This article presents the network design schemes of CERNET2 including overall architecture, the backbone, core nodes, access solutions and the CNGI peer centers. CERNET2 connects 25 core nodes distributed in 20 cities...This article presents the network design schemes of CERNET2 including overall architecture, the backbone, core nodes, access solutions and the CNGI peer centers. CERNET2 connects 25 core nodes distributed in 20 cities of China at the speed of 2.5-10 Gb/s. CERNET2 has four unique features. First, its backbone adopts native IPv6 protocols, rather than IPv4/IPv6 dual stack. It is the largest pure IPv6 network in the world. Second, it provides an environment for testing and trial operation of China-made IPv6 core routers. It also allows tests of interconnection, interworking and interoperation among multiple vendors. Third, the large IPv6 address space enables the study on network addresses in a real network environment, which ensures the construction of a secured and trusted CNGI. Last, it is a test-bed for NGI applications.展开更多
A convenient photocatalytic multi-component reaction of alkenes,quinoxalin-2(1H)-ones,and diazo compounds has been developed in the presence of water.A number of ester-containing quinoxalin-2(1H)-ones could be efficie...A convenient photocatalytic multi-component reaction of alkenes,quinoxalin-2(1H)-ones,and diazo compounds has been developed in the presence of water.A number of ester-containing quinoxalin-2(1H)-ones could be efficiently obtained in moderate to good yields at room temperature.This metal-free visiblelight-driven tandem reaction was conducted through proton-coupled electron transfer(PCET)process using water as the hydrogen donor and 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4CzIPN)as the photocatalyst.展开更多
3-(4-Chlorophenyl)-7-[2-(piperazin-1-yl)ethoxy]-4H-chromen-4-one(CPEO-43)is a derivative of soybean isoflavone(SI),synthesized by introducing a chlorine atom and a piperazine group into the structure of natural SI.In ...3-(4-Chlorophenyl)-7-[2-(piperazin-1-yl)ethoxy]-4H-chromen-4-one(CPEO-43)is a derivative of soybean isoflavone(SI),synthesized by introducing a chlorine atom and a piperazine group into the structure of natural SI.In vitro experiments have demonstrated that CPEO-43 exhibits a notable inhibitory effect on both A549 cells and HCT116 cells.For the further development and utilization of CPEO-43,this study aims to establish and validate a liquid chromatography-tandem mass spectrometry(LC-MS/MS)quantitative analysis method for the pharmacokinetic study of CPEO-43.Normal rats were intragastrically administered different doses(2,6,and 20 mg/kg)of CPEO-43,and blood was taken from the ocular venous plexus at different time points.The blood concentration of CPEO-43 at different time points was determined using LC-MS/MS technology,and the pharmacokinetic parameters of the compound were calculated using the pharmacokinetic software DAS.The results indicated that the established LC-MS/MS method complies with the standards for bioanalytical method validation in the Chinese Pharmacopoeia(CHP)and can be applied to the pharmacokinetic study of CPEO-43.The pharmacokinetic software DAS non-compartmental model was successfully used to calculate the C_(max),T_(max),t_(1/2),AUC_(0-∞),MRTs,CL,and Vd pharmacokinetic parameters of the compound at different doses.The results were as follows:62.0±10.5,222.0±28.7,and 1384.5±376.4 ng/mL;8.5±1.2,6.0±0.0,and 11.0±6.2 h;15.6,15.0,and 18.5 h;1517.8±317.0,5328.7±864.4,and 45556.3±22735.6 ng·h/mL;17.8±1.2,17.7±0.8,and 20.0±3.2 h;1370.3±305.9,1153.5±205.6,and 505.3±179.8 mL/kg/h;30843.0±7458.0,24344.0±5237.0,and 13950.3±5996.9 mL/kg.These characteristics are of great significance for understanding the in vivo process of the drug,formulating dosing regimens,and evaluating the safety and efficacy of the drug.展开更多
The first example of sono-photocatalytic bond formation was reported.With both visible light and ultrasound wave as the energy,various 3-aminoquinoxalin-2(1H)-ones were efficiently obtained with good functional group ...The first example of sono-photocatalytic bond formation was reported.With both visible light and ultrasound wave as the energy,various 3-aminoquinoxalin-2(1H)-ones were efficiently obtained with good functional group tolerance in the absence of any additive or external photocatalyst.Compared with the conventional photocatalysis,sono-photocatalysis not only dramatically improved the reaction rates and yields,but also reduced energy consumption.展开更多
A facile visible-light-induced 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4Cz IPN)catalyzed fourcomponent reaction of alkenes,quinoxalin-2(1H)-ones,P4S10and alcohols has been developed at room temperature.This...A facile visible-light-induced 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4Cz IPN)catalyzed fourcomponent reaction of alkenes,quinoxalin-2(1H)-ones,P4S10and alcohols has been developed at room temperature.This tandem reaction provides an efficient strategy for the construction of various phosphorodithioate-containing quinoxalin-2(1H)-ones with moderate to good yields by using air(dioxygen)as the green oxidant.Experimental studies revealed a radical process was involved in this photochemical reaction.展开更多
文摘This article presents the network design schemes of CERNET2 including overall architecture, the backbone, core nodes, access solutions and the CNGI peer centers. CERNET2 connects 25 core nodes distributed in 20 cities of China at the speed of 2.5-10 Gb/s. CERNET2 has four unique features. First, its backbone adopts native IPv6 protocols, rather than IPv4/IPv6 dual stack. It is the largest pure IPv6 network in the world. Second, it provides an environment for testing and trial operation of China-made IPv6 core routers. It also allows tests of interconnection, interworking and interoperation among multiple vendors. Third, the large IPv6 address space enables the study on network addresses in a real network environment, which ensures the construction of a secured and trusted CNGI. Last, it is a test-bed for NGI applications.
基金supported by Sichuan Science and Technology Program(No.2023NSFSC0101)the 2024 Provincial platform project of Chengdu Normal University(No.GNFZ202404)+1 种基金Natural Science Foundation of Shandong Province(No.ZR2021MB065)National Natural Science Foundation of China(No.22101237)。
文摘A convenient photocatalytic multi-component reaction of alkenes,quinoxalin-2(1H)-ones,and diazo compounds has been developed in the presence of water.A number of ester-containing quinoxalin-2(1H)-ones could be efficiently obtained in moderate to good yields at room temperature.This metal-free visiblelight-driven tandem reaction was conducted through proton-coupled electron transfer(PCET)process using water as the hydrogen donor and 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4CzIPN)as the photocatalyst.
基金Scientific Research Projects of Hebei North University(Grant No.XJ2024022).
文摘3-(4-Chlorophenyl)-7-[2-(piperazin-1-yl)ethoxy]-4H-chromen-4-one(CPEO-43)is a derivative of soybean isoflavone(SI),synthesized by introducing a chlorine atom and a piperazine group into the structure of natural SI.In vitro experiments have demonstrated that CPEO-43 exhibits a notable inhibitory effect on both A549 cells and HCT116 cells.For the further development and utilization of CPEO-43,this study aims to establish and validate a liquid chromatography-tandem mass spectrometry(LC-MS/MS)quantitative analysis method for the pharmacokinetic study of CPEO-43.Normal rats were intragastrically administered different doses(2,6,and 20 mg/kg)of CPEO-43,and blood was taken from the ocular venous plexus at different time points.The blood concentration of CPEO-43 at different time points was determined using LC-MS/MS technology,and the pharmacokinetic parameters of the compound were calculated using the pharmacokinetic software DAS.The results indicated that the established LC-MS/MS method complies with the standards for bioanalytical method validation in the Chinese Pharmacopoeia(CHP)and can be applied to the pharmacokinetic study of CPEO-43.The pharmacokinetic software DAS non-compartmental model was successfully used to calculate the C_(max),T_(max),t_(1/2),AUC_(0-∞),MRTs,CL,and Vd pharmacokinetic parameters of the compound at different doses.The results were as follows:62.0±10.5,222.0±28.7,and 1384.5±376.4 ng/mL;8.5±1.2,6.0±0.0,and 11.0±6.2 h;15.6,15.0,and 18.5 h;1517.8±317.0,5328.7±864.4,and 45556.3±22735.6 ng·h/mL;17.8±1.2,17.7±0.8,and 20.0±3.2 h;1370.3±305.9,1153.5±205.6,and 505.3±179.8 mL/kg/h;30843.0±7458.0,24344.0±5237.0,and 13950.3±5996.9 mL/kg.These characteristics are of great significance for understanding the in vivo process of the drug,formulating dosing regimens,and evaluating the safety and efficacy of the drug.
基金financial support from the University of South China。
文摘The first example of sono-photocatalytic bond formation was reported.With both visible light and ultrasound wave as the energy,various 3-aminoquinoxalin-2(1H)-ones were efficiently obtained with good functional group tolerance in the absence of any additive or external photocatalyst.Compared with the conventional photocatalysis,sono-photocatalysis not only dramatically improved the reaction rates and yields,but also reduced energy consumption.
基金supported by Natural Science Foundation of Hunan Province(No.2024JJ7198)Science Research Excellent Youth Project of Hunan Provincial Department of Education(No.23B0751)+1 种基金Natural Science Foundation of Shandong Province(No.ZR2021MB065)National Natural Science Foundation of China(No.22101237)。
文摘A facile visible-light-induced 1,2,3,5-tetrakis(carbazol-9-yl)-4,6-dicyanobenzene(4Cz IPN)catalyzed fourcomponent reaction of alkenes,quinoxalin-2(1H)-ones,P4S10and alcohols has been developed at room temperature.This tandem reaction provides an efficient strategy for the construction of various phosphorodithioate-containing quinoxalin-2(1H)-ones with moderate to good yields by using air(dioxygen)as the green oxidant.Experimental studies revealed a radical process was involved in this photochemical reaction.
