Chase the Dream of Coral is an inspiring book that shines a light on the brave scientists dedicated to saving our coral reefs.Coral reefs are often called the rainforests of the sea because they support a vast number ...Chase the Dream of Coral is an inspiring book that shines a light on the brave scientists dedicated to saving our coral reefs.Coral reefs are often called the rainforests of the sea because they support a vast number of marine species.However,they are facing serious threats from climate change,pollution and overfishing.This book highlights the urgent need to protect these beautiful and vital ecosystems.展开更多
While many metaheuristic optimization algorithms strive to address optimization challenges,they often grapple with the delicate balance between exploration and exploitation,leading to issues such as premature converge...While many metaheuristic optimization algorithms strive to address optimization challenges,they often grapple with the delicate balance between exploration and exploitation,leading to issues such as premature convergence,sensitivity to parameter settings,and difficulty in maintaining population diversity.In response to these challenges,this study introduces the Chase,Pounce,and Escape(CPE)algorithm,drawing inspiration from predator-prey dynamics.Unlike traditional optimization approaches,the CPE algorithm divides the population into two groups,each independently exploring the search space to efficiently navigate complex problem domains and avoid local optima.By incorporating a unique search mechanism that integrates both the average of the best solution and the current solution,the CPE algorithm demonstrates superior convergence properties.Additionally,the inclusion of a pouncing process facilitates rapid movement towards optimal solutions.Through comprehensive evaluations across various optimization scenarios,including standard test functions,Congress on Evolutionary Computation(CEC)-2017 benchmarks,and real-world engineering challenges,the effectiveness of the CPE algorithm is demonstrated.Results consistently highlight the algorithm’s performance,surpassing that of other well-known optimization techniques,and achieving remarkable outcomes in terms of mean,best,and standard deviation values across different problem domains,underscoring its robustness and versatility.展开更多
AtCRE1 is known to be a cytokinin receptor in Arabidopsis. The AtCRE1 protein contains CHASE domain at the N-terminal part, followed by a transmitter (histidine kinase) domain and two receiver domains. The N-terminal...AtCRE1 is known to be a cytokinin receptor in Arabidopsis. The AtCRE1 protein contains CHASE domain at the N-terminal part, followed by a transmitter (histidine kinase) domain and two receiver domains. The N-terminal CHASE domain of AtCRE1 contains putative recognition sites for cytokinin. Five CHASE domains containing proteins were found in rice, OsCRL1a, OsCRL1b, OsCRL2, OsCRL3, and OsCRL4. OsCRL1a, OsCRL1b, OsCRL2 and OsCRL3 contain the four domains existing in CRE1, whereas OsCRL4 only contains the CHASE domain and a putative Ser/Thr protein kinase domain. The authors cloned the encoding gene OsCRL4 and found that it represents a new member of the cytokinin receptor protein in rice.展开更多
AIM: To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome.METHODS: Purified anti-CEA monoclonal antibody (McAb)wa...AIM: To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome.METHODS: Purified anti-CEA monoclonal antibody (McAb)was biotinylated with NHS-biotin, and then radiolabeled with 188Re by the direct method. 188Re-labeledbiotinylated anti-CEA McAb (188Re-CEA McAb-Bt) was intravenously injected followed by intravenous injection of avidin after 24 h. SPECT imaging and biodistribution study were performed at 28-48 h after the injection of 188Re-CEA McAb-Bt. Three groups of nude mice subcutaneously grafted with human colon carcinoma were treated 7 d after the graft. Mice in the avidin chase group received intravenous injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg) followed by intravenous injection of cold avidin (80 μg) after 24 h. Mice in the control group (treated group without avidin chase) only received the injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg), another control group (non-treated group) only received 0.1 mL normal saline solution. Toxicity was evaluated on the basis of change of body weight and peripheral WBC counts, and therapy effects were determined by variation in tumor volume. Histological analysis of tumors was also performed.RESULTS: Avidin chase markedly accelerated the clearance of 188Re-CEA McAb-Bt from the blood and normal tissues. The tumor uptakes of 188Re-CEA Mc Ab-Bt at 28 h were 5.90 and 6.42% ID/g, respectively, in chase group and in non-chase group, while the tumor-to-background (T/NT) ratios were 3.19 and 0.56, respectively. The tumor uptake was slightly decreased by avidin chase, but the T/NT ratios were increased. In treated groups the growth rate of body weight and the number of WBC decreased after injection of 188Re-CEA McAb-Bt, and the WBC counts recovered earlier in the group with avidin chase than in the group without avidin chase. Compared to the nontreated group, treated groups with and without avidin chase showed significant anti-tumor effects.CONCLUSION: Avidin chase can effectively reduce the side effects of RIT, and improve therapeutic efficacy.展开更多
文摘Chase the Dream of Coral is an inspiring book that shines a light on the brave scientists dedicated to saving our coral reefs.Coral reefs are often called the rainforests of the sea because they support a vast number of marine species.However,they are facing serious threats from climate change,pollution and overfishing.This book highlights the urgent need to protect these beautiful and vital ecosystems.
文摘While many metaheuristic optimization algorithms strive to address optimization challenges,they often grapple with the delicate balance between exploration and exploitation,leading to issues such as premature convergence,sensitivity to parameter settings,and difficulty in maintaining population diversity.In response to these challenges,this study introduces the Chase,Pounce,and Escape(CPE)algorithm,drawing inspiration from predator-prey dynamics.Unlike traditional optimization approaches,the CPE algorithm divides the population into two groups,each independently exploring the search space to efficiently navigate complex problem domains and avoid local optima.By incorporating a unique search mechanism that integrates both the average of the best solution and the current solution,the CPE algorithm demonstrates superior convergence properties.Additionally,the inclusion of a pouncing process facilitates rapid movement towards optimal solutions.Through comprehensive evaluations across various optimization scenarios,including standard test functions,Congress on Evolutionary Computation(CEC)-2017 benchmarks,and real-world engineering challenges,the effectiveness of the CPE algorithm is demonstrated.Results consistently highlight the algorithm’s performance,surpassing that of other well-known optimization techniques,and achieving remarkable outcomes in terms of mean,best,and standard deviation values across different problem domains,underscoring its robustness and versatility.
基金Project supported by the National Natural Science Foundation of China
文摘AtCRE1 is known to be a cytokinin receptor in Arabidopsis. The AtCRE1 protein contains CHASE domain at the N-terminal part, followed by a transmitter (histidine kinase) domain and two receiver domains. The N-terminal CHASE domain of AtCRE1 contains putative recognition sites for cytokinin. Five CHASE domains containing proteins were found in rice, OsCRL1a, OsCRL1b, OsCRL2, OsCRL3, and OsCRL4. OsCRL1a, OsCRL1b, OsCRL2 and OsCRL3 contain the four domains existing in CRE1, whereas OsCRL4 only contains the CHASE domain and a putative Ser/Thr protein kinase domain. The authors cloned the encoding gene OsCRL4 and found that it represents a new member of the cytokinin receptor protein in rice.
基金Supported by the China Postdoctoral Science Foundation, No. 2003033345Medical Sciences and Technology Foundation of Guangdong Province, No.A2000389
文摘AIM: To evaluate the influence of avidin chase on the side effects of radioimmunotherapy (RIT) in nude mice bearing human colon carcinoma and therapeutic outcome.METHODS: Purified anti-CEA monoclonal antibody (McAb)was biotinylated with NHS-biotin, and then radiolabeled with 188Re by the direct method. 188Re-labeledbiotinylated anti-CEA McAb (188Re-CEA McAb-Bt) was intravenously injected followed by intravenous injection of avidin after 24 h. SPECT imaging and biodistribution study were performed at 28-48 h after the injection of 188Re-CEA McAb-Bt. Three groups of nude mice subcutaneously grafted with human colon carcinoma were treated 7 d after the graft. Mice in the avidin chase group received intravenous injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg) followed by intravenous injection of cold avidin (80 μg) after 24 h. Mice in the control group (treated group without avidin chase) only received the injection of 188Re-CEA McAb-Bt (11.1 MBq/20 μg), another control group (non-treated group) only received 0.1 mL normal saline solution. Toxicity was evaluated on the basis of change of body weight and peripheral WBC counts, and therapy effects were determined by variation in tumor volume. Histological analysis of tumors was also performed.RESULTS: Avidin chase markedly accelerated the clearance of 188Re-CEA McAb-Bt from the blood and normal tissues. The tumor uptakes of 188Re-CEA Mc Ab-Bt at 28 h were 5.90 and 6.42% ID/g, respectively, in chase group and in non-chase group, while the tumor-to-background (T/NT) ratios were 3.19 and 0.56, respectively. The tumor uptake was slightly decreased by avidin chase, but the T/NT ratios were increased. In treated groups the growth rate of body weight and the number of WBC decreased after injection of 188Re-CEA McAb-Bt, and the WBC counts recovered earlier in the group with avidin chase than in the group without avidin chase. Compared to the nontreated group, treated groups with and without avidin chase showed significant anti-tumor effects.CONCLUSION: Avidin chase can effectively reduce the side effects of RIT, and improve therapeutic efficacy.
