In this study, the CaP/pDNA nanoparticles were prepared using Triton X-100/Butanol/Cyclohexane/Water reverse microemulsion system. Optimization of preparation conditions was based on evaluation of particle size by Box...In this study, the CaP/pDNA nanoparticles were prepared using Triton X-100/Butanol/Cyclohexane/Water reverse microemulsion system. Optimization of preparation conditions was based on evaluation of particle size by Box–Behnken design method. The particle sizes of the optimized CaP/pDNA nanoparticles were found to be 60.23 ± 4.72 nm, polydispersity index was 0.252 and pDNA encapsulate efficiency was more than 90%. The optimized CaP/pDNA nanoparticles have pH sensitivity and biocompatibility. Further, optimized CaP/pDNA nanoparticles showed higher transfection efficiency.展开更多
A series of novel ester-capped carbosilane dendrimers（G0-COOCH3–G2-COOCH3） were designed and successfully synthesized via a hybrid divergent–convergent method through a facile hydrosilylation reaction. The structu...A series of novel ester-capped carbosilane dendrimers（G0-COOCH3–G2-COOCH3） were designed and successfully synthesized via a hybrid divergent–convergent method through a facile hydrosilylation reaction. The structures of these dendrimers were confirmed by FTIR,1H NMR, and HRMS analyses.展开更多
利用湖北与重庆区域台网共9个台的宽频带数字地震记录,采用CAP法(Cut and Paste Method)反演了湖北巴东2013年12月16日MS5.1地震震源机制解,其最佳双力偶解为节面I:走向166°,倾角82°,滑动角41°;节面Ⅱ:走向69°,倾角...利用湖北与重庆区域台网共9个台的宽频带数字地震记录,采用CAP法(Cut and Paste Method)反演了湖北巴东2013年12月16日MS5.1地震震源机制解,其最佳双力偶解为节面I:走向166°,倾角82°,滑动角41°;节面Ⅱ:走向69°,倾角49°,滑动角169°;最佳震源深度主要集中分布在5.5km附近。分析认为此次地震的发震断层为带有逆冲成分的走滑性质断层,主压应力P轴近EW向,主张应力轴近NS向。余震序列主要呈EW分布,少部分呈NS方向分布,较大余震的发震破裂滑动类型以正走滑型的居多,其次为逆倾滑型及逆走滑型。结合7次较大余震的机制解判断,近EW向节面为发震断层。展开更多
利用晋冀蒙危险区临时虚拟台网的宽频带数字化观测资料,采用CAP(Cut and Paste)方法计算得到2016年6月23日河北尚义地震的震源机制解。节面Ⅰ:走向247°、倾角62°、滑动角-32°;节面Ⅱ:走向353°、倾角62°、滑动...利用晋冀蒙危险区临时虚拟台网的宽频带数字化观测资料,采用CAP(Cut and Paste)方法计算得到2016年6月23日河北尚义地震的震源机制解。节面Ⅰ:走向247°、倾角62°、滑动角-32°;节面Ⅱ:走向353°、倾角62°、滑动角-147°,震源深度8km,震级M_W3.93。结合地质构造隐伏断层推断,该地震可能是NNE向的大满—前黑沙土隐伏断裂构造引起的,发震断层性质为左旋、走滑兼有正断分量。展开更多
基金the Natural Science Foundation Committee of China for the financial support (No.81173004 and No.81202483)
文摘In this study, the CaP/pDNA nanoparticles were prepared using Triton X-100/Butanol/Cyclohexane/Water reverse microemulsion system. Optimization of preparation conditions was based on evaluation of particle size by Box–Behnken design method. The particle sizes of the optimized CaP/pDNA nanoparticles were found to be 60.23 ± 4.72 nm, polydispersity index was 0.252 and pDNA encapsulate efficiency was more than 90%. The optimized CaP/pDNA nanoparticles have pH sensitivity and biocompatibility. Further, optimized CaP/pDNA nanoparticles showed higher transfection efficiency.
基金support by the National Natural Science Foundation of China(No.21307053)China Postdoctoral Science Foundation Funded Project(No.2013M541911)+1 种基金Promotive Research Fund for Excellent Young and Middle-Aged Scientists of Shandong Province(No.BS2013CL044)Natural Science Foundation of Ludong University(No.LY2011004)
文摘A series of novel ester-capped carbosilane dendrimers（G0-COOCH3–G2-COOCH3） were designed and successfully synthesized via a hybrid divergent–convergent method through a facile hydrosilylation reaction. The structures of these dendrimers were confirmed by FTIR,1H NMR, and HRMS analyses.
文摘利用湖北与重庆区域台网共9个台的宽频带数字地震记录,采用CAP法(Cut and Paste Method)反演了湖北巴东2013年12月16日MS5.1地震震源机制解,其最佳双力偶解为节面I:走向166°,倾角82°,滑动角41°;节面Ⅱ:走向69°,倾角49°,滑动角169°;最佳震源深度主要集中分布在5.5km附近。分析认为此次地震的发震断层为带有逆冲成分的走滑性质断层,主压应力P轴近EW向,主张应力轴近NS向。余震序列主要呈EW分布,少部分呈NS方向分布,较大余震的发震破裂滑动类型以正走滑型的居多,其次为逆倾滑型及逆走滑型。结合7次较大余震的机制解判断,近EW向节面为发震断层。
文摘利用晋冀蒙危险区临时虚拟台网的宽频带数字化观测资料,采用CAP(Cut and Paste)方法计算得到2016年6月23日河北尚义地震的震源机制解。节面Ⅰ:走向247°、倾角62°、滑动角-32°;节面Ⅱ:走向353°、倾角62°、滑动角-147°,震源深度8km,震级M_W3.93。结合地质构造隐伏断层推断,该地震可能是NNE向的大满—前黑沙土隐伏断裂构造引起的,发震断层性质为左旋、走滑兼有正断分量。
