Objective:To analyze the therapeutic effects of carteolol hydrochloride(CAR)eye drops combined with travoprost(TRA)eye drops in the treatment of open-angle glaucoma(OAG).Methods:A total of 72 OAG patients(87 eyes)hosp...Objective:To analyze the therapeutic effects of carteolol hydrochloride(CAR)eye drops combined with travoprost(TRA)eye drops in the treatment of open-angle glaucoma(OAG).Methods:A total of 72 OAG patients(87 eyes)hospitalized between October 2020 and October 2023 were randomly divided into two groups.The combination group received CAR and TRA eye drops,while the control group received CAR eye drops alone.Treatment outcomes were compared in terms of total efficacy rate,visual acuity,intraocular pressure,visual function indicators,hemodynamic parameters,and ocular surface damage indicators.Results:The combination group showed a higher total efficacy rate compared to the control group.After 3 months of treatment,the combination group had better visual acuity,lower intraocular pressure,higher mean sensitivity,lower mean defect,lower resistance index,and higher end-diastolic velocity and peak systolic velocity compared to the control group(P<0.05).Additionally,the combination group exhibited higher corneal fluorescein staining scores,shorter tear breakup time,and lower Schirmer tear test values compared to the control group(P<0.05).Conclusion:The combination of CAR and TRA eye drops improves visual acuity,effectively reduces intraocular pressure,enhances visual function,regulates ocular hemodynamics,and mitigates ocular surface damage in OAG patients,demonstrating superior therapeutic efficacy.展开更多
AIM： To investigate the intraocular pressure（IOP） of adult guinea pig eyes with rebound tonometry（RBT）,and assess the effects of four distinctive topical IOP reducing medications including Carteolol,Brimonidine,B...AIM： To investigate the intraocular pressure（IOP） of adult guinea pig eyes with rebound tonometry（RBT）,and assess the effects of four distinctive topical IOP reducing medications including Carteolol,Brimonidine,Brinzolamide and Latanoprost.METHODS： The IOPs of twenty-four 12-week-old guinea pigs（48 eyes） were measured every two hours in one day with RBT as baselines.All the animals were then divided into four groups（Carteolol,Brimonidine,Brinzolamide and Latanaprost groups,n=6）.The IOPs were measured and compared to the baseline 1,2,3,5,7,9,15 and 24 h after treatment.RESULTS： The mean baseline IOP of 24 guinea pigs（48 eyes） was 10.3±0.36 mm Hg（6-13 mm Hg） and no binocular significant differences of IOPs were observed（t=1.76,P〉0.05）.No significant difference of IOP in Carteolol group at each time point was observed before and after treatment（t=1.48,P〉0.05）.In Brimonidine group,IOP was 2.2±1.9 mm Hg lower than the baseline after one hour（t=3.856,P=0.003） and lasted for one hour.In Brinzolamide group,IOP was 1.4±1.1 mm Hg lower than the baseline after one hour（t=4.53,P=0.001） and lasted for 7h and the IOP declined most at 3h.In Latanaprost group,IOP was 2.1±1.3 mm Hg lower than the baseline after one hour（t=6.11,P=0.001） and lasted for one hour.CONCLUSION： The IOP of guinea pig eyes is relatively stable compared to human eyes.In four reducing IOP medications,no significant effect of Carteolol is observed.Brinzolamide has the longest duration,while the Brimonidine has the shortest duration and the maximum level of treatment.展开更多
文摘Objective:To analyze the therapeutic effects of carteolol hydrochloride(CAR)eye drops combined with travoprost(TRA)eye drops in the treatment of open-angle glaucoma(OAG).Methods:A total of 72 OAG patients(87 eyes)hospitalized between October 2020 and October 2023 were randomly divided into two groups.The combination group received CAR and TRA eye drops,while the control group received CAR eye drops alone.Treatment outcomes were compared in terms of total efficacy rate,visual acuity,intraocular pressure,visual function indicators,hemodynamic parameters,and ocular surface damage indicators.Results:The combination group showed a higher total efficacy rate compared to the control group.After 3 months of treatment,the combination group had better visual acuity,lower intraocular pressure,higher mean sensitivity,lower mean defect,lower resistance index,and higher end-diastolic velocity and peak systolic velocity compared to the control group(P<0.05).Additionally,the combination group exhibited higher corneal fluorescein staining scores,shorter tear breakup time,and lower Schirmer tear test values compared to the control group(P<0.05).Conclusion:The combination of CAR and TRA eye drops improves visual acuity,effectively reduces intraocular pressure,enhances visual function,regulates ocular hemodynamics,and mitigates ocular surface damage in OAG patients,demonstrating superior therapeutic efficacy.
基金Supported by the National Natural Science Foundation of China(No.81400428)Science and Technology Commission of Shanghai Municipality(No.134119b1600)
文摘AIM： To investigate the intraocular pressure（IOP） of adult guinea pig eyes with rebound tonometry（RBT）,and assess the effects of four distinctive topical IOP reducing medications including Carteolol,Brimonidine,Brinzolamide and Latanoprost.METHODS： The IOPs of twenty-four 12-week-old guinea pigs（48 eyes） were measured every two hours in one day with RBT as baselines.All the animals were then divided into four groups（Carteolol,Brimonidine,Brinzolamide and Latanaprost groups,n=6）.The IOPs were measured and compared to the baseline 1,2,3,5,7,9,15 and 24 h after treatment.RESULTS： The mean baseline IOP of 24 guinea pigs（48 eyes） was 10.3±0.36 mm Hg（6-13 mm Hg） and no binocular significant differences of IOPs were observed（t=1.76,P〉0.05）.No significant difference of IOP in Carteolol group at each time point was observed before and after treatment（t=1.48,P〉0.05）.In Brimonidine group,IOP was 2.2±1.9 mm Hg lower than the baseline after one hour（t=3.856,P=0.003） and lasted for one hour.In Brinzolamide group,IOP was 1.4±1.1 mm Hg lower than the baseline after one hour（t=4.53,P=0.001） and lasted for 7h and the IOP declined most at 3h.In Latanaprost group,IOP was 2.1±1.3 mm Hg lower than the baseline after one hour（t=6.11,P=0.001） and lasted for one hour.CONCLUSION： The IOP of guinea pig eyes is relatively stable compared to human eyes.In four reducing IOP medications,no significant effect of Carteolol is observed.Brinzolamide has the longest duration,while the Brimonidine has the shortest duration and the maximum level of treatment.
