The United States Food and Drug Administration's(FDA's)August 2024 determination that an additional phase Ⅱ study will be required to consider the approval of midomafetamine for the treatment of posttraumatic...The United States Food and Drug Administration's(FDA's)August 2024 determination that an additional phase Ⅱ study will be required to consider the approval of midomafetamine for the treatment of posttraumatic stress disorder(PTSD)could delay the potential approval of this promising treatment by several years.展开更多
British English and American English are regarded as the two major varieties of English in the world, and Canadian English is often treated as a variation of American English. The paper aims to identify the major phon...British English and American English are regarded as the two major varieties of English in the world, and Canadian English is often treated as a variation of American English. The paper aims to identify the major phonetic features of Canadian English by addressing its differences from British and American English based on a historical, demographical, and regional and dialectal analysis. Canadian English is a cultural phenomenon that has evolved on the basis of British English and under the heavy influence of American English. As a distinctive variety of English, Canadian English possesses its phonetic uniqueness. And in the context of globalization, Canadian English will remain subject to Americanization.展开更多
安德烈·波切利无疑有着敏锐的艺术和歌唱方面的嗅觉力。通常，他公开夸奖的歌手是不多的；而但凡被夸过的，则一定也拥有不容小觑的实力。“世界最完美的跨界古典与流行的男声组合”这句话夸的是来自加拿大的天籁男伶四人演唱组合...安德烈·波切利无疑有着敏锐的艺术和歌唱方面的嗅觉力。通常，他公开夸奖的歌手是不多的；而但凡被夸过的，则一定也拥有不容小觑的实力。“世界最完美的跨界古典与流行的男声组合”这句话夸的是来自加拿大的天籁男伶四人演唱组合（The canadian Tenors）。而这个组台．也是近年来在跨界歌坛走红速度飞快的团体。展开更多
在经济全球化背景下,出于贸易交流、文化传播等活动的需要,世界语言—英语被广泛学习。各国语言学家粗略地把英语分为英国英语和美国英语两大变体。因为美国的强国地位及其好莱坞效应,美国英语在各种场合较之英国英语被更广泛使用。而...在经济全球化背景下,出于贸易交流、文化传播等活动的需要,世界语言—英语被广泛学习。各国语言学家粗略地把英语分为英国英语和美国英语两大变体。因为美国的强国地位及其好莱坞效应,美国英语在各种场合较之英国英语被更广泛使用。而在与美国接壤的加拿大,一直被语言学家定义为以英国英语为基础,受美国英语强烈影响的加拿大英语仍在全球化背景下保持着自己的语言特色。文章通过对Guide to Canadian English Usage(第二版)的解析,粗略列举加拿大英语中现存的特色词汇并与英、美英语进行比较、分析。展开更多
210pb was measured during the 3rd Chinese National Arctic Research Expedition cruise to investigate its spa- tial pattern in the western Arctic Ocean, as well as its relation with the thermocline in the Canadian Basin...210pb was measured during the 3rd Chinese National Arctic Research Expedition cruise to investigate its spa- tial pattern in the western Arctic Ocean, as well as its relation with the thermocline in the Canadian Basin. The specific activities varied from 0.04 to 2.72, 〈0.013 to 4.37, and 0.1 to 4.85 Bq/m3 for dissolved, particu- late, and bulk 210pb, respectively, corresponding to respective averages of 0.65, 0.43, and 1.08 Bq/m3. In the Canadian Basin, the minimum 210pb activities occurred in the thermocline, which was characterized by low temperature of-1.52℃ and salinity of 33.1. Combining the spatial distribution of 210pb and hydrographical characteristics in the western Arctic Ocean, this scenario was ascribed to the effective scavenging of 210pb when the Pacific water flowed across the Chukchi Shelf. Quantitatively, this interpretation was supported by both the shorter residence times and higher scavenging efficiencies （SE） of dissolved 210pb over the Chukchi Shelf. The highest SE values were observed in the Herald Shoal and bottom waters over the slope.展开更多
Ground Penetrating Radar （GPR） measurements of sea ice thickness including undeformed ice and ridged ice were carried out in the central north Canadian Archipelago in spring 2010. Results have shown a significant sp...Ground Penetrating Radar （GPR） measurements of sea ice thickness including undeformed ice and ridged ice were carried out in the central north Canadian Archipelago in spring 2010. Results have shown a significant spatial heterogeneity of sea ice thickness across the shelf. The undeformed multi-year fast ice of （2.05±0.09） m thick was investigated southern inshore zone of Borden island located at middle of the observational section, which was the observed maximum thickness in the field work. The less thick sea ice was sampled across a flaw lead with the thicknesses of （1.05±0.11） m for the pack ice and （1.24±0.13） m for the fast ice. At the northernmost spot of the section, the undeformed multi-year pack ice was （1.54±0.22） m thick with a ridged ice of 2.5 to 3 m, comparing to the multi-year fast ice with the thickness of （1.67±0.16） m at the southernmost station in the Prince Gustaf Adolf Sea.展开更多
Canadian iron concentrate(CIC)can elevate the ferrous grade and lower the contents of gangue components and harmful elements in the sinter.To understand high-temperature characteristics of CIC and typical iron ore,the...Canadian iron concentrate(CIC)can elevate the ferrous grade and lower the contents of gangue components and harmful elements in the sinter.To understand high-temperature characteristics of CIC and typical iron ore,the formation of the melt was calculated mainly through FactSage 7.2,and melt fluidity(MF)test for iron ore fines and penetration characteristic test of CIC melt into iron ore nuclei were carried out via micro-sintering method.The results show that hematite,calcium ferrites,dicalcium silicate,and magnetite take part in the formation of the melt in N2.The formation temperature of the liquid for CIC is higher than that for hematite/limonite ore.The MF of CIC is lower than that of hematite/limonite ore fines.The MF of hematite/limonite ore fines is dominated by the liquid amount and melt viscosity.The penetration depth(PD)of CIC melt into limonite ore nuclei is smaller than that into hematite ore nuclei.The PD is related to the reaction ability of the nuclei with the melt.Based on above results,sinter pot tests were conducted.The result shows that in the base ore blends including two hematite ores and two limonite ores,adding CIC deteriorates the sintering indexes.Increasing the proportion of high-MF and small-PD hematite ore can significantly improve the sintering indexes.10 mass%is a suit-able proportion for adding CIC in ore blends.展开更多
OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older adults.METHODS 26,954 individuals aged 45-85 years from t...OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older adults.METHODS 26,954 individuals aged 45-85 years from the baseline data of the Canadian Longitudinal Study for Aging were in-cluded in this study.DoFA was categorized into five groups by answer to the question“Over the last month,how often did it take you more than 30 min to fall asleep?”Response options are“Never,<1 time/week,1−2 times/week,3−5 times/week,or 6−7 times/week”.Non-HDL-C,the difference of total cholesterol and HDL-C,were categorized into five categories based on these cut-offs(<2.6 mmol/L,2.6−3.7 mmol/L,3.7−4.8 mmol/L,4.8−5.7 mmol/L,and≥5.7 mmol/L).Ordinal logistic regression(logit link)continuation ratio models were used to estimate the odds of higher non-HDL-C levels for DoFA status.Adjusted means of non-HDL-C by DoFA status were estimated by general linear models.All analyses were sex separately using analytic weights to en-sure generalizability.RESULTS The proportions of DoFA in five categories were 41.6%,25.7%,13.6%,9.4%,9.7%for females and 52.9%,24.9%,10.5%,6.1%,5.6%for males,respectively.After adjustment of demographical and other covariates(such as depression,comorbidity,sleeping hour,etc.)compared to those who reported never having DoFA,the ORs(95%CIs)of higher levels of non-HDL-C for those whose DoFA status in<1 time/week,1−2 times/week,3−5 times/week,and 6−7 times/week were 1.12(1.05−1.21),1.09(0.99−1.18),1.20(1.09−1.33),1.29(1.17−1.43)in females and 1.05(0.98−1.13),0.95(0.87−1.05),1.21(1.08−1.37),0.97(0.85−1.09)in males,respectively.The adjusted means of non-HDL-C among the five DoFA status were 3.68 mmol/L,3.73 mmol/L,3.74 mmol/L,3.82 mmol/L,3.84 mmol/L for females and 3.54 mmol/L,3.58 mmol/L,3.51 mmol/L,3.69 mmol/L,3.54 mmol/L for males,respectively.CONCLUSIONS The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females but not in males.Further research is needed to confirm these findings.展开更多
The occurrence percentage and abundance of General Aerobic Hetero- trophic Bacteria （GAB） were determined by using the method of MPN for 182 sub- samples from 10 sediment cores taken from the Canadian basin and the ...The occurrence percentage and abundance of General Aerobic Hetero- trophic Bacteria （GAB） were determined by using the method of MPN for 182 sub- samples from 10 sediment cores taken from the Canadian basin and the Chukchi Sea at two different culturing temperatures. The results showed that the general occurrence percentage of GAB was quite high, average abundanees of GAB at cultured temperatares of 4℃ and 25℃ were 4.46 ×10^7 and 5.47×10^7 cells·g^-1（wt）, respectively. The highest abundance of GAB occurred at 20 -22 cm section in the sediment. GAB abundances changed among the section of sediments, but there is a trend ： the a-bundances at the middle or lower sections were lower than those at upper section. Cultivation at 25℃ could improve the occurrence percentage and abundances of GAB, which suggests that the increasing of temperature may change the living circum-stances of GAB. The differences of GAB among the latitudes areas indicated that occurrence percentage and abundances of GAB in middle latitude areas were higher than those in the higher or lower latitude areas, and were more obvious at 4℃ than those at 25℃. The GAB abundances in sediment under the shallower water seemed to be low- er than those in sediments under the deeper water and this status was more obvious at 25℃ than that at 4℃.展开更多
With the rapid progress of modernization in the human society,the contradiction between economic development and ecological harmony has become a global problem.The Canadian literature contains a lot of ecological phil...With the rapid progress of modernization in the human society,the contradiction between economic development and ecological harmony has become a global problem.The Canadian literature contains a lot of ecological philosophy,which includes the love of nature,the care for animals and the spiritual ecology.Literary writers in Canada write about the relationship between man and nature,man and animals as well as the relationship among different people in the society.Under the three perspectives mentioned above,writers reveal many serious ecological problems.Using Canadian Literature as an example,we can dig out some valuable ecological ideas.These are very helpful for us to solve the increasingly serious crisis related to ecology.展开更多
Time:June 7-10,2020,Venue:Banff,Alberta,Canada,Website:http://congress.cnsfederation.org/The 55th Canadian Neurological Sciences Federation(CNSF)Congress 2020 will take place in Banff,Alberta,Canada on June7-10,2020.T...Time:June 7-10,2020,Venue:Banff,Alberta,Canada,Website:http://congress.cnsfederation.org/The 55th Canadian Neurological Sciences Federation(CNSF)Congress 2020 will take place in Banff,Alberta,Canada on June7-10,2020.This is a collegial meeting providing multidisciplinary courses relevant to all neuroscience specialties.展开更多
Data on Late Cenomanian and Early Turonian foraminiferal assemblages in the northern palaeo biogeographical district of the West Siberian province are summarized in the paper. In addition, the section of borehole 1016...Data on Late Cenomanian and Early Turonian foraminiferal assemblages in the northern palaeo biogeographical district of the West Siberian province are summarized in the paper. In addition, the section of borehole 1016 of the Parusovaya area located in the far north of the province is considered. New information on the foraminiferal zones of this stratigraphic level along with the previously known sections of the Tazovskaya, Purpeiskaya, Van-Eganskaya areas provided an opportunity to carry out a correlation of these zones between the West Siberian and the Canadian provinces (Western Canada, Northern Alaska). The West Siberian Late Cenomanian Trochammina wetteri tumida, Verneuilinoides kansasensis and the Early Turonian Gaudryinopsis angustus foraminiferal zones have their analogues as similar zones in the Canadian province. Due to the provided correlation of the micropalaeontological (foraminiferal) zones, their age in the West Siberian province has been clarified. Besides, similarity of the conditions of dwelling within the boundaries of the entire Arctic palaeobiogeographical realm has been observed.展开更多
文摘The United States Food and Drug Administration's(FDA's)August 2024 determination that an additional phase Ⅱ study will be required to consider the approval of midomafetamine for the treatment of posttraumatic stress disorder(PTSD)could delay the potential approval of this promising treatment by several years.
文摘British English and American English are regarded as the two major varieties of English in the world, and Canadian English is often treated as a variation of American English. The paper aims to identify the major phonetic features of Canadian English by addressing its differences from British and American English based on a historical, demographical, and regional and dialectal analysis. Canadian English is a cultural phenomenon that has evolved on the basis of British English and under the heavy influence of American English. As a distinctive variety of English, Canadian English possesses its phonetic uniqueness. And in the context of globalization, Canadian English will remain subject to Americanization.
文摘安德烈·波切利无疑有着敏锐的艺术和歌唱方面的嗅觉力。通常，他公开夸奖的歌手是不多的；而但凡被夸过的，则一定也拥有不容小觑的实力。“世界最完美的跨界古典与流行的男声组合”这句话夸的是来自加拿大的天籁男伶四人演唱组合（The canadian Tenors）。而这个组台．也是近年来在跨界歌坛走红速度飞快的团体。
文摘在经济全球化背景下,出于贸易交流、文化传播等活动的需要,世界语言—英语被广泛学习。各国语言学家粗略地把英语分为英国英语和美国英语两大变体。因为美国的强国地位及其好莱坞效应,美国英语在各种场合较之英国英语被更广泛使用。而在与美国接壤的加拿大,一直被语言学家定义为以英国英语为基础,受美国英语强烈影响的加拿大英语仍在全球化背景下保持着自己的语言特色。文章通过对Guide to Canadian English Usage(第二版)的解析,粗略列举加拿大英语中现存的特色词汇并与英、美英语进行比较、分析。
基金The Chinese Polar Environment Comprehensive Investigation and Assessment Programs under contract No.CHINARE2014-03-04-03the National Natural Science Foundation of China under contract No.41125020+1 种基金the 4th Chinese Arctic Research Programthe Polar Science Strategic Research Foundation of China under contract No.20120307
文摘210pb was measured during the 3rd Chinese National Arctic Research Expedition cruise to investigate its spa- tial pattern in the western Arctic Ocean, as well as its relation with the thermocline in the Canadian Basin. The specific activities varied from 0.04 to 2.72, 〈0.013 to 4.37, and 0.1 to 4.85 Bq/m3 for dissolved, particu- late, and bulk 210pb, respectively, corresponding to respective averages of 0.65, 0.43, and 1.08 Bq/m3. In the Canadian Basin, the minimum 210pb activities occurred in the thermocline, which was characterized by low temperature of-1.52℃ and salinity of 33.1. Combining the spatial distribution of 210pb and hydrographical characteristics in the western Arctic Ocean, this scenario was ascribed to the effective scavenging of 210pb when the Pacific water flowed across the Chukchi Shelf. Quantitatively, this interpretation was supported by both the shorter residence times and higher scavenging efficiencies （SE） of dissolved 210pb over the Chukchi Shelf. The highest SE values were observed in the Herald Shoal and bottom waters over the slope.
基金The National Natural Science Foundation of China under contract No.41206174China Postdoctoral Science Foundation under contract No.2012M511546the Key Project of Chinese National Science Fundation under contract No.41330960
文摘Ground Penetrating Radar （GPR） measurements of sea ice thickness including undeformed ice and ridged ice were carried out in the central north Canadian Archipelago in spring 2010. Results have shown a significant spatial heterogeneity of sea ice thickness across the shelf. The undeformed multi-year fast ice of （2.05±0.09） m thick was investigated southern inshore zone of Borden island located at middle of the observational section, which was the observed maximum thickness in the field work. The less thick sea ice was sampled across a flaw lead with the thicknesses of （1.05±0.11） m for the pack ice and （1.24±0.13） m for the fast ice. At the northernmost spot of the section, the undeformed multi-year pack ice was （1.54±0.22） m thick with a ridged ice of 2.5 to 3 m, comparing to the multi-year fast ice with the thickness of （1.67±0.16） m at the southernmost station in the Prince Gustaf Adolf Sea.
基金The authors are grateful for the financial support of the Fundamental Research Funds for the Central Universities(Grant No.FRF-IC-18-010).
文摘Canadian iron concentrate(CIC)can elevate the ferrous grade and lower the contents of gangue components and harmful elements in the sinter.To understand high-temperature characteristics of CIC and typical iron ore,the formation of the melt was calculated mainly through FactSage 7.2,and melt fluidity(MF)test for iron ore fines and penetration characteristic test of CIC melt into iron ore nuclei were carried out via micro-sintering method.The results show that hematite,calcium ferrites,dicalcium silicate,and magnetite take part in the formation of the melt in N2.The formation temperature of the liquid for CIC is higher than that for hematite/limonite ore.The MF of CIC is lower than that of hematite/limonite ore fines.The MF of hematite/limonite ore fines is dominated by the liquid amount and melt viscosity.The penetration depth(PD)of CIC melt into limonite ore nuclei is smaller than that into hematite ore nuclei.The PD is related to the reaction ability of the nuclei with the melt.Based on above results,sinter pot tests were conducted.The result shows that in the base ore blends including two hematite ores and two limonite ores,adding CIC deteriorates the sintering indexes.Increasing the proportion of high-MF and small-PD hematite ore can significantly improve the sintering indexes.10 mass%is a suit-able proportion for adding CIC in ore blends.
基金the Government of Canada through the Canadian Institutes of Health Research(CLSA 94473)and the Canada Foundation for Innovation.
文摘OBJECTIVE To examine whether difficulty of falling asleep(DoFA)is associated with non-high-density lipoprotein cholesterol(non-HDL-C)level among Canadian older adults.METHODS 26,954 individuals aged 45-85 years from the baseline data of the Canadian Longitudinal Study for Aging were in-cluded in this study.DoFA was categorized into five groups by answer to the question“Over the last month,how often did it take you more than 30 min to fall asleep?”Response options are“Never,<1 time/week,1−2 times/week,3−5 times/week,or 6−7 times/week”.Non-HDL-C,the difference of total cholesterol and HDL-C,were categorized into five categories based on these cut-offs(<2.6 mmol/L,2.6−3.7 mmol/L,3.7−4.8 mmol/L,4.8−5.7 mmol/L,and≥5.7 mmol/L).Ordinal logistic regression(logit link)continuation ratio models were used to estimate the odds of higher non-HDL-C levels for DoFA status.Adjusted means of non-HDL-C by DoFA status were estimated by general linear models.All analyses were sex separately using analytic weights to en-sure generalizability.RESULTS The proportions of DoFA in five categories were 41.6%,25.7%,13.6%,9.4%,9.7%for females and 52.9%,24.9%,10.5%,6.1%,5.6%for males,respectively.After adjustment of demographical and other covariates(such as depression,comorbidity,sleeping hour,etc.)compared to those who reported never having DoFA,the ORs(95%CIs)of higher levels of non-HDL-C for those whose DoFA status in<1 time/week,1−2 times/week,3−5 times/week,and 6−7 times/week were 1.12(1.05−1.21),1.09(0.99−1.18),1.20(1.09−1.33),1.29(1.17−1.43)in females and 1.05(0.98−1.13),0.95(0.87−1.05),1.21(1.08−1.37),0.97(0.85−1.09)in males,respectively.The adjusted means of non-HDL-C among the five DoFA status were 3.68 mmol/L,3.73 mmol/L,3.74 mmol/L,3.82 mmol/L,3.84 mmol/L for females and 3.54 mmol/L,3.58 mmol/L,3.51 mmol/L,3.69 mmol/L,3.54 mmol/L for males,respectively.CONCLUSIONS The results of this study have identified a risk association pattern between DoFA status and non-HDL-C levels in females but not in males.Further research is needed to confirm these findings.
基金sponsored by the national ministry of finance.And as a part of the second Arctic research expedition(CHINARE-2003) which is organized by Polar Expedition Office of State Oceanic Administration of China,we would like to thank the crew on RV Xuelong for their support and assistance.Research funds are supplied by National Natural Science Foundation of China(No.40576060,40376017 and 40176017).
文摘The occurrence percentage and abundance of General Aerobic Hetero- trophic Bacteria （GAB） were determined by using the method of MPN for 182 sub- samples from 10 sediment cores taken from the Canadian basin and the Chukchi Sea at two different culturing temperatures. The results showed that the general occurrence percentage of GAB was quite high, average abundanees of GAB at cultured temperatares of 4℃ and 25℃ were 4.46 ×10^7 and 5.47×10^7 cells·g^-1（wt）, respectively. The highest abundance of GAB occurred at 20 -22 cm section in the sediment. GAB abundances changed among the section of sediments, but there is a trend ： the a-bundances at the middle or lower sections were lower than those at upper section. Cultivation at 25℃ could improve the occurrence percentage and abundances of GAB, which suggests that the increasing of temperature may change the living circum-stances of GAB. The differences of GAB among the latitudes areas indicated that occurrence percentage and abundances of GAB in middle latitude areas were higher than those in the higher or lower latitude areas, and were more obvious at 4℃ than those at 25℃. The GAB abundances in sediment under the shallower water seemed to be low- er than those in sediments under the deeper water and this status was more obvious at 25℃ than that at 4℃.
基金supported by National Social Science Foundation of China(Grant No.16BWW042)Anhui Province Excellent Young Talents Support Program(Grant No.gxyq2019325).
文摘With the rapid progress of modernization in the human society,the contradiction between economic development and ecological harmony has become a global problem.The Canadian literature contains a lot of ecological philosophy,which includes the love of nature,the care for animals and the spiritual ecology.Literary writers in Canada write about the relationship between man and nature,man and animals as well as the relationship among different people in the society.Under the three perspectives mentioned above,writers reveal many serious ecological problems.Using Canadian Literature as an example,we can dig out some valuable ecological ideas.These are very helpful for us to solve the increasingly serious crisis related to ecology.
文摘Time:June 7-10,2020,Venue:Banff,Alberta,Canada,Website:http://congress.cnsfederation.org/The 55th Canadian Neurological Sciences Federation(CNSF)Congress 2020 will take place in Banff,Alberta,Canada on June7-10,2020.This is a collegial meeting providing multidisciplinary courses relevant to all neuroscience specialties.
文摘Data on Late Cenomanian and Early Turonian foraminiferal assemblages in the northern palaeo biogeographical district of the West Siberian province are summarized in the paper. In addition, the section of borehole 1016 of the Parusovaya area located in the far north of the province is considered. New information on the foraminiferal zones of this stratigraphic level along with the previously known sections of the Tazovskaya, Purpeiskaya, Van-Eganskaya areas provided an opportunity to carry out a correlation of these zones between the West Siberian and the Canadian provinces (Western Canada, Northern Alaska). The West Siberian Late Cenomanian Trochammina wetteri tumida, Verneuilinoides kansasensis and the Early Turonian Gaudryinopsis angustus foraminiferal zones have their analogues as similar zones in the Canadian province. Due to the provided correlation of the micropalaeontological (foraminiferal) zones, their age in the West Siberian province has been clarified. Besides, similarity of the conditions of dwelling within the boundaries of the entire Arctic palaeobiogeographical realm has been observed.
