Ceramics in general and particularly alumina （Al2O3） are important materials in various industries, but the main problem with these materials is related to some of their mechanical properties including low resistanc...Ceramics in general and particularly alumina （Al2O3） are important materials in various industries, but the main problem with these materials is related to some of their mechanical properties including low resistance against mechanical shock （hardness-toughness）, which makes them to be so brittle, and possession of high degree of porosity which reduces their strength and gives them fragile characteristics. Researchers report indicates that the presence of the second phase with suitable properties can improve some of the mechanical properties of these materials and optimize their characteristic. Carbon nanotubes with unique physical characteristics such as large aspect ratio, high strength and Young＇s modulus and improved thermal properties could be suitable candidates for this purpose. In this study, the growth of multi wall carbon nanotubes （MWCNTs） on the alumina support as the matrix of the composite has been carried out, using catalytic chemical vapor deposition （CCVD） method in which the iron nanoparticles has been selected as catalyst materials. Ethylene gas is used as feed materials for carbon source and argon as the carrier gas. In order to achieve a more comprehensive results, we have investigated the effects of some fabricating parameters like catalyst particle size, its weight percentage related to support material, alumina and to the some synthesizing temperature gases flow rate. Fabricated ceramics composites samples structures were analyzed using SEM images as well as Raman scattering spectra and X-ray diffraction pattern.展开更多
目的:基于网络药理学探究心脑宁胶囊治疗心脑血管疾病(Cardiovascular and cerebrovascular disease,CCVD)的作用机制。方法:本研究依托中药系统药理学平台及文献检索收集心脑宁胶囊所含化合物,通过类药五原则和生物利用度筛选活性化合...目的:基于网络药理学探究心脑宁胶囊治疗心脑血管疾病(Cardiovascular and cerebrovascular disease,CCVD)的作用机制。方法:本研究依托中药系统药理学平台及文献检索收集心脑宁胶囊所含化合物,通过类药五原则和生物利用度筛选活性化合物,采用Targetnet数据库及CTD数据库获得相关靶点及对应疾病。利用Cytoscape3.5.1网络可视化工具构建网络图。最终通过生物学信息注释库对关键靶点进行生物通路分析。结果:经筛选得到心脑宁胶囊中175个活性化合物,可通过作用于NOS2、NOS3、PTGS2及PTGS1等关键靶点调控VEGF、cAMP及PI3K-Akt等信号通路,对心肌梗塞、心力衰竭、动脉粥样硬化及脑缺血等疾病发挥作用,表明心脑宁胶囊的多成分、多通路共同作用于CCVD的治疗。结论:本研究有助于揭示心脑宁胶囊活性化合物的作用机制。展开更多
文摘Ceramics in general and particularly alumina （Al2O3） are important materials in various industries, but the main problem with these materials is related to some of their mechanical properties including low resistance against mechanical shock （hardness-toughness）, which makes them to be so brittle, and possession of high degree of porosity which reduces their strength and gives them fragile characteristics. Researchers report indicates that the presence of the second phase with suitable properties can improve some of the mechanical properties of these materials and optimize their characteristic. Carbon nanotubes with unique physical characteristics such as large aspect ratio, high strength and Young＇s modulus and improved thermal properties could be suitable candidates for this purpose. In this study, the growth of multi wall carbon nanotubes （MWCNTs） on the alumina support as the matrix of the composite has been carried out, using catalytic chemical vapor deposition （CCVD） method in which the iron nanoparticles has been selected as catalyst materials. Ethylene gas is used as feed materials for carbon source and argon as the carrier gas. In order to achieve a more comprehensive results, we have investigated the effects of some fabricating parameters like catalyst particle size, its weight percentage related to support material, alumina and to the some synthesizing temperature gases flow rate. Fabricated ceramics composites samples structures were analyzed using SEM images as well as Raman scattering spectra and X-ray diffraction pattern.
文摘目的:基于网络药理学探究心脑宁胶囊治疗心脑血管疾病(Cardiovascular and cerebrovascular disease,CCVD)的作用机制。方法:本研究依托中药系统药理学平台及文献检索收集心脑宁胶囊所含化合物,通过类药五原则和生物利用度筛选活性化合物,采用Targetnet数据库及CTD数据库获得相关靶点及对应疾病。利用Cytoscape3.5.1网络可视化工具构建网络图。最终通过生物学信息注释库对关键靶点进行生物通路分析。结果:经筛选得到心脑宁胶囊中175个活性化合物,可通过作用于NOS2、NOS3、PTGS2及PTGS1等关键靶点调控VEGF、cAMP及PI3K-Akt等信号通路,对心肌梗塞、心力衰竭、动脉粥样硬化及脑缺血等疾病发挥作用,表明心脑宁胶囊的多成分、多通路共同作用于CCVD的治疗。结论:本研究有助于揭示心脑宁胶囊活性化合物的作用机制。
