An increasing number of physicians realize that chronic graft-versus-host disease(cGVHD)is not just dominated by T cells and that B cells also play a vital role in cGVHD development.It has been reported that altered B...An increasing number of physicians realize that chronic graft-versus-host disease(cGVHD)is not just dominated by T cells and that B cells also play a vital role in cGVHD development.It has been reported that altered B cell subsets,aberrant B cell signaling pathways,antibody deposition,and abnormal T-B interactions can be observed in many cGVHD patients.Studies of B cells in cGVHD development are now mainly focused on B cell subsets and GC destruction.These two aspects describe the process of B cell evolution in cGVHD patients and are associated with some original treatments.In this review,we summarize recent literature and discuss mechanisms and novel ideas of therapeutic strategies regarding the two aspects mentioned above.展开更多
Plasma immunoglobulin has been used widely in clinic for the prophylaxis and treatment of infections in patients after bone marrow transplantation(BMT).However,there are no hard data demonstrating that it can act agai...Plasma immunoglobulin has been used widely in clinic for the prophylaxis and treatment of infections in patients after bone marrow transplantation(BMT).However,there are no hard data demonstrating that it can act against GVHD,展开更多
基金supported by Army Key Foundation(No.AWS14C014)National Key research and development plan(No.2017YFA0105502)+3 种基金Chinese National Natural Science Foundation(No.81570097)National Natural Youth Science Foundation of China(No.81400081)Foundation of Xinqiao Hospital(2016D413)Clinical Foundation of Xinqiao Hospital(2015LYC02).
文摘An increasing number of physicians realize that chronic graft-versus-host disease(cGVHD)is not just dominated by T cells and that B cells also play a vital role in cGVHD development.It has been reported that altered B cell subsets,aberrant B cell signaling pathways,antibody deposition,and abnormal T-B interactions can be observed in many cGVHD patients.Studies of B cells in cGVHD development are now mainly focused on B cell subsets and GC destruction.These two aspects describe the process of B cell evolution in cGVHD patients and are associated with some original treatments.In this review,we summarize recent literature and discuss mechanisms and novel ideas of therapeutic strategies regarding the two aspects mentioned above.
文摘Plasma immunoglobulin has been used widely in clinic for the prophylaxis and treatment of infections in patients after bone marrow transplantation(BMT).However,there are no hard data demonstrating that it can act against GVHD,
