The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate （IP3） on intracellular Ca^2＋spiral pattern evolution is studied numerically. The results indicate that when the IP3 concentra...The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate （IP3） on intracellular Ca^2＋spiral pattern evolution is studied numerically. The results indicate that when the IP3 concentration decreases from 0.27 μM, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP3 concentration. On the other hand, when the IP3 concentration increases from 0.27 μM, a homogeneous area with a high Ca^2＋ concentration emerges and competes with the spiral pattern. A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca^2＋ concentration.展开更多
中国气象局乌鲁木齐沙漠气象研究所自2017年开始推进中亚区域快速更新多尺度分析和预报系统RMAPS-CA的研发工作,并在多源资料联合同化技术、参数化方案优化和动力框架调整方面取得了一定的研究成果。在回顾RMAPS-CA业务研发历程的基础上...中国气象局乌鲁木齐沙漠气象研究所自2017年开始推进中亚区域快速更新多尺度分析和预报系统RMAPS-CA的研发工作,并在多源资料联合同化技术、参数化方案优化和动力框架调整方面取得了一定的研究成果。在回顾RMAPS-CA业务研发历程的基础上,重点对雷达反射率同化、高空次网格地形重力波拖曳与近地层阻塞拖曳分离的次网格物理过程、混合地形追随坐标动力框架以及基于贝叶斯模式平均(Bayesian Model Averaging,BMA)方法订正预报产品等方面所取得的研究成果进行综述。针对中亚地区常规观测稀疏且沙漠下垫面范围广等特点,从卫星地面通道同化等方面提出了加强中亚区域数值天气预报业务研发及应用的建议。展开更多
基金Project supported by the National Natural Science Foundation of China (Grant Nos 10575041 and 10747005)
文摘The effect of change in concentration of messenger molecule inositol 1,4,5-trisphosphate （IP3） on intracellular Ca^2＋spiral pattern evolution is studied numerically. The results indicate that when the IP3 concentration decreases from 0.27 μM, a physiologically reasonable value, to different values, the spiral centre drifts to the edge of the medium and disappears for a small enough IP3 concentration. The instability of spiral pattern can be understood in terms of excitability-change controlled by the IP3 concentration. On the other hand, when the IP3 concentration increases from 0.27 μM, a homogeneous area with a high Ca^2＋ concentration emerges and competes with the spiral pattern. A high enough IP3 concentration can lead the homogeneous area to occupy the whole medium. The instability of spiral pattern is ascribed to the change in stability of a stationary state with a high Ca^2＋ concentration.
文摘中国气象局乌鲁木齐沙漠气象研究所自2017年开始推进中亚区域快速更新多尺度分析和预报系统RMAPS-CA的研发工作,并在多源资料联合同化技术、参数化方案优化和动力框架调整方面取得了一定的研究成果。在回顾RMAPS-CA业务研发历程的基础上,重点对雷达反射率同化、高空次网格地形重力波拖曳与近地层阻塞拖曳分离的次网格物理过程、混合地形追随坐标动力框架以及基于贝叶斯模式平均(Bayesian Model Averaging,BMA)方法订正预报产品等方面所取得的研究成果进行综述。针对中亚地区常规观测稀疏且沙漠下垫面范围广等特点,从卫星地面通道同化等方面提出了加强中亚区域数值天气预报业务研发及应用的建议。
