Objectives To assess the possible association between P2Y12 C34T、G52T polymorphism and clopidogrel resistance in coronary artery disease(CAD) of North China. Methods A case-control study was conducted in 615 patients...Objectives To assess the possible association between P2Y12 C34T、G52T polymorphism and clopidogrel resistance in coronary artery disease(CAD) of North China. Methods A case-control study was conducted in 615 patients with angiographically documented CAD.All 615 patients was detected platelet aggregation ratio,and accorded the platelet aggregation ratio to defined Clopidogrel resistance (CR) and None-Clopidogrel resistance(NCR),5μmol/L ADP-induced platelet aggregation ratio≥70%was defined CR.The P2Y12 C34T、G52T single nucleotide polymorphism was selected and genotyped.Results The genotype frequencies of CC,CT and TT of P2Y12 C34T polymorphism were 38.36%,50.68%and 10.96%in clopidogrel resistance patients, 50.96%,43.07%and 5.97%in non-clopidogrel resistance patients(P=0.010).The frequencies of P2Y12 C34T T allele frequencies in CR and NCR were 36.30%and 27.51% (P=0.004).The genotype frequencies of GG,GT and TT of P2Y12 G52T polymorphism were 74.66%,24.66%and 0.68%in clopidogrel resistance patients,79.74%,19.83% and 0.43%in non-clopidogrel resistance patients(P】0.05). The frequencies of P2Y12 G52T T allele frequencies in CR and NCR were 13.01%and 10.34%(P】0.05).After adjustment for conventional risk factors,including gender,age, body mass index,smoking status,hypertension,diabetes mellitus and hypercholesterolemia,there was significant difference between P2Y12 C34T polymorphism and clopidogel resistance (P =0.007).Conclusions The results suggest that P2Y12 C34T polymorphism might associated with clopidogrel resistance in CAD population of North China.展开更多
文摘Objectives To assess the possible association between P2Y12 C34T、G52T polymorphism and clopidogrel resistance in coronary artery disease(CAD) of North China. Methods A case-control study was conducted in 615 patients with angiographically documented CAD.All 615 patients was detected platelet aggregation ratio,and accorded the platelet aggregation ratio to defined Clopidogrel resistance (CR) and None-Clopidogrel resistance(NCR),5μmol/L ADP-induced platelet aggregation ratio≥70%was defined CR.The P2Y12 C34T、G52T single nucleotide polymorphism was selected and genotyped.Results The genotype frequencies of CC,CT and TT of P2Y12 C34T polymorphism were 38.36%,50.68%and 10.96%in clopidogrel resistance patients, 50.96%,43.07%and 5.97%in non-clopidogrel resistance patients(P=0.010).The frequencies of P2Y12 C34T T allele frequencies in CR and NCR were 36.30%and 27.51% (P=0.004).The genotype frequencies of GG,GT and TT of P2Y12 G52T polymorphism were 74.66%,24.66%and 0.68%in clopidogrel resistance patients,79.74%,19.83% and 0.43%in non-clopidogrel resistance patients(P】0.05). The frequencies of P2Y12 G52T T allele frequencies in CR and NCR were 13.01%and 10.34%(P】0.05).After adjustment for conventional risk factors,including gender,age, body mass index,smoking status,hypertension,diabetes mellitus and hypercholesterolemia,there was significant difference between P2Y12 C34T polymorphism and clopidogel resistance (P =0.007).Conclusions The results suggest that P2Y12 C34T polymorphism might associated with clopidogrel resistance in CAD population of North China.
