胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研...胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研究了CEACAM8在胃癌预后中的作用。发现CEACAM8的过表达与胃癌患者的临床肿瘤分期和病理肿瘤分级显著相关。此外,CEACAM8 mRNA的高表达与胃癌患者较短的总生存期(OS)显著相关。总的来说,CEACAM8可能是胃癌患者生存的预后生物标志物。Gastric cancer directly affects human quality of life worldwide, and some members of the carcinoembryonic antigen-associated cell adhesion molecule (CEACAM) subfamily are not regulated in tumors. Little is known about the function of CEACAM8 in gastric cancer. In order to solve this problem, this study used UALCAN, Kaplan-Meier Plotter and metascape databases to study the role of CEACAM8 in the prognosis of gastric cancer. It was found that the overexpression of CEACAM8 was significantly correlated with the clinical tumor stage and pathological tumor grade of gastric cancer patients. In addition, high expression of CEACAM8 mRNA was significantly associated with shorter overall survival (OS) in patients with gastric cancer. Overall, CEACAM8 may be a prognostic biomarker for survival in patients with gastric cancer.展开更多
目的探讨血清癌胚抗原相关细胞粘附分子1(carcino-embryonic antigen related cellular adhesion molecule 1,CEACAM1)、四次跨膜蛋白1(transmembrane 4 L six family member 1,TM4SF1)在乳腺癌组织中的表达及诊断价值。方法收集乳腺癌9...目的探讨血清癌胚抗原相关细胞粘附分子1(carcino-embryonic antigen related cellular adhesion molecule 1,CEACAM1)、四次跨膜蛋白1(transmembrane 4 L six family member 1,TM4SF1)在乳腺癌组织中的表达及诊断价值。方法收集乳腺癌96例。采用酶联免疫吸附试验检测血清CEACAM1、TM4SF1水平。统计血清CEACAM1、TM4SF1水平与临床病理参数的关系及诊断效能。结果乳腺癌血清CEACAM1、TM4SF1水平与患者年龄、肿瘤直径、病理类型、雌激素受体、孕激素受体均无关,P>0.05,与病理分化程度、TNM分期、转移情况均有关。血清CEACAM1、TM4SF1水平联合诊断效能均较单一诊断效能高,P<0.05。结论血清CEACAM1、TM4SF1水平与乳腺癌病理分化程度、TNM分期、转移情况均有关,可作为肿瘤诊断标志物,联合诊断效能更高。展开更多
目的:探讨CEACAM1和OCT-4在膀胱移行上皮癌(transitional cell carcinoma of bladder,TCC)中的免疫组化表达及与膀胱癌病理分级、临床病理分期和预后的相关性。方法:随机选择2007年1月至2009年1月间62例TCC和12例正常膀胱黏膜病理切片...目的:探讨CEACAM1和OCT-4在膀胱移行上皮癌(transitional cell carcinoma of bladder,TCC)中的免疫组化表达及与膀胱癌病理分级、临床病理分期和预后的相关性。方法:随机选择2007年1月至2009年1月间62例TCC和12例正常膀胱黏膜病理切片用SP免疫组化行CEACAM1和OCT-4的检测,将结果与病理分级、临床分期和预后进行分析。结果:OCT-4在膀胱移行细胞癌中的阳性表达率明显高于正常膀胱黏膜(P<0.05),OCT-4在低分化、浸润性癌组织中的阳性表达率明显高于高分化、浅表性癌组织,在膀胱癌的病理分级和临床分期之间表达差异有统计学意义(P<0.05),而CEACAM1与之相反。CEACAM1和OCT-4在复发病例中的阳性表达率与初发病例之间无统计学意义(P>0.05)。结论:膀胱癌存在着CEACAM1表达的下调和OCT-4表达的上调,两者表达异常均与膀胱癌的病理分级和临床分期有关。CEACAM1和OCT-4可以作为判断TCCB的预后的肿瘤标记物。展开更多
文摘胃癌在世界范围内直接影响着人类的生活质量,癌胚抗原相关细胞粘附分子(CEACAM)亚家族的一些成员在肿瘤中不受调控。对于CEACAM8在胃癌中的功能知之甚少。为了解决这一问题,本研究使用UALCAN、Kaplan-Meier Plotter、metascape数据库研究了CEACAM8在胃癌预后中的作用。发现CEACAM8的过表达与胃癌患者的临床肿瘤分期和病理肿瘤分级显著相关。此外,CEACAM8 mRNA的高表达与胃癌患者较短的总生存期(OS)显著相关。总的来说,CEACAM8可能是胃癌患者生存的预后生物标志物。Gastric cancer directly affects human quality of life worldwide, and some members of the carcinoembryonic antigen-associated cell adhesion molecule (CEACAM) subfamily are not regulated in tumors. Little is known about the function of CEACAM8 in gastric cancer. In order to solve this problem, this study used UALCAN, Kaplan-Meier Plotter and metascape databases to study the role of CEACAM8 in the prognosis of gastric cancer. It was found that the overexpression of CEACAM8 was significantly correlated with the clinical tumor stage and pathological tumor grade of gastric cancer patients. In addition, high expression of CEACAM8 mRNA was significantly associated with shorter overall survival (OS) in patients with gastric cancer. Overall, CEACAM8 may be a prognostic biomarker for survival in patients with gastric cancer.
文摘目的探讨血清癌胚抗原相关细胞粘附分子1(carcino-embryonic antigen related cellular adhesion molecule 1,CEACAM1)、四次跨膜蛋白1(transmembrane 4 L six family member 1,TM4SF1)在乳腺癌组织中的表达及诊断价值。方法收集乳腺癌96例。采用酶联免疫吸附试验检测血清CEACAM1、TM4SF1水平。统计血清CEACAM1、TM4SF1水平与临床病理参数的关系及诊断效能。结果乳腺癌血清CEACAM1、TM4SF1水平与患者年龄、肿瘤直径、病理类型、雌激素受体、孕激素受体均无关,P>0.05,与病理分化程度、TNM分期、转移情况均有关。血清CEACAM1、TM4SF1水平联合诊断效能均较单一诊断效能高,P<0.05。结论血清CEACAM1、TM4SF1水平与乳腺癌病理分化程度、TNM分期、转移情况均有关,可作为肿瘤诊断标志物,联合诊断效能更高。
文摘目的:探讨CEACAM1和OCT-4在膀胱移行上皮癌(transitional cell carcinoma of bladder,TCC)中的免疫组化表达及与膀胱癌病理分级、临床病理分期和预后的相关性。方法:随机选择2007年1月至2009年1月间62例TCC和12例正常膀胱黏膜病理切片用SP免疫组化行CEACAM1和OCT-4的检测,将结果与病理分级、临床分期和预后进行分析。结果:OCT-4在膀胱移行细胞癌中的阳性表达率明显高于正常膀胱黏膜(P<0.05),OCT-4在低分化、浸润性癌组织中的阳性表达率明显高于高分化、浅表性癌组织,在膀胱癌的病理分级和临床分期之间表达差异有统计学意义(P<0.05),而CEACAM1与之相反。CEACAM1和OCT-4在复发病例中的阳性表达率与初发病例之间无统计学意义(P>0.05)。结论:膀胱癌存在着CEACAM1表达的下调和OCT-4表达的上调,两者表达异常均与膀胱癌的病理分级和临床分期有关。CEACAM1和OCT-4可以作为判断TCCB的预后的肿瘤标记物。
