Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders....Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.展开更多
Despite being an excellent candidate for a photocathode,Cu_(2)ZnSnS_4(CZTS)performance is limited by suboptimal bulk and interfacial charge carrier dynamics.In this work,we introduce a facile and versatile CZTS precur...Despite being an excellent candidate for a photocathode,Cu_(2)ZnSnS_4(CZTS)performance is limited by suboptimal bulk and interfacial charge carrier dynamics.In this work,we introduce a facile and versatile CZTS precursor seed layer engineering technique,which significantly enhances crystal growth and mitigates detrimental defects in the postsulfurized CZTS light-absorbing films.This effective optimization of defects and charge carrier dynamics results in a highly efficient CZTS/CdS/TiO_(2)/Pt thin-film photocathode,achieving a record half-cell solar-to-hydrogen(HC-STH)conversion efficiency of 9.91%.Additionally,the photocathode exhibits a highest photocurrent density(J_(ph))of 29.44 m A cm^(-2)(at 0 VRHE)and favorable onset potential(Von)of 0.73 VRHE.Furthermore,our CTZS photocathode demonstrates a remarkable Jph of 16.54 m A cm^(-2)and HC-STH efficiency of 2.56%in natural seawater,followed by an impressive unbiased STH efficiency of 2.20%in a CZTS-BiVO_4 tandem cell.The scalability of this approach is underscored by the successful fabrication of a 4×4 cm^(2)module,highlighting its significant potential for practical,unbiased in situ solar seawater splitting applications.展开更多
Heterojunction engineering is recognized as a promising strategy to modulate the photocatalytic properties of semiconductors.Herein,lead-free Cs_(2)CuBr_(4)perovskite quantum dots(PQDs)were confined in a mesoporous Cu...Heterojunction engineering is recognized as a promising strategy to modulate the photocatalytic properties of semiconductors.Herein,lead-free Cs_(2)CuBr_(4)perovskite quantum dots(PQDs)were confined in a mesoporous CuO framework and a p-n type S-scheme heterojunction of Cs_(2)CuBr_(4)/CuO(CCB/CuO)photocatalyst was fabricated.Experimental characterizations confirmed the effective confinement of the Cs_(2)CuBr_(4)PQDs in the mesoporous CuO framework,which enabled intimate contact in the interface of CCB/CuO heterojunction,thus facilitating the interfacial charge migration and separation between p-type CuO and n-type Cs_(2)CuBr_(4).Owing to the outstanding charge transport property and CO_(2)adsorption capacity,the developed CCB/CuO heterojunction exhibited remarkably enhanced photocatalytic CO_(2)conversion efficiency with an electron consumption rate(R_(electron))of 281.1μmol g^(-1)h^(-1),which was approximately2.8 times higher than that of pristine Cs_(2)CuBr_(4).These findings provide some insights into the rational engineering design of lead-free perovskite-based heterostructures for efficient photocatalytic CO_(2)conversion.展开更多
The electrochemical CO_(2)reduction(ECR)to hydrocarbon products is an attractive pathway to decrease CO_(2)emission and advance a carbon-neutral process.Among the products of ECR,methane(CH_(4))stands out due to its h...The electrochemical CO_(2)reduction(ECR)to hydrocarbon products is an attractive pathway to decrease CO_(2)emission and advance a carbon-neutral process.Among the products of ECR,methane(CH_(4))stands out due to its high calorific value,serving as the main component of natural gas.However,the development of ECR catalysts capable of producing CH_(4)with both high activity and stability remains critically urgent.This review summarizes and explores the research progress and future application strategies for ECR toward CH_(4)production.Combining experiments,in-situ characterizations,and theoretical calculations,this review examines mechanism of CH_(4)formation in ECR.It then clarifies key factors affecting Cu-based catalysts for CH_(4)production,including facet dependence,size effects,and valence states.Next,this review details emerging strategies such as sub-nanoscale catalysts,Cu/oxides interface engineering,and Cu surface modification.Finally,future directions highlight in-situ characterization,reactor design,and high-throughput screening,guiding industrial CH_(4)production.展开更多
To recover titanium from tionite, a new process consisting of NaOH hydrothermal conversion, water washing, and H2SO4 leaching for TiO2 preparation was developed. The experimental results show that under the optimum ...To recover titanium from tionite, a new process consisting of NaOH hydrothermal conversion, water washing, and H2SO4 leaching for TiO2 preparation was developed. The experimental results show that under the optimum hydrothermal conversion conditions, i.e., 50% NaOH （mass fraction） solution, NaOH/tionite mass ratio of 4：1, reaction temperature of 240 ℃reaction time of 1 h and oxygen partial pressure of 0.25 MPa, the titanium was mainly converted into Na2TiO3, and the conversion was 97.2%. The unwanted product Na2TiSiO5 remained stable in water washing, and its formation was prevented by improving NaOH concentration. In water washing process, about 97.6% of Na＋ could be recycled by washing the hydrothermal product. The NaOH solutions could be reused after concentration. 96.7% of titanium in the washed product was easily leached in H2SO4 solution at low temperatures, forming titanyl sulfate solution to further prepare TiO2.展开更多
The construction of S‐scheme heterojunction photocatalysts has been regarded as an effective avenue to facilitate the conversion of solar energy to fuel.However,there are still considerable challenges with regard to ...The construction of S‐scheme heterojunction photocatalysts has been regarded as an effective avenue to facilitate the conversion of solar energy to fuel.However,there are still considerable challenges with regard to efficient charge transfer,the abundance of catalytic sites,and extended light absorption.Herein,an S‐scheme heterojunction of 2D/2D zinc porphyrin‐based metal‐organic frameworks/BiVO_(4)nanosheets(Zn‐MOF/BVON)was fabricated for efficient photocatalytic CO_(2)conversion.The optimal one shows a 22‐fold photoactivity enhancement when compared to the previously reported BiVO4 nanoflake(ca.15 nm),and even exhibits~2‐time improvement than the traditional g‐C3N4/BiVO4 heterojunction.The excellent photoactivities are ascribed to the strengthened S‐scheme charge transfer and separation,promoted CO_(2)activation by the well‐dispersed metal nodes Zn_(2)(COO)_(4)in the Zn‐MOF,and extended visible light response range based on the results of the electrochemical reduction,electron paramagnetic resonance,and in‐situ diffuse reflectance infrared Fourier transform spectroscopy.The dimension‐matched Zn‐MOF/BVON S‐scheme heterojunction endowed with highly efficient charge separation and abundant catalytic active sites contributed to the superior CO2 conversion.This study offers a facile strategy for constructing S‐scheme heterojunctions involving porphyrin‐based MOFs for solar fuel production.展开更多
The hierarchical ZnMn2O4/Mn3O4 composite sub-microrods were synthesized via a water-in-oil microemulsion method followed by calcination.The ZnMn2O4/Mn3O4 electrode displays an intriguing capacity increasing from 440 t...The hierarchical ZnMn2O4/Mn3O4 composite sub-microrods were synthesized via a water-in-oil microemulsion method followed by calcination.The ZnMn2O4/Mn3O4 electrode displays an intriguing capacity increasing from 440 to 910 mA·h/g at 500 mA/g during 550 consecutive discharge/charge cycles,and delivers an ultrahigh capacity of 1276 mA·h/g at 100 mA/g,which is much greater than the theoretical capacity of either ZnMn2O4 or Mn3O4 electrode.To investigate the underlying mechanism of this phenomenon,cyclic voltammetry and differential capacity analysis were applied,both of which reveal the emergence and the growth of new reversible redox reactions upon charge/discharge cycling.The new reversible conversions are probably the results of an activation process of the electrode material during the cycling process,leading to the climbing charge storage.However,the capacity exceeding the theoretical value indicates that there are still other factors contributing to the increasing capacity.展开更多
Wastewater treatment systems are important anthropogenic sources of CH4 emission. A full-scale experiment was carried out to monitor the CH4 emission from anoxic/anaerobic/oxic process （A2O） and sequencing batch rea...Wastewater treatment systems are important anthropogenic sources of CH4 emission. A full-scale experiment was carried out to monitor the CH4 emission from anoxic/anaerobic/oxic process （A2O） and sequencing batch reactor （SBR） wastewater treatment plants （WWTPs） for one year from May 2011 to April 2012. The main emission unit of the A2O process was an oxic tank, accounting for 76.2% of CH4 emissions; the main emission unit of the SBR process was the feeding and aeration phase, accounting for 99.5% of CH4 emissions. CH4 can be produced in the anaerobic condition, such as in the primary settling tank and anaerobic tank of the A2O process. While CH4 can be consumed in anoxic denitrification or the aeration condition, such as in the anoxic tank and oxic tank of the A2O process and the feeding and aeration phase of the SBR process. The CH4 emission flux and the dissolved CH4 concentration rapidly decreased in the oxic tank of the A2O process. These metrics increased during the first half of the phase and then decreased during the latter half of the phase in the feeding and aeration phase of the SBR process. The CH4 oxidation rate ranged from 32.47% to 89.52% （mean： 67.96%） in the A2O process and from 12.65% to 88.31% （mean： 47.62%） in the SBR process. The mean CH4 emission factors were 0.182 g/ton of wastewater and 24.75 g CH4/（person.year） for the A2O process, and 0.457 g/ton of wastewater and 36.55 g CH4/（person.year） for the SBR process.展开更多
Porous core-shell CoMn204 microspheres of ca. 3-5μm in diameter were synthesized and served as an-ode of lithium ion battery. Results demonstrate that the as-synthesized CoMn204 materials exhibit excel-lent electroch...Porous core-shell CoMn204 microspheres of ca. 3-5μm in diameter were synthesized and served as an-ode of lithium ion battery. Results demonstrate that the as-synthesized CoMn204 materials exhibit excel-lent electrochemical properties. The CoMn204 anode can deliver a large capacity of 1070 mAh g-1 in thefirst discharge, a reversible capacity of 500 mAh g^-1 after 100 cycles with a coulombic efficiency of 98.5% at a charge-discharge current density of 200 mA g^-l, and a specific capacity of 385 mAh g^-1 at a muchhigher charge-discharge current density of 1600mA g^-1. Synchrotron X-ray absorption fine structure（XAFS） techniques were applied to investigate the conversion reaction mechanism of the CoMn204 anode.The X-ray absorption near edge structure （XANES） spectra revealed that, in the first discharge-charge cy-cle, Co and Mn in CoMn204 were reduced to metallic Co and Mn when the electrode was discharged to0.01 V, while they were oxidized respectively to CoO and MnO when the electrode was charged to 3.0V.Experiments of both XANE5 and extended X-ray absorption fine structure （EXAFS） revealed that neithervalence evolution nor phase transition of the porous core-shell CoMn204 microspheres could happen inthe discharge plateau from 0.8 to 0.6V, which demonstrates the formation of solid electrolyte interface（SEI） on the anode.展开更多
基金supported by the Key Project of Guangzhou City,No.202206060002Science and Technology Project of Guangdong Province,No.2018B030332001Guangdong Provincial Pearl River Project,No.2021ZT09Y552 (all to GC)。
文摘Direct in vivo conversion of astrocytes into functional new neurons induced by neural transcription factors has been recognized as a potential new therapeutic intervention for neural injury and degenerative disorders. However, a few recent studies have claimed that neural transcription factors cannot convert astrocytes into neurons, attributing the converted neurons to pre-existing neurons mis-expressing transgenes. In this study, we overexpressed three distinct neural transcription factors––NeuroD1, Ascl1, and Dlx2––in reactive astrocytes in mouse cortices subjected to stab injury, resulting in a series of significant changes in astrocyte properties. Initially, the three neural transcription factors were exclusively expressed in the nuclei of astrocytes. Over time, however, these astrocytes gradually adopted neuronal morphology, and the neural transcription factors was gradually observed in the nuclei of neuron-like cells instead of astrocytes. Furthermore,we noted that transcription factor-infected astrocytes showed a progressive decrease in the expression of astrocytic markers AQP4(astrocyte endfeet signal), CX43(gap junction signal), and S100β. Importantly, none of these changes could be attributed to transgene leakage into preexisting neurons. Therefore, our findings suggest that neural transcription factors such as NeuroD1, Ascl1, and Dlx2 can effectively convert reactive astrocytes into neurons in the adult mammalian brain.
基金supported by National Natural Science Foundation of China(No.62474114,52472225)Guangdong Basic and Applied Basic Research Foundation(2025A1515012041,2025A1515011515)China+1 种基金Science and Technology plan project of Shenzhen(JCYJ20240813141620027,20231122102326002)ChinaShenzhen University 2035 Program for Excellent Research(Grants 2024B003)。
文摘Despite being an excellent candidate for a photocathode,Cu_(2)ZnSnS_4(CZTS)performance is limited by suboptimal bulk and interfacial charge carrier dynamics.In this work,we introduce a facile and versatile CZTS precursor seed layer engineering technique,which significantly enhances crystal growth and mitigates detrimental defects in the postsulfurized CZTS light-absorbing films.This effective optimization of defects and charge carrier dynamics results in a highly efficient CZTS/CdS/TiO_(2)/Pt thin-film photocathode,achieving a record half-cell solar-to-hydrogen(HC-STH)conversion efficiency of 9.91%.Additionally,the photocathode exhibits a highest photocurrent density(J_(ph))of 29.44 m A cm^(-2)(at 0 VRHE)and favorable onset potential(Von)of 0.73 VRHE.Furthermore,our CTZS photocathode demonstrates a remarkable Jph of 16.54 m A cm^(-2)and HC-STH efficiency of 2.56%in natural seawater,followed by an impressive unbiased STH efficiency of 2.20%in a CZTS-BiVO_4 tandem cell.The scalability of this approach is underscored by the successful fabrication of a 4×4 cm^(2)module,highlighting its significant potential for practical,unbiased in situ solar seawater splitting applications.
基金financially supported by Natural Science Foundation of Shanghai(No.22ZR1460700)Shanghai Institute of Technology(No.XTCX2022-28)。
文摘Heterojunction engineering is recognized as a promising strategy to modulate the photocatalytic properties of semiconductors.Herein,lead-free Cs_(2)CuBr_(4)perovskite quantum dots(PQDs)were confined in a mesoporous CuO framework and a p-n type S-scheme heterojunction of Cs_(2)CuBr_(4)/CuO(CCB/CuO)photocatalyst was fabricated.Experimental characterizations confirmed the effective confinement of the Cs_(2)CuBr_(4)PQDs in the mesoporous CuO framework,which enabled intimate contact in the interface of CCB/CuO heterojunction,thus facilitating the interfacial charge migration and separation between p-type CuO and n-type Cs_(2)CuBr_(4).Owing to the outstanding charge transport property and CO_(2)adsorption capacity,the developed CCB/CuO heterojunction exhibited remarkably enhanced photocatalytic CO_(2)conversion efficiency with an electron consumption rate(R_(electron))of 281.1μmol g^(-1)h^(-1),which was approximately2.8 times higher than that of pristine Cs_(2)CuBr_(4).These findings provide some insights into the rational engineering design of lead-free perovskite-based heterostructures for efficient photocatalytic CO_(2)conversion.
文摘The electrochemical CO_(2)reduction(ECR)to hydrocarbon products is an attractive pathway to decrease CO_(2)emission and advance a carbon-neutral process.Among the products of ECR,methane(CH_(4))stands out due to its high calorific value,serving as the main component of natural gas.However,the development of ECR catalysts capable of producing CH_(4)with both high activity and stability remains critically urgent.This review summarizes and explores the research progress and future application strategies for ECR toward CH_(4)production.Combining experiments,in-situ characterizations,and theoretical calculations,this review examines mechanism of CH_(4)formation in ECR.It then clarifies key factors affecting Cu-based catalysts for CH_(4)production,including facet dependence,size effects,and valence states.Next,this review details emerging strategies such as sub-nanoscale catalysts,Cu/oxides interface engineering,and Cu surface modification.Finally,future directions highlight in-situ characterization,reactor design,and high-throughput screening,guiding industrial CH_(4)production.
基金Project(51090380)supported by the National Natural Science Foundation of ChinaProjects(2013CB632604,2013CB632601)supported by the National Basic Research Program of China+2 种基金Project(51125018)supported by the National Science Foundation for Distinguished Young Scholars of ChinaProject(KGZD-EW-201-2)supported by the Key Research Program of the Chinese Academy of SciencesProjects(51374191,51402303)supported by the Natural Science Foundation for the Youth,China
文摘To recover titanium from tionite, a new process consisting of NaOH hydrothermal conversion, water washing, and H2SO4 leaching for TiO2 preparation was developed. The experimental results show that under the optimum hydrothermal conversion conditions, i.e., 50% NaOH （mass fraction） solution, NaOH/tionite mass ratio of 4：1, reaction temperature of 240 ℃reaction time of 1 h and oxygen partial pressure of 0.25 MPa, the titanium was mainly converted into Na2TiO3, and the conversion was 97.2%. The unwanted product Na2TiSiO5 remained stable in water washing, and its formation was prevented by improving NaOH concentration. In water washing process, about 97.6% of Na＋ could be recycled by washing the hydrothermal product. The NaOH solutions could be reused after concentration. 96.7% of titanium in the washed product was easily leached in H2SO4 solution at low temperatures, forming titanyl sulfate solution to further prepare TiO2.
文摘The construction of S‐scheme heterojunction photocatalysts has been regarded as an effective avenue to facilitate the conversion of solar energy to fuel.However,there are still considerable challenges with regard to efficient charge transfer,the abundance of catalytic sites,and extended light absorption.Herein,an S‐scheme heterojunction of 2D/2D zinc porphyrin‐based metal‐organic frameworks/BiVO_(4)nanosheets(Zn‐MOF/BVON)was fabricated for efficient photocatalytic CO_(2)conversion.The optimal one shows a 22‐fold photoactivity enhancement when compared to the previously reported BiVO4 nanoflake(ca.15 nm),and even exhibits~2‐time improvement than the traditional g‐C3N4/BiVO4 heterojunction.The excellent photoactivities are ascribed to the strengthened S‐scheme charge transfer and separation,promoted CO_(2)activation by the well‐dispersed metal nodes Zn_(2)(COO)_(4)in the Zn‐MOF,and extended visible light response range based on the results of the electrochemical reduction,electron paramagnetic resonance,and in‐situ diffuse reflectance infrared Fourier transform spectroscopy.The dimension‐matched Zn‐MOF/BVON S‐scheme heterojunction endowed with highly efficient charge separation and abundant catalytic active sites contributed to the superior CO2 conversion.This study offers a facile strategy for constructing S‐scheme heterojunctions involving porphyrin‐based MOFs for solar fuel production.
基金Ting-ting FENG acknowledges the financial support from Professor Paul V.BRAUN at Department of Materials Science and Engineering,University of Illinois at Urbana-Champaign,the support from Chinese Scholarship Council during her visit to University of Illinois at Urbana-Champaign,partial financial supports from Department of Science and Technology of Sichuan Province,China(2019YFH0002,2019YFG0222 and 2019YFG0526).The research was partly carried out in the Frederick Seitz Materials Research Laboratory Central Research Facilities,University of Illinois at Urbana-Champaign.
文摘The hierarchical ZnMn2O4/Mn3O4 composite sub-microrods were synthesized via a water-in-oil microemulsion method followed by calcination.The ZnMn2O4/Mn3O4 electrode displays an intriguing capacity increasing from 440 to 910 mA·h/g at 500 mA/g during 550 consecutive discharge/charge cycles,and delivers an ultrahigh capacity of 1276 mA·h/g at 100 mA/g,which is much greater than the theoretical capacity of either ZnMn2O4 or Mn3O4 electrode.To investigate the underlying mechanism of this phenomenon,cyclic voltammetry and differential capacity analysis were applied,both of which reveal the emergence and the growth of new reversible redox reactions upon charge/discharge cycling.The new reversible conversions are probably the results of an activation process of the electrode material during the cycling process,leading to the climbing charge storage.However,the capacity exceeding the theoretical value indicates that there are still other factors contributing to the increasing capacity.
基金supported by the Fundamental Research Funds for the Central Universities,China(No.TD2011-22)the China Welfare Funds for Environmental Protection(No.201009053)+1 种基金the Beijing Municipal Science and Technology Commission(No.Z111100058911003)the National Natural Science Fundation of China(No.51008023,51078034,51278051)
文摘Wastewater treatment systems are important anthropogenic sources of CH4 emission. A full-scale experiment was carried out to monitor the CH4 emission from anoxic/anaerobic/oxic process （A2O） and sequencing batch reactor （SBR） wastewater treatment plants （WWTPs） for one year from May 2011 to April 2012. The main emission unit of the A2O process was an oxic tank, accounting for 76.2% of CH4 emissions; the main emission unit of the SBR process was the feeding and aeration phase, accounting for 99.5% of CH4 emissions. CH4 can be produced in the anaerobic condition, such as in the primary settling tank and anaerobic tank of the A2O process. While CH4 can be consumed in anoxic denitrification or the aeration condition, such as in the anoxic tank and oxic tank of the A2O process and the feeding and aeration phase of the SBR process. The CH4 emission flux and the dissolved CH4 concentration rapidly decreased in the oxic tank of the A2O process. These metrics increased during the first half of the phase and then decreased during the latter half of the phase in the feeding and aeration phase of the SBR process. The CH4 oxidation rate ranged from 32.47% to 89.52% （mean： 67.96%） in the A2O process and from 12.65% to 88.31% （mean： 47.62%） in the SBR process. The mean CH4 emission factors were 0.182 g/ton of wastewater and 24.75 g CH4/（person.year） for the A2O process, and 0.457 g/ton of wastewater and 36.55 g CH4/（person.year） for the SBR process.
基金financially supported by NSFC (Grant Nos.21621091,21373008)the National Key Research and Development Program of China (2016YFB0100202)
文摘Porous core-shell CoMn204 microspheres of ca. 3-5μm in diameter were synthesized and served as an-ode of lithium ion battery. Results demonstrate that the as-synthesized CoMn204 materials exhibit excel-lent electrochemical properties. The CoMn204 anode can deliver a large capacity of 1070 mAh g-1 in thefirst discharge, a reversible capacity of 500 mAh g^-1 after 100 cycles with a coulombic efficiency of 98.5% at a charge-discharge current density of 200 mA g^-l, and a specific capacity of 385 mAh g^-1 at a muchhigher charge-discharge current density of 1600mA g^-1. Synchrotron X-ray absorption fine structure（XAFS） techniques were applied to investigate the conversion reaction mechanism of the CoMn204 anode.The X-ray absorption near edge structure （XANES） spectra revealed that, in the first discharge-charge cy-cle, Co and Mn in CoMn204 were reduced to metallic Co and Mn when the electrode was discharged to0.01 V, while they were oxidized respectively to CoO and MnO when the electrode was charged to 3.0V.Experiments of both XANE5 and extended X-ray absorption fine structure （EXAFS） revealed that neithervalence evolution nor phase transition of the porous core-shell CoMn204 microspheres could happen inthe discharge plateau from 0.8 to 0.6V, which demonstrates the formation of solid electrolyte interface（SEI） on the anode.
