;it has also been investigated when D is a Dedekind domain.We study integral domains D such that D^[w] is a Krull domain.We also provide an example of an integral domain D such that D ■ D ■ D^[w],t-dim(D)=1,D is a Priifer multiplication domain with v-dim(D)=2,and D^[w] is a UFD.
基金Supported in part by the National Natural Science Foundation of China(11205083,11505100,11705055)the Construct Program of the Key Discipline in Hunan Province,the Research Foundation of Education Bureau of Hunan Province,China(15A159,18A237)+4 种基金the Natural Science Foundation of Hunan Province,China(2015JJ3103,2015JJ2121,2018JJ3324)the Innovation Group of Nuclear and Particle Physics in USC,the Shandong Province Natural Science Foundation,China(ZR2015AQ007)the Hunan Provincial Innovation Foundation For Postgraduate(CX20190714,CX20200909)the National Innovation Training Foundation of China(201910555161)and the Opening Project of Cooperative Innovation Center for Nuclear Fuel Cycle Technology and Equipment,University of South China(2019KFZ10)。
文摘In this study,we systematically investigate theαdecay preformation factors,Pα,and theαdecay half-lives of 152 nuclei around Z=82,N=126 closed shells based on the generalized liquid drop model(GLDM)with Pαbeing extracted from the ratio of the calculatedαdecay half-life to the experimental one.The results show that there is a remarkable linear relationship between Pαand the product of valance protons(holes)Np and valance neutrons(holes)Nn.At the same time,we extract theαdecay preformation factor values of the even–even nuclei around the Z=82,N=126 closed shells from the study of Sun et al.[J.Phys.G:Nucl.Part.Phys.,45:075106(2018)],in which theαdecay was calculated by two different microscopic formulas.We find that theαdecay preformation factors are also related to NpNn.Combining with our previous studies[Sun et al.,Phys.Rev.C,94:024338(2016);Deng et al.,ibid.96:024318(2017);Deng et al.,ibid.97:044322(2018)]and that of Seif et al.,[Phys.Rev.C,84:064608(2011)],we suspect that this phenomenon of linear relationship for the nuclei around the above closed shells is model-independent.This may be caused by the effect of the valence protons(holes)and valence neutrons(holes)around the shell closures.Finally,using the formula obtained by fitting theαdecay preformation factor data calculated by the GLDM,we calculate theαdecay half-lives of these nuclei.The calculated results agree with the experimental data well.
文摘In the first half of 2025,practitioners in the beauty industry are barely feeling at ease.The industry is in the throes of intense pressure.Several international giants continue to face operational performance challenges;domestic beauty enterprises are trapped in“business wars”;several listed companies have delisted either voluntarily or passively;news of brand store closures and bankruptcies is spreading...
基金support from National Natural Science Foundation of China(NSFC,Grant numbers U22A20185,U21A20128,52175302 and 52305353)Aeronautical Science Foundation(ASFC-20230036077001)Fundamental Research Funds for the Central Universities(2022FRFK060009,HIT.DZI1.2023012).
文摘The excellent irradiation resistance,high strength and plasticity exhibited by high-entropy alloys(HEAs)make it candidate for engin-eering applications.Diffusion bonding of Al_(0.3)CoCrFeNi single-phase HEAs was carried out using electric-assisted diffusion bonding(EADB),and the effect of bonding temperature on the evolution of the interfacial microstructure and the mechanical properties was investigated.The results indicate that as the bonding temperature increases,the pores at the interface gradually decrease in size and undergo closure.The electric current significantly promotes the pore closure mechanism dominated by plastic deformation at the diffusion interface and promotes the recrystallisation behavior at the interface,and the fracture mode changes from intergranular fracture at the interface to jagged fracture along the grains spanning the weld parent material.Due to the activation effect of EADB,higher-strength diffusion bonding of high-entropy alloys can be achieved at the same temperature compared with the conventional hot-pressure diffusion bonding(HPDB)process.
基金supported by the Natural Science Foundation of Heilongjiang Province(No.ZD2021E006)the National Natural Science Foundation of China(Nos.52174075 and 52074110).
文摘The models constructed by particle flow simulation method can effectively simulate the heterogeneous substance characteristics and failure behaviors of rocks.However,existing contact models overlook the rock cracks,and the various simulation methods that do consider cracks still exhibit certain limitations.In this paper,based on Flat-Joint model and Linear Parallel Bond model,a crack contact model considering linked substance in the crack is proposed by splitting the crack contact into two portions:linked portion and unlinked portion for calculation.The new contact model considers the influence of crack closure on the contact force-displacement law.And a better compressive tensile strength ratio(UCS/T)was obtained by limiting the failure of the contact bond to be solely controlled by the contact force and moment of the linked portion.Then,by employing the FISH Model tool within the Particle Flow Code,the contact model was constructed and verified through contact force–displacement experiments and loading-unloading tests with cracked model.Finally,the contact model was tested through simulations of rock mechanics experiments.The results indicate that the contact model can effectively simulate the axial and lateral strain laws of rocks simultaneously and has a relatively good reproduction of the bi-modularity of rocks.
基金National Natural Science Foundation of China(41573121,42174115,42394114)Open Fundation of the United Laboratory of High-Pressure Physics and Earthquake Science(2019HPPES06)。
文摘Understanding the diffusion mechanisms of indium(In)in ZnS minerals can clarify the kinetic processes governing its migration,enrichment,or depletion in these typical In-host minerals,thereby establishing a theoretical foundation for the exploration of high-grade In deposits.This study investigates sphalerite and wurtzite to identify stable In incorporation sites and diffusion pathways,and systematically calculates In transport properties in two types of ZnS minerals using first-principles calculations combined with the climbing image-nudged elastic band(CI-NEB)method.The results demonstrate that structural anisotropy significantly governs In diffusion characteristics,with wurtzite exhibiting stronger directiondependent diffusion behavior and superior In retention capacity compared to sphalerite.Across the 0−10 GPa pressure range,In diffusion in wurtzite shows markedly higher anisotropy(2−3 orders of magnitude greater than in sphalerite)and consistently lower diffusion rates.Furthermore,closure temperature calculations reveal spatial heterogeneity,with the[111]direction in sphalerite(about 65 K higher than[110]direction)and the[001]direction in wurtzite(about 100 K higher than[100]direction)displaying elevated closure thresholds.Overall,wurtzite achieves higher closure temperatures than sphalerite.These computational findings indicate that wurtzite exhibits stronger In retention capabilities than sphalerite,suggesting its potential as a critical host mineral for In.These insights provide valuable implications for understanding In geochemical cycling and offer some guidance for mineral exploration and ore genesis studies.
文摘Global warming and climate change are accelerating,and drought has become a major threat to global agriculture,severely affecting crop yields and food security.To survive water scarcity,plants have developed various strategies.One important mechanism is stomatal closure(气孔关闭).Stomata,the tiny holes on leaf surfaces,regulate gas exchange and water loss.
基金Supported by Shenyang Science and Technology,No.22-321-32-15.
文摘Recently,the continuous advancement of endoscopic technology has led to the widespread application of endoscopic full-thickness resection(EFTR)in clinical practice.The crucial aspect of EFTR is the successful closure of the wound.Initially,endoscopic clip and nylon thread suturing was employed;subsequently,a variety of innovative suturing techniques based on that have been developed,driving ongoing technological innovation in this field.Given the unique characteristics of EFTR,an increasing number of specialized endoscopic suturing devices are being explored.This article aims to systematically evaluate the efficacy,limitations,and clinical applicability of current endoscopic closure techniques for EFTR-induced defects.
基金Supported by the Surface Project of National Natural Science Foundation of China(No.82070957)the Shandong Medical and Health Technology Development Project(No.202107021077).
文摘AIM:To study the relationship between ultrasound biomicroscopy(UBM)and Lenstar when measuring anterior chamber depth(ACD)in eyes with shallow anterior chamber,and the necessity of conducting both examinations.METHODS:This is a retrospective observational study including 56 acute primary angle closure(APAC)eyes and 47 primary angle closure suspect(PACS)eyes with shallow ACD.ACD value measured by Lenstar and UBM were documented.The Bland-Altman plots were examined separately in all included eyes,APAC eyes and PACS eyes,for the assessment of agreement between two measurements.The agreement was compared across different population by evaluating mean difference,width of 95%limit of agreement(LoA)and the presence of proportional bias or outliers in Bland-Altman plots.R E S U LT S:The average ACD in APAC eyes(1.71±0.23 mm)was significantly smaller than that in PACS eyes(1.79±0.25 mm,P=0.038).Bland-Altman plots of both APAC eyes and PACS eyes showed small mean difference without the presence of proportional bias.However,compared with PACS eyes,the Bland-Altman plot of APAC eyes had wider 95%LoA and more outliers outside the 95%LoA.CONCLUSION:Despite the small ACD values,the two methods in measuring ACD,Lenstar and UBM,demonstrate substantial consistency when measuring PACS eyes.However,for the APAC population,the agreement might be limited,and thus the measured values should be interpreted with caution.
基金Supported by Capital’s Funds for Health Improvement and Research(No.2024-2-4087)Central Guidance for Local Scientific and Technological Development Funding Projects(No.2022ZY0026).
文摘Dear Editor,X-linked retinoschisis(XLRS)is a rare X-linked recessive disorder predominantly afflicting young males.The schisis of the retinal layers is a result of deleterious mutations in the RS1 gene.Insufficient epidemiological data has caused significant variation in reported global prevalence,with estimates fluctuating between 1 in 5000 and 1 in 30000 individuals[1].A large follow-up multicenter study recently published has yielded noteworthy findings concerning the phenotypic spectrum,long-term natural history,and genotype of XLRS.The investigation revealed a significant variability in visual function and disease progression,with particular variants of the RS1 gene displaying diverse phenotypic expressions,suggesting the intricate genetic basis underlying this disorder[2].The range of visual impairments associated with XLRS is extensive,varying from minor to severe.This condition is also characterized by specific retinal abnormalities,including radial streaks emanating from a divided central fovea,schisis affecting the inner layers of the retina in peripheral areas,and a diminished amplitude ratio of b-to a-wave,or even an electronegative electroretinography(ERG)[3].At their initial consultation,the majority of individuals with XLRS exhibit visual acuity(VA)levels between 20/60 and 20/120.However,there is a significant diversity in the condition’s presentation and progression,even among relatives,with VA levels spanning from near-normal to complete loss of sight[4-5].While vision tends to be reasonably consistent over several years for those with XLRS,there is documentation of a more rapid decline in later adulthood,specifically during the fourth and fifth decades,due to central retinal degeneration[5-7].Moreover,those with XLRS face an elevated risk for serious visual issues,such as retinal detachment,vitreous hemorrhages,and neovascular glaucoma[4].Female carriers could be found with slightly abnormal retinal changes without clinical symptoms[5].Even within the same family,the manifestation and progression of the condition can vary greatly,with individuals experiencing anything from nearly normal vision to complete loss of sight[8-9].Earlier investigations have revealed that retinoschisisrelated cystoid degeneration can impact multiple layers of the retina,beginning at the retinal nerve fiber zone and continuing to the nuclear stratum,with considerable fluctuation in the severity of the schisis[10-13].
