Digital Elevation Models(DEM)of a hilly–valley region are prepared using stereo images of Cartosat-1 and Shuttle Radar Topography Mission(SRTM)images.The procedure of ortho-image generation from Cartosat-1 stereo ima...Digital Elevation Models(DEM)of a hilly–valley region are prepared using stereo images of Cartosat-1 and Shuttle Radar Topography Mission(SRTM)images.The procedure of ortho-image generation from Cartosat-1 stereo images and the estimation of ground features from ortho-image are elaborated in the paper.Comparison of DEMs prepared from both images is discussed in terms of the quality of ground features detection,hydrological applications and geometrical calculations.It is found that DEM prepared from Cartosat-1 images are more accurate in the valley region and hence it is better suited for hydrological applications.On the contrary,for hilly region,SRTM images produce better DEM.However,if ground control points and Rational Polynomial Coefficients can be obtained in the hilly region,more accurate DEM can be prepared using Cartosat-1 stereo images.展开更多
The objective of the study was to estimate the change detection in a surface area and volume ana- lysis of the lime stone quarry for the year 2006 and 2014 in Mannur, Tirunelveli district, Tamilnadu. Though the mining...The objective of the study was to estimate the change detection in a surface area and volume ana- lysis of the lime stone quarry for the year 2006 and 2014 in Mannur, Tirunelveli district, Tamilnadu. Though the mining activities are essential for the cement factory, it depletes the ground water table and causes pollution to the Environment. The Integration of Remote Sensing and GIS are effective for analyzing the impact of quarrying on natural resources. In this study, Cartosat-1 satellite data generated Digital Elevation Model (DEM) for measuring surface area and the volume of Lime stone quarry. Temporal volume change study is essential for the government to restrain the misuse of the natural resources by the private sector. In 2006, the surface area and volume of lime stone excavated by 8 mining quarries was 1,991,759.68 m<sup>2</sup> and 112,398,931.9 m<sup>3</sup> respectively. Meanwhile, the surface area utilized and volume of limestone production by the quarry was increased to 2,881,384.64 m<sup>2</sup> and 156,806,929.9 m<sup>3</sup> respectively during the year<sup> </sup>2014. In these 8 years period, quarry surface area utilization increased by 30% and limestone production increased by 28% was observed. This study is useful for the government to monitor the natural resources restrain to over use by the private sector.展开更多
目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)...目的探索酮还原酶家族1成员C3(aldo-keto reductase family 1 member C3,AKR1C3)对乳腺癌恶性细胞生物学行为的干预作用及对程序性细胞死亡蛋白/程序性死亡-配体1(programmed cell death protein1/programmed death-ligand1,PD-1/PD-L)通路的影响。方法把MCF-7人乳腺癌细胞中NC组和AKR1C3组分别转染空质粒和AKR1C3质粒,采用MTT法检测转染后24 h、48 h、72 h细胞活力;采用流式细胞技术测定各组细胞的存活率以及早期、晚期凋亡比例;通过Transwell实验对各组细胞的迁移和侵袭能力进行检测;通过Western blot检测各组细胞PD-1、PD-L1、蛋白激酶B(protein kinase b,AKT)蛋白表达水平。使用C57BL/6小鼠构建荷瘤模型,将采用人乳腺癌MCF-7细胞转染NC质粒和AKR1C3质粒进行细胞荷瘤,每3 d测量瘤体积,持续21 d,绘制两组小鼠肿瘤生长曲线,并于实验终点测量肿瘤质量。结果相较于NC组,AKR1C3组细胞活力降低(P<0.05),并且具有时间依赖效应(P<0.05),迁移和侵袭能力降低(P<0.05),早期凋亡和晚期凋亡比例升高(P<0.05),PD-1、PD-L1、AKT蛋白表达水平降低(P<0.05)。动物实验表明,AKR1C3组小鼠肿瘤体积降低,肿瘤质量下降(P<0.05)。结论AKR1C3可以抑制人乳腺癌细胞恶性生物学行为,抑制PD-1/PDL1信号通路蛋白表达。展开更多
基金The authors acknowledge Board of Research in Nuclear Sciences(BRNS),Bhabha Atomic Research Centre(BARC),Mumbai for sponsoring this project.
文摘Digital Elevation Models(DEM)of a hilly–valley region are prepared using stereo images of Cartosat-1 and Shuttle Radar Topography Mission(SRTM)images.The procedure of ortho-image generation from Cartosat-1 stereo images and the estimation of ground features from ortho-image are elaborated in the paper.Comparison of DEMs prepared from both images is discussed in terms of the quality of ground features detection,hydrological applications and geometrical calculations.It is found that DEM prepared from Cartosat-1 images are more accurate in the valley region and hence it is better suited for hydrological applications.On the contrary,for hilly region,SRTM images produce better DEM.However,if ground control points and Rational Polynomial Coefficients can be obtained in the hilly region,more accurate DEM can be prepared using Cartosat-1 stereo images.
文摘The objective of the study was to estimate the change detection in a surface area and volume ana- lysis of the lime stone quarry for the year 2006 and 2014 in Mannur, Tirunelveli district, Tamilnadu. Though the mining activities are essential for the cement factory, it depletes the ground water table and causes pollution to the Environment. The Integration of Remote Sensing and GIS are effective for analyzing the impact of quarrying on natural resources. In this study, Cartosat-1 satellite data generated Digital Elevation Model (DEM) for measuring surface area and the volume of Lime stone quarry. Temporal volume change study is essential for the government to restrain the misuse of the natural resources by the private sector. In 2006, the surface area and volume of lime stone excavated by 8 mining quarries was 1,991,759.68 m<sup>2</sup> and 112,398,931.9 m<sup>3</sup> respectively. Meanwhile, the surface area utilized and volume of limestone production by the quarry was increased to 2,881,384.64 m<sup>2</sup> and 156,806,929.9 m<sup>3</sup> respectively during the year<sup> </sup>2014. In these 8 years period, quarry surface area utilization increased by 30% and limestone production increased by 28% was observed. This study is useful for the government to monitor the natural resources restrain to over use by the private sector.
文摘目的探讨胃癌组织中EB病毒的感染状况,分析其与小核核糖核蛋白多肽A(Small nuclear ribonucleoprotein polypeptide A,SNRPA)及端粒沉默破坏因子1样蛋白(Disruptor of telomeric silencing 1-like,DOT1L)表达的相关性。方法收集2022年2月至2025年5月南阳市第一人民医院收治的280例胃癌患者的癌组织及癌旁正常组织标本。分析EB病毒感染与患者临床病理特征的关系,比较EB病毒感染阳性组与阴性组中SNRPA、DOT1L的表达水平,采用Spearman分析EB病毒感染与癌组织SNRPA、DOT1L表达的相关性,受试者工作(Receiver operating characteristic,ROC)曲线分析SNRPA、DOT1L对胃癌EB病毒感染的诊断价值。结果280例胃癌患者癌组织标本中EB病毒阳性者33例,阳性率11.79%(33/280);胃癌患者EB病毒感染与淋巴结转移相关(P<0.05);SNRPA与DOT1L在胃癌组织中的表达均高于癌旁组织,EB病毒感染组SNRPA与DOT1L的表达均高于EB病毒未感染组(P<0.05);Spearman相关性分析显示,癌组织SNRPA、DOT1L表达与EB病毒感染呈正相关(r=0.709、0.658,P<0.05)。ROC曲线显示,SNRPA、DOT1L、两种指标联合评估胃癌EB病毒感染的曲线下面积(Area Under the Curve,AUC)分别为0.807、0.773、0.886。结论EB病毒感染与胃癌患者淋巴结转移、SNRPA、DOT1L表达水平有关,联合检测SNRPA、DOT1L可提高胃癌EB病毒感染的诊断效能。
