Heart disease(HD)is a serious widespread life-threatening disease.The heart of patients with HD fails to pump sufcient amounts of blood to the entire body.Diagnosing the occurrence of HD early and efciently may preven...Heart disease(HD)is a serious widespread life-threatening disease.The heart of patients with HD fails to pump sufcient amounts of blood to the entire body.Diagnosing the occurrence of HD early and efciently may prevent the manifestation of the debilitating effects of this disease and aid in its effective treatment.Classical methods for diagnosing HD are sometimes unreliable and insufcient in analyzing the related symptoms.As an alternative,noninvasive medical procedures based on machine learning(ML)methods provide reliable HD diagnosis and efcient prediction of HD conditions.However,the existing models of automated ML-based HD diagnostic methods cannot satisfy clinical evaluation criteria because of their inability to recognize anomalies in extracted symptoms represented as classication features from patients with HD.In this study,we propose an automated heart disease diagnosis(AHDD)system that integrates a binary convolutional neural network(CNN)with a new multi-agent feature wrapper(MAFW)model.The MAFW model consists of four software agents that operate a genetic algorithm(GA),a support vector machine(SVM),and Naïve Bayes(NB).The agents instruct the GA to perform a global search on HD features and adjust the weights of SVM and BN during initial classication.A nal tuning to CNN is then performed to ensure that the best set of features are included in HD identication.The CNN consists of ve layers that categorize patients as healthy or with HD according to the analysis of optimized HD features.We evaluate the classication performance of the proposed AHDD system via 12 common ML techniques and conventional CNN models by using across-validation technique and by assessing six evaluation criteria.The AHDD system achieves the highest accuracy of 90.1%,whereas the other ML and conventional CNN models attain only 72.3%–83.8%accuracy on average.Therefore,the AHDD system proposed herein has the highest capability to identify patients with HD.This system can be used by medical practitioners to diagnose HD efciently。展开更多
During the Fifth International Conference onEnvironmental Mutagens which was held in Cleveland,Ohio,USA on July 10-15,1989,the idea of organizing anInternational Symposium on Environmental Mutagenesisand Carcinogenesi...During the Fifth International Conference onEnvironmental Mutagens which was held in Cleveland,Ohio,USA on July 10-15,1989,the idea of organizing anInternational Symposium on Environmental Mutagenesisand Carcinogenesis in China was conceived.The ChineseEnvironmental Mutagen Society and the Institute of Genet-ics of Fudan University accepted the responsibility.展开更多
文摘Heart disease(HD)is a serious widespread life-threatening disease.The heart of patients with HD fails to pump sufcient amounts of blood to the entire body.Diagnosing the occurrence of HD early and efciently may prevent the manifestation of the debilitating effects of this disease and aid in its effective treatment.Classical methods for diagnosing HD are sometimes unreliable and insufcient in analyzing the related symptoms.As an alternative,noninvasive medical procedures based on machine learning(ML)methods provide reliable HD diagnosis and efcient prediction of HD conditions.However,the existing models of automated ML-based HD diagnostic methods cannot satisfy clinical evaluation criteria because of their inability to recognize anomalies in extracted symptoms represented as classication features from patients with HD.In this study,we propose an automated heart disease diagnosis(AHDD)system that integrates a binary convolutional neural network(CNN)with a new multi-agent feature wrapper(MAFW)model.The MAFW model consists of four software agents that operate a genetic algorithm(GA),a support vector machine(SVM),and Naïve Bayes(NB).The agents instruct the GA to perform a global search on HD features and adjust the weights of SVM and BN during initial classication.A nal tuning to CNN is then performed to ensure that the best set of features are included in HD identication.The CNN consists of ve layers that categorize patients as healthy or with HD according to the analysis of optimized HD features.We evaluate the classication performance of the proposed AHDD system via 12 common ML techniques and conventional CNN models by using across-validation technique and by assessing six evaluation criteria.The AHDD system achieves the highest accuracy of 90.1%,whereas the other ML and conventional CNN models attain only 72.3%–83.8%accuracy on average.Therefore,the AHDD system proposed herein has the highest capability to identify patients with HD.This system can be used by medical practitioners to diagnose HD efciently。
文摘During the Fifth International Conference onEnvironmental Mutagens which was held in Cleveland,Ohio,USA on July 10-15,1989,the idea of organizing anInternational Symposium on Environmental Mutagenesisand Carcinogenesis in China was conceived.The ChineseEnvironmental Mutagen Society and the Institute of Genet-ics of Fudan University accepted the responsibility.
