Osteoporosis represents a growing public health challenge in ageing societies,resulting in serious health threats and economic burdens.Fermented dairy products have shown the potential as an intervention strategy for ...Osteoporosis represents a growing public health challenge in ageing societies,resulting in serious health threats and economic burdens.Fermented dairy products have shown the potential as an intervention strategy for osteoporosis.The present work aimed to evaluate the effect of whey from fermented milk by Lactobacillus hel-veticus in ovariectomized rats.The results demonstrated that whey from L.helveticus CCFM1263-fermented milk markedly increased bone mineral density,restored trabecular microarchitecture(p<0.05),as well as prevented fluctuations in bone turnover markers.Based on metabolomic analysis,whey from fermented milk by L.helveticus CCFM1263 significantly reshaped the systemic metabolic profile(p<0.05),and increased the levels of aden-osine,arginine,and tryptophan.Additionally,the intervention effectively reversed the ovariectomy-induced depletion of serum bile acids,specifically restoring cholic acid and lithocholic acid levels.Together,our re-sults suggested that whey from fermented milk by L.helveticus CCFM1263 ameliorated osteoporosis and had potential for intervene with the onset and progression of postmenopausal osteoporosis.展开更多
基金supported by the National Natural Science Foundation of China(No.32472347)Jiangsu Provincial Policy Guidance Programme-International Cooperation Projects(No.BZ2024045).
文摘Osteoporosis represents a growing public health challenge in ageing societies,resulting in serious health threats and economic burdens.Fermented dairy products have shown the potential as an intervention strategy for osteoporosis.The present work aimed to evaluate the effect of whey from fermented milk by Lactobacillus hel-veticus in ovariectomized rats.The results demonstrated that whey from L.helveticus CCFM1263-fermented milk markedly increased bone mineral density,restored trabecular microarchitecture(p<0.05),as well as prevented fluctuations in bone turnover markers.Based on metabolomic analysis,whey from fermented milk by L.helveticus CCFM1263 significantly reshaped the systemic metabolic profile(p<0.05),and increased the levels of aden-osine,arginine,and tryptophan.Additionally,the intervention effectively reversed the ovariectomy-induced depletion of serum bile acids,specifically restoring cholic acid and lithocholic acid levels.Together,our re-sults suggested that whey from fermented milk by L.helveticus CCFM1263 ameliorated osteoporosis and had potential for intervene with the onset and progression of postmenopausal osteoporosis.
