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一种Java程序Chopping方法 被引量:2
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作者 蒋曹清 应时 +1 位作者 倪友聪 管华 《计算机科学》 CSCD 北大核心 2011年第1期150-155,161,共7页
程序Chopping对于程序理解、分析、调试、测试等具有重要的意义。已有的Chopping方法主要基于相互连接的系统依赖图(SDG),对于大程序这种SDG描述通常非常复杂,易导致程序Chopping结果不准确。针对这一问题,基于带标签的Java程序描述方法... 程序Chopping对于程序理解、分析、调试、测试等具有重要的意义。已有的Chopping方法主要基于相互连接的系统依赖图(SDG),对于大程序这种SDG描述通常非常复杂,易导致程序Chopping结果不准确。针对这一问题,基于带标签的Java程序描述方法,提出一种Java程序Chopping方法。该方法利用这种描述附带的程序依赖信息,分析参数依赖关系,并在此基础上给出Chopping算法。此程序Chopping方法能把Java程序方法间的程序Chop-ping问题转换到Java程序方法内进行分析,程序依赖图具有结点少、可重用、可并发构造等优点。最后通过实例和实验给出程序Chopping方法的实施过程及有效性。 展开更多
关键词 程序chopping chopping算法 JAVA程序 chopping方法
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Chopping-peaking开关形成高功率超宽带双极脉冲的实验研究 被引量:13
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作者 樊亚军 石磊 +4 位作者 刘国治 汪文秉 周金山 刘峰 朱郁丰 《强激光与粒子束》 EI CAS CSCD 北大核心 2004年第4期501-504,共4页
 设计研制了一种chopping peaking组合开关型高功率双极脉冲形成装置,通过调节两个开关的导通时刻来得到不同形状的双极脉冲。理想情况下,形成的双极脉冲电压峰 峰值等于入射脉冲峰值电压的2倍,实验中入射脉冲峰值电压为205kV的单极脉...  设计研制了一种chopping peaking组合开关型高功率双极脉冲形成装置,通过调节两个开关的导通时刻来得到不同形状的双极脉冲。理想情况下,形成的双极脉冲电压峰 峰值等于入射脉冲峰值电压的2倍,实验中入射脉冲峰值电压为205kV的单极脉冲,获得了最大峰 峰电压为360kV的双极脉冲,是入射脉冲峰值电压的1.76倍。双极脉冲的持续时间可以改变,最大值为单极脉冲的脉宽。入射脉冲上升时间越小,得到的双极脉冲峰 峰电压就越大。 展开更多
关键词 超宽带 双极脉冲 陡化 chopping开关 peaking开关
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基于Chopping的Web应用SQL注入漏洞检测方法 被引量:3
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作者 尤枫 马金慧 张雅峰 《计算机系统应用》 2018年第1期86-91,共6页
随着Web应用的不断普及,其安全问题越来越显突出,特别是SQL注入漏洞攻击,给用户的安全体验造成了巨大的威胁.针对二阶SQL注入漏洞,本文提出了一种基于chopping技术的二阶SQL注入漏洞检测方法.首先通过对待测应用程序进行chopping,获取... 随着Web应用的不断普及,其安全问题越来越显突出,特别是SQL注入漏洞攻击,给用户的安全体验造成了巨大的威胁.针对二阶SQL注入漏洞,本文提出了一种基于chopping技术的二阶SQL注入漏洞检测方法.首先通过对待测应用程序进行chopping,获取到一阶SQL注入疑似路径;然后对一阶SQL注入疑似路径中的SQL语句进行分析,确定二阶SQL注入操作对,进而得到二阶SQL注入疑似路径;最后通过构造攻击向量并运行,确认二阶SQL注入疑似路径中漏洞是否实际存在.实验结果表明,本方法能够有效地检测出二阶SQL注入漏洞. 展开更多
关键词 二阶SQL注入 污点分析 WEB应用 漏洞检测 chopping 程序切片
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Efficacy of wet-lab training versus surgical-simulator training on performance of ophthalmology residents during chopping in cataract surgery 被引量:5
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作者 Ya-Guang Hu Qiu-Ping Liu +4 位作者 Ning Gao Chang-Rui Wu Jian Zhang Li Qin Jing-Ming Li 《International Journal of Ophthalmology(English edition)》 SCIE CAS 2021年第3期366-370,共5页
AIM: To analyze whether wet-lab training(WLT) or surgical-simulator training(SST) is better for ophthalmology residents to master the chopping technique.METHODS: Sixty ophthalmology residents(in their second year) and... AIM: To analyze whether wet-lab training(WLT) or surgical-simulator training(SST) is better for ophthalmology residents to master the chopping technique.METHODS: Sixty ophthalmology residents(in their second year) and three cataract surgeons participated in the study. The residents were randomly separated into two groups, WLT group and SST group. The residents in WLT group were asked to perform 10 trials of chopping using pig eyes and scored by the surgeons, and then they performed and scored using simulator for one time. The residents in SST group underwent 10 trials of chopping using simulator, and the simulator scored each trail. Then, this group were asked to perform the chopping using pig eyes and scored by the surgeons. At last, we investigated the residents’ satisfaction about the training.RESULTS: The demographic characteristics had no significant differences between the two groups. Recorded by the simulator, the residents in SST group got significantly higher overall score(83.90±1.31) than WLT group(78.73±1.92, P=0.03). And the residents in SST group got less corner area injured, and they spend less time than WLT group(P<0.05). Moreover, the residents in WLT group used more ultrasonic energy value than SST group(P=0.03). However, scored by the surgeons, the residents in two groups got nearly the same overall score. The residents in WLT group performed better on the frequencies of posterior capsule torn and incisional stress(P=0.03, 0.008, respectively). In the survey, the residents in two groups held the same opinion that the training was helpful and they strongly recommended this training. And all of them enjoyed the training, and enjoyed being randomized in their own group. However, with respect to the realistic character, the residents thought that WLT was better than SST(P<0.001).CONCLUSION: Both of the Eyesi surgical-stimulator and the wet-lab improve the residents’ chopping ability and each has its own advantages. The combination of the two training ways could be considered to be a part of the training curriculum for new residents. 展开更多
关键词 chopping in cataract simulator wet-lab
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SRG POSITION SENSORLESS TECHNIQUE WITH CURRENT CHOPPING MODE 被引量:2
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作者 ZhuXuezhong LiuDiji +1 位作者 GuiXiaojie LiuChuang 《Transactions of Nanjing University of Aeronautics and Astronautics》 EI 2002年第1期14-18,共5页
A onvel current chopping strategy for switched reluc-tance generator(SRG)-a full conducted current chopping(FCCC)scheme is presented,According to characteristics lf phase current wave of SRG generating operation,it ca... A onvel current chopping strategy for switched reluc-tance generator(SRG)-a full conducted current chopping(FCCC)scheme is presented,According to characteristics lf phase current wave of SRG generating operation,it can be generated under sensorless condition without an addi-tional circuit or a position signal algorithm.Simulational results show the feasibility of this scheme.Experimental results of a 6kW6/4configuration SRG show its simplic-ity and high reliability with little decrease in efficiency.Soit will be widely used. 展开更多
关键词 SRG position SENSORLESS current chopping control 开关磁阻发电机 无位置传感器 电流斩波控制
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Reduction of current chopping noise with DSP controller in switched reluctance motor drive system
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作者 郭伟 詹琼华 马志源 《Journal of Harbin Institute of Technology(New Series)》 EI CAS 2002年第4期419-423,共5页
A novel current chopping mode was used in a switched reluctance motor drive system to make full use of the characteristics of digital signal processor (DSP) TMS320F240. The necessity of this 180° phase-shift curr... A novel current chopping mode was used in a switched reluctance motor drive system to make full use of the characteristics of digital signal processor (DSP) TMS320F240. The necessity of this 180° phase-shift current control (PSCC) mode is introduced first and then the principle of PSCC covering both hardware requirement and software programming is described in detail. The analysis made indicated that with this mode, the chopping frequency in winding can reach 20 kHz with 10 kHz power switches and the control frequency can reach 40 kHz at the same time. Subsequently, based on the linear and nonlinear mathematical models of the switched reluctance motor (SRM), some simulation work has been done. The simulation results show that when this mode is applied to SRM drive (SRD) system, the current waveform becomes better. So the ripple of the torque is reduced simultaneously and the vibration and acoustic noise are reduced involuntarily. Stationary tests show that the acoustic noise is greatly diminished. Finally, some experiments were made using a 50 kW SRD system for electric vehicle (EV). Experimental results indicate that this mode can be implemented feasibly and it has a good action on the SRD system. 展开更多
关键词 SWITCHED reluctance MOTOR current chopping control DSP VIBRATION ACOUSTIC noise INVERTER
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CHOPPING WAVE METHOD FOR REMOVING ELECTROMAGNETIC INDUCTION COUPLING
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作者 He Jishan Wang +1 位作者 Shaowu Tang Jingtian(Central South University of technology , Changsha 410083) 《中国有色金属学会会刊:英文版》 CSCD 1995年第1期1-10,共10页
CHOPPINGWAVEMETHODFORREMOVINGELECTROMAGNETICINDUCTIONCOUPLINGHe;JishanWang;ShaowuTang;Jingtian(CentralSouthU... CHOPPINGWAVEMETHODFORREMOVINGELECTROMAGNETICINDUCTIONCOUPLINGHe;JishanWang;ShaowuTang;Jingtian(CentralSouthUniversityoftechno... 展开更多
关键词 induced polarization effect electromagnetic INDUCTION COUPLING chopping WAVE METHOD DECOUPLING METHOD
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Design of New Farm Machine for Chopping Field Straw,Pressing it into Soil and Cleaning up Plastic Film
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作者 Jiqiang CUI Lele HE 《Asian Agricultural Research》 2017年第3期110-111,共2页
In this paper,we design a farm machine integrating the functions of chopping field straw,pressing field straw into soil,breaking stubble,and cleaning up plastic film,in order to improve the efficiency of plastic film ... In this paper,we design a farm machine integrating the functions of chopping field straw,pressing field straw into soil,breaking stubble,and cleaning up plastic film,in order to improve the efficiency of plastic film cleaning,enrich the function of straw chopping equipment,reduce the noise generated at work,and further realize the intelligent harmony. The remote control button is used to control the work of the entire system,and the bluetooth remote control module and matrix keyboard are used to control the vehicle. With STM32 microcontroller as the main control chip,the machine controls the motion of the electric motor by relay,and employs LCD screen to realize real-time display of system work. It is convenient and easy to operate,with good human-computer interaction. 展开更多
关键词 Field straw chopping Pressing straw into soil Plastic film clean-up Microcontroller
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Altering wilting time and chopping length to optimize Medicago polymorpha L.fermentation ripening rate and flavour
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作者 Ning Mao Hanyu Zhang +8 位作者 Ermei Du Meiling Fan Shihao Liu Chaosheng Liao Chao Chen Hong Sun Yulong Zheng Ping Li Yixiao Xie 《Food Bioscience》 2025年第6期4225-4233,共9页
Medicago polymorpha L(MPL),a high-protein legume from southern China,is difficult to ferment and preserve due to its high moisture content and buffering capacity.Effects of three different wilting times(4,8,and 12 h)a... Medicago polymorpha L(MPL),a high-protein legume from southern China,is difficult to ferment and preserve due to its high moisture content and buffering capacity.Effects of three different wilting times(4,8,and 12 h)and chopping lengths(2,4,and 6 cm)on the fermentation ripening rate,chemical composition,microbial communities,and functional properties of MPL during anaerobic fermentation in small packages were evaluated.The results indicate that reducing the wilting time and chopping length increased the lactic acid content and decreased the pH during fermentation.Additionally,the content of Lactobacillus brevis was positively correlated with free amino acids.Shortening the chopping length increased the abundance of Levilactobacillus brevis(7.913%vs.26.100%)and Ligilactobacillus animalis(0.038%vs.0.163%).Under shorter chopping lengths,extending the wilting time increased the abundance of Methylobacterium adhaesivum and Methylorubrum extorquens(0.121%vs.1.292%)and decreased the content of non-protein nitrogen.Bacterial community analysis showed that Lactobacillus and Weissella were the core microbiota after fermentation,with the former promoting the increase of organic acids,free amino acids,and flavor compounds.In conclusion,the high quality and rich flavor compounds of fermented MPL can be ensured by reducing the wilting time(4 h)and shortening the chopping length(2 cm). 展开更多
关键词 Medicago polymorpha L Small-package anaerobic fermentation Wilting time chopping length Fermentation ripening rate
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利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤患者的临床效果观察
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作者 赵变锋 王松云 +2 位作者 焦愿愿 王慧睿 杨二青 《实用癌症杂志》 2026年第2期315-318,共4页
目的探讨利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤(DLBCL)的效果。方法选取100例DLBCL患者,按随机数字表法分为2组,各50例。对照组采用CHOP方案治疗,观察组联合利妥昔单抗治疗。比较两组临床疗效、血清T淋巴细胞亚群、炎性因子水... 目的探讨利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤(DLBCL)的效果。方法选取100例DLBCL患者,按随机数字表法分为2组,各50例。对照组采用CHOP方案治疗,观察组联合利妥昔单抗治疗。比较两组临床疗效、血清T淋巴细胞亚群、炎性因子水平、生活质量及不良反应。结果观察组疾病控制率高于对照组,有统计学差异(P<0.05);观察组治疗后CD3^(+)、CD4^(+)、CD4^(+)/CD8^(+)高于对照组,有统计学差异(P<0.05);观察组治疗后炎性因子水平低于对照组,有统计学差异(P<0.05);观察组治疗后生活质量评分高于对照组,有统计学差异(P<0.05);两组不良反应相比,无统计学差异(P>0.05)。结论利妥昔单抗联合CHOP方案可提高DLBCL患者疗效,减轻机体炎症反应,改善生活质量,且对免疫功能影响更小,安全性良好。 展开更多
关键词 弥漫大B细胞淋巴瘤 利妥昔单抗 CHOP方案 T淋巴细胞亚群 炎性因子
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基于ATF6/CHOP通路探究壮医药线点灸对糖尿病胃轻瘫大鼠胃平滑肌组织凋亡相关蛋白表达的影响
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作者 吴宇 范郁山 +5 位作者 王子彬 许慧 张芳之 苗芙蕊 贺煜竣 麦威 《针刺研究》 北大核心 2026年第2期178-188,共11页
目的:观察壮医药线点灸对糖尿病胃轻瘫(DGP)模型大鼠内质网应激相关凋亡蛋白的作用,并探究其潜在的治疗机制。方法:将SD大鼠随机分为空白组、模型组、西药组、非经非穴组和阳明经穴组,每组12只。通过一次性腹腔注射2%链脲佐菌素(55 mg/k... 目的:观察壮医药线点灸对糖尿病胃轻瘫(DGP)模型大鼠内质网应激相关凋亡蛋白的作用,并探究其潜在的治疗机制。方法:将SD大鼠随机分为空白组、模型组、西药组、非经非穴组和阳明经穴组,每组12只。通过一次性腹腔注射2%链脲佐菌素(55 mg/kg),持续观察8周建立DGP大鼠模型。西药组采用枸橼酸莫沙必利混悬液(0.15 mg/mL)灌胃治疗;阳明经穴组选取“梁门”“气冲”“足三里”“丰隆”进行壮医药线点灸治疗,每穴3壮;非经非穴组操作同阳明经穴组,但穴位位于阳明经穴旁开2.5 mm和5 mm处;以上干预均每日1次,连续3周。评定各组大鼠症状积分,血糖仪测量随机血糖,酚红灌胃法检测大鼠胃排空率,TUNEL法检测胃窦平滑肌细胞凋亡指数,Western blot法检测胃窦平滑肌组织葡萄糖调节蛋白78(GRP78)、活化转录因子6(ATF6)、CCAAT增强子结合蛋白同源蛋白(CHOP)表达,免疫组织化学染色检测胃平滑肌组织B细胞淋巴瘤/白血病-2(Bcl-2)、Bcl-2相关X蛋白(Bax)、半胱氨酸天冬氨酸蛋白酶-12(Caspase-12)表达。结果:与空白组相比,模型组大鼠症状积分升高(P<0.01),血糖升高(P<0.01),胃排空率降低(P<0.01),胃平滑肌细胞凋亡指数升高(P<0.01),GRP78、ATF6、CHOP蛋白表达水平升高(P<0.01),Caspase-12、Bax表达上调(P<0.01),Bcl-2表达下调(P<0.01)。与模型组相比,阳明经穴组大鼠血糖降低(P<0.01);阳明经穴组和西药组大鼠症状积分降低(P<0.01),胃排空率升高(P<0.01),胃平滑肌凋亡指数降低(P<0.01),GRP78、ATF6、CHOP蛋白表达水平降低(P<0.01,P<0.05),Caspase-12、Bax表达下调(P<0.01),Bcl-2表达上调(P<0.01)。非经非穴组各项指标结果均与阳明经穴组趋势相反(P<0.01,P<0.05)。结论:壮医药线点灸阳明经穴通过调节血糖水平,促进胃排空,改善DGP症状,调节内质网应激相关凋亡蛋白的表达,通过抑制ATF6/CHOP通路中GRP78、ATF6、CHOP、Caspase-12、Bax蛋白表达,上调Bcl-2蛋白表达,减轻DGP模型大鼠胃平滑肌细胞凋亡,缓解DGP进展。 展开更多
关键词 壮医药线点灸 糖尿病胃轻瘫 内质网应激 ATF6/CHOP通路 细胞凋亡 胃排空
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Optimization design and experiment on feeding and chopping device of silage maize harvester 被引量:6
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作者 Meizhou Chen Guangfei Xu +5 位作者 Maojian Wei Xiaowei Li Yuanzhen Wei Peisong Diao Peide Cui Shaomin Teng 《International Journal of Agricultural and Biological Engineering》 SCIE 2023年第3期64-77,共14页
Horizontal feeding devices and plate hob chopping devices are the key component of silage maize harvester.To solve the problem of feeding blockage,reduce energy consumption,and improve the chopping quality of the chop... Horizontal feeding devices and plate hob chopping devices are the key component of silage maize harvester.To solve the problem of feeding blockage,reduce energy consumption,and improve the chopping quality of the chopping device a horizontal different diameter five-rollers device(HDDFD)was designed and the plate hob chopping device was simultaneously optimized and analyzed.Through the dynamic analysis,the feeding conveying speed was determined to be 2.0-4.5 m/s.The distance equation of the actual and theoretical cutting-edge curve and the position of the fixed blade were finally obtained.Single factor and response surface orthogonal tests in the bench site were carried out with feeding speed,rotating speed of chopping cylinder,feeding amount,and feeding direction as influencing factors,standard grass length rate(SGLR),and energy consumption per unit mass(ECPUM)as evaluation indexes.The optimal working parameters for chopping performance could be concluded as a feeding speed of 3.39 m/s,rotating speed of the chopping cylinder of 1016.17 r/min,feeding amount of 8.04 kg/s,and feeding direction of 52.2°.In addition,the SGLR and ECPUM were obtained as 95.35%and 37.63 kJ/kg,respectively.The relative error between the experimental results with round parameter combination and the predicted value was verified to be less than 5%.Field tests verified the reliability of the optimized feeding and chopping device.It can be seen that the HDDFD and optimized plate hob chopping device can meet the requirements of mechanized silage harvesting which obviously improves the working quality and reduce the energy consumption of chopping. 展开更多
关键词 silage maize feeding device chopping device stand grass length ratio energy consumption
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Design and parameter optimization of spiral-dragon type straw chopping test rig 被引量:2
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作者 Pengbo Ma Liqiao Li +3 位作者 Baoqin Wen Yunheng Xue Za Kan Jingbin Li 《International Journal of Agricultural and Biological Engineering》 SCIE EI CAS 2020年第1期47-56,共10页
In order to address the problems of large chop length,high energy consumption and poor chopping effect that were associated with a horizontal total mixed rations(TMR)mixer,a straw chopping device was designed;further,... In order to address the problems of large chop length,high energy consumption and poor chopping effect that were associated with a horizontal total mixed rations(TMR)mixer,a straw chopping device was designed;further,its structure and working principle were analyzed.In this study,wheat straw was chosen as the test object.The number of processing times,number of fixed blades,cutting speed,number of tooth plates and the inclined angle of the box were considered as the test factors.The standard straw length rate and average power were used as evaluation indices for conducting the orthogonal rotation combination experiment with five factors and five levels of quadratic regression.The experimental results denoted that the order of influencing factors on the standard straw length rate can be given as follows:the number of processing times,number of fixed blades,cutting speed,number of tooth plates and inclined angle of the box.The order of the influence of each factor on the average power can be given as follows:the cutting speed,number of fixed blades and number of tooth plates.Further,the optimum structural and working parameters of the device can be determined as follows:linear cutting speed of 17-20 m/min,box inclined angle of 70°-80°,20-23 fixed blades,5-6 processing times and 4-7 tooth plates.Under such a circumstance,the standard straw length rate reached up to 70.5%-77.4%and the average power was low at 5.8-7 kW.The results can be used as reference for designing a chopping device for a TMR mixer. 展开更多
关键词 total mixed rations STRAW chopping device parameter optimization
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Distribution properties of airflow in the full envelope type maize stalk chopping chamber
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作者 Peng Liu Jin He +4 位作者 Changchang Yu Shangyi Lou Chunlei Wang Mingxu Wang Huipeng Shen 《International Journal of Agricultural and Biological Engineering》 SCIE 2024年第5期137-150,共14页
Chopped and spread maize stalks improve soil structure and fertility. However, because of the absence of research on airflow distribution in the chopping chamber, improvement of the spreading uniformity of chopped sta... Chopped and spread maize stalks improve soil structure and fertility. However, because of the absence of research on airflow distribution in the chopping chamber, improvement of the spreading uniformity of chopped stalks has been limited. Therefore, in this study, computational fluid dynamics (CFD) technology was applied to analyze the influence of structural and operational parameters of the chopping and spreading machine on the velocity, pressure, and turbulent kinetic energy distribution of airflow in the chopping chamber. The experimental factors considered were the relative position angle (RPA) between the collecting-chopping shaft and the sliding-supporting shaft, working velocity (WV) of the chopping chamber, and rotational velocity of the collecting-chopping blade (RVCCB). The results revealed that RPA and RVCCB had a significant influence on the maximum negative pressure in the inlet (MNPI), the proportion of negative pressure area at inlet (PNPAI), and the maximum pressure drop at inlet and outlet (MPDIO). Additionally, RVCCB had a strong influence on the maximum velocity, average velocity, and velocity variation coefficient of airflow at the outlet. Moreover, maximum turbulence (MT) and maximum turbulent kinetic energy dissipation rate (MTKEDR) showed a positive relationship with RVCCB. To determine the values of RPA, RVCCB, and WV, a multivariate parameters optimization regression model was constructed, which yielded the optimal values of 15°, 1800 r/min, and 0.50 m/s, respectively. Subsequently, a hyperbolic spiral-type guiding shell with an arc length of 90° was designed to enhance the uniform distribution of airflow in the chopping chamber. Finally, a validation experiment of airflow distribution was conducted. The results showed that the velocity difference between the simulation and the validation experiment was less than 15%, indicating the accuracy of CFD simulation, and the spreading uniformities of the chopped stalks were better than national standards. These findings can serve as technical and theoretical support for the design and optimization of chopping and spreading machines. 展开更多
关键词 maize stalk retention conservation tillage spreading process airflow distribution full envelope-type chopping chamber
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血清GRP78、CHOP、caspase-12对AECOPD合并肺动脉高压的诊断价值
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作者 张楠 钱晶 +4 位作者 韩英 邵宪萍 张丹 邹婷婷 金小乐 《中南医学科学杂志》 2026年第2期268-271,共4页
目的分析血清内质网应激(ERS)标志物葡萄糖调节蛋白78(GRP78)、C/EBP同源蛋白(CHOP)、caspase-12对慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压(PH)的诊断价值。方法回顾性搜集AECOPD患者的临床资料,根据超声心动图结果,分为PH组... 目的分析血清内质网应激(ERS)标志物葡萄糖调节蛋白78(GRP78)、C/EBP同源蛋白(CHOP)、caspase-12对慢性阻塞性肺疾病急性加重期(AECOPD)合并肺动脉高压(PH)的诊断价值。方法回顾性搜集AECOPD患者的临床资料,根据超声心动图结果,分为PH组(n=58)和非PH组(n=66)。比较两组患者临床资料及血清葡萄糖调节蛋白78(GRP78)、C/EBP同源蛋白(CHOP)及半胱氨酸天冬氨酸蛋白水解酶-12(caspase-12)水平。采用Logistic回归分析AECOPD合并PH的影响因素,采用ROC曲线分析ERS标志物对AECOPD合并PH的诊断价值。结果PH组C反应蛋白(CRP)、动脉血二氧化碳分压(PaCO_(2))、GRP78、CHOP、caspase-12水平高于非PH组,动脉血氧分压(PaO_(2))低于非PH组(P<0.05)。多因素Logistic回归分析显示,血清CHOP、GRP78、caspase-12是AECOPD合并PH的影响因素(P<0.05)。血清CHOP、GRP78、caspase-12联合检测诊断AECOPD合并PH的效能最高。结论ERS激活与AECOPD合并PH相关,血清ERS标志物GRP78、CHOP、caspase-12联合检测对AECOPD合并PH具有较好的诊断价值。 展开更多
关键词 AECOPD 肺动脉高压 内质网应激 GRP78 CHOP CASPASE-12
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CHOP方案治疗非霍奇金淋巴瘤患者期间发生肺部感染的影响因素分析
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作者 陈冬梅 顾婷婷 +2 位作者 陈瑶瑶 李庆 龚海健 《药学进展》 2026年第1期58-63,共6页
目的 考察CHOP方案(环磷酰胺+多柔比星+长春新碱+泼尼松)治疗非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)患者期间发生肺部感染的影响因素。方法 回顾性分析2022年1月至2025年1月启东市人民医院收治的90例NHL患者临床资料,患者均行CHOP... 目的 考察CHOP方案(环磷酰胺+多柔比星+长春新碱+泼尼松)治疗非霍奇金淋巴瘤(non-Hodgkin lymphoma,NHL)患者期间发生肺部感染的影响因素。方法 回顾性分析2022年1月至2025年1月启东市人民医院收治的90例NHL患者临床资料,患者均行CHOP方案化疗。依据患者感染情况,将其分为肺部感染组(28例)、非肺部感染组(15例)及未感染组(47例);同时依据患者感染严重程度,将肺部感染组分为轻中度感染组(13例)及重度感染组(15例)。收集NHL患者一般资料,比较各组系统免疫-炎症指数(systemic immune-inflammation index,SII)、中性粒细胞-淋巴细胞比值(neutrophil-lymphocyte ratio,NLR)、血小板-淋巴细胞比值(platelet-lymphocyte ratio,PLR)及预后营养指数(prognostic nutritional index,PNI),并采用单因素及多因素Logistic回归分析NHL患者发生肺部感染的影响因素。结果 化疗后,NHL患者的SII、NLR及PLR水平显著低于化疗前,PNI显著高于化疗前(P<0.05)。3组间吸烟者比例、淋巴细胞计数及化疗前第1秒用力呼气容积(forced expiratory volume in one second,FEV_(1))存在显著差异(P<0.05)。3组间PNI无显著差异(P>0.05);SII、NLR及PLR存在显著差异(P<0.05)。轻中度感染及重度感染患者的NLR及PNI无显著差异(P>0.05);轻中度感染患者的SII、PLR显著低于重度感染患者(P<0.05)。多因素Logistic回归分析结果显示,化疗前FEV_(1)高是降低NHL患者肺部感染风险的独立保护因素(P<0.05)。结论 在CHOP方案治疗NHL的过程中,化疗前FEV_(1)高是降低肺部感染风险的独立保护因素,吸烟史、淋巴细胞计数及炎症指标也有一定的预测价值。 展开更多
关键词 非霍奇金淋巴瘤 化疗 CHOP方案 肺部感染 风险分析
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利妥昔单抗在弥漫大B细胞淋巴瘤治疗中的应用分析
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作者 韩丽丽 《中国科技期刊数据库 医药》 2026年第2期041-045,共5页
探讨利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤(DLBCL)的临床疗效和安全性,为临床方案的选择提供参考。方法 回顾性分析2022年6月至2025年6月本院收治的60例初治DLBCL患者,按治疗方案分为观察组(利妥昔单抗+CHOP,n=30)和对照组(CHOP... 探讨利妥昔单抗联合CHOP方案治疗弥漫大B细胞淋巴瘤(DLBCL)的临床疗效和安全性,为临床方案的选择提供参考。方法 回顾性分析2022年6月至2025年6月本院收治的60例初治DLBCL患者,按治疗方案分为观察组(利妥昔单抗+CHOP,n=30)和对照组(CHOP,n=30),均连续治疗6个周期,随访12个月。比较两组临床疗效、肿瘤负荷和免疫功能指标、12个月无进展生存期(PFS)和总生存期(OS),分析不良反应。结果 观察组客观缓解率(ORR)90.0%>对照组70.0%x²=4.812P=0.028完全缓解率(CR)66.7%>对照组43.3%x²=3.857P=0.049。治疗后,观察组的乳酸脱氢酶(LDH)、β2微球蛋白(β2-MG)降低程度以及CD4⁺/CD8⁺比值增加程度都大于对照组(P<0.05)。观察组12个月PFS率83.3%、OS率90.0%均高于对照组60.0%、73.3%,PFS Log-rank x2=4527,P值为0.033;OS Log-rank x2为3.981,P值为0.046。两组不良反应多为1~2级,血液学和非血液学毒性发生率差异均无统计学意义,没有出现4级严重不良反应。结论 利妥昔单抗联合CHOP方案治疗DLBCL疗效好,能改善免疫功能,延长生存时间,安全性高,可以推广使用。 展开更多
关键词 利妥昔单抗 弥漫大B细胞淋巴瘤 CHOP方案
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利多卡因调控PERK/ATF4/CHOP通路对OGD/R诱导的星形胶质细胞损伤的影响
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作者 陈星 武苗 杨丽娟 《微循环学杂志》 2026年第1期24-32,47,共10页
目的:探讨利多卡因(LID)通过调控PERK/ATF4/CHOP通路对氧糖剥夺再灌注(OGD/R)诱导的星形胶质细胞损伤的保护作用及其分子机制。方法:采用终浓度分别为0、2.5、5、7.5、10、12.5、15μmol/L的LID处理大鼠星形胶质细胞,通过检测细胞活力... 目的:探讨利多卡因(LID)通过调控PERK/ATF4/CHOP通路对氧糖剥夺再灌注(OGD/R)诱导的星形胶质细胞损伤的保护作用及其分子机制。方法:采用终浓度分别为0、2.5、5、7.5、10、12.5、15μmol/L的LID处理大鼠星形胶质细胞,通过检测细胞活力筛选适宜的干预浓度;将大鼠星形胶质细胞分为对照(NC)组、OGD/R组、LID低剂量(LID-L)组、LID高剂量(LID-H)组、LID-H联合PERK激活剂CCT020312(LID-H+CCT020312)组和PERK抑制剂GSK2606414组;运用MTT法检测细胞增殖能力,流式细胞术检测细胞凋亡率,ELISA法检测炎性因子[肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)]水平及乳酸脱氢酶(LDH)活性,生化法检测氧化应激指标[丙二醛(MDA)含量、谷胱甘肽过氧化物酶(GSH-PX)及超氧化物歧化酶(SOD)活性],Hoechst/PI双染色评估细胞膜损伤,Western blot检测凋亡相关蛋白[Bcl-2相关X蛋白(Bax)、B细胞淋巴瘤-2(Bcl-2)、半胱天冬酶-3(Caspase-3)、裂解形式的半胱天冬酶-3(cleaved Caspase-3)]及PERK/ATF4/CHOP通路相关蛋白(p-PERK、PERK、p-eIF2α、eIF2α、ATF4、CHOP)的表达水平。结果:LID浓度低于10μmol/L时对正常星形胶质细胞无明显毒性。与NC组比较,OGD/R组细胞OD 490(24h、48h)值、GSH-PX和SOD活性、Bcl-2蛋白表达水平降低(P<0.05),细胞凋亡率、TNF-α、IL-6、IL-1β水平和LDH活性、MDA含量、PI阳性细胞比例、Bax、Caspase-3、cleaved Caspase-3、p-PERK/PERK、p-eIF2α/eIF2α、ATF4和CHOP蛋白表达水平均升高(P<0.05);与OGD/R组比较,LID-L组、LID-H组和GSK2606414组细胞上述损伤指标均显著改善(P<0.05),且LID-H组改善效果优于LID-L组。PERK激活剂CCT020312可显著削弱LID对OGD/R诱导星形胶质细胞损伤的保护作用(P<0.05)。结论:LID通过抑制PERK/ATF4/CHOP通路降低OGD/R诱导的星形胶质细胞炎症反应、氧化应激和细胞凋亡,发挥细胞保护作用。 展开更多
关键词 利多卡因 PERK/ATF4/CHOP通路 氧糖剥夺再灌注 星形胶质细胞损伤
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银杏二萜内酯通过PERK/ATF4/CHOP通路抑制血小板活化因子介导的神经元损伤 被引量:1
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作者 郭家欣 王艳 +6 位作者 梁淳杰 杨颖博 吴伟 王团结 王欣 肖保国 肖伟 《中草药》 北大核心 2025年第9期3152-3164,共13页
目的 探讨银杏二萜内酯(ginkgo diterpene lactone,GDL)对血小板活化因子(platelet-activating factor,PAF)诱导神经元损伤的保护作用及相关机制。方法 构建PAF诱导神经元损伤的细胞模型与动物模型,给予GDL或PERK激动剂CCT020312进行处... 目的 探讨银杏二萜内酯(ginkgo diterpene lactone,GDL)对血小板活化因子(platelet-activating factor,PAF)诱导神经元损伤的保护作用及相关机制。方法 构建PAF诱导神经元损伤的细胞模型与动物模型,给予GDL或PERK激动剂CCT020312进行处理。分别使用CCK-8和Annexin V-FITC细胞凋亡检测试剂盒测定小鼠海马神经元细胞系HT22细胞活力和凋亡;使用乳酸脱氢酶(lactate dehydrogenase,LDH)检测试剂盒检测HT22细胞培养上清液中LDH活性;采用Fluo-4钙离子检测试剂盒测定HT22细胞钙离子水平;采用分子对接探究相关分子机制;使用Western blotting检测HT22细胞与小鼠脑组织的细胞凋亡相关蛋白[半胱氨酸天冬氨酸蛋白酶-3(cystein-asparate protease-3,Caspase-3)、cleaved Caspase-3、B细胞淋巴瘤-2(B-cell lymphoma-2,Bcl-2)、Bcl-2相关X蛋白(Bcl-2 associated X protein,Bax)]和内质网应激相关蛋白[蛋白激酶R样内质网激酶(protein kinase R-like ER kinase,PERK)、p-PERK、真核翻译起始因子-2α(eukaryotic initiation factor-2α,eIF-2α)、p-e IF2α、转录激活因子4(activating transcription factor 4,ATF4)、C/EBP同源蛋白(C/EBP-homologous protein,CHOP)]的表达。结果 体外细胞实验结果显示,与对照组比较,模型组细胞活性显著降低(P<0.001),LDH释放率升高(P<0.001),钙离子水平升高(P<0.001),凋亡细胞显著增加(P<0.001),cleaved Caspase-3、Bax蛋白表达水平显著升高(P<0.001),Bcl-2蛋白表达水平显著下降(P<0.001),内质网应激相关蛋白表达水平显著升高(P<0.05、0.001);与模型组比较,GDL显著升高了细胞活力(P<0.05、0.001),显著上调Bcl-2的表达(P<0.05、0.001),显著下调cleaved Caspase-3、Bax、p-PERK、p-e IF2α、ATF4、CHOP的表达(P<0.05、0.01、0.001);CCT020312处理后GDL的效果均被逆转(P<0.001)。体内动物实验结果显示,与对照组比较,模型组小鼠脑组织Bax蛋白表达水平显著升高(P<0.001),Bcl-2蛋白表达水平显著下降(P<0.001),内质网应激相关蛋白表达水平显著升高(P<0.001);与模型组比较,GDL显著上调Bcl-2的表达(P<0.01、0.001),显著下调p-PERK、p-e IF2α、ATF4、CHOP、Bax的表达(P<0.001);CCT020312处理后GDL的效果均被逆转(P<0.001)。结论 PAF可以激活神经元内质网应激的PERK/ATF4/CHOP通路来诱导钙超载,从而使神经元凋亡;而GDL可以通过抑制PERK/ATF4/CHOP通路来抑制内质网应激、钙超载和凋亡,以减轻PAF诱导的神经元损伤。 展开更多
关键词 银杏二萜内酯 银杏内酯A 银杏内酯B 银杏内酯K 血小板活化因子 PERK/ATF4/CHOP信号通路 内质网应激 凋亡
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基于PERK/eIF2α/CHOP信号通路探讨白虎人参合枳实薤白桂枝汤对糖尿病心肌病MKR小鼠心肌损伤的保护作用
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作者 吕霞琳 刘秀 +2 位作者 向琴 肖凡 喻嵘 《中华中医药杂志》 北大核心 2025年第2期642-648,共7页
目的:观察白虎人参合枳实薤白桂枝汤对糖尿病心肌病MKR小鼠心肌损伤的保护作用,并基于PERK/eIF2α/CHOP通路探讨其作用机制。方法:MKR小鼠按随机数表法分为模型组,二甲双胍组,白虎人参合枳实薤白桂枝汤低、中、高剂量组(以下简称中药低... 目的:观察白虎人参合枳实薤白桂枝汤对糖尿病心肌病MKR小鼠心肌损伤的保护作用,并基于PERK/eIF2α/CHOP通路探讨其作用机制。方法:MKR小鼠按随机数表法分为模型组,二甲双胍组,白虎人参合枳实薤白桂枝汤低、中、高剂量组(以下简称中药低、中、高剂量组),FVB小鼠作为对照组。高脂饮食联合链脲佐菌素诱导糖尿病心肌病模型。二甲双胍(200 mg·kg^(-1)·d^(-1))和白虎人参合枳实薤白桂枝汤低、中、高剂量(10、20、40 g·kg^(-1)·d^(-1))灌胃4周后测量小鼠空腹血糖(FBG),检测血清甘油三酯(TG)、总胆固醇(TC)及B型心房钠尿肽(BNP)含量;心脏超声检测小鼠左心室射血分数(EF)、缩短分数(FS);HE染色、透射电子显微镜观察心肌组织病理形态和超微结构;Western Blot检测小鼠心肌组织GRP78、p-eIF2α、p-PERK、CHOP、Caspase12蛋白表达情况。结果:与模型组比较,各给药组小鼠FBG显著下降(P<0.01),中药高剂量组下降更明显(P<0.01,P<0.05);各给药组EF与FS显著升高(P<0.01),血清TC及BNP含量显著减少(P<0.01),二甲双胍组及中药高剂量组TG含量显著减少(P<0.01);各给药组心肌组织排列渐趋整齐,细胞质染色及细胞核分布均匀,心肌细胞线粒体嵴排列渐趋整齐,损伤断裂减少;各给药组小鼠心肌组织GRP78、p-eIF2α、p-PERK、CHOP、Caspase12蛋白显著减少(P<0.01)。结论:白虎人参合枳实薤白桂枝汤能改善糖尿病心肌病MKR小鼠心功能,调整糖脂代谢,减少PERK/eIF2α/CHOP信号通路蛋白表达,从而减少心肌损伤,保护心肌组织,延缓疾病进程。 展开更多
关键词 糖尿病心肌病 白虎人参合枳实薤白桂枝汤 心肌保护 内质网应激 PERK/eIF2α/CHOP信号通路
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