Porcine reproductive and respiratory syndrome virus （PRRSV） is a major pathogen that causes reproductive failure and respiratory disease in pigs, resulting in devastating economic losses worldwide. Porcine alveolar ...Porcine reproductive and respiratory syndrome virus （PRRSV） is a major pathogen that causes reproductive failure and respiratory disease in pigs, resulting in devastating economic losses worldwide. Porcine alveolar macrophages （PAMs） are the primary target cells of PRRSV , and the putative receptors, including CD163, CD169, and CD151, play key roles during infection . However, the understanding of PRRSV infection and pathogenesis is limited by its narrow host range. Pig is the unparalleled animal susceptible to PRRSV, but not well-suited for the study of long-term chronic infection or immune response in vivo because of their long breed- ing cvcle, size, high cost, and lack of biological materials.展开更多
基金supported in part by the National Key Research and Development Program of China (2017YFA0104401)the National Natural Science Foundation of China (31422037 and 31571522)
文摘Porcine reproductive and respiratory syndrome virus （PRRSV） is a major pathogen that causes reproductive failure and respiratory disease in pigs, resulting in devastating economic losses worldwide. Porcine alveolar macrophages （PAMs） are the primary target cells of PRRSV , and the putative receptors, including CD163, CD169, and CD151, play key roles during infection . However, the understanding of PRRSV infection and pathogenesis is limited by its narrow host range. Pig is the unparalleled animal susceptible to PRRSV, but not well-suited for the study of long-term chronic infection or immune response in vivo because of their long breed- ing cvcle, size, high cost, and lack of biological materials.
