Background：A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome （ACS）. However, the results are not consistent. ...Background：A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome （ACS）. However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T poly-morphism and ACS. Methods and results：We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under al elic comparison （odd ratio （OR） 0.73;95%confidence intervals （CI） 0.64–0.83）, dominant model （OR 0.71;95%CI 0.62–0.82）, and homozygote comparison （OR 0.57;95%CI 0.35–0.92）. However, in the overal population and es-pecial y with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger’s linear regression test. Conclusions： Taken together, our results suggest that the C242T poly-morphism might be a protective factor against developing ACS in the Asian population. Further researches wil be needed to identify the confounding factors which modified the protective effect of T al ele among Caucasians.展开更多
文摘Background：A lot of studies have demonstrated that C242T polymorphism in CYBA genes may play an important role in the pathological process of acute coronary syndrome （ACS）. However, the results are not consistent. To further evaluate this debate, we performed a meta-analysis to determine the relationship between C242T poly-morphism and ACS. Methods and results：We screened PubMed/MEDLINE, EBSCIO, and EMBASE research reports until Mar. 2014 and extracted data from 10 studies involving 6102 ACS patients and 8669 controls. Subgroup analysis by ethnicity documented a significant decreased risk of ACS for C242T polymorphism in the Asian population under al elic comparison （odd ratio （OR） 0.73;95%confidence intervals （CI） 0.64–0.83）, dominant model （OR 0.71;95%CI 0.62–0.82）, and homozygote comparison （OR 0.57;95%CI 0.35–0.92）. However, in the overal population and es-pecial y with Caucasians, no significant association was uncovered. Further meta-regression analysis revealed that the heterogeneity among studies was largely attributed to ethnicity. No publication bias was detected through a funnel plot and an Egger’s linear regression test. Conclusions： Taken together, our results suggest that the C242T poly-morphism might be a protective factor against developing ACS in the Asian population. Further researches wil be needed to identify the confounding factors which modified the protective effect of T al ele among Caucasians.
