多发性骨髓瘤(multiple myeloma,MM)是一种不可治愈的血液系统恶性肿瘤,尽管新型蛋白酶体抑制剂、免疫调节剂及CD38单抗等药物的应用显著延长了患者的生存时间,但复发耐药仍难以避免。细胞免疫治疗,特别是嵌合抗原受体(chimeric antigen...多发性骨髓瘤(multiple myeloma,MM)是一种不可治愈的血液系统恶性肿瘤,尽管新型蛋白酶体抑制剂、免疫调节剂及CD38单抗等药物的应用显著延长了患者的生存时间,但复发耐药仍难以避免。细胞免疫治疗,特别是嵌合抗原受体(chimeric antigen receptor,CAR)T细胞疗法的快速发展,极大程度的改变了复发/难治性(relapsed/refractory,R/R)MM患者的治疗现状。FDA目前已批准了2款靶向B细胞成熟抗原(B cell maturation antigen,BCMA)的CAR-T细胞产品,使其用于既往接受过4线及以上治疗的R/R MM患者。随着临床研究的不断深入,靶向GPRC5D(G protein-coupled receptor C class Group 5 member D,G蛋白偶联受体C类第5组成员D)的CAR-T细胞治疗也显示出其独特的优势。除了应用于难治复发的患者,多项临床试验支持CAR-T在MM中治疗线数的前移。本文就CAR-T细胞治疗在MM中开展的关键性临床研究展开综述,旨在为临床应用提供参考。展开更多
A two‐step photocatalytic water splitting system,termed a“Z‐scheme system”,was achieved using Zn‐doped g‐C3N4for H2evolution and BiVO4for O2evolution with Fe2+/Fe3+as a shuttle redox mediator.H2and O2were evalua...A two‐step photocatalytic water splitting system,termed a“Z‐scheme system”,was achieved using Zn‐doped g‐C3N4for H2evolution and BiVO4for O2evolution with Fe2+/Fe3+as a shuttle redox mediator.H2and O2were evaluated simultaneously when the doping amount of zinc was10%.Moreover,Zn‐doped(10%)g‐C3N4synthesized by an impregnation method showed superior active ability to form the Z‐scheme with BiVO4than by in‐situ synthesis.X‐ray diffraction,UV‐Vis spectroscopy,scanning electron microscopy,and X‐ray photoelectron spectroscopy were used to characterize the samples.It was determined that more Zn?N bonds could be formed on the surface of g‐C3N4by impregnation,which could facilitate charge transfer.展开更多
The 23-year-old T. flousiana plantation and successive rotation plantation of C. lanceolata at Shankou Forest Farm of Nandan County, Guangxi were tested by the method of plot investigation combining with biomass m...The 23-year-old T. flousiana plantation and successive rotation plantation of C. lanceolata at Shankou Forest Farm of Nandan County, Guangxi were tested by the method of plot investigation combining with biomass measurement. Carbon storage and spatial distribution of different components in the two forests were analyzed. The results indicated that carbon content in different organs of T. flousiana ranged from 426.0 to 503.9 g/kg, and the order was bark 〉stem 〉 root 〉 branch 〉 leaf. The carbon contents in shrub, herb and litter layers were452.9 , 408.0 and 428.9 g/kg, respectively. Carbon content in the soil （0 -80 cm）was 16.59 g/kg. The carbon content in different organs of C. lanceolata ranged from 464.5 to 508.9 g/kg, and the order was bark 〉 stem 〉 branch 〉 root 〉 leaf. The carbon contents in shrub, herb and litter layers were 456.2, 416.3 and 468.1 g/kg, respectively. Carbon content in the soil （0 -80 cm）was 15.77 g/kg. Total carbon storage amounts of T. flousiana plantation and successive rotation plantation of C. lanceolata were 245.83 and 213.52 t/hm^2, respectively. The carbon storage order of different structure layers from T. flousiana plantation and successive rotation plantation of C. lanceolata was soil layer （0 -8 0 cm） 〉 vegetation layer 〉 litter layer. Annual net productivity in the arbor layers of T. flousiana plantation and successive rotation plantation of C. lanceolata plantations was 10.75 and 17.13 t/（hm^2 · a） ; annual net carbon fixation amounts were estimated as 5.05 and 3.47 t /（hm^2 · a） ; annual net absorption C02 amounts were 18.53 and 12.73 t/（hm^2 · a） respectively.展开更多
The synergistic effect of high voltage discharge non‐thermal plasma(NTP)and photocatalysts on contaminant removal has repeatedly confirmed by plenty of researches.Most previous plasma‐photocatalyst synergistic syste...The synergistic effect of high voltage discharge non‐thermal plasma(NTP)and photocatalysts on contaminant removal has repeatedly confirmed by plenty of researches.Most previous plasma‐photocatalyst synergistic systems focused on the utilization of the ultraviolet light but ignored the visible light generated by high voltage discharge.Graphitic carbon nitride(g‐C3N4),a metal‐free semiconductor that exhibits high chemical stability,can utilize both the ultraviolet and visible light from high voltage discharge.However,the synergistic system of NTP and g‐C3N4 has been researched little.In this paper,the effect of NTP generated by dielectric barrier discharge(DBD)on g‐C3N4 is studied by comparing the photocatalytic activities,the surface physical structure and the surface chemical characteristics of pristine and plasma treated g‐C3N4.Experimental results indicate that the DBD plasma can change the physical structure and the chemical characteristics and to further affect the photocatalytic activity of g‐C3N4.The effect of NTP on g‐C3N4 is associated with the discharge intensity and the discharge time.For a long time scale,the effect of NTP on g‐C3N4 photocatalysts presents a periodic change trend.展开更多
The photocatalytic reduction of aqueous Cr(VI)to Cr(III)was preliminarily studied using porousg‐C3N4as a photocatalyst under acidic conditions.The observed synergistic photocatalytic effect ofporous g‐C3N4on a Cr(VI...The photocatalytic reduction of aqueous Cr(VI)to Cr(III)was preliminarily studied using porousg‐C3N4as a photocatalyst under acidic conditions.The observed synergistic photocatalytic effect ofporous g‐C3N4on a Cr(VI)/4‐chlorophenol(4‐CP)composite pollution system was further studiedunder different pH conditions.Compared with single‐component photocatalytic systems for Cr(VI)reduction or4‐CP degradation,the Cr(VI)reduction efficiency and4‐CP degradation efficiency weresimultaneously improved in the Cr(VI)/4‐CP composite pollution system.The synergistic photocatalyticeffect in the Cr(VI)/4‐CP composite pollution system can be attributed to the acceleratedredox reaction between dichromate and4‐CP by electron transfer with porous g‐C3N4.展开更多
Various application domains require the integration of distributed real-time or near-real-time systems with non-real-time systems.Smart cities,smart homes,ambient intelligent systems,or network-centric defense systems...Various application domains require the integration of distributed real-time or near-real-time systems with non-real-time systems.Smart cities,smart homes,ambient intelligent systems,or network-centric defense systems are among these application domains.Data Distribution Service(DDS)is a communication mechanism based on Data-Centric Publish-Subscribe(DCPS)model.It is used for distributed systems with real-time operational constraints.Java Message Service(JMS)is a messaging standard for enterprise systems using Service Oriented Architecture(SOA)for non-real-time operations.JMS allows Java programs to exchange messages in a loosely coupled fashion.JMS also supports sending and receiving messages using a messaging queue and a publish-subscribe interface.In this article,we propose an architecture enabling the automated integration of distributed real-time and non-real-time systems.We test our proposed architecture using a distributed Command,Control,Communications,Computers,and Intelligence(C4I)system.The system has DDS-based real-time Combat Management System components deployed to naval warships,and SOA-based non-real-time Command and Control components used at headquarters.The proposed solution enables the exchange of data between these two systems efficiently.We compare the proposed solution with a similar study.Our solution is superior in terms of automation support,ease of implementation,scalability,and performance.展开更多
AP deployment is significant for indoor WLAN system to achieve seamless coverage. The available algorithms do not take user distribution into consideration so that poor user coverage and imbalanced network load occur....AP deployment is significant for indoor WLAN system to achieve seamless coverage. The available algorithms do not take user distribution into consideration so that poor user coverage and imbalanced network load occur. Therefore, this paper proposed a novel AP placement algorithm to bridge the AP deployment with user distribution. The proposed algorithm employs statistics theory to model the user distribution as its location and probability. Then we obtain the AP location based on the fuzzy C-clustering algorithm. The proposed algorithm is practical for implementation, which means the actual signal transmission isn't required in our proposed method. The simulation results show that the proposed algorithm could automatically achieve a good AP deployment with different user distribution, and provide a good performance in the maximum users and AP load balance in WLAN.展开更多
The picosecond accelerator (PA) is a low energy electron linear accelerator facility under commissioning, which is built for the experiment of ps level pulse radiolysis in Shanghai Institute of Applied Physics (SINAP)...The picosecond accelerator (PA) is a low energy electron linear accelerator facility under commissioning, which is built for the experiment of ps level pulse radiolysis in Shanghai Institute of Applied Physics (SINAP). A practical distributed DA&C system for this facility has been developed. In view of the upgrading-ability and main-tainability of the control system and controlled devices, Advantech? distributed intelligent DA&C products are adopted into the control system. ADAM 5000/TCPs with the protocol of Modbus/TCP are employed to accomplish data acquisition and device control. The PC-compatible programmable logic controller, ADAM-5511, is also adopted to handle the interlocks and the emergency events. On the software side, the integrated software package King-view?V6.5, which friendly supports all Advantech products, has been used to develop the upper layer control logic and process the data. This paper describes the control system design and system architecture. The intelligent ADAM controllers and the software platform are also discussed in detail.展开更多
This paper provides a numerical analysis model of unsteady heat trans-fer in piston-liner set of an internal combustion engine.The model simulates the un-steady heat transfer process among the combustion mixture,pisto...This paper provides a numerical analysis model of unsteady heat trans-fer in piston-liner set of an internal combustion engine.The model simulates the un-steady heat transfer process among the combustion mixture,piston set,lubricantfilm,liner and coolant in a whole engine cycle,and can predict the temperature fluc-tuation and distribution on piston crown,inner surface of liner,piston ring and thelubricant film.A computer program is developed to calculate the unsteady heat trans-fer process of piston-liner system in a water-cooled diesel engine.展开更多
The paper presents the distributed control system for rice mill using C#language.The real-time manufacturing system can be implemented by utilizing the signal from the real time control units that is more operative th...The paper presents the distributed control system for rice mill using C#language.The real-time manufacturing system can be implemented by utilizing the signal from the real time control units that is more operative than other old-fashioned control systems in the extent of modern industrial days.The software-based Distributed Control System(DCS)is novel fashionable than any other conventional control systems in the state-ofthe-art manufacturing developments.This research study emphasizes on the implementation of the DCS-based rice mill using visual C#.net.The Industrial Ethernet(IE)is realized between the top level controller for the operator and the controlled station for the remote devices.The model of client-server approach is more appropriate for the automation and manufacturing research purposes.In this study,the computer graphical simulation of the complete control development is depicted in real-time status quo by visual C#language under Visual Studio 2008 software.The parallel ports in the computers of remote terminal level and the master terminal level controllers have been interconnected with port interface coding by visual C#program.展开更多
文摘多发性骨髓瘤(multiple myeloma,MM)是一种不可治愈的血液系统恶性肿瘤,尽管新型蛋白酶体抑制剂、免疫调节剂及CD38单抗等药物的应用显著延长了患者的生存时间,但复发耐药仍难以避免。细胞免疫治疗,特别是嵌合抗原受体(chimeric antigen receptor,CAR)T细胞疗法的快速发展,极大程度的改变了复发/难治性(relapsed/refractory,R/R)MM患者的治疗现状。FDA目前已批准了2款靶向B细胞成熟抗原(B cell maturation antigen,BCMA)的CAR-T细胞产品,使其用于既往接受过4线及以上治疗的R/R MM患者。随着临床研究的不断深入,靶向GPRC5D(G protein-coupled receptor C class Group 5 member D,G蛋白偶联受体C类第5组成员D)的CAR-T细胞治疗也显示出其独特的优势。除了应用于难治复发的患者,多项临床试验支持CAR-T在MM中治疗线数的前移。本文就CAR-T细胞治疗在MM中开展的关键性临床研究展开综述,旨在为临床应用提供参考。
基金supported by the National Natural Science Foundation of China (21773153)~~
文摘A two‐step photocatalytic water splitting system,termed a“Z‐scheme system”,was achieved using Zn‐doped g‐C3N4for H2evolution and BiVO4for O2evolution with Fe2+/Fe3+as a shuttle redox mediator.H2and O2were evaluated simultaneously when the doping amount of zinc was10%.Moreover,Zn‐doped(10%)g‐C3N4synthesized by an impregnation method showed superior active ability to form the Z‐scheme with BiVO4than by in‐situ synthesis.X‐ray diffraction,UV‐Vis spectroscopy,scanning electron microscopy,and X‐ray photoelectron spectroscopy were used to characterize the samples.It was determined that more Zn?N bonds could be formed on the surface of g‐C3N4by impregnation,which could facilitate charge transfer.
基金Supported by Guangxi Key R&D Plan Project(Guike AB17292008)Guangxi Science Research and Technology Development Plan Program(Guikeneng 1598025-38)Major Science and Technology Project of Guangxi Forestry(Guilin Science Word[2010]No.7)
文摘The 23-year-old T. flousiana plantation and successive rotation plantation of C. lanceolata at Shankou Forest Farm of Nandan County, Guangxi were tested by the method of plot investigation combining with biomass measurement. Carbon storage and spatial distribution of different components in the two forests were analyzed. The results indicated that carbon content in different organs of T. flousiana ranged from 426.0 to 503.9 g/kg, and the order was bark 〉stem 〉 root 〉 branch 〉 leaf. The carbon contents in shrub, herb and litter layers were452.9 , 408.0 and 428.9 g/kg, respectively. Carbon content in the soil （0 -80 cm）was 16.59 g/kg. The carbon content in different organs of C. lanceolata ranged from 464.5 to 508.9 g/kg, and the order was bark 〉 stem 〉 branch 〉 root 〉 leaf. The carbon contents in shrub, herb and litter layers were 456.2, 416.3 and 468.1 g/kg, respectively. Carbon content in the soil （0 -80 cm）was 15.77 g/kg. Total carbon storage amounts of T. flousiana plantation and successive rotation plantation of C. lanceolata were 245.83 and 213.52 t/hm^2, respectively. The carbon storage order of different structure layers from T. flousiana plantation and successive rotation plantation of C. lanceolata was soil layer （0 -8 0 cm） 〉 vegetation layer 〉 litter layer. Annual net productivity in the arbor layers of T. flousiana plantation and successive rotation plantation of C. lanceolata plantations was 10.75 and 17.13 t/（hm^2 · a） ; annual net carbon fixation amounts were estimated as 5.05 and 3.47 t /（hm^2 · a） ; annual net absorption C02 amounts were 18.53 and 12.73 t/（hm^2 · a） respectively.
文摘The synergistic effect of high voltage discharge non‐thermal plasma(NTP)and photocatalysts on contaminant removal has repeatedly confirmed by plenty of researches.Most previous plasma‐photocatalyst synergistic systems focused on the utilization of the ultraviolet light but ignored the visible light generated by high voltage discharge.Graphitic carbon nitride(g‐C3N4),a metal‐free semiconductor that exhibits high chemical stability,can utilize both the ultraviolet and visible light from high voltage discharge.However,the synergistic system of NTP and g‐C3N4 has been researched little.In this paper,the effect of NTP generated by dielectric barrier discharge(DBD)on g‐C3N4 is studied by comparing the photocatalytic activities,the surface physical structure and the surface chemical characteristics of pristine and plasma treated g‐C3N4.Experimental results indicate that the DBD plasma can change the physical structure and the chemical characteristics and to further affect the photocatalytic activity of g‐C3N4.The effect of NTP on g‐C3N4 is associated with the discharge intensity and the discharge time.For a long time scale,the effect of NTP on g‐C3N4 photocatalysts presents a periodic change trend.
基金supported by the National Natural Science Foundation of China(51568049,51468043,21366024,21665018)the National Science Fund for Excellent Young Scholars(51422807)+2 种基金the Natural Science Foundation of Jiangxi Province,China(20161BAB206118,20171ACB21035)the Distinguished Youth Science Fund of Jiangxi Province(20162BCB23043)the Natural Science Foundation of Jiangxi Provincial Department of Education,China(GJJ14515)~~
文摘The photocatalytic reduction of aqueous Cr(VI)to Cr(III)was preliminarily studied using porousg‐C3N4as a photocatalyst under acidic conditions.The observed synergistic photocatalytic effect ofporous g‐C3N4on a Cr(VI)/4‐chlorophenol(4‐CP)composite pollution system was further studiedunder different pH conditions.Compared with single‐component photocatalytic systems for Cr(VI)reduction or4‐CP degradation,the Cr(VI)reduction efficiency and4‐CP degradation efficiency weresimultaneously improved in the Cr(VI)/4‐CP composite pollution system.The synergistic photocatalyticeffect in the Cr(VI)/4‐CP composite pollution system can be attributed to the acceleratedredox reaction between dichromate and4‐CP by electron transfer with porous g‐C3N4.
文摘Various application domains require the integration of distributed real-time or near-real-time systems with non-real-time systems.Smart cities,smart homes,ambient intelligent systems,or network-centric defense systems are among these application domains.Data Distribution Service(DDS)is a communication mechanism based on Data-Centric Publish-Subscribe(DCPS)model.It is used for distributed systems with real-time operational constraints.Java Message Service(JMS)is a messaging standard for enterprise systems using Service Oriented Architecture(SOA)for non-real-time operations.JMS allows Java programs to exchange messages in a loosely coupled fashion.JMS also supports sending and receiving messages using a messaging queue and a publish-subscribe interface.In this article,we propose an architecture enabling the automated integration of distributed real-time and non-real-time systems.We test our proposed architecture using a distributed Command,Control,Communications,Computers,and Intelligence(C4I)system.The system has DDS-based real-time Combat Management System components deployed to naval warships,and SOA-based non-real-time Command and Control components used at headquarters.The proposed solution enables the exchange of data between these two systems efficiently.We compare the proposed solution with a similar study.Our solution is superior in terms of automation support,ease of implementation,scalability,and performance.
基金the financial support by National Natural Science Foundation of China (61571162)Science and Technology Project of Ministry of Public Security Foundation (2015GABJC38)Major National Science and Technology Project (2015ZX03004002-004)
文摘AP deployment is significant for indoor WLAN system to achieve seamless coverage. The available algorithms do not take user distribution into consideration so that poor user coverage and imbalanced network load occur. Therefore, this paper proposed a novel AP placement algorithm to bridge the AP deployment with user distribution. The proposed algorithm employs statistics theory to model the user distribution as its location and probability. Then we obtain the AP location based on the fuzzy C-clustering algorithm. The proposed algorithm is practical for implementation, which means the actual signal transmission isn't required in our proposed method. The simulation results show that the proposed algorithm could automatically achieve a good AP deployment with different user distribution, and provide a good performance in the maximum users and AP load balance in WLAN.
文摘The picosecond accelerator (PA) is a low energy electron linear accelerator facility under commissioning, which is built for the experiment of ps level pulse radiolysis in Shanghai Institute of Applied Physics (SINAP). A practical distributed DA&C system for this facility has been developed. In view of the upgrading-ability and main-tainability of the control system and controlled devices, Advantech? distributed intelligent DA&C products are adopted into the control system. ADAM 5000/TCPs with the protocol of Modbus/TCP are employed to accomplish data acquisition and device control. The PC-compatible programmable logic controller, ADAM-5511, is also adopted to handle the interlocks and the emergency events. On the software side, the integrated software package King-view?V6.5, which friendly supports all Advantech products, has been used to develop the upper layer control logic and process the data. This paper describes the control system design and system architecture. The intelligent ADAM controllers and the software platform are also discussed in detail.
文摘This paper provides a numerical analysis model of unsteady heat trans-fer in piston-liner set of an internal combustion engine.The model simulates the un-steady heat transfer process among the combustion mixture,piston set,lubricantfilm,liner and coolant in a whole engine cycle,and can predict the temperature fluc-tuation and distribution on piston crown,inner surface of liner,piston ring and thelubricant film.A computer program is developed to calculate the unsteady heat trans-fer process of piston-liner system in a water-cooled diesel engine.
文摘The paper presents the distributed control system for rice mill using C#language.The real-time manufacturing system can be implemented by utilizing the signal from the real time control units that is more operative than other old-fashioned control systems in the extent of modern industrial days.The software-based Distributed Control System(DCS)is novel fashionable than any other conventional control systems in the state-ofthe-art manufacturing developments.This research study emphasizes on the implementation of the DCS-based rice mill using visual C#.net.The Industrial Ethernet(IE)is realized between the top level controller for the operator and the controlled station for the remote devices.The model of client-server approach is more appropriate for the automation and manufacturing research purposes.In this study,the computer graphical simulation of the complete control development is depicted in real-time status quo by visual C#language under Visual Studio 2008 software.The parallel ports in the computers of remote terminal level and the master terminal level controllers have been interconnected with port interface coding by visual C#program.
