在汽车仪表板横梁(Cross Car Beam,CCB)的设计开发初始阶段,选取一些设计参数作为设计变量,利用SFE建立针对这些变量的参数化模型,选取适当的DOE正交矩阵列表输出参数化模型.使用Kriging方法构建性能结果的响应面近似模型,通过主效应和...在汽车仪表板横梁(Cross Car Beam,CCB)的设计开发初始阶段,选取一些设计参数作为设计变量,利用SFE建立针对这些变量的参数化模型,选取适当的DOE正交矩阵列表输出参数化模型.使用Kriging方法构建性能结果的响应面近似模型,通过主效应和贡献量的对比分析发现圆管梁的直径和壁厚是最关键的设计变量,为仪表板横梁的设计提供指导.借助Isight优化算法在整个样本空间中寻找最优结构设计并进行虚拟仿真验证,从而得到最优的实际产品结构.展开更多
In the present study, we aimed to evaluate the effects of cilnidipine and L-type calcium channel blockers（L-type CCBs） on renal function in hypertensive patients. The randomized controlled trials（RCTs） of cilnidip...In the present study, we aimed to evaluate the effects of cilnidipine and L-type calcium channel blockers（L-type CCBs） on renal function in hypertensive patients. The randomized controlled trials（RCTs） of cilnidipine and L-type CCBs on hypertension treatment were selected from Pubmed, Embase, Google Scholar, CNKI, Science Direct, Ebsco, Springer, Ovid, Cochrane Library, Medline, VIP and Wanfang databases（from the date of databases＇ establishment to September 2014）. Data were independently evaluated following the Jadad standard. The percentage changes of serum creatinine（SCr） value, urinary protein excretion（UPE）, urinary protein/creatinine ratio（UPCR） and estimated glomerular filtration rate（e GFR） pre- and post-treatment were extracted for the subsequent meta-analysis. The mean difference（MD） and the 95% confidence interval（95% CI） were determined using RevM an 5.3 software. A total of 10 RCTs of high quality were included and analyzed by fixedor random-effect models. The results indicated that UPE（MD = –36.59, 95% CI： –70.85, –2.33） or UPCR（MD = –46.56, 95% CI： –88.50, –4.62） was significantly reduced by cilnidipine compared with L-type CCBs. However, such significant difference was not detected in reduction of SCr（MD = 0.01, 95% CI： –2.97, 2.98） or eG FR（MD = 1.56, 95% CI： –0.19, 3.31）. Compared with L-type CCBs, cilnidipine was more effective in reducing proteinuria or preventing the proteinuria progression. In addition, we did not find significant differences in SCr and eG FR between the two groups.展开更多
文摘在汽车仪表板横梁(Cross Car Beam,CCB)的设计开发初始阶段,选取一些设计参数作为设计变量,利用SFE建立针对这些变量的参数化模型,选取适当的DOE正交矩阵列表输出参数化模型.使用Kriging方法构建性能结果的响应面近似模型,通过主效应和贡献量的对比分析发现圆管梁的直径和壁厚是最关键的设计变量,为仪表板横梁的设计提供指导.借助Isight优化算法在整个样本空间中寻找最优结构设计并进行虚拟仿真验证,从而得到最优的实际产品结构.
基金Chongqing Municipal Commission of Health and Family Planning(Grant No.2015ZBXM005)
文摘In the present study, we aimed to evaluate the effects of cilnidipine and L-type calcium channel blockers（L-type CCBs） on renal function in hypertensive patients. The randomized controlled trials（RCTs） of cilnidipine and L-type CCBs on hypertension treatment were selected from Pubmed, Embase, Google Scholar, CNKI, Science Direct, Ebsco, Springer, Ovid, Cochrane Library, Medline, VIP and Wanfang databases（from the date of databases＇ establishment to September 2014）. Data were independently evaluated following the Jadad standard. The percentage changes of serum creatinine（SCr） value, urinary protein excretion（UPE）, urinary protein/creatinine ratio（UPCR） and estimated glomerular filtration rate（e GFR） pre- and post-treatment were extracted for the subsequent meta-analysis. The mean difference（MD） and the 95% confidence interval（95% CI） were determined using RevM an 5.3 software. A total of 10 RCTs of high quality were included and analyzed by fixedor random-effect models. The results indicated that UPE（MD = –36.59, 95% CI： –70.85, –2.33） or UPCR（MD = –46.56, 95% CI： –88.50, –4.62） was significantly reduced by cilnidipine compared with L-type CCBs. However, such significant difference was not detected in reduction of SCr（MD = 0.01, 95% CI： –2.97, 2.98） or eG FR（MD = 1.56, 95% CI： –0.19, 3.31）. Compared with L-type CCBs, cilnidipine was more effective in reducing proteinuria or preventing the proteinuria progression. In addition, we did not find significant differences in SCr and eG FR between the two groups.
