Bacckground:Based on the 3C model,this study explores the current situation of HPV vaccine hesitancy among women of childbearing age and the factors influencing vaccine hesitancy.Methods:Based on the free cervical can...Bacckground:Based on the 3C model,this study explores the current situation of HPV vaccine hesitancy among women of childbearing age and the factors influencing vaccine hesitancy.Methods:Based on the free cervical cancer screening project in Baoan District,this study designed a questionnaire under the framework of vaccine hesitation 3C theory and carried out a self-filling electronic questionnaire survey among women of childbearing age.Results:The rate of HPV vaccination awareness among women of childbearing age in Bao’an District was 93.25%.HPV vaccine acceptance reached 71.55%,and 24.59%of the survey respondents experienced HPV vaccine hesitation,a high percentage of whom were hesitant.The influencing factors of HPV vaccine hesitation among women of childbearing age were perceived necessity of HPV vaccination(0.482),no one around them receiving the HPV vaccine(0.411),perception of the price of the vaccine(0.354),degree of trust in the safety of the vaccine(0.223),and degree of concern about the HPV vaccine(0.153).Conclusion:The 3C model can be used for the study of HPV vaccine hesitancy.Strengthening the publicity of HPV vaccination and improving women’s knowledge of the HPV vaccine can reduce their hesitation toward HPV vaccination.展开更多
With the widespread application of large language models(LLMs)in natural language processing and code generation,traditional High-Level Language Programming courses are facing unprecedented challenges and opportunitie...With the widespread application of large language models(LLMs)in natural language processing and code generation,traditional High-Level Language Programming courses are facing unprecedented challenges and opportunities.As a core programming language for computer science majors,C language remains irreplaceable due to its foundational nature and engineering adaptability.This paper,based on the rapid development of large model technologies,proposes a systematic reform design for C language teaching,focusing on teaching objectives,content structure,teaching methods,and evaluation systems.The article suggests a teaching framework centered on“human-computer collaborative programming,”integrating prompt training,AI-assisted debugging,and code generation analysis,aiming to enhance students’problem modeling ability,programming expression skills,and AI collaboration literacy.展开更多
Based on the data of daily precipitation in Lianyungang area from 1951 to 2012 and various climate signal data from the National Climate Center website and the NOAA website,a model for predicting whether the number of...Based on the data of daily precipitation in Lianyungang area from 1951 to 2012 and various climate signal data from the National Climate Center website and the NOAA website,a model for predicting whether the number of rainstorm days in summer in Lianyungang area is large was established by the classical C5. 0 decision tree algorithm. The data samples in 48 years( accounting for about 80% of total number of samples)was as the training set of a model,and the training accuracy rate of the model was 95. 83%. The data samples in the remaining 14 years( accounting for about 20% of total number of samples) were used as the test set of the model to test the model,and the test accuracy of the model was 85. 71%. The results showed that the prediction model of number of rainstorm days in summer constructed by C5. 0 algorithm had high accuracy and was easy to explain. Moreover,it is convenient for meteorological staff to use directly. At the same time,this study provides a new idea for short-term climate prediction of number of rainstorm days in summer.展开更多
Thermal conductivity is one of the most significant criterion of three-dimensional carbon fiber-reinforced SiC matrix composites(3D C/SiC).Represent volume element(RVE)models of microscale,void/matrix and mesoscale pr...Thermal conductivity is one of the most significant criterion of three-dimensional carbon fiber-reinforced SiC matrix composites(3D C/SiC).Represent volume element(RVE)models of microscale,void/matrix and mesoscale proposed in this work are used to simulate the thermal conductivity behaviors of the 3D C/SiC composites.An entirely new process is introduced to weave the preform with three-dimensional orthogonal architecture.The 3D steady-state analysis step is created for assessing the thermal conductivity behaviors of the composites by applying periodic temperature boundary conditions.Three RVE models of cuboid,hexagonal and fiber random distribution are respectively developed to comparatively study the influence of fiber package pattern on the thermal conductivities at the microscale.Besides,the effect of void morphology on the thermal conductivity of the matrix is analyzed by the void/matrix models.The prediction results at the mesoscale correspond closely to the experimental values.The effect of the porosities and fiber volume fractions on the thermal conductivities is also taken into consideration.The multi-scale models mentioned in this paper can be used to predict the thermal conductivity behaviors of other composites with complex structures.展开更多
Coal has a highly complex chemical structure,similar to polymers,coal is a macromolecular structure composed of a large number of“similar compounds”,which is called the basic structural unit.Understanding coal struc...Coal has a highly complex chemical structure,similar to polymers,coal is a macromolecular structure composed of a large number of“similar compounds”,which is called the basic structural unit.Understanding coal structure is the basis of its transformation and utilization.Shendong(SD)coal was analyzed by FTIR,XRD,XPS,and NMR.The results show that SD coal normalized structure formula is C_(100)H_(68.5)O_(35.7)N_(1.2)S_(0.2)and the average number of aromatic rings is 1.98.-CH_(2)-content accounts for about 82%in aliphatic CeH region,and the ratio of ether bond CeO,aromatic ether C-O and C=O is about 2:1:11 in oxygen-containing functional group region.The d_(002),L_(C),L_(a)and N_(C)of S_(D)coal microcrystalline structure parameters are 0.1832 nm,1.4688 nm,2.0852 nm and 9.017,respectively.Aromatic carbon and aliphatic carbon ratios of SD coal are 55.67%and 29.97%,aromatic cluster size and average methylene chain length are 0.224 and 1.817.Based on these structural parameters,molecular model of SD coal was constructed with^(13)C SSNMR experimental spectra as a reference.The model was constructed with an atom composition of C_(214)H_(214)O_(49)N_(2)S.展开更多
Human adenoviruses(HAdVs)are highly contagious pathogens with various genotypes implicated in acute respiratory disease(ARD)and linked to fatality,especially in immunosuppressed patients,young children,and military re...Human adenoviruses(HAdVs)are highly contagious pathogens with various genotypes implicated in acute respiratory disease(ARD)and linked to fatality,especially in immunosuppressed patients,young children,and military recruits.Currently,no vaccines or specific drugs are approved for clinical use.The hosts of adenoviruses are strictly species-specific,which strongly limits the development of vaccines and drugs against HAdVs.In this study,immunocompetent BALB/c mice were challenged with different doses of human adenovirus type 5(HAdV-5)via tail intravenous injection(i.v.).All mice challenged with a high dose of HAdV-5(3.21010 TCID50/kg)died within 3–5 days,while those receiving a low dose of HAdV-5(8109 or 4109 TCID50/kg)survived.Interestingly,among the mice receiving a medium dose of HAdV-5(1.61010 TCID50/kg),60%(n¼3/5)of male mice died,while all female mice survived.This suggests that male mice may be more susceptible to HAdV-5 infection than female mice,consistent with clinical findings in children.HAdV-5 DNA was mainly distributed in the liver,followed by the spleen and lung.Pathological changes were observed in the lung,liver,and spleen,with severity increasing in correlation with the virus challenge dosage.Transcriptome and qPCR analyses of the liver indicated that the down-regulated expression of the H2-Aa,H2-Ea-ps,CD74,and H2-Eb1 genes in male mice,as well as the AHR gene in female mice,may contribute to the observed higher mortality rates in male mice.Therefore,this effective,feasible,and costefficient mouse model could serve as a candidate for evaluating HAdV vaccines and anti-adenovirus therapeutics.展开更多
Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on ...Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on the 5C caring theory,the teaching design and teaching content were revising and implementing in the intervention group.Before and after the implementation of the course,a questionnaire survey was conducted using the Caring Ability Inventory(CAI).The results of the surveys were collected,and the data were statistically analysis using SPSS.Results:After the implementation of the course,the cognitive dimension,patience dimension,and humanistic caring ability scores of the nursing students in the intervention group improved compared with those before the implementation of the course(P<0.05).There were no significant difference in the control group(P>0.05).Conclusion:The humanistic caring teaching model based on 5C caring theory has a positive effect on improving nursing students'humanistic caring ability.In the future nursing teaching,the modules with the characteristics of humanistic caring ability can be increased,and carry out the educational reform throughout the humanistic caring ability.Actively guiding nursing students to establish the awareness of humanistic caring,so as to lay a solid foundation for high-quality clinical nursing work.展开更多
煤焦的反应性受其化学结构影响,该文基于碳-13固体核磁共振(^(13)C solid-state nuclear magnetic resonance,^(13)C-NMR)技术构建了准东脱灰煤焦大分子结构模型,采用反应力场分子动力学模拟方法(reactive force field molecular dynami...煤焦的反应性受其化学结构影响,该文基于碳-13固体核磁共振(^(13)C solid-state nuclear magnetic resonance,^(13)C-NMR)技术构建了准东脱灰煤焦大分子结构模型,采用反应力场分子动力学模拟方法(reactive force field molecular dynamics,ReaxFF MD)对准东脱灰煤焦在O_(2)/H_(2)O条件下的燃烧过程进行模拟。结果表明:不同O_(2)/H_(2)O浓度下,C+H_(2)O气化和C+O_(2)氧化反应相互竞争,O、H、OH自由基对准东脱灰煤焦活性位的竞争程度不同。压力越高,则C+O_(2)氧化反应较C+H_(2)O气化反应的化学活性越大,燃烧程度也越深,故温度升高有利于提高煤焦的燃烧转化率、缩短燃尽时间。准东脱灰煤焦燃烧始于侧支链及脂肪碳的分解,随后稠环芳烃开环断裂为小分子结构碎片,与活性自由基相互作用形成燃烧产物。该文从分子层面直观地追踪了燃烧的中间产物及演变过程,有利于深入理解燃烧机理,为后续燃烧技术及应用提供理论支持。展开更多
基金District of Medical and Health Research Project(2023JD212)Shenzhen Bao’an District of Traditional Chinese Medicine Clinical Research Project(2023ZYYLCZX-12)+2 种基金Shenzhen“Medical and Health Three Projects”Project Grant(SZZYSM 202106003)Weifang Health Committee Scientific Research Project(wfwsjk-2023-170)Shenzhen Pingshan District of Health System Research Project(2024334).
文摘Bacckground:Based on the 3C model,this study explores the current situation of HPV vaccine hesitancy among women of childbearing age and the factors influencing vaccine hesitancy.Methods:Based on the free cervical cancer screening project in Baoan District,this study designed a questionnaire under the framework of vaccine hesitation 3C theory and carried out a self-filling electronic questionnaire survey among women of childbearing age.Results:The rate of HPV vaccination awareness among women of childbearing age in Bao’an District was 93.25%.HPV vaccine acceptance reached 71.55%,and 24.59%of the survey respondents experienced HPV vaccine hesitation,a high percentage of whom were hesitant.The influencing factors of HPV vaccine hesitation among women of childbearing age were perceived necessity of HPV vaccination(0.482),no one around them receiving the HPV vaccine(0.411),perception of the price of the vaccine(0.354),degree of trust in the safety of the vaccine(0.223),and degree of concern about the HPV vaccine(0.153).Conclusion:The 3C model can be used for the study of HPV vaccine hesitancy.Strengthening the publicity of HPV vaccination and improving women’s knowledge of the HPV vaccine can reduce their hesitation toward HPV vaccination.
基金Education and Teaching Research Project of Beijing University of Technology(ER2024KCB08)。
文摘With the widespread application of large language models(LLMs)in natural language processing and code generation,traditional High-Level Language Programming courses are facing unprecedented challenges and opportunities.As a core programming language for computer science majors,C language remains irreplaceable due to its foundational nature and engineering adaptability.This paper,based on the rapid development of large model technologies,proposes a systematic reform design for C language teaching,focusing on teaching objectives,content structure,teaching methods,and evaluation systems.The article suggests a teaching framework centered on“human-computer collaborative programming,”integrating prompt training,AI-assisted debugging,and code generation analysis,aiming to enhance students’problem modeling ability,programming expression skills,and AI collaboration literacy.
基金Support by Meteorological Open Research Foundation for the Huaihe River Basin(HRM201602)Foundation for Young Scholars of Jiangsu Meteorological Bureau(Q201708,KQ201802)+2 种基金Science and Technology Innovation Team Foundation for Marine Meteorological Forecast Technology of Lianyungang Meteorological BureauKey Technology R&D Program Project of Lianyungang City(SH1634)Special Project for Forecasters of Jiangsu Meteorological Bureau(JSYBY201811,JSYBY201812,JSYBY201810)
文摘Based on the data of daily precipitation in Lianyungang area from 1951 to 2012 and various climate signal data from the National Climate Center website and the NOAA website,a model for predicting whether the number of rainstorm days in summer in Lianyungang area is large was established by the classical C5. 0 decision tree algorithm. The data samples in 48 years( accounting for about 80% of total number of samples)was as the training set of a model,and the training accuracy rate of the model was 95. 83%. The data samples in the remaining 14 years( accounting for about 20% of total number of samples) were used as the test set of the model to test the model,and the test accuracy of the model was 85. 71%. The results showed that the prediction model of number of rainstorm days in summer constructed by C5. 0 algorithm had high accuracy and was easy to explain. Moreover,it is convenient for meteorological staff to use directly. At the same time,this study provides a new idea for short-term climate prediction of number of rainstorm days in summer.
基金Supported by Science Center for Gas Turbine Project of China (Grant No.P2022-B-IV-014-001)Frontier Leading Technology Basic Research Special Project of Jiangsu Province of China (Grant No.BK20212007)the BIT Research and Innovation Promoting Project of China (Grant No.2022YCXZ019)。
文摘Thermal conductivity is one of the most significant criterion of three-dimensional carbon fiber-reinforced SiC matrix composites(3D C/SiC).Represent volume element(RVE)models of microscale,void/matrix and mesoscale proposed in this work are used to simulate the thermal conductivity behaviors of the 3D C/SiC composites.An entirely new process is introduced to weave the preform with three-dimensional orthogonal architecture.The 3D steady-state analysis step is created for assessing the thermal conductivity behaviors of the composites by applying periodic temperature boundary conditions.Three RVE models of cuboid,hexagonal and fiber random distribution are respectively developed to comparatively study the influence of fiber package pattern on the thermal conductivities at the microscale.Besides,the effect of void morphology on the thermal conductivity of the matrix is analyzed by the void/matrix models.The prediction results at the mesoscale correspond closely to the experimental values.The effect of the porosities and fiber volume fractions on the thermal conductivities is also taken into consideration.The multi-scale models mentioned in this paper can be used to predict the thermal conductivity behaviors of other composites with complex structures.
基金financed by the Department of education of Gansu Province:Young Doctor Fund Project(2022QB-029)the Fundamental Research Funds for the Central Universities(31920240125-06,31920240059)+1 种基金the Scientific Research Project of Introducing Talents of Northwest Minzu University(xbmuyjrc202215,xbmuyjrc202216)the National Natural Science Foundation of China(22178289).
文摘Coal has a highly complex chemical structure,similar to polymers,coal is a macromolecular structure composed of a large number of“similar compounds”,which is called the basic structural unit.Understanding coal structure is the basis of its transformation and utilization.Shendong(SD)coal was analyzed by FTIR,XRD,XPS,and NMR.The results show that SD coal normalized structure formula is C_(100)H_(68.5)O_(35.7)N_(1.2)S_(0.2)and the average number of aromatic rings is 1.98.-CH_(2)-content accounts for about 82%in aliphatic CeH region,and the ratio of ether bond CeO,aromatic ether C-O and C=O is about 2:1:11 in oxygen-containing functional group region.The d_(002),L_(C),L_(a)and N_(C)of S_(D)coal microcrystalline structure parameters are 0.1832 nm,1.4688 nm,2.0852 nm and 9.017,respectively.Aromatic carbon and aliphatic carbon ratios of SD coal are 55.67%and 29.97%,aromatic cluster size and average methylene chain length are 0.224 and 1.817.Based on these structural parameters,molecular model of SD coal was constructed with^(13)C SSNMR experimental spectra as a reference.The model was constructed with an atom composition of C_(214)H_(214)O_(49)N_(2)S.
基金supported by grants from the National Natural Science Foundation of China(32170139 and 92269103)the R&D Program of Guangzhou Laboratory(No.SRPG22-006)+4 种基金the Guangdong Basic and Applied Basic Research Foundation(2022A1515011190)the Science and Technology Program of Guangzhou,China(202201011115)the Open Foundation of Key Laboratory of Viral Pathogenesis&Infection Prevention and Control(Jinan University),Ministry of Education(2023VPPC-R07)China Postdoctoral Science Foundation(2023M731321)the Lifting Project Foundation of the Affiliated Guangdong Second Provincial General Hospital of Jinan University(TJGC-2022004).
文摘Human adenoviruses(HAdVs)are highly contagious pathogens with various genotypes implicated in acute respiratory disease(ARD)and linked to fatality,especially in immunosuppressed patients,young children,and military recruits.Currently,no vaccines or specific drugs are approved for clinical use.The hosts of adenoviruses are strictly species-specific,which strongly limits the development of vaccines and drugs against HAdVs.In this study,immunocompetent BALB/c mice were challenged with different doses of human adenovirus type 5(HAdV-5)via tail intravenous injection(i.v.).All mice challenged with a high dose of HAdV-5(3.21010 TCID50/kg)died within 3–5 days,while those receiving a low dose of HAdV-5(8109 or 4109 TCID50/kg)survived.Interestingly,among the mice receiving a medium dose of HAdV-5(1.61010 TCID50/kg),60%(n¼3/5)of male mice died,while all female mice survived.This suggests that male mice may be more susceptible to HAdV-5 infection than female mice,consistent with clinical findings in children.HAdV-5 DNA was mainly distributed in the liver,followed by the spleen and lung.Pathological changes were observed in the lung,liver,and spleen,with severity increasing in correlation with the virus challenge dosage.Transcriptome and qPCR analyses of the liver indicated that the down-regulated expression of the H2-Aa,H2-Ea-ps,CD74,and H2-Eb1 genes in male mice,as well as the AHR gene in female mice,may contribute to the observed higher mortality rates in male mice.Therefore,this effective,feasible,and costefficient mouse model could serve as a candidate for evaluating HAdV vaccines and anti-adenovirus therapeutics.
基金supported by the Research Program on Educational Teaching Reform of Tianjin University of Traditional Chinese Medicine(2020JY041)。
文摘Objective:To construct a scientific and feasible teaching mode based on 5C caring theory and evaluate it,so as to provide a reference basis for future study about nursing humanistic quality education.Methods:Based on the 5C caring theory,the teaching design and teaching content were revising and implementing in the intervention group.Before and after the implementation of the course,a questionnaire survey was conducted using the Caring Ability Inventory(CAI).The results of the surveys were collected,and the data were statistically analysis using SPSS.Results:After the implementation of the course,the cognitive dimension,patience dimension,and humanistic caring ability scores of the nursing students in the intervention group improved compared with those before the implementation of the course(P<0.05).There were no significant difference in the control group(P>0.05).Conclusion:The humanistic caring teaching model based on 5C caring theory has a positive effect on improving nursing students'humanistic caring ability.In the future nursing teaching,the modules with the characteristics of humanistic caring ability can be increased,and carry out the educational reform throughout the humanistic caring ability.Actively guiding nursing students to establish the awareness of humanistic caring,so as to lay a solid foundation for high-quality clinical nursing work.
文摘煤焦的反应性受其化学结构影响,该文基于碳-13固体核磁共振(^(13)C solid-state nuclear magnetic resonance,^(13)C-NMR)技术构建了准东脱灰煤焦大分子结构模型,采用反应力场分子动力学模拟方法(reactive force field molecular dynamics,ReaxFF MD)对准东脱灰煤焦在O_(2)/H_(2)O条件下的燃烧过程进行模拟。结果表明:不同O_(2)/H_(2)O浓度下,C+H_(2)O气化和C+O_(2)氧化反应相互竞争,O、H、OH自由基对准东脱灰煤焦活性位的竞争程度不同。压力越高,则C+O_(2)氧化反应较C+H_(2)O气化反应的化学活性越大,燃烧程度也越深,故温度升高有利于提高煤焦的燃烧转化率、缩短燃尽时间。准东脱灰煤焦燃烧始于侧支链及脂肪碳的分解,随后稠环芳烃开环断裂为小分子结构碎片,与活性自由基相互作用形成燃烧产物。该文从分子层面直观地追踪了燃烧的中间产物及演变过程,有利于深入理解燃烧机理,为后续燃烧技术及应用提供理论支持。
