As a rising immune checkpoint on tumor cells,CD24 is closely related to tumorigenesis and progression.CD24 can directly regulate the malignant behavior of tumor cells and indirectly inhibit the function of immune cell...As a rising immune checkpoint on tumor cells,CD24 is closely related to tumorigenesis and progression.CD24 can directly regulate the malignant behavior of tumor cells and indirectly inhibit the function of immune cells in the meantime,which promotes the immune escape of tumor cells,induces cancer invasion and causes poor prognosis.The basic principle of cancer treatment is to induce cell death and inhibit cell survival.Resistance to chemoradiotherapy is a critical challenge in oncology,which limits the effectiveness of anti-cancer treatments.Many studies have shown a strong association between CD24 and chemoradiotherapy resistance in tumor cells,but the specific mechanism remains unclear.Understanding the mechanisms that CD24 induces chemoradiotherapy resistance may allow us to develop new promising therapeutic strategies to enhance the efficacy of chemoradiotherapy and improve clinical outcomes in the treatment of cancer patients.In this review,we summarized the basic characteristics and functions of CD24,as well as its role in the development of cancer.We focused on the resistance to radiotherapy and chemotherapy mediated by CD24,deciphered fundamental mechanisms and introduced existing clinical studies,with an attempt to propose potential solutions for future explorations.展开更多
分化簇24(cluster of differentiation 24,CD24)是一种黏蛋白样磷脂酰肌醇锚定的表面蛋白,在大部分恶性肿瘤中高表达,通过多种机制促进肿瘤的发生及进展,并在肿瘤微环境中发挥重要作用,在体内外试验中已展现出较好的抗肿瘤治疗前景。本...分化簇24(cluster of differentiation 24,CD24)是一种黏蛋白样磷脂酰肌醇锚定的表面蛋白,在大部分恶性肿瘤中高表达,通过多种机制促进肿瘤的发生及进展,并在肿瘤微环境中发挥重要作用,在体内外试验中已展现出较好的抗肿瘤治疗前景。本文综述了CD24在肿瘤微环境中参与恶性肿瘤的生长、增殖、侵袭转移等方面的生物学行为,阐述以CD24为靶点的单克隆抗体、抗体偶联药物、嵌合抗原受体免疫疗法、纳米颗粒介导的药物递送等相关治疗策略,以期为CD24作为靶点的治疗提供参考。展开更多
基金supported by Health Commission of Hubei Province Scientific Research Project(No.WJ2023M068)Leading Discipline of Oncology Construction Project of Zhongnan Hospital of Wuhan University(No.XKJS202005)+8 种基金Youth Interdisciplinary Special Fund of Zhongnan Hospital of Wuhan University(No.ZNQNJC2022003)Knowledge Innovation Program of Wuhan-Shuguang Project(No.2023020201020510)Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNJC202322)Fundamental Research Funds for the Central Universities(Wuhan University,Clinical Medicine+X,2042024YXB017)Hubei Province Chinese Medicine Research Project(ZY2023Q015)Natural Science Foundation of Hubei Province(2023A FB665)Medical Young Talents Program of Hubei Province,Wuhan Young Medical Talents Training Project to L.-L.Bu,Youth Fund of the National Natural Science Foundation of China(82001644)Medical Young Talents Program of Hubei Province(7020206)“Dawn of Scientific and Technological Innovation”Program of Wuhan(703030804).
文摘As a rising immune checkpoint on tumor cells,CD24 is closely related to tumorigenesis and progression.CD24 can directly regulate the malignant behavior of tumor cells and indirectly inhibit the function of immune cells in the meantime,which promotes the immune escape of tumor cells,induces cancer invasion and causes poor prognosis.The basic principle of cancer treatment is to induce cell death and inhibit cell survival.Resistance to chemoradiotherapy is a critical challenge in oncology,which limits the effectiveness of anti-cancer treatments.Many studies have shown a strong association between CD24 and chemoradiotherapy resistance in tumor cells,but the specific mechanism remains unclear.Understanding the mechanisms that CD24 induces chemoradiotherapy resistance may allow us to develop new promising therapeutic strategies to enhance the efficacy of chemoradiotherapy and improve clinical outcomes in the treatment of cancer patients.In this review,we summarized the basic characteristics and functions of CD24,as well as its role in the development of cancer.We focused on the resistance to radiotherapy and chemotherapy mediated by CD24,deciphered fundamental mechanisms and introduced existing clinical studies,with an attempt to propose potential solutions for future explorations.
文摘分化簇24(cluster of differentiation 24,CD24)是一种黏蛋白样磷脂酰肌醇锚定的表面蛋白,在大部分恶性肿瘤中高表达,通过多种机制促进肿瘤的发生及进展,并在肿瘤微环境中发挥重要作用,在体内外试验中已展现出较好的抗肿瘤治疗前景。本文综述了CD24在肿瘤微环境中参与恶性肿瘤的生长、增殖、侵袭转移等方面的生物学行为,阐述以CD24为靶点的单克隆抗体、抗体偶联药物、嵌合抗原受体免疫疗法、纳米颗粒介导的药物递送等相关治疗策略,以期为CD24作为靶点的治疗提供参考。
