Significant temperature difference(300-77 K or even 4 K) can cause large deformations and displacements of the beam position monitors(BPMs),which affect BPMs measurement resolution or even cause their malfunction in c...Significant temperature difference(300-77 K or even 4 K) can cause large deformations and displacements of the beam position monitors(BPMs),which affect BPMs measurement resolution or even cause their malfunction in cryogenic situations.In this paper,to check the offset from the mechanical to electrical center in low temperature(77 K),Fourier's law and finite element method are used to simulate cryo-deformation.Laser tracker and micro-alignment telescope are employed in combined BPM calibration,installation and monitoring.The calibration error is<0.02 mm,and the installation and monitoring precision are 0.06 mm and 0.01 mm,respectively.The monitored cryo-deformation agrees well with the simulation results.These indicate that the combined alignment can improve performance of the BPM system.All these guaranteed the success of running the 9.55 MeV@2.14 mA cw protons.展开更多
Chronic exposure to coplanar polychlorinated biphenyls（PCBs）,a potent inducer of toxic reactive oxygen species（ROS）,in the environment and food can cause liver diseases.It remains unknown whether caffeic acid deri...Chronic exposure to coplanar polychlorinated biphenyls（PCBs）,a potent inducer of toxic reactive oxygen species（ROS）,in the environment and food can cause liver diseases.It remains unknown whether caffeic acid derivatives（CADs） exerted protective effect on PCB-induced hepatotoxicity.We sought to evaluate the activities of 3CADs on PCB169-induced oxidative stress and DNA damage in the liver.Male ICR mice were administered with1 μmol/mL PCB169 at 5 mL/kg body weight for 2 weeks.The mice were given CADs by gastric gavage for 3weeks.We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase（SOD）,glutathione（GSH） and GSH peroxidase（GPx）.It increased the liver weight,malondialdehyde（MDA）and 8-hydroxy-2＇-deoxyguanosine（8-OHdG） levels and CYPlAl activity in the liver tissues and plasma of mice（P〈0.05）.Pretreatment of mice with CADs restored the above parameters to normal levels.There was a synergistic protective effect between CADs in preventing MDA and 8-OHdG formation and inducing CYPlAl and phase II metabolism enzyme（SOD,GPx） activities（P〈0.05）.In conclusion,PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.展开更多
China Initiative Accelerator Driven System (CIADS) proposed by the Chinese Academy of Sciences which is one of the twelve Major National Scientific and Technological Infrastructures has been approved by National Devel...China Initiative Accelerator Driven System (CIADS) proposed by the Chinese Academy of Sciences which is one of the twelve Major National Scientific and Technological Infrastructures has been approved by National Development and Reform Commission of China, and supposed to be the first principle prototype ADS experimental facility in the world.展开更多
The demo facility of china ADS injector II was installed in the tunnel in 2014. The on-site layout of demo facility is shown in the Fig. 1. The demo faclity mainly includes ECRIS, LEBT, RFQ acclerator, MEBT and TCM6. ...The demo facility of china ADS injector II was installed in the tunnel in 2014. The on-site layout of demo facility is shown in the Fig. 1. The demo faclity mainly includes ECRIS, LEBT, RFQ acclerator, MEBT and TCM6. The TCM6 is composed by six SC HWR cavity,six SC soleniods and five BPMs. The TCM6 will be the prototype for the future 2025 MeV CADS superconducting linac. The beam commissioning of CADS Injector II started in June 2015. It mainly consists of three steps.展开更多
A Medium Energy Beam Transport line 1 （MEBT1） has been designed for Injector Scheme II of the China, ADS project. To match the beam from RFQ to Superconducting （SC） Half Wave Resonator （HWR） sections with emitta...A Medium Energy Beam Transport line 1 （MEBT1） has been designed for Injector Scheme II of the China, ADS project. To match the beam from RFQ to Superconducting （SC） Half Wave Resonator （HWR） sections with emittance preservation, the MEBT1 has been designed to be mechanically compact. Working at 162.5 MHz, the MEBT1 transports a 10 mA, 2.1 MeV proton beam using seven quadrupoles and two bunching cavities within 2.7 meters. Three collimators are placed between every two adjacent quadrupoles to collimate the beam halo. Design and construction of the MEBT1 are presented in this paper.展开更多
基金supported by the National Natural Science Foundation of China(No.11605262)
文摘Significant temperature difference(300-77 K or even 4 K) can cause large deformations and displacements of the beam position monitors(BPMs),which affect BPMs measurement resolution or even cause their malfunction in cryogenic situations.In this paper,to check the offset from the mechanical to electrical center in low temperature(77 K),Fourier's law and finite element method are used to simulate cryo-deformation.Laser tracker and micro-alignment telescope are employed in combined BPM calibration,installation and monitoring.The calibration error is<0.02 mm,and the installation and monitoring precision are 0.06 mm and 0.01 mm,respectively.The monitored cryo-deformation agrees well with the simulation results.These indicate that the combined alignment can improve performance of the BPM system.All these guaranteed the success of running the 9.55 MeV@2.14 mA cw protons.
基金supported by the National Natural Science Foundation of China(No:81072338)a project funded by the Priority Academic Program Development of Jiangsu Higher Education Institutions (2010)
文摘Chronic exposure to coplanar polychlorinated biphenyls（PCBs）,a potent inducer of toxic reactive oxygen species（ROS）,in the environment and food can cause liver diseases.It remains unknown whether caffeic acid derivatives（CADs） exerted protective effect on PCB-induced hepatotoxicity.We sought to evaluate the activities of 3CADs on PCB169-induced oxidative stress and DNA damage in the liver.Male ICR mice were administered with1 μmol/mL PCB169 at 5 mL/kg body weight for 2 weeks.The mice were given CADs by gastric gavage for 3weeks.We found that PCB169 decreased the growth rate and reduced the levels of superoxide dismutase（SOD）,glutathione（GSH） and GSH peroxidase（GPx）.It increased the liver weight,malondialdehyde（MDA）and 8-hydroxy-2＇-deoxyguanosine（8-OHdG） levels and CYPlAl activity in the liver tissues and plasma of mice（P〈0.05）.Pretreatment of mice with CADs restored the above parameters to normal levels.There was a synergistic protective effect between CADs in preventing MDA and 8-OHdG formation and inducing CYPlAl and phase II metabolism enzyme（SOD,GPx） activities（P〈0.05）.In conclusion,PCB169 induced hepatotoxicity and pretreatment with CADs had synergistic protective effects on liver damage.
文摘China Initiative Accelerator Driven System (CIADS) proposed by the Chinese Academy of Sciences which is one of the twelve Major National Scientific and Technological Infrastructures has been approved by National Development and Reform Commission of China, and supposed to be the first principle prototype ADS experimental facility in the world.
文摘The demo facility of china ADS injector II was installed in the tunnel in 2014. The on-site layout of demo facility is shown in the Fig. 1. The demo faclity mainly includes ECRIS, LEBT, RFQ acclerator, MEBT and TCM6. The TCM6 is composed by six SC HWR cavity,six SC soleniods and five BPMs. The TCM6 will be the prototype for the future 2025 MeV CADS superconducting linac. The beam commissioning of CADS Injector II started in June 2015. It mainly consists of three steps.
基金Supported by National Natural Science Foundation of China(11079001)
文摘A Medium Energy Beam Transport line 1 （MEBT1） has been designed for Injector Scheme II of the China, ADS project. To match the beam from RFQ to Superconducting （SC） Half Wave Resonator （HWR） sections with emittance preservation, the MEBT1 has been designed to be mechanically compact. Working at 162.5 MHz, the MEBT1 transports a 10 mA, 2.1 MeV proton beam using seven quadrupoles and two bunching cavities within 2.7 meters. Three collimators are placed between every two adjacent quadrupoles to collimate the beam halo. Design and construction of the MEBT1 are presented in this paper.
