目的 探讨血清孤独G蛋白偶联受体配体-13(solitary G protein-coupled receptor ligand-13,Apelin-13)、碱性成纤维细胞生长因子(fibroblast growth factor 2,FGF2)、中枢神经特异蛋白(central nervous system specific protein B,S100B...目的 探讨血清孤独G蛋白偶联受体配体-13(solitary G protein-coupled receptor ligand-13,Apelin-13)、碱性成纤维细胞生长因子(fibroblast growth factor 2,FGF2)、中枢神经特异蛋白(central nervous system specific protein B,S100B)水平与脑卒中后抑郁(post-stroke depression, PSD)的关系。方法 回顾性分析河南科技大学附属黄河医院/黄河三门峡医院2022年4月至2024年1月收治的260例脑卒中患者临床资料,随访1个月,参考17项汉密尔顿抑郁量表(Hamilton Depression Rating Scale, HAMD-17)评估结果统计PSD发生率,并将其分为发生组和未发生组,比较两组血清Apelin-13、FGF2、S100B水平及其他临床资料,采用Logistic回归模型分析PSD发生的影响因素;绘制受试者工作特征曲线(Receiver operating characteristic curve, ROC)评价血清Apelin-13、FGF2、S100B对PSD的预测价值。结果 PSD发生率为37.31%;与未发生组比较,发生组女性、糖尿病、左侧大脑半球病灶占比、美国国立卫生研究院卒中量表(national Institutes of health stroke scale, NIHSS)评分、同型半胱氨酸水平、系统性免疫炎症指数(systemic immune-inflammatory index, SII)、血清Apelin-13、S100B水平较高(P<0.05),月均可支配医疗费用、血清FGF2水平较低(P<0.05);月均可支配医疗费用(OR=0.732,95%CI:0.599~0.894)、左侧大脑半球病灶(OR=1.478,95%CI:1.159~1.885)、NIHSS评分(OR=1.293,95%CI:1.095~1.527)、同型半胱氨酸水平(OR=1.278,95%CI:1.058~1.542)、SII(OR=1.370,95%CI:1.133~1.657)、Apelin-13水平(OR=1.278,95%CI:1.086~1.503)、FGF2水平(OR=0.807,95%CI:0.689~0.946)、S100B水平(OR=1.357,95%CI:1.089~1.690)为PSD发生的影响因素(P<0.05);血清Apelin-13、FGF2、S100B联合预测PSD的灵敏度高于单独预测,曲线下面积(area under curve, AUC)高于单独预测方法(P<0.05),特异度与单独预测基本一致。结论 血清Apelin-13、FGF2、S100B水平与月均可支配医疗费用、左侧大脑半球病灶、NIHSS评分、同型半胱氨酸、SII可能是PSD发生的影响因素,且血清Apelin-13、FGF2、S100B可能对PSD有预测价值,其中联合预测价值更显著。展开更多
Objective:This study was designed to observe the effect of electroacupuncture at Hégǔ(合谷L14),or Hòuxī(后溪SI3) or Wàiguān(外关TE5) acupoints on the function of the brain regions of a healthy human,...Objective:This study was designed to observe the effect of electroacupuncture at Hégǔ(合谷L14),or Hòuxī(后溪SI3) or Wàiguān(外关TE5) acupoints on the function of the brain regions of a healthy human,and to explore the neural information mechanism of a specific connection between LI4 and the facialoral area from the point of view of the brain function connection network.A further objective was to enrich knowledge of the specific connection between the body surface and the meridian route,and the specificity of acupoint effects.Methods:A total of 30 healthy volunteers were randomly assigned to LI4,SI3,and TE5 groups.The members of each group were stimulated with electroacupuncture,and their heads were scanned using fMRI.DPARSFA 2.4 and REST 1.8 software were used for data preprocessing and statistical analysis.The paired t-test was used within group and the double sample t-test was used for two-group comparisons.Results:In healthy people,left LI4 with electroacupuncture mainly caused a decrease of the functional connection of the right orofacial motor area of the brain,which remained decreased after removing the needle.When LI4 was compared with SI3 and TE5,LI4 caused a more significant decline in the functional connection of the right side of the brain during acupuncture.Conclusions:Acupuncture at LI4 has a significant effect on the function of the face-and mouth-related areas in the brain,and there is a continuous effect.It is suggested that LI4 and the face and mouth have a specific relationship in the brain,which is most obvious during acupuncture.展开更多
基金Supported by grants from National Key R&D Program of China:2019YFC1709001the National Natural Science Foundation of China:81973959+4 种基金8177443581674068the Foundation of Sichuan Provincial Administration of Traditional Chinese Medicine:2018JC007the Foundation of Chengdu University of Traditional Chinese Medicine:QNXZ2018034the National Program on Key Basic Research Project of China:2010CB530501.
文摘Objective:This study was designed to observe the effect of electroacupuncture at Hégǔ(合谷L14),or Hòuxī(后溪SI3) or Wàiguān(外关TE5) acupoints on the function of the brain regions of a healthy human,and to explore the neural information mechanism of a specific connection between LI4 and the facialoral area from the point of view of the brain function connection network.A further objective was to enrich knowledge of the specific connection between the body surface and the meridian route,and the specificity of acupoint effects.Methods:A total of 30 healthy volunteers were randomly assigned to LI4,SI3,and TE5 groups.The members of each group were stimulated with electroacupuncture,and their heads were scanned using fMRI.DPARSFA 2.4 and REST 1.8 software were used for data preprocessing and statistical analysis.The paired t-test was used within group and the double sample t-test was used for two-group comparisons.Results:In healthy people,left LI4 with electroacupuncture mainly caused a decrease of the functional connection of the right orofacial motor area of the brain,which remained decreased after removing the needle.When LI4 was compared with SI3 and TE5,LI4 caused a more significant decline in the functional connection of the right side of the brain during acupuncture.Conclusions:Acupuncture at LI4 has a significant effect on the function of the face-and mouth-related areas in the brain,and there is a continuous effect.It is suggested that LI4 and the face and mouth have a specific relationship in the brain,which is most obvious during acupuncture.
