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Cronkhite-Canada综合征诊疗的中国专家共识意见(2025年,北京)
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作者 中国罕见病联盟/北京罕见病诊疗与保障学会消化病学分会 中华医学会消化病学分会罕见病协作组 +7 位作者 李景南 房静远 李骥 徐天铭 俎明 银新 周澄蓓 游燕 《罕见病研究》 2025年第2期221-231,共11页
Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)是一种以胃肠道多发息肉和外胚层改变为特征的罕见非遗传性疾病。其病因尚不明确,缺乏诊断的金标准,并发消化道肿瘤风险高于一般人群,早期诊断较为困难,疾病容易复发,需长期随访... Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)是一种以胃肠道多发息肉和外胚层改变为特征的罕见非遗传性疾病。其病因尚不明确,缺乏诊断的金标准,并发消化道肿瘤风险高于一般人群,早期诊断较为困难,疾病容易复发,需长期随访。中国罕见病联盟/北京罕见病诊疗与保障学会消化病学分会联合中华医学会消化病学分会罕见病协作组制定该共识,旨在对CCS的发病机制、临床表现、诊断及治疗给予相应的建议。 展开更多
关键词 CRONKHITE-canada综合征 诊疗 共识
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Cronkhite-Canada综合征的血清免疫球蛋白特征:单中心回顾性研究
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作者 刘爽 区成铸 +7 位作者 李沐涵 徐秋实 智云飞 张杏芳 唐颢 徐天铭 阮戈冲 李骥 《罕见病研究》 2025年第2期194-201,共8页
目的探讨Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)患者血清免疫球蛋白特征及其临床价值。方法纳入2009年12月至2024年9月于北京协和医院收治并进行血清免疫球蛋白检测的CCS患者,回顾性分析其临床特点及辅助检查结果。结... 目的探讨Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)患者血清免疫球蛋白特征及其临床价值。方法纳入2009年12月至2024年9月于北京协和医院收治并进行血清免疫球蛋白检测的CCS患者,回顾性分析其临床特点及辅助检查结果。结果共纳入52例患者,男36例(69.2%),女16例(30.8%),中位起病年龄60(54~64)岁,起病至诊断的中位时间为5(3~12)个月。常见临床表现包括腹泻(86.5%)、腹痛(40.4%)、便血(19.2%)、体重下降(86.5%)、指甲营养不良(100.0%)、色素沉着(88.5%)、毛发脱落(84.6%)、味觉减退(69.2%)等。21例(50.0%)患者存在血清IgG下降,20例(71.4%)的患者存在总IgE升高。11例(23.4%)血清IgG4高于参考值,IgG4升高组与IgG4正常组间的临床指标无显著差异,活动期CCS患者(n=43)与缓解期患者(n=27)的IgG4水平比较差异无统计学意义。总IgE升高组的毛发脱落率显著高于IgE正常组(P=0.0383)。结论CCS患者存在外周血免疫球蛋白紊乱,其中IgE升高与毛发脱落有关,提示CCS患者的毛发脱落可能与免疫介导机制相关。 展开更多
关键词 CRONKHITE-canada综合征 IGG4 IGE 免疫紊乱
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Cronkhite-Canada综合征诊治及随访1例
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作者 刘维丽 王紫琼 +1 位作者 陈辉 杨玉霞 《世界华人消化杂志》 2025年第6期507-512,共6页
背景Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)又称息肉-色素沉着-脱发-爪甲营养不良综合征,临床极为罕见.病因尚不清楚,是一种罕见的病因不明的非遗传性疾病,其发病机制尚不明确,暂无特异性治疗.由于其罕见性,临床上医... 背景Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)又称息肉-色素沉着-脱发-爪甲营养不良综合征,临床极为罕见.病因尚不清楚,是一种罕见的病因不明的非遗传性疾病,其发病机制尚不明确,暂无特异性治疗.由于其罕见性,临床上医生常无法诊断或误诊为其他息肉病延误治疗.病例简介63岁女性,因“间断腹痛、腹泻3 mo余”入院,入院查体可见双颊色素沉着、头发脱落、甲床萎缩、指甲脱落,胃肠镜提示:胃、十二指肠及结肠广泛可见增生性息肉,病理提示:(胃)黏膜固有层增宽、水肿伴部分急慢性细胞浸润,诊断为CCS,给予营养支持、护胃、糖皮质激素等治疗.结论本病例明确诊断后给予护胃、营养支持及糖皮质激素治疗半年,效果良好,无明显不良反应发生,可为临床医师提供诊断及治疗思路. 展开更多
关键词 CRONKHITE-canada综合征 诊治 随访 病例报告
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Cronkhite-Canada综合征1例
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作者 黄九香 施林林 《皮肤性病诊疗学杂志》 2024年第4期266-269,共4页
报告Cronkhite-Canada综合征1例。患者男,68岁,因腹痛、腹泻3个月就诊。皮肤科检查:头发弥漫性稀疏,额顶部明显。上下唇部、双手部、双足底可见对称性弥漫性褐色色素沉着,其上多个绿豆大小的点滴状分布的黑色斑疹,趾指甲远端2/3断裂缺如... 报告Cronkhite-Canada综合征1例。患者男,68岁,因腹痛、腹泻3个月就诊。皮肤科检查:头发弥漫性稀疏,额顶部明显。上下唇部、双手部、双足底可见对称性弥漫性褐色色素沉着,其上多个绿豆大小的点滴状分布的黑色斑疹,趾指甲远端2/3断裂缺如,甲板表面粗糙、凹凸不平无光泽。双上眼睑及小腿出现凹陷性水肿。实验室检查:贫血、低蛋白血症。电子肠镜检查:结肠多发息肉。诊断:Cronkhite-Canada综合征。给予高蛋白等营养支持治疗和对症处理。治疗后贫血及低蛋白血症明显改善,肠息肉暂无复发。目前仍在进一步随访中。 展开更多
关键词 CRONKHITE-canada综合征 色素沉着 脱发 甲营养不良 胃肠道息肉
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Cronkhite-Canada综合征合并无症状新型冠状病毒感染一例 被引量:2
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作者 张宁 杨晨皓 +5 位作者 周良瑞 孙晓红 刘晓红 康琳 李骥 李海龙 《协和医学杂志》 CSCD 北大核心 2024年第2期406-412,共7页
本文报道Cronkhite⁃Canada综合征合并无症状新型冠状病毒感染1例。该患者临床表现为食欲减退,毛发及指甲脱落,皮肤色素沉着。内镜检查见胃、十二指肠及结肠黏膜呈弥漫性、大小不一、密集分布的息肉样改变。病程中检出新型冠状病毒核酸... 本文报道Cronkhite⁃Canada综合征合并无症状新型冠状病毒感染1例。该患者临床表现为食欲减退,毛发及指甲脱落,皮肤色素沉着。内镜检查见胃、十二指肠及结肠黏膜呈弥漫性、大小不一、密集分布的息肉样改变。病程中检出新型冠状病毒核酸阳性。经中等剂量泼尼松治疗后,患者毛发恢复生长,皮肤色素沉着减退。本文总结该患者的诊疗经过并结合文献复习,以期提升临床医生对该病的认知。 展开更多
关键词 Cronkhite⁃canada综合征 新型冠状病毒感染 治疗
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Severe Global Environmental Issues Caused by Canada’s Record-Breaking Wildfires in 2023 被引量:7
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作者 Zhe WANG Zifa WANG +8 位作者 Zhiyin ZOU Xueshun CHEN Huangjian WU Wending WANG Hang SU Fang LI Wenru XU Zhihua LIU Jiaojun ZHU 《Advances in Atmospheric Sciences》 SCIE CAS CSCD 2024年第4期565-571,共7页
Due to the record-breaking wildfires that occurred in Canada in 2023,unprecedented quantities of air pollutants and greenhouse gases were released into the atmosphere.The wildfires had emitted more than 1.3 Pg CO_(2)a... Due to the record-breaking wildfires that occurred in Canada in 2023,unprecedented quantities of air pollutants and greenhouse gases were released into the atmosphere.The wildfires had emitted more than 1.3 Pg CO_(2)and 0.14 Pg CO_(2)equivalent of other greenhouse gases(GHG)including CH4 and N_(2)O as of 31 August.The wildfire-related GHG emissions constituted more than doubled Canada’s planned cumulative anthropogenic emissions reductions in 10 years,which represents a significant challenge to climate mitigation efforts.The model simulations showed that the Canadian wildfires impacted not only the local air quality but also that of most areas in the northern hemisphere due to long-range transport,causing severe PM_(2.5)pollution in the northeastern United States and increasing daily mean PM_(2.5)concentration in northwestern China by up to 2μg m-3.The observed maximum daily mean PM_(2.5)concentration in New York City reached 148.3μg m-3,which was their worst air quality in more than 50 years,nearly 10 times that of the air quality guideline(i.e.,15μg m-3)issued by the World Health Organization(WHO).Aside from the direct emissions from forest fires,the peat fires beneath the surface might smolder for several months or even longer and release substantial amounts of CO_(2).The substantial amounts of greenhouse gases from forest and peat fires might contribute to the positive feedback to the climate,potentially accelerating global warming.To better understand the comprehensive environmental effects of wildfires and their interactions with the climate system,more detailed research based on advanced observations and Earth System Models is essential. 展开更多
关键词 canada forest fire greenhouse gases PM_(2.5) transboundary air pollution
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Cronkhite-Canada综合征2例并文献复习
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作者 张泽雨 康其乐 +4 位作者 郭驰伟 王农荣 谢桂生 付小君 斯轶凡 《南昌大学学报(医学版)》 2024年第2期98-104,共7页
目的探讨Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)的临床特征、治疗方法及预后。方法收集南昌大学第四附属医院消化内科收治的2例CCS患者的临床资料,结合相关文献,对其诊疗、转归以及长期消化内镜的随访资料进行分析。结... 目的探讨Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)的临床特征、治疗方法及预后。方法收集南昌大学第四附属医院消化内科收治的2例CCS患者的临床资料,结合相关文献,对其诊疗、转归以及长期消化内镜的随访资料进行分析。结果2例患者均以胃息肉病变为突出表现。例1于2013年5月确诊CCS并结肠癌,予外科手术、内镜下部分息肉切除术及营养支持治疗后,患者营养状况明显好转,确诊后2年间进行6次胃镜随访,2015年4月确诊胃窦恶性溃疡,2017年7月死亡。例2于2019年6月入院时诊断不明,结合患者其他症状及体征,诊断为CCS,采用激素治疗效果不佳,后因病情进展行全胃切除,术后随访2年,目前病情稳定。结论CCS病情多呈进行性加重,具有恶变趋势,治疗上以糖皮质激素为主,必要时可考虑切除严重病变部位,长期消化内镜下随访有助于诊断疾病及发现早期癌变。 展开更多
关键词 CRONKHITE-canada综合征 外胚层改变 胃镜随访 病例报告
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Impact of Reservoir Heterogeneity on Bitumen Content in the Mackay River Oil Sands,Athabasca(Canada)
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作者 YANG Xiaofa YU Diyun +6 位作者 WU Suwei REN Junhao CHENG Dingsheng HUANG Jixin YANG Chengyu MA Guoqing LI Meijun 《Acta Geologica Sinica(English Edition)》 SCIE CAS CSCD 2024年第5期1285-1300,共16页
The Lower Cretaceous Manville Group of Upper Mc Murray Formation is one of the main bitumen reservoirs in Athabasca.In this study,the relationship between reservoirs heterogeneity and bitumen geochemical characteristi... The Lower Cretaceous Manville Group of Upper Mc Murray Formation is one of the main bitumen reservoirs in Athabasca.In this study,the relationship between reservoirs heterogeneity and bitumen geochemical characteristics were analyzed through core and microscopic observation,lab analysis,petrophysics and logging data.Based on the sedimentology framework,the formation environment of high-quality oil sand reservoirs and their significance for development were discussed.The results indicate that four types lithofacies were recognized in the Upper Mc Murray Formation based on their depositional characteristics.Each lithofacies reservoirs has unique physical properties,and is subject to varying degrees of degradation,resulting in diversity of bitumen content and geochemical composition.The tidal bar(TB)or tidal channel(TC)facies reservoir have excellent physical properties,which are evaluated as gas or water intervals due to strong degradation.The reservoir of sand bar(SB)facies was evaluated as oil intervals,due to its poor physical properties and weak degradation.The reservoir of mixed flat(MF)facies is composed of sand intercalated with laminated shale,which is evaluated as poor oil intervals due to its poor connectivity.The shale content in oil sand reservoir is very important for the reservoir physical properties and bitumen degradation degree.In the context of regional biodegradation,oil sand reservoirs with good physical properties will suffer from strong degradation,while oil sand reservoirs with relatively poor physical properties are more conducive to the bitumen preservation. 展开更多
关键词 oil sands reservoir heterogeneity geochemical characteristics bitumen content Upper Mc Murray Formation canada
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Biogeochemical and physical properties influencing the nutrient reservoirs of subsurface water in the changing Canada Basin
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作者 Tianzhen Zhang Qiang Hao +3 位作者 Haiyan Jin Youcheng Bai Yanpei Zhuang Jianfang Chen 《Acta Oceanologica Sinica》 SCIE CAS CSCD 2024年第10期40-47,共8页
The Canada Basin is the largest basin in the Arctic Ocean.Its unique physical features have the highest concentration of nutrients being found in the subsurface layer,referred to as the subsurface nutrient maximum lay... The Canada Basin is the largest basin in the Arctic Ocean.Its unique physical features have the highest concentration of nutrients being found in the subsurface layer,referred to as the subsurface nutrient maximum layer(SNM).Under climate change in the Arctic,the SNM is an essential material base for primary productivity.However,long-term trends of nutrient variations and dominant factors related to nutrient levels in the SNM are still unclear.In this study,we analyzed the SNM variations and main influencing factors of the Canada Basin based on the Global Ocean Data Analysis Project Version 2 between 1990 and 2015 and the Chinese Arctic Research Expedition between 2010 and 2016.We found that the nutrient concentrations in the SNM were relatively stable for decades[average concentrations of nitrate,phosphate,and silicate were(13.6±2.4)μmol/L,(1.8±0.2)μmol/L,and(31.5±5.7)μmol/L,respectively].Nutrient reservoirs were dominated by physical processes.Inflow and outflow water of the SNM contributed about 60.4%and-50.2%to the nutrient stocks,respectively,while particle deposition and remineralization in the Canada Basin contributed approximately one-third to the nutrient stocks.Nitrogen fixation and denitrification in the Canada Basin had no substantial impact on nutrient stocks.The overall stabilization of the SNM over the past few decades implied that the SNM would not substantially affect short term primary productivity.Understanding the long-term trends and dominant factors of reservoirs in the SNM will provide useful insights into the changing Canada Basin ecosystem. 展开更多
关键词 subsurface nutrients maximum layer canada Basin biogeochemical cycles Arctic climate changes
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Mental illness segregation and truncated autonomy within medical assistance in dying legislative frameworks in Colombia and Canada
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作者 Hamer Bastidas-Bilbao Ximena Palacios-Espinosa +1 位作者 Donna E Stewart Vicky Stergiopoulos 《General Psychiatry》 CSCD 2024年第6期606-613,共8页
Colombia and Canada are the only jurisdictions in the Americas that have adopted countrywide frameworks on medical assistance in dying(MAiD),also known as physicianassisted death,for terminal and non-terminal illnesse... Colombia and Canada are the only jurisdictions in the Americas that have adopted countrywide frameworks on medical assistance in dying(MAiD),also known as physicianassisted death,for terminal and non-terminal illnesses.Both countries have excluded mental illness as a sole condition from eligibility to date.In this forum article,we adopt the notion of truncated autonomy to critically analyse how individuals with mental illness have been impacted by specific instances of legislative inaction and misdirected action,identified throughout the development of the current legislative frameworks on MAiD in each country. 展开更多
关键词 canada illness AUTONOMY
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The Perception of Stakeholders on the Forest Ecosystem Services:National Parks in China and Canada
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作者 Yangyang Zhang Guangyu Wang +7 位作者 Mingjun Teng Jiaoyang Xu Shuling Li Anil Shresth Jiaojiao Yin Zhaogui Yan Qiang Fu Pengcheng Wang 《Ecosystem Health and Sustainability》 CSCD 2024年第5期132-146,共15页
The stakeholders'perceptions of forest ecosystem services(FESs)vary among different stakeholder groups.This study,using China's Shennongjia National Park Pilot(SNP)and Canada's Banff National Park(BNP)as c... The stakeholders'perceptions of forest ecosystem services(FESs)vary among different stakeholder groups.This study,using China's Shennongjia National Park Pilot(SNP)and Canada's Banff National Park(BNP)as case studies,identifies and evaluates the preference characteristics of key stakeholders(including farmers,individual operators,government officials,and tourists)toward various FESs.We utilized Q-methodology and semistructured interviews to conduct a sorting of 23 Q-statements regarding FESs,across 7 categories(ranging from−3 to+3),with 24 Q-participants.Stakeholders'preferences toward FESs were categorized into 3 common perspectives:tourism and culture,production and livelihood,and ecological conservation.Different types of stakeholders hold both consensus and divergence regarding their views on FESs.For instance,there was strong consensus on services related to“natural ecotourism and biodiversity conservation”,while stakeholders expressed strong opposition regarding services related to“forest protection”.Furthermore,stakeholders elucidated the reasons behind their preferences for different types of FESs.Overall,our study indicates that besides considering the services provided by forests themselves,policymakers also need to pay attention to the preferences and divergences in needs among stakeholders of national parks.This ensures a more comprehensive fulfillment of diverse societal needs and facilitates the formulation of more effective policies to promote the sustainable management and conservation of national parks. 展开更多
关键词 forest ecosystem services fess vary canada China STAKEHOLDERS Q methodology forest ecosystem services semistructured interviews preference characteristics
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Study of Canada’s Economic System from a System Thinking Perspective
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作者 Wei Zhang Yuejun Cui 《Proceedings of Business and Economic Studies》 2024年第3期179-187,共9页
This article analyzes Canada’s economic system from a systems thinking perspective.The content includes patterns of public choice(party system and power distribution),organizational framework of decision-making arran... This article analyzes Canada’s economic system from a systems thinking perspective.The content includes patterns of public choice(party system and power distribution),organizational framework of decision-making arrangements,information provision and coordination mechanisms,property rights system,incentive system,and welfare system.Canada’s economic system significantly influences the development of the Canadian economy,and its economic system arrangements hold reference significance for other developed and developing countries. 展开更多
关键词 canada Economic system Party system Power distribution Property rights system
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12例Cronkhite Canada综合征患者临床及病理特点 被引量:21
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作者 刘颖娴 吴东 +6 位作者 费贵军 孙钢 钱家鸣 蔡建芳 樊晓红 李亚建 罗妍 《基础医学与临床》 CSCD 北大核心 2012年第11期1349-1352,共4页
目的分析北京协和医院CCS患者流行病学及临床病理特点、治疗策略及预后。方法回顾性分析,非参数Spearman相关分析判断各治疗方法的短期及远期疗效。结果 12例CCS患者均存在上消化道和下消化道息肉,以及至少1项外胚层异常。1/3患者尿蛋... 目的分析北京协和医院CCS患者流行病学及临床病理特点、治疗策略及预后。方法回顾性分析,非参数Spearman相关分析判断各治疗方法的短期及远期疗效。结果 12例CCS患者均存在上消化道和下消化道息肉,以及至少1项外胚层异常。1/3患者尿蛋白阳性,1例合并肾病综合征。若联合腹痛、腹泻及便潜血阳性3项指标,则灵敏度为100%。胃镜下可见多发黏膜下黑褐色素斑,息肉病理类型以增生性息肉及腺管状腺瘤最常见。平均随访44.7月,存活率100%;10例在初始或后续治疗中加用糖皮质激素,均获不同程度缓解。糖皮质激素停药后复发者再次使用仍然有效。泼尼松≥40 mg/d较≤40 mg/d预后更佳(n=10,r=-0.655,P<0.05);单用氨基水杨酸制剂、胃黏膜保护剂、肠道益生菌、息肉电切术及肠内外营养支持均无明显疗效;氨基水杨酸制剂与较差预后相关(r=0.598,P<0.05)。结论 CCS患者可见黏膜下色素沉着及尿蛋白阳性,糖皮质激素为基础的综合治疗临床缓解率较高,提示其发病机制可能有免疫因素参与。 展开更多
关键词 CRONKHITE canada综合征 胃肠道息肉 泼尼松 免疫
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Cronkhite-Canada综合征2例报告并国内外文献评价 被引量:9
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作者 贾岩 孙刚 +1 位作者 郭明洲 杨云生 《胃肠病学和肝病学杂志》 CAS 2009年第7期632-636,共5页
目的总结Cronkhite-Canada综合征(CCS)的临床表现、消化道息肉特点、病理改变及诊断治疗,以提高临床医生对本病的认识。方法对我院诊断明确的2例CCS病例及1990年以来72篇文献报告的31例病例的临床资料回顾性研究。结果符合CCS诊断标准... 目的总结Cronkhite-Canada综合征(CCS)的临床表现、消化道息肉特点、病理改变及诊断治疗,以提高临床医生对本病的认识。方法对我院诊断明确的2例CCS病例及1990年以来72篇文献报告的31例病例的临床资料回顾性研究。结果符合CCS诊断标准的入组病例33例,男20例,女13例;年龄17~77岁,中位年龄51岁。临床表现为脱发、指(趾)甲改变、皮肤色素沉着、腹部不适及低蛋白血症。全部患者均有消化道多发息肉,累及胃、小肠、大肠。息肉病理无特异性,其中8例癌变。治疗方法包括激素治疗17例,内镜下息肉摘除2例,因癌变、消化道梗阻及蛋白丢失性肠病手术11例(3例同时激素治疗)和其他治疗6例,其中1年内激素治疗有效14例,最长1例随访7年无复发。结论Cronkhite-Canada综合征(CCS)是以消化道多发息肉伴外胚层改变为主要临床特点的综合征,诊断较困难,激素治疗能改善症状,长期疗效仍待进一步研究。 展开更多
关键词 Cronkhite—canada综合征(CCS) 胃肠道息肉病 息肉 激素
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Cronkhite-Canada综合征43例临床分析 被引量:10
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作者 李曼 朱明欣 黄浩 《中国现代医学杂志》 CAS CSCD 北大核心 2010年第18期2806-2808,共3页
目的分析Cronkhite-Canada综合征(CCS)的临床特点。方法报告该院收治的1例CCS患者,并检索1985年1月~2008年12月国内42例CCS患者的临床资料进行临床分析。结果国内43例CCS患者以外胚层变化、胃肠道多发性息肉为主要临床特点,2例患者合... 目的分析Cronkhite-Canada综合征(CCS)的临床特点。方法报告该院收治的1例CCS患者,并检索1985年1月~2008年12月国内42例CCS患者的临床资料进行临床分析。结果国内43例CCS患者以外胚层变化、胃肠道多发性息肉为主要临床特点,2例患者合并胃肠道肿瘤。19例患者经综合治疗症状不同程度缓解,20例随访患者平均生存时间为15个月。结论 CCS发病率极低,本病的确诊有赖于内镜及组织学检查,目前国内外暂无特异性治疗方案。本病预后不佳,半数患者确诊后2年内死亡。 展开更多
关键词 CRONKHITE-canada综合征 胃肠道息肉 临床分析
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罕见的息肉病-Cronkhite-Canada综合征 被引量:10
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作者 陈鑫 李变霞 +4 位作者 朱兰平 马双 赵经文 仲威龙 王邦茂 《世界华人消化杂志》 CAS 2019年第16期977-983,共7页
Cronkhite-Canada综合征(Cronkhite-Canadasyndrome,CCS)是一组以胃肠道弥漫性息肉、指(趾)甲营养不良、脱发、皮肤色素沉着、腹泻、体重减轻和味觉障碍等为表现的非遗传性罕见病.多数CCS临床预后不良,常合并危及生命的严重并发症.目前... Cronkhite-Canada综合征(Cronkhite-Canadasyndrome,CCS)是一组以胃肠道弥漫性息肉、指(趾)甲营养不良、脱发、皮肤色素沉着、腹泻、体重减轻和味觉障碍等为表现的非遗传性罕见病.多数CCS临床预后不良,常合并危及生命的严重并发症.目前关于CCS疾病的病因、发病机制及合理的治疗方案仍处于探索阶段.本文通过综述CCS目前常见病因、临床表现、内镜特点以及治疗方案,旨在提高临床工作中对CCS认识水平的同时并探索其病因及最佳的治疗策略. 展开更多
关键词 CRONKHITE-canada综合征 自身免疫 IGG4 幽门螺杆菌 肠道菌群
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Cronkhite-Canada综合征1例报道及现况分析 被引量:3
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作者 陈慧群 戴林 +1 位作者 李爱萍 刘云 《胃肠病学和肝病学杂志》 CAS 2013年第5期442-442,445,共2页
Cronkhite-Canada综合征罕见,发病机制不清,治疗经验缺乏,内镜检查是确诊的主要手段。现报道我院近期收治Cronkhite-Canada综合征病例1例。
关键词 Cronkhite—canada综合征
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Cronkhite-Canada综合征1例临床病理分析 被引量:3
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作者 高汉青 韩静 +1 位作者 孙淑珍 马怡晖 《胃肠病学和肝病学杂志》 CAS 2018年第4期452-454,共3页
Cronkhite-Canada综合征(Cronkhite-Canada syndrome,CCS)是一种罕见的非遗传性疾病,以外胚层异常伴弥漫性息肉病为特征。现报道1例CCS。
关键词 CRONKHITE-canada综合征 砷中毒 消化内镜 病理
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Cronkhite-Canada综合征 被引量:3
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作者 汪盛 蒋献 +1 位作者 张敏 李薇 《临床皮肤科杂志》 CAS CSCD 北大核心 2008年第5期293-296,共4页
报告1例Cronkhite-Canada综合征。患者男,36岁。味觉减退、腹泻1个月余,面部、四肢末端皮肤变黑20d,脱发10d入院。皮肤科检查:面部、四肢末端色素沉着,指(趾)甲变薄脆裂,普秃。内镜检查发现全肠道息肉。出院2个月后症状自行缓解。1年后... 报告1例Cronkhite-Canada综合征。患者男,36岁。味觉减退、腹泻1个月余,面部、四肢末端皮肤变黑20d,脱发10d入院。皮肤科检查:面部、四肢末端色素沉着,指(趾)甲变薄脆裂,普秃。内镜检查发现全肠道息肉。出院2个月后症状自行缓解。1年后因肠道息肉增大行右半结肠切除术。 展开更多
关键词 CRONKHITE-canada综合征
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Cronkhite-Canada综合征1例 被引量:1
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作者 姜娜 于亚男 +4 位作者 丁雪丽 田字彬 杨林 荆雪 江月萍 《世界华人消化杂志》 CAS 2018年第28期1672-1676,共5页
Cronkhite-Canada综合征(Cronkhite-Canada’s syndrome, CCS)是临床罕见病,病因及发病机制尚不明确,该病以胃肠道多发息肉及外胚层两大症候群为主,临床表现以腹泻为主,全消化道多发息肉,伴有皮肤色素沉着、毛发脱落、指(趾)甲萎缩脱落... Cronkhite-Canada综合征(Cronkhite-Canada’s syndrome, CCS)是临床罕见病,病因及发病机制尚不明确,该病以胃肠道多发息肉及外胚层两大症候群为主,临床表现以腹泻为主,全消化道多发息肉,伴有皮肤色素沉着、毛发脱落、指(趾)甲萎缩脱落等.预后较差,本文报道1例CCS患者并对62篇国内文献进行回顾性分析. 展开更多
关键词 CRONKHITE-canada综合征 胃肠道息肉 外胚层改变 治疗
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