Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This co...Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This condition is thought to affect approximately 2%of the Western population,with diagnosis peaking in early adulthood[2].Vitamin D,a fat-soluble vitamin,is essential for phospho-calcium metabolism,calcium homeostasis,and bone health.展开更多
Accurate fission cross-sectional data for actinide nuclides are critical for nuclear energy,astrophysics,and defense applications.Traditional detectors,such as fission chambers,face limitations in achieving sub-3% unc...Accurate fission cross-sectional data for actinide nuclides are critical for nuclear energy,astrophysics,and defense applications.Traditional detectors,such as fission chambers,face limitations in achieving sub-3% uncertainty owing to particle identification challenges and dynamic range constraints.The time projection chamber(TPC)can record both the energy deposition dE/dx and the three-dimensional track of an event,providing the ability to identify particles and fission fragments.Based on this characteristic,we developed a novel TPC,INPC-TPC,featuring a symmetrical dual-chamber structure and gas electron multiplier(GEM)-based readout technology.The dual-chamber design isolates fission fragments and recoils protons,thereby reducing the dynamic range requirements of a single chamber,whereas the GEM ensures high spatial resolution and stable gain.Experiments conducted at the Chinese Spallation Neutron Source(CSNS)Back-n white neutron beamline validated the performance of the proposed detector.The INPC-TPC demonstrated effective fission fragment identification through particle energy-length correlation measurements and accurately measured the neutron beam spot size with a diameter relative error of<2%.The results highlight the capability of the system to achieve high-precision measurements of neutroninduced fission cross sections,particularly for ^(235)U and ^(238)U.展开更多
Let M be a compact n-manifold of positive sectional curvature.We will review classical results on the fundamental group of M,a motivation on the c(n)-cyclic conjecture that the fundamental group of M contains a cyclic...Let M be a compact n-manifold of positive sectional curvature.We will review classical results on the fundamental group of M,a motivation on the c(n)-cyclic conjecture that the fundamental group of M contains a cyclic subgroup of index bounded above by c(n),a constant depending only on n,and we will survey partial results(up to date)on the c(n)-cyclic conjecture.展开更多
In this paper,the Jiangxi section of the red army's long march is taken as the research object to construct a red cultural heritage corridor.Introducing the theory of heritage corridor,on the basis of its hierarch...In this paper,the Jiangxi section of the red army's long march is taken as the research object to construct a red cultural heritage corridor.Introducing the theory of heritage corridor,on the basis of its hierarchical decomposition and comparative judgment,a hierarchy model of the red cultural heritage corridor resource is established.The comprehensive scores of each factor are obtained through expert scoring,and the overall pattern of red army corridor is constructed as"ring-shape-point".New ideas for protection and utilization as well as protection implementation measures are proposed,and the spiritual and cultural connotations of long march in Jiangxi are fully explored.This could help the social and economic development of the areas along the long march of red army in Jiangxi,and promote the integrated utilization and coordinated development of resources in the red cultural heritage corridor region.展开更多
Background:Prostate adenocarcinoma(PRAD)is one of the most commonly diagnosed cancers in men.Expanding evidence suggests a significant association between cancer progression and RNA modifications.However,our knowledge...Background:Prostate adenocarcinoma(PRAD)is one of the most commonly diagnosed cancers in men.Expanding evidence suggests a significant association between cancer progression and RNA modifications.However,our knowledge of the link between m^(5)C and hm^(5)C pathways with PRAD is limited.Therefore,we aimed to explore the diagnostic and prognostic values of m^(5)C and hm^(5)C regulators in PRAD.Methods:In this study,genetic alterations in m^(5)C and hm^(5)C regulators were identified using publicly available databases.Expression levels of regulators in PRAD samples were retrieved via the RTCGA package in the R environment.Differentially expressed genes in these pathways between tumor and non-tumor samples were identified using the R‘limma’package.Correlation among m^(5)C and hm^(5)C pathway members was examined employing the‘Hmisc’package in R.We utilized the‘survminer’package in R for applying the Kaplan-Meier method to estimate the overall survival rate of m^(5)C and hm^(5)C regulators.The discrimination power of selected regulators between tumor and non-tumor samples was analyzed by the receiver operating characteristic curve.Furthermore,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were carried out to enrich the affected biological processes and pathways.Results:Differentially expressed genes in these pathways between tumor and non-tumor samples,correlation among m^(5)C and hm^(5)C pathway members,and prognostic value of the regulators were evaluated.Obtained results unveiled the mRNA level differences as the key genetic alterations for m^(5)C and hm^(5)C regulators between tumor and non-tumor samples.UHRF1,TET3,and NEIL1 were significantly upregulated in tumor samples,whereas MECP2 and EGR1 were significantly downregulated for m^(5)C and hm^(5)C regulators.UHRF1,DNMT1,NSUN2,NSUN4,C1orf77,C3orf37,WDR77,NEIL1,and TDG genes were identified as candidate prognostic markers of overall survival.The upregulated genes in patient samples with genetic alterations in m^(5)C and hm^(5)C pathways enriched cell cycle-related processes.Conclusion:In summary,our findings suggest that the m^(5)C and hm^(5)C regulators might play a role in PRAD development by activation of proliferation,and the UHRF1,NSUN2,and NEIL1 genes have the potential to be utilized as clinical biomarkers.Established correlative relationships require experimental validation through functional studies in prostate cancer cell lines.展开更多
基金supported by the National Natural Science Foundation of China(Grant Nos.82573974 and 82373475)to Z.Y.
文摘Dear Editor,Psoriasis,a chronic inflammatory cutaneous condition,is characterized by the development of red plaques with silvery scales,significantly affecting patients'quality of life and mental health[1].This condition is thought to affect approximately 2%of the Western population,with diagnosis peaking in early adulthood[2].Vitamin D,a fat-soluble vitamin,is essential for phospho-calcium metabolism,calcium homeostasis,and bone health.
基金supported by the auspices of the Youth Doctoral Talent Incubation Program of the Second Affiliated Hospital of Army Medical University(No.2024YQB060)。
文摘Accurate fission cross-sectional data for actinide nuclides are critical for nuclear energy,astrophysics,and defense applications.Traditional detectors,such as fission chambers,face limitations in achieving sub-3% uncertainty owing to particle identification challenges and dynamic range constraints.The time projection chamber(TPC)can record both the energy deposition dE/dx and the three-dimensional track of an event,providing the ability to identify particles and fission fragments.Based on this characteristic,we developed a novel TPC,INPC-TPC,featuring a symmetrical dual-chamber structure and gas electron multiplier(GEM)-based readout technology.The dual-chamber design isolates fission fragments and recoils protons,thereby reducing the dynamic range requirements of a single chamber,whereas the GEM ensures high spatial resolution and stable gain.Experiments conducted at the Chinese Spallation Neutron Source(CSNS)Back-n white neutron beamline validated the performance of the proposed detector.The INPC-TPC demonstrated effective fission fragment identification through particle energy-length correlation measurements and accurately measured the neutron beam spot size with a diameter relative error of<2%.The results highlight the capability of the system to achieve high-precision measurements of neutroninduced fission cross sections,particularly for ^(235)U and ^(238)U.
文摘Let M be a compact n-manifold of positive sectional curvature.We will review classical results on the fundamental group of M,a motivation on the c(n)-cyclic conjecture that the fundamental group of M contains a cyclic subgroup of index bounded above by c(n),a constant depending only on n,and we will survey partial results(up to date)on the c(n)-cyclic conjecture.
基金Supported by the Humanities and Social Science Research Project of Jiangxi Provincial Universities(YS23104).
文摘In this paper,the Jiangxi section of the red army's long march is taken as the research object to construct a red cultural heritage corridor.Introducing the theory of heritage corridor,on the basis of its hierarchical decomposition and comparative judgment,a hierarchy model of the red cultural heritage corridor resource is established.The comprehensive scores of each factor are obtained through expert scoring,and the overall pattern of red army corridor is constructed as"ring-shape-point".New ideas for protection and utilization as well as protection implementation measures are proposed,and the spiritual and cultural connotations of long march in Jiangxi are fully explored.This could help the social and economic development of the areas along the long march of red army in Jiangxi,and promote the integrated utilization and coordinated development of resources in the red cultural heritage corridor region.
基金Health Institutes of Turkey(TUSEBProject No.TA01-4213)for the financial support of the present study.
文摘Background:Prostate adenocarcinoma(PRAD)is one of the most commonly diagnosed cancers in men.Expanding evidence suggests a significant association between cancer progression and RNA modifications.However,our knowledge of the link between m^(5)C and hm^(5)C pathways with PRAD is limited.Therefore,we aimed to explore the diagnostic and prognostic values of m^(5)C and hm^(5)C regulators in PRAD.Methods:In this study,genetic alterations in m^(5)C and hm^(5)C regulators were identified using publicly available databases.Expression levels of regulators in PRAD samples were retrieved via the RTCGA package in the R environment.Differentially expressed genes in these pathways between tumor and non-tumor samples were identified using the R‘limma’package.Correlation among m^(5)C and hm^(5)C pathway members was examined employing the‘Hmisc’package in R.We utilized the‘survminer’package in R for applying the Kaplan-Meier method to estimate the overall survival rate of m^(5)C and hm^(5)C regulators.The discrimination power of selected regulators between tumor and non-tumor samples was analyzed by the receiver operating characteristic curve.Furthermore,gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)analyses were carried out to enrich the affected biological processes and pathways.Results:Differentially expressed genes in these pathways between tumor and non-tumor samples,correlation among m^(5)C and hm^(5)C pathway members,and prognostic value of the regulators were evaluated.Obtained results unveiled the mRNA level differences as the key genetic alterations for m^(5)C and hm^(5)C regulators between tumor and non-tumor samples.UHRF1,TET3,and NEIL1 were significantly upregulated in tumor samples,whereas MECP2 and EGR1 were significantly downregulated for m^(5)C and hm^(5)C regulators.UHRF1,DNMT1,NSUN2,NSUN4,C1orf77,C3orf37,WDR77,NEIL1,and TDG genes were identified as candidate prognostic markers of overall survival.The upregulated genes in patient samples with genetic alterations in m^(5)C and hm^(5)C pathways enriched cell cycle-related processes.Conclusion:In summary,our findings suggest that the m^(5)C and hm^(5)C regulators might play a role in PRAD development by activation of proliferation,and the UHRF1,NSUN2,and NEIL1 genes have the potential to be utilized as clinical biomarkers.Established correlative relationships require experimental validation through functional studies in prostate cancer cell lines.
