The aim of this study was to investigate the stability of Carbocysteine (CBC) contained in a reference substance (RS) and in a sample of opened RHINATHIOL<sup>®</sup> 5% syrup (RNTL 5%) under the effe...The aim of this study was to investigate the stability of Carbocysteine (CBC) contained in a reference substance (RS) and in a sample of opened RHINATHIOL<sup>®</sup> 5% syrup (RNTL 5%) under the effect of some physicochemical parameters (temperature, light, time, pH, bile salts). The developed method was linear, precise and accurate according to USP 38. The co-efficient of determination R<sup>2</sup> for linearity was 0.9993. The respective RSD of intra-day and inter-day between days (1st, 2nd and 3rd day) were respectively 0.338% and the interval from 0.05% to 0.387%. The average recovery rate ranged from 98.490% to 100.450%. The detection and quantification limits were 0.0001 mg/mL and 0.001 mg/mL respectively. The method was applied to four samples of opened syrup containing CBC and the CBC content in these samples was found to be in accordance with USP 38. The CBC content in the opened sample of RNTL 5% was obtained by UV-visible spectrophotometry at 217 nm and was 4.887 g/100mL. The study of the influence of physico-chemical factors on the content of CBC in RS and RNTL 5% showed that the evolution of CBC contents in each drug matrix remained dependent on pH and temperature. However, these levels remained stable in the presence of light.展开更多
Background/Purpose: Although stretch marks (or striae) do not represent a medical problem, they are considered as the cause of psychological distress for women of any age that need to be treated. There are many cosmet...Background/Purpose: Although stretch marks (or striae) do not represent a medical problem, they are considered as the cause of psychological distress for women of any age that need to be treated. There are many cosmetic products or procedures claiming to improve the appearance of striae, but most of them are able to affect only striae appearance rather than physical characteristics or, even worse, they are provided with untoward effects. Our aim was to find a more efficacious and safe alternative to the existing tools. Methods: A randomized, blind observer study was conducted on 33 women to test the efficacy and safety of P-3059, a new product containing carboxymethylcysteine, Vitamin E and sweet almond oil. P-3059 was applied twice daily for 8 weeks and it was tested intra-subject in a split-body design versus an untreated area (negative control), comparing two symmetric areas with striae selected on the body/legs of each subject. The main study endpoint was the visual evaluation of striae, by means of the validated POSAS scale (consisting of two parts, OSAS and PSAS), at the end of treatment in comparison with baseline. Results: The comparison of the individual parameters of OSAS, showed significantly improved mean values for striae thickness, relief and pliability at the end of treatment (p < 0.05). The PSAS evaluation showed a statistically significant benefit in the improvement in thickness of the striae towards that of normal skin (p < 0.044). Conclusion: The new product based on carboxymethylcysteine leads to an improvement in the appearance and in the physical characteristics of striae, reducing their thickness and improving relief and pliability, as well as subjects satisfaction.展开更多
1|INTRODUCTION.Obstructive sleep apnea(OSA)is a prevalent sleeprelated breathing disorder characterized by recurrent upper airway collapse,leading to intermittent hypoxia,oxidative stress,and systemic inflammation,whi...1|INTRODUCTION.Obstructive sleep apnea(OSA)is a prevalent sleeprelated breathing disorder characterized by recurrent upper airway collapse,leading to intermittent hypoxia,oxidative stress,and systemic inflammation,which can result in multi‐organ comorbidities,particularly cardiovascular and metabolic diseases.展开更多
文摘The aim of this study was to investigate the stability of Carbocysteine (CBC) contained in a reference substance (RS) and in a sample of opened RHINATHIOL<sup>®</sup> 5% syrup (RNTL 5%) under the effect of some physicochemical parameters (temperature, light, time, pH, bile salts). The developed method was linear, precise and accurate according to USP 38. The co-efficient of determination R<sup>2</sup> for linearity was 0.9993. The respective RSD of intra-day and inter-day between days (1st, 2nd and 3rd day) were respectively 0.338% and the interval from 0.05% to 0.387%. The average recovery rate ranged from 98.490% to 100.450%. The detection and quantification limits were 0.0001 mg/mL and 0.001 mg/mL respectively. The method was applied to four samples of opened syrup containing CBC and the CBC content in these samples was found to be in accordance with USP 38. The CBC content in the opened sample of RNTL 5% was obtained by UV-visible spectrophotometry at 217 nm and was 4.887 g/100mL. The study of the influence of physico-chemical factors on the content of CBC in RS and RNTL 5% showed that the evolution of CBC contents in each drug matrix remained dependent on pH and temperature. However, these levels remained stable in the presence of light.
文摘Background/Purpose: Although stretch marks (or striae) do not represent a medical problem, they are considered as the cause of psychological distress for women of any age that need to be treated. There are many cosmetic products or procedures claiming to improve the appearance of striae, but most of them are able to affect only striae appearance rather than physical characteristics or, even worse, they are provided with untoward effects. Our aim was to find a more efficacious and safe alternative to the existing tools. Methods: A randomized, blind observer study was conducted on 33 women to test the efficacy and safety of P-3059, a new product containing carboxymethylcysteine, Vitamin E and sweet almond oil. P-3059 was applied twice daily for 8 weeks and it was tested intra-subject in a split-body design versus an untreated area (negative control), comparing two symmetric areas with striae selected on the body/legs of each subject. The main study endpoint was the visual evaluation of striae, by means of the validated POSAS scale (consisting of two parts, OSAS and PSAS), at the end of treatment in comparison with baseline. Results: The comparison of the individual parameters of OSAS, showed significantly improved mean values for striae thickness, relief and pliability at the end of treatment (p < 0.05). The PSAS evaluation showed a statistically significant benefit in the improvement in thickness of the striae towards that of normal skin (p < 0.044). Conclusion: The new product based on carboxymethylcysteine leads to an improvement in the appearance and in the physical characteristics of striae, reducing their thickness and improving relief and pliability, as well as subjects satisfaction.
基金Basic Research Project Jointly Funded by Guangzhou City and the School,Grant/Award Number:202201020586School-Enterprise Cooperation Funding Project of Guangzhou,Grant/Award Number:2024A03J1141。
文摘1|INTRODUCTION.Obstructive sleep apnea(OSA)is a prevalent sleeprelated breathing disorder characterized by recurrent upper airway collapse,leading to intermittent hypoxia,oxidative stress,and systemic inflammation,which can result in multi‐organ comorbidities,particularly cardiovascular and metabolic diseases.
