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Information Diffusion Models and Fuzzing Algorithms for a Privacy-Aware Data Transmission Scheduling in 6G Heterogeneous ad hoc Networks
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作者 Borja Bordel Sánchez Ramón Alcarria Tomás Robles 《Computer Modeling in Engineering & Sciences》 2026年第2期1214-1234,共21页
In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic h... In this paper,we propose a new privacy-aware transmission scheduling algorithm for 6G ad hoc networks.This system enables end nodes to select the optimum time and scheme to transmit private data safely.In 6G dynamic heterogeneous infrastructures,unstable links and non-uniform hardware capabilities create critical issues regarding security and privacy.Traditional protocols are often too computationally heavy to allow 6G services to achieve their expected Quality-of-Service(QoS).As the transport network is built of ad hoc nodes,there is no guarantee about their trustworthiness or behavior,and transversal functionalities are delegated to the extreme nodes.However,while security can be guaranteed in extreme-to-extreme solutions,privacy cannot,as all intermediate nodes still have to handle the data packets they are transporting.Besides,traditional schemes for private anonymous ad hoc communications are vulnerable against modern intelligent attacks based on learning models.The proposed scheme fulfills this gap.Findings show the probability of a successful intelligent attack reduces by up to 65%compared to ad hoc networks with no privacy protection strategy when used the proposed technology.While congestion probability can remain below 0.001%,as required in 6G services. 展开更多
关键词 6G networks ad hoc networks PRIVACY scheduling algorithms diffusion models fuzzing algorithms
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托珠单抗通过抑制IL-6-JAK-STAT3信号逆转骨髓基质细胞介导的AML化疗耐药
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作者 肖启荣 李晓静 +5 位作者 林碧寸 林凯婷 林晓斌 王匡非 李暐 陈萍 《中国药理学通报》 北大核心 2026年第1期49-55,共7页
目的研究托珠单抗(tocilizumab,TCZ)通过阻断IL-6/JAK/STAT3信号通路,逆转骨髓微环境介导的急性髓系白血病(acute myeloid leukemia,AML)细胞化疗耐药。方法建立AML细胞(U937、HL-60)与HS-5基质细胞的共培养体系,Western blot检测IL-6-J... 目的研究托珠单抗(tocilizumab,TCZ)通过阻断IL-6/JAK/STAT3信号通路,逆转骨髓微环境介导的急性髓系白血病(acute myeloid leukemia,AML)细胞化疗耐药。方法建立AML细胞(U937、HL-60)与HS-5基质细胞的共培养体系,Western blot检测IL-6-JAK-STAT3通路活化状态;利用IL-6敲除HS-5细胞及TCZ干预,结合CCK-8和AnnexinVAPC/7-AAD双染法分析AML细胞对阿糖胞苷(cytarabine,Ara-C)的敏感性变化;最后通过AML异种移植模型体内验证TCZ对Ara-C的协同抗白血病作用。结果在黏附共培养体系中,HS-5细胞高表达IL-6,AML细胞表现STAT3信号通路激活。通过基因敲低IL-6或使用TCZ干预,可有效抑制AML细胞中JAK2/STAT3的磷酸化激活。另外,体内外实验证实TCZ能够明显增强AML细胞对Ara-C化疗的敏感性。结论TCZ通过靶向抑制IL-6/JAK/STAT3信号通路,明显增强AML细胞对Ara-C的化学敏感性。 展开更多
关键词 急性髓细胞白血病 骨髓基质细胞 共培养模型 白细胞介素6 托珠单抗 化疗耐药
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Temperature and Precipitation Change over South China in CMIP5 and CMIP6 Models:Historical Simulation and Future Projection
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作者 Dongdong PENG Tianjun ZHOU +3 位作者 Sheng HU Lixia ZHANG Jiayu ZHENG Jingxuan QU 《Advances in Atmospheric Sciences》 2025年第7期1423-1441,共19页
Revealing regional climate changes is vital for policymaking activities related to climate change adaptation and mitigation.South China is a well-developed region with a dense population,but the level of uncertainty i... Revealing regional climate changes is vital for policymaking activities related to climate change adaptation and mitigation.South China is a well-developed region with a dense population,but the level of uncertainty in climate projections remains to be evaluated in detail.In this study,we comprehensively assessed the historical simulations and future projections of climate change in South China based on CMIP5/CMIP6 models.We show evidence that CMIP5/CMIP6 models can skillfully reproduce the observed distributions of annual/seasonal mean temperature but show much lower skill for precipitation.CMIP6 outperforms CMIP5 in the historical simulations,as evidenced by more models with lower bias magnitude and higher skill scores.During 2021–2100,the annual mean temperature over South China is projected to increase significantly at a rate of 0.53(0.42–0.63)and 0.59(0.52–0.66)℃(10 yr)^(-1),while precipitation is projected to increase slightly at a rate of 0.78(0.15–1.56)and 1.52(0.91–2.30)%(10 yr)^(-1),under the RCP8.5 and SSP5-8.5 scenarios,respectively.CMIP6 models project larger annual/seasonal mean temperature and precipitation trends than CMIP5 models under equivalent scenarios.The temperature in South China is projected to increase robustly by more than1.5℃during 2041–2060 under RCP4.5 and SSP2-4.5,but by 4.5℃during 2081–2100,under RCP8.5 and SSP5-8.5 with respect to 1850–1900.The uncertainty in temperature projections is mainly dominated by model uncertainty and scenario uncertainty,while internal uncertainty contributes some of the uncertainty during the near-term.The uncertainty in precipitation projection stems mainly from internal uncertainty and model uncertainty.For both the temperature and precipitation projection uncertainty,the relative sizes of contributions from the main contributors vary with time and show obvious seasonal differences. 展开更多
关键词 projection uncertainty model performance CMIP6 South China
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Simulated Asymmetric Connection of SST in the Tasman Sea with Respect to the Opposite Phases of ENSO in Austral Summer in CMIP6 Models
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作者 Hui CAI Xueqian SUN Shuanglin LI 《Advances in Atmospheric Sciences》 2025年第9期1833-1849,共17页
A prior observational study indicated an asymmetric link between sea surface temperature(SST)in the Tasman Sea and ENSO during austral summer.Specifically,El Niño is associated with a dipolar SST anomaly pattern,... A prior observational study indicated an asymmetric link between sea surface temperature(SST)in the Tasman Sea and ENSO during austral summer.Specifically,El Niño is associated with a dipolar SST anomaly pattern,featuring warming in the northwest and cooling in the southeast,whereas La Niña corresponds to basin-scale warming.This study employs the experiments of coupled models from the sixth phase of the Coupled Model Intercomparison Project(CMIP6)to assess ENSO’s impact on Tasman Sea SST.While all 15 models capture the observed dipolar SST anomalies(SSTAs)in the Tasman Sea during El Niño years,only 7 models capture the basin-scale warmth in the Tasman Sea during La Niña years.Consequently,the models are bifurcated into two groups:group-one models yield one physically reasonable asymmetric connection as observed,including the asymmetry of oceanic heat transport,especially the Ekman meridional transport anomalies induced by zonal wind stress driven by the asymmetric atmospheric circulation over the Tasman Sea.However,due to abnormal responses to ENSO and systematic biases in model simulations,including jet and storm tracks,oceanic heat fluxes,ocean currents,and SST,the group-two models fail to reproduce the asymmetric connection between the Tasman Sea and ENSO.This study not only validates the observational asymmetric connection of SSTAs in the Tasman Sea with respect to the two opposite ENSO phases,but also provides evidence and clues to reduce the bias in group-two models. 展开更多
关键词 asymmetric connection SST Tasman Sea ENSO CMIP6 model thermodynamics systematic bias
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N_(6)-甲基腺苷相关长非编码RNA作为胃癌患者预后预测的潜在生物标志物
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作者 徐思远 奚锦森 +2 位作者 杨逸 顾晓冬 项建斌 《上海医药》 2026年第1期13-25,53,共14页
RNA甲基化占整个RNA修饰的60%以上,而N_(6)-甲基腺苷(N_(6)-methyladenosine,m^(6)A)修饰是人类最常见的一种RNA修饰。m^(6)A修饰对基因表达的调节至关重要,其失调与多种疾病如肿瘤相关。我们以癌症基因组图谱(The Cancer Genome Atlas,... RNA甲基化占整个RNA修饰的60%以上,而N_(6)-甲基腺苷(N_(6)-methyladenosine,m^(6)A)修饰是人类最常见的一种RNA修饰。m^(6)A修饰对基因表达的调节至关重要,其失调与多种疾病如肿瘤相关。我们以癌症基因组图谱(The Cancer Genome Atlas,TCGA)胃癌数据集中的375例患者为对象,研究了m^(6)A相关长非编码RNA(long noncoding RNAs,lncRNAs)的预后意义:先进行Pearson相关性分析,以筛选m^(6)A相关lncRNAs,然后再进行单变量Cox回归分析,确定胃癌患者的预后。确定23种m^(6)A相关lncRNAs为预后lncRNAs后,运用LASSO-Cox回归方法,在TCGA胃癌数据集中构建m^(6)A相关lncRNAs(包括9种m^(6)A相关预后lncRNAs)预后模型。通过计算相关风险评分,并根据风险评分的中位值将胃癌患者分为低、高风险亚组。生存分析曲线和受试者操作特征曲线显示,此预后模型能对胃癌患者的预后进行可靠的预测。本研究揭示了m^(6)A RNA甲基化调节剂在胃癌发生发展中的重要性,并建立了一种m^(6)A基因表达分类模型,该模型可以令人满意地预测胃癌的预后。 展开更多
关键词 N_(6)-甲基腺苷 长非编码RNA 胃癌 预后模型 生物标志物
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A study of ENSO magnitude and lifespan in CMIP6 models
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作者 Siyu Ou De-Zheng Sun Ronghui Zhang 《Acta Oceanologica Sinica》 2025年第9期19-37,共19页
The magnitude of El Nino determines the level of its global impact.Yet,how well our state-of-the-art models simulate this key aspect of El Nino is not well documented.Previous studies tend to ignore El Nino-Southern O... The magnitude of El Nino determines the level of its global impact.Yet,how well our state-of-the-art models simulate this key aspect of El Nino is not well documented.Previous studies tend to ignore El Nino-Southern Oscillation(ENSO)asymmetry and equate the variance of ENSO to the magnitude of El Nino.Moreover,previous evaluations are more focused on the surface manifestation of El Nino.Here,we quantify the magnitudes of El Nino and La Nina separately,both at the surface and subsurface levels.At the surface,we find that while the magnitude of La Nina events in most models is generally stronger than observed,the magnitude of El Nino is more diverse to observations.In fact,in many models,El Nino is weaker than observed.This bias in the magnitude of El Nino is more pronounced in the subsurface.We attribute this weakness in the subsurface to the generally weaker coupling strength and the apparent stronger ENSO at the surface to a lack of sufficiently strong negative feedback from the surface heat flux in the models.When normalized by the variance of ENSO,the lack of exceptionally strong El Nino events in the models is more common and pronounced.We further studied the lifespan of El Nino and La Nina events and have found that multi-year duration is not confined to just La Nina events.There are also El Nino events that last more than one year.Moreover,we have found that multi-year long La Nina events tend to occur over the decades with strong El Nino events.The study also briefly explores the impact of global warming on the duration of ENSO events through the use of a simple model and simulations by CMIP6 models.It has been found that the frequency of multi-year El Nino and La Nina events increases with global warming. 展开更多
关键词 MAGNITUDE LIFESPAN El Nino and La Nina coupled models CMIP6
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Westward shift of western North Pacific tropical cyclones in CMIP6-High Res MIP models
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作者 Zhuoying Li Wen Zhou 《Atmospheric and Oceanic Science Letters》 2025年第2期86-93,共8页
Against the backdrop of climate change,the activity of tropical cyclones(TCs)has captured widespread attention.Observational datasets indicate a declining trend in the genesis longitude of western North Pacific(WNP)TC... Against the backdrop of climate change,the activity of tropical cyclones(TCs)has captured widespread attention.Observational datasets indicate a declining trend in the genesis longitude of western North Pacific(WNP)TCs.This study investigates the zonal changes of WNP TCs with CMIP6-HighResMIP models.These models capture the genesis density of WNP TCs fairly well.The results reveal a westward shift in TC genesis longitude.This trend is associated with the significant reduction in the TC frequency over the southeastern WNP.The study also discusses changes in large-scale circulation patterns and the impact of the strengthening Pacific Walker circulation. 展开更多
关键词 Tropical cyclones Westward shift CMIP6-HighResMIP models Pacific walker circulation
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Differentiated Cloud-Radiation Characteristics over East Asian Subtropical and Tropical Regions Revealed by CMIP6 Models
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作者 WU Rui-xue LI Jian-dong +4 位作者 XU Jian-jun ZHANG Yu LIAO Xiao-qing LIU Chun-lei DU Zhen-cai 《Journal of Tropical Meteorology》 2025年第1期43-63,共21页
Pronounced climatic differences occur over subtropical South China(SC)and tropical South China Sea(SCS)and understanding the key cloud-radiation characteristics is essential to simulating East Asian climate.This study... Pronounced climatic differences occur over subtropical South China(SC)and tropical South China Sea(SCS)and understanding the key cloud-radiation characteristics is essential to simulating East Asian climate.This study investigated cloud fractions and cloud radiative effects(CREs)over SC and SCS simulated by CMIP6 atmospheric models.Remarkable differences in cloud-radiation characteristics appeared over these two regions.In observations,considerable amounts of low-middle level clouds and cloud radiative cooling effect appeared over SC.In contrast,high clouds prevailed over SCS,where longwave and shortwave CREs offset each other,resulting in a weaker net cloud radiative effect(NCRE).The models underestimated NCRE over SC mainly due to weaker shortwave CRE and less cloud fractions.Conversely,most models overestimated NCRE over SCS because of stronger shortwave CRE and weaker longwave CRE.Regional CREs were closely linked to their dominant cloud fractions.Both observations and simulations showed a negative spatial correlation between total(low)cloud fraction and shortwave CRE over SC,especially in winter,and exhibited a positive correlation between high cloud fraction and longwave CRE over these two regions.Compared with SCS,most models overestimated the spatial correlation between low(high)cloud fraction and SWCRE(LWCRE)over SC,with larger bias ranges among models,indicating the exaggerated cloud radiative cooling(warming)effect caused by low(high)clouds.Moreover,most models struggled to describe regional ascent and its connection with CREs over SC while they can better reproduce these connections over SCS.This study further suggests that reasonable circulation conditions are crucial to simulating well cloud-radiation characteristics over the East Asian regions. 展开更多
关键词 cloud fraction cloud radiative effect CMIP6 model South China South China Sea
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An Integrated Experimental-Simulation Calibration Method for the Constitutive Model of 6005A-T6 Aluminum Alloy Welds
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作者 Yu Zhu Lele Zhang +1 位作者 Weiyuan Dou Wen Liu 《Chinese Journal of Mechanical Engineering》 2025年第1期233-245,共13页
Due to the different microstructures caused by the heat source effect,welding joints exhibit significant differences in mechanical properties compared to the base material.Precise characterization of the constitutive ... Due to the different microstructures caused by the heat source effect,welding joints exhibit significant differences in mechanical properties compared to the base material.Precise characterization of the constitutive characteristics of the welded joint requires a large number of repetitive experiments,which are costly,inefficient,and have limited accuracy improvements.This paper proposes an integrated experimental-simulation-based inverse calibration method,which establishes a calibration optimization problem based on the corresponding constitutive model and a finite element calculation model built by the distribution of hardness in the weldment.Using the global tensile force-displacement curve of the MIG-welded 6005A-T6 aluminum alloy specimen and the experimental data of local deformation with time change obtained from DIC(Digital Image Correlation),the parameters involved in the constitutive models are optimized accordingly.This method can directly obtain the constitutive characteristics of the weldment under conditions of limited experiments and insufficient data.Additionally,the adaptability of the constitutive model to the calibration method and the influence of optimization results are discussed and analyzed.The results indicate that the global force-displacement response of the non-saturated Ramberg-Osgood(R-O)model is in the best agreement with that of the experimental data,and the energy error is only 2.62%,followed by the MPL model,while the saturation-based Voce model shows the largest simulation error in terms of the presented object.Furthermore,the simulation results of R-O,Voce,and MPL models in the local area are far superior to traditional fitting methods. 展开更多
关键词 6005A-T6 aluminum alloy MIG-weld joint Parameter calibration Elastic-plastic constitutive model DIC
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6G Digital Twin Enabled Channel Modeling for Beijing Central Business District
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作者 LU Mengyuan BAI Lu +3 位作者 HAN Zengrui HUANG Ziwei LU Shiliang CHENG Xiang 《ZTE Communications》 2025年第2期31-45,共15页
A novel digital twin(DT)enabled channel model for 6G vehicular communications in Beijing Central Business District(Beijing CBD)is proposed,which can support the design of intelligent transportation systems(ITSs).A DT ... A novel digital twin(DT)enabled channel model for 6G vehicular communications in Beijing Central Business District(Beijing CBD)is proposed,which can support the design of intelligent transportation systems(ITSs).A DT space for Beijing CBD is constructed,and two typical transportation periods,i.e.,peak and off-peak hours,are considered to characterize the vehicular communication channel better.Based on the constructed DT space,a DT-enabled vehicular communication dataset is developed,including light detection and ranging(LiDAR)point clouds,RGB images,and channel information.With the assistance of LiDAR point clouds and RGB images,the scatterer parameters,including number,distance,angle,power,and velocity,are analyzed under different transportation periods.The channel non-stationarity and consistency are mimicked in the proposed model.The key channel statistical properties are derived and simulated.Compared to ray-tracing(RT)results,the accuracy of the proposed model is verified. 展开更多
关键词 DT channel modeling 6G vehicular communications Beijing CBD DT-enabled vehicular communication dataset
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Experimental and Neural Network Modeling of the Thermal Behavior of an Agricultural Greenhouse Integrated with a Phase Change Material(CaCl_(2)⋅6H_(2)O)
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作者 Abdelouahab Benseddik Djamel Daoud +4 位作者 Ahmed Badji Hocine Bensaha Tarik Hadibi Yunfeng Wang Li Ming 《Energy Engineering》 2025年第12期5021-5037,共17页
In Saharan climates,greenhouses face extreme diurnal temperature fluctuations that generate thermal stress,reduce crop productivity,and hinder sustainable agricultural practices.Passive thermal storage using Phase Cha... In Saharan climates,greenhouses face extreme diurnal temperature fluctuations that generate thermal stress,reduce crop productivity,and hinder sustainable agricultural practices.Passive thermal storage using Phase Change Materials(PCM)is a promising solution to stabilize microclimatic conditions.This study aims to evaluate experimentally and numerically the effectiveness of PCM integration for moderating greenhouse temperature fluctuations under Saharan climatic conditions.Two identical greenhouse prototypes were constructed in Ghardaia,Algeria:a reference greenhouse and a PCM-integrated greenhouse using calcium chloride hexahydrate(CaCl_(2)⋅6H_(2)O).Thermal performance was assessed during a five-day experimental period(7–11May 2025)under severe ambient conditions.To complement this,a Nonlinear Auto-Regressive with eXogenous inputs(NARX)neural network model was developed and trained using a larger dataset(7–25 May 2025)to predict greenhouse thermal dynamics.The PCM greenhouse reduced peak daytime air temperature by an average of 8.14℃and decreased the diurnal temperature amplitude by 53.6%compared to the reference greenhouse.The NARX model achieved high predictive accuracy(R^(2)=0.990,RMSE=0.425℃,MAE=0.223℃,MBE=0.008℃),capturing both sensible and latent heat transfer mechanisms,including PCM melting and solidification.The combined experimental and predictive modeling results confirm the potential of PCM integration as an effective passive thermal regulation strategy for greenhouses in arid regions.This approach enhances microclimatic stability,improves energy efficiency,and supports the sustainability of protected agriculture under extreme climatic conditions. 展开更多
关键词 Agricultural greenhouse phase changematerial(PCM) CaCl_(2)⋅6H_(2)O thermal regulation NARX neural network experimental study modeling
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“Water”accelerated B(C_(6)F_(5))_(3)-catalyzed Mukaiyama-aldol reaction:Outer-sphere activation model
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作者 Zhenguo Zhang Lanyang Li +6 位作者 Xinlong Zong Yongheng Lv Shuanglei Liu Liang Ji Xuefei Zhao Zhenhua Jia Teck-Peng Loh 《Chinese Chemical Letters》 2025年第7期334-339,共6页
A“water”accelerated metal-free catalytic system has been discovered for the Mukaiyama-aldol reaction.The system involves the use of B(C_(6)F_(5))_(3) as a catalyst,which is water-tolerant and able to activate the ca... A“water”accelerated metal-free catalytic system has been discovered for the Mukaiyama-aldol reaction.The system involves the use of B(C_(6)F_(5))_(3) as a catalyst,which is water-tolerant and able to activate the carbonyl group through a hydrogen bonding network generated by the catalyst.This activation method allows the reactions to be performed with very low catalyst loading,as low as 0.5 mol%.The scope of substrates is broad and a wide variety of functional groups are well tolerated.Diverse aliphatic aldehydes,aromatic aldehydes,unsaturated aldehydes and aromatic ketones coupled with silyl enol ethers/silyl ketone acetals to generate their correspondingβ-hydroxy carbonyl compounds in moderate to good yields.This discovery represents a significant advancement in the field of organic synthesis,as it provides a new,practical and sustainable solution for carbon-carbon bond formation in water. 展开更多
关键词 B(C_(6)F_(5))_(3)-catalysis Hydrogen bonding network Water-acceleration Mukaiyama-aldol reaction Outer-sphere activation model
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Modeling of Precipitation over Africa:Progress,Challenges,and Prospects
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作者 A.A.AKINSANOLA C.N.WENHAJI +21 位作者 R.BARIMALALA P.-A.MONERIE R.D.DIXON A.T.TAMOFFO M.O.ADENIYI V.ONGOMA I.DIALLO M.GUDOSHAVA C.M.WAINWRIGHT R.JAMES K.C.SILVERIO A.FAYE S.S.NANGOMBE M.W.POKAM D.A.VONDOU N.C.G.HART I.PINTO M.KILAVI S.HAGOS E.N.RAJAGOPAL R.K.KOLLI S.JOSEPH 《Advances in Atmospheric Sciences》 2026年第1期59-86,共28页
In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and cha... In recent years,there has been an increasing need for climate information across diverse sectors of society.This demand has arisen from the necessity to adapt to and mitigate the impacts of climate variability and change.Likewise,this period has seen a significant increase in our understanding of the physical processes and mechanisms that drive precipitation and its variability across different regions of Africa.By leveraging a large volume of climate model outputs,numerous studies have investigated the model representation of African precipitation as well as underlying physical processes.These studies have assessed whether the physical processes are well depicted and whether the models are fit for informing mitigation and adaptation strategies.This paper provides a review of the progress in precipitation simulation overAfrica in state-of-the-science climate models and discusses the major issues and challenges that remain. 展开更多
关键词 RAINFALL MONSOON climate modeling CORDEX CMIP6 convection-permitting models
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基于CMIP6的岷沱江流域径流预估
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作者 江楠 倪福全 +4 位作者 邓玉 向军 吴明炎 康文东 岳紫莹 《水生态学杂志》 北大核心 2026年第1期25-36,共12页
揭示岷沱江流域未来径流变化趋势,为岷沱江流域水资源管理和决策提供科学依据。基于SWAT模型和第六次国际耦合模式比较计划(CMIP6),采用6个全球气候模式(GCMs)的多模式集合平均(MME),将基准期(1981—2014年)与未来2个时期2017—2050年和... 揭示岷沱江流域未来径流变化趋势,为岷沱江流域水资源管理和决策提供科学依据。基于SWAT模型和第六次国际耦合模式比较计划(CMIP6),采用6个全球气候模式(GCMs)的多模式集合平均(MME),将基准期(1981—2014年)与未来2个时期2017—2050年和2057—2090年对比,评估4种不同的共享社会经济路径(SSPs)下岷沱江流域未来径流情况。结果表明:(1)SWAT模型在岷沱江流域径流模拟中具有较好的适用性,研究区7个水文监测站月径流模拟效果较好;(2)采用MME模拟气温和降水相关系数分别为0.99和0.93,模拟值与观测值有极高的相似度;(3)相较基准期,在各种情景下,未来岷沱江流域年均气温呈增加趋势,SSP5-8.5增温最为明显,年均降水量呈波动上升趋势;(4)不同情景下的未来2个时期,岷沱江流域的径流量将会减少,2017—2050年期间径流减少的幅度大于2057—2090年,减少的区域集中在岷江上游、沱江下游和青衣江流域。降雨的增加并不能完全消弭流域持续温升驱动的径流量减少。 展开更多
关键词 第六次国际耦合模式比较计划 SWAT模型 径流 集合预估 岷沱江流域
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基于ADA、GR、VE、Hb、RBC的G6PD缺乏症列线图诊断模型构建及其诊断效能验证
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作者 吕碧绿 罗文英 《检验医学与临床》 2026年第3期358-365,共8页
目的基于血清腺苷脱氨酶(ADA)、谷胱甘肽还原酶(GR)、维生素E(VE)、血红蛋白(Hb)、红细胞计数(RBC)构建葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症列线图诊断模型,并进行效能验证。方法选取2022年9月1日至2024年12月31日在广东省茂名市妇幼保健... 目的基于血清腺苷脱氨酶(ADA)、谷胱甘肽还原酶(GR)、维生素E(VE)、血红蛋白(Hb)、红细胞计数(RBC)构建葡萄糖-6-磷酸脱氢酶(G6PD)缺乏症列线图诊断模型,并进行效能验证。方法选取2022年9月1日至2024年12月31日在广东省茂名市妇幼保健院接受G6PD筛查的521例就诊者作为研究对象,根据《葡萄糖-6-磷酸脱氢酶缺乏症新生儿筛查、诊断和治疗专家共识》中G6PD缺乏症的诊断标准将研究对象分为病例组(243例)和对照组(278例)。按7∶3比例采用分层抽样法将数据集随机分为训练集和验证集。收集所有研究对象的基线资料,并检测ADA、GR、VE水平。采用LASSO回归分析筛选变量,再用多因素Logistic回归分析G6PD缺乏症发生的影响因素,构建列线图诊断模型。绘制受试者工作特征(ROC)曲线、校准曲线及决策曲线对模型进行效能验证。结果训练集中病例组的总胆红素(TBIL)、直接胆红素(DBIL)、间接胆红素(IBIL)、ADA、GR水平高于对照组,VE、Hb水平及RBC低于对照组,差异均有统计学意义(P<0.05)。通过LASSO回归筛选出IBIL、DBIL、VE、ADA、GR、Hb、RBC作为核心变量,多因素Logistic回归分析结果显示,ADA、GR水平升高为G6PD缺乏症发生的独立危险因素(P<0.05),RBC、VE、Hb水平升高为G6PD缺乏症发生的独立保护因素(P<0.05)。据此构建的诊断模型表达式为Logit(P)=2.89-0.08 X_(VE)+0.85 X_(ADA)+0.92 X_(GR)-0.73 X_(Hb)-1.47 X_(RBC)。ROC曲线分析结果显示,G6PD缺乏症的列线图诊断模型在训练集中诊断G6PD缺乏症的曲线下面积(AUC)为0.98,在验证集中诊断G6PD缺乏症的AUC为0.99。Hosmer-Lemeshow检验结果为χ_(训练集)^(2)=4.12,P_(训练集)=0.763,χ_(验证集)^(2)=3.85,P_(验证集)=0.802,诊断概率与实际观察值高度贴合。训练集和验证集决策曲线分析结果显示,模型在阈值0.00~1.00内具有临床净收益。结论VE缺乏、ADA及GR水平升高、Hb及RBC水平降低与G6PD缺乏症密切相关,本研究构建的G6PD缺乏症列线图诊断模型具有较优的稳定性和诊断效能,为临床早期筛查提供了新工具。 展开更多
关键词 葡萄糖-6-磷酸脱氢酶缺乏症 腺苷脱氨酶 谷胱甘肽还原酶 维生素E 诊断模型
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A modified Johnson-Cook model for NC warm bending of large diameter thin-walled Ti-6Al-4V tube in wide ranges of strain rates and temperatures 被引量:7
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作者 陶智君 樊晓光 +2 位作者 杨合 马俊 李恒 《Transactions of Nonferrous Metals Society of China》 SCIE EI CAS CSCD 2018年第2期298-308,共11页
Numerical control(NC) warm bending is a proven strategy to form the large diameter thin-walled(LDTW) Ti-6 Al-4 V tubes, which are typical light-weight and high-performance structural components urgently required i... Numerical control(NC) warm bending is a proven strategy to form the large diameter thin-walled(LDTW) Ti-6 Al-4 V tubes, which are typical light-weight and high-performance structural components urgently required in many industries. In virtue of unveiling the thermo-mechanical coupled deformation behaviors, uniaxial tensile tests were conducted on Ti-6 Al-4 V tube within wide ranges of temperatures(25-600 ℃) and strain rates(0.00067-0.1 s~(-1)). Moreover, a modified Johnson-Cook(JC) model is proposed with a consideration of nonlinear strain rate hardening and the interaction between strain hardening and thermal softening. Resultantly, the present model gives more accurate predictions for flow stress over the entire deformation ranges and the maximum error decreases by about 90%. By employing proposed model to NC warm bending, preferable precision is obtained in predicting forming defects including fracture, wrinkling and over thinning. The present work lays foundation for the forming limit prediction and process optimization in NC warm bending of LDTW Ti-6 Al-4 V tubes. 展开更多
关键词 NC warm bending Ti-6Al-4V tube Johnson-Cook model
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Protective Effects of Oral Fructose-1, 6-diphosphate on Liver Injury in Animal Models
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作者 刘晓岩 李凤云 +1 位作者 池志宏 王银叶 《Journal of Chinese Pharmaceutical Sciences》 CAS 2006年第3期188-193,共6页
Aim To investigate the effects of FDP on different liver injury models to explore the possibility of FDP used as an oral liver protective agent. Methods Chronic liver injury model in rats was induced by carbon tetrach... Aim To investigate the effects of FDP on different liver injury models to explore the possibility of FDP used as an oral liver protective agent. Methods Chronic liver injury model in rats was induced by carbon tetrachloride ( CCl4 ) ; Acute liver injury model in mice was induced by aminogalactose (GAIN) or lipopolysaccharide (LPS). Results In CCl4-induced chronic liver injury model, FDP (1 , 4 g·kg^-1·d^-1, q.d., for 10 weeks) significantly lowered ALT, AST,γ-glutamyl transpeptidase (γ-GT), alkaline phosphatase (ALP), and total bilirubin (T-BIL) in serum compared with vehicle; simultaneously it evidently elevated abnormal total protein (TP), albumin (ALB) and total cholesterol ( T-CHO ) levels in serum; it also dose-dependently reduced hydroxyproline contents in hepatic tissue. 4 g·kg^-1·d^-1 of FDP apparently decreased incidence of hepatic cirrhosis, and alleviated pathological changes of liver tissue. In GaiN-induced model, 1.0 - 4. 0 g·kg^-1·d^-1 of FDP ( bid, for 3 d ) significantly lowered alanine aminotransferase ( ALT ) and aspartate aminotransferase ( AST ) levels in serum ; it also decreased liver coefficient. 4. 0 g·kg^-1·d^-1 of FDP significantly alleviated pathological changes of cell ultra-structures. In LPS-induced model, only high dose of FDP (4. 0 g·kg^-1·d^-1, bid, for 12 d) significantly decreased ALT level in serum. Conclusion This study first demonstrated the protective effect of oral FDP on chronic liver injury caused by CCl4, and confirmed its effect on acute liver injury at the same time, suggesting that Long-term oral FDP is efficacious against liver injury induced by different factors and can be used as an oral liver protective agent in clinic. 展开更多
关键词 liver injury oral fructose-1 6-diphosphate animal models
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18CrNiMo7-6合金钢表面变质层准静态本构参数确定 被引量:2
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作者 徐广涛 李灿 +3 位作者 路留成 张悦 王刚 李凌霄 《机械工程学报》 北大核心 2025年第6期184-193,共10页
基于逐层反演思想,提出一种确定表面变质层准静态本构参数的方法,使用该方法对渗碳热处理之后的18CrNiMo7-6合金钢表面变质层准静态本构参数进行确定。对基体样品进行渗碳热处理,使其表层微观结构发生改变形成表面变质层,进而对渗碳试... 基于逐层反演思想,提出一种确定表面变质层准静态本构参数的方法,使用该方法对渗碳热处理之后的18CrNiMo7-6合金钢表面变质层准静态本构参数进行确定。对基体样品进行渗碳热处理,使其表层微观结构发生改变形成表面变质层,进而对渗碳试样进行化学腐蚀剥层获取含有不同厚度表面变质层的圆棒试样。采用伺服疲劳试验机获取基体以及不同厚度表面变质层试样在25℃,应变率为0.0005s^(-1)下的应力应变关系。选用Johnson-Cook(J-C)本构模型,忽略应变率以及温度的影响,对18CrNiMo7-6合金钢的准静态力学性能进行描述,基于试验数据,结合遗传优化算法,确定表面变质层的J-C模型参数。结果表明,经过渗碳热处理后,试样的弹性模量没有展现出明显的差异,但其屈服强度以及抗拉强度明显增大。对表面变质层进行表征,给出了表面变质层的微观结构信息,从而揭示导致不同厚度表面变质层试样的力学性能展现出明显差异的物理本质。并通过有限元软件LS-DYNA对试样的准静态拉伸试验过程进行有限元模拟,验证了所得参数的可靠性,可为实际工程应用中的数值模拟计算问题提供重要依据。 展开更多
关键词 18CrNiMo7-6合金钢 表面变质层 Johnson-Cook本构模型 拉伸试验 有限元模拟
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LICOM Model Datasets for the CMIP6 Ocean Model Intercomparison Project 被引量:17
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作者 Pengfei LIN Zhipeng YU +14 位作者 Hailong LIU Yongqiang YU Yiwen LI Jirong JIANG Wei XUE Kangjun CHEN Qian YANG Bowen ZHAO Jilin WEI Mengrong DING Zhikuo SUN Yaqi WANG Yao MENG Weipeng ZHENG Jinfeng MA 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2020年第3期239-249,共11页
The datasets of two Ocean Model Intercomparison Project(OMIP)simulation experiments from the LASG/IAP Climate Ocean Model,version 3(LICOM3),forced by two different sets of atmospheric surface data,are described in thi... The datasets of two Ocean Model Intercomparison Project(OMIP)simulation experiments from the LASG/IAP Climate Ocean Model,version 3(LICOM3),forced by two different sets of atmospheric surface data,are described in this paper.The experiment forced by CORE-II(Co-ordinated Ocean–Ice Reference Experiments,Phase II)data(1948–2009)is called OMIP1,and that forced by JRA55-do(surface dataset for driving ocean–sea-ice models based on Japanese 55-year atmospheric reanalysis)data(1958–2018)is called OMIP2.First,the improvement of LICOM from CMIP5 to CMIP6 and the configurations of the two experiments are described.Second,the basic performances of the two experiments are validated using the climatological-mean and interannual time scales from observation.We find that the mean states,interannual variabilities,and long-term linear trends can be reproduced well by the two experiments.The differences between the two datasets are also discussed.Finally,the usage of these data is described.These datasets are helpful toward understanding the origin system bias of the fully coupled model. 展开更多
关键词 OMIP CMIP6 ocean sea-ice model model bias
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18CrNiMo7-6合金钢表面变质层动态本构模型的分层反演方法
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作者 徐广涛 李功 +2 位作者 常晓安 韩光照 赵明皞 《机械强度》 北大核心 2025年第9期54-61,共8页
针对18CrNiMo7-6合金钢表面变质层的静、动态力学行为表征问题,提出表面变质层(Surface-Modified Layer, SML)Johnson-Cook(J-C)本构模型分层反演方法。将SML进行分层处理,开展了含有不同表面变质层厚度的圆柱试样动态压缩试验;通过递... 针对18CrNiMo7-6合金钢表面变质层的静、动态力学行为表征问题,提出表面变质层(Surface-Modified Layer, SML)Johnson-Cook(J-C)本构模型分层反演方法。将SML进行分层处理,开展了含有不同表面变质层厚度的圆柱试样动态压缩试验;通过递进式参数反演,分别确定了SML各层深处的应变率敏感系数C;结合SML各层深处不同温度准静态薄板拉伸试验,确定了其对应的屈服强度A、应变硬化系数B、应变硬化指数n及热软化指数m。试验结果表明,18CrNiMo7-6合金钢SML呈明显的应变硬化、应变率强化及温度软化效应。此外,建立了J-C本构模型参数与无量纲深度h/hb(到SML表面的距离/SML有效深度)的关联模型,为后续的复合强化仿真提供支撑。 展开更多
关键词 表面变质层 Johnson-Cook本构模型 渗碳 18CrNiMo7-6合金钢
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