A novel T-type specimen enabled the separation of the thermal and athermal contributions of electropulsing treatment(EPT)in pretwinned AZ31 Mg alloy.The combination of T-type geometry and carefully selected EPT condit...A novel T-type specimen enabled the separation of the thermal and athermal contributions of electropulsing treatment(EPT)in pretwinned AZ31 Mg alloy.The combination of T-type geometry and carefully selected EPT conditions equalized the thermal contributions at two distinct locations(J70-C and J77-D)in a thermally stable regime,which isolated the athermal effect in J70-C.The results were verified using finite element analysis.Although the athermal EPT contribution did not alter the fundamental microstructural evolution mechanisms,the evolution rate increased significantly.As a result,the J70-C region exhibited faster grain growth,annihilation of twin boundaries,reduction of low-angle grain boundaries,dislocation annihilation,and static recrystallization compared to its counterpart,as further supported by the microhardness trends.These results were interpreted in light of the additional driving force by the athermal EPT contribution,which accelerated the strain-induced boundary migrations beyond Joule heating alone.The proposed T-type specimen methodology offers a robust framework for decoupling the thermal and athermal effects in macroscale EPT processes.展开更多
BACKGROUND Endoscopic submucosal dissection(ESD)is a standardized therapeutic approach for early carcinoma of the digestive tracts.In this regard,the process of histopathological diagnosis requires standardization.How...BACKGROUND Endoscopic submucosal dissection(ESD)is a standardized therapeutic approach for early carcinoma of the digestive tracts.In this regard,the process of histopathological diagnosis requires standardization.However,the uneven development of healthcare in China,especially in eastern and western China,creates challenges for sharing a standardized diagnostic process.AIM To optimize the process of ESD specimen sampling,embedding and slide production,and to provide complete and accurate pathological reports.METHODS We established a practical process of specimen sampling,created standardized reporting templates,and trained pathologists from neighboring hospitals and those in the western region.A training effectiveness survey was conducted,and the collected data were assessed by the corresponding percentages.RESULTS A total of 111 valid feedback forms have been received,among which 58%of the participants obtained photographs during specimen collection,whereas the percentage increased to 79%after training.Only 58%and 62%of the respondents ensured the mucosal tissue strips were flat and their order remained unchanged;after training,these two proportions increased to 95%and 92%,respectively.Approximately half the participants measured the depth of the submucosal infiltration,which significantly increased to 95%after training.The percentage of pathologists who did not evaluate lymphovascular invasion effectively reduced.Only 22%of the participants had fixed clinic-pathological meetings before training,which increased to 49%after training.The number of participants who had a thorough understanding of endoscopic diagnosis also significantly increased.CONCLUSION There have been significant improvements in the process of specimen collection,section quality,and pathology reporting in trained hospitals.Therefore,our study provides valuable insights for others facing similar challenges.展开更多
The objective of this study is to evaluate the efficacy of laparoscopic surgery combined with the rectal inversion and specimen extraction(RIES)technique for rectal cancer,focusing on both short-term and long-term out...The objective of this study is to evaluate the efficacy of laparoscopic surgery combined with the rectal inversion and specimen extraction(RIES)technique for rectal cancer,focusing on both short-term and long-term outcomes.A retrospective comparative analysis was performed on 120 patients who underwent laparoscopic radical excision for rectal cancer from June 2017 to June 2021.Patients were categorized into two groups:Group RIES(n=58),which received the novel RIES technique,and Group AIES(n=62),which underwent the conventional abdominal incision for specimen extraction.Short-term outcomes,such as postoperative pelvic sepsis,temporary ileus,anastomotic leakage,and anastomotic stricture,were meticulously recorded.Longterm efficacy was evaluated through the 3-year overall survival(OS),disease-free survival(DFS),and local recurrence rate(LRR).The RIES group demonstrated a 3-year OS,DFS,and LRR of 86.2%,77.6%,and 8.6%,respectively,with a low incidence of short-term complications.Comparatively,the AIES group showed a 3-year OS,DFS,and LRR of 83.9%,74.2%,and 19.4%,respectively,with slightly higher rates of postoperative complications.Statistical analysis using the Student's t-test,the chi-square(χ^(2))test revealed no significant differences in the primary outcomes between the two groups,and suggested the noninferiority of the RIES technique.The study suggests that the RIES technique is a safe,feasible,and potentially functional and oncological superior approach to rectal cancer treatment,without compromising clinical efficacy.Further research is warranted to validate thesefindings in a larger,multicenter,and randomized controlled trial.展开更多
The paper designs a novel material-level specimen and its dedicated fixture suitable for applying Combined high-and low-Cycle Fatigue(CCF)loads.Unlike full-scale or simulation specimens,the CCF specimen eliminates geo...The paper designs a novel material-level specimen and its dedicated fixture suitable for applying Combined high-and low-Cycle Fatigue(CCF)loads.Unlike full-scale or simulation specimens,the CCF specimen eliminates geometrically induced stress gradients in the test region.Experimental data on CCF life and strain responses of ZSGH4169 alloy are acquired under different CCF loads.The Maximum Strain within Each(MSE)CCF cycle is demonstrated to be independent of the Low-Cycle Fatigue(LCF)loads and High-Cycle Fatigue(HCF)stress amplitudes,but exhibits a correlation with the Cycle Ratio of HCF/LCF(Rf).The growth law of MSE changes from linear to logarithmic as Rfdecreases.Strain amplitudes in the dwell stage,observed unaffected by Rf,are quantified as a function of LCF nominal stresses and HCF stress amplitudes.However,under a defined CCF load,strain amplitudes in the dwell stage remain constant.Strain peaks in the dwell stage in a single CCF cycle decrease in a power function with increasing HCF cycles.展开更多
Alloying with Gd and Ag can significantly enhance the comprehensive properties of magnesium alloys,and accurate phase equilibria are a necessity for advanced alloy design.However,literature review reveals limited info...Alloying with Gd and Ag can significantly enhance the comprehensive properties of magnesium alloys,and accurate phase equilibria are a necessity for advanced alloy design.However,literature review reveals limited information on the phase equilibria in the ternary Mg-Gd-Ag system.Thus,in this paper,the phase equilibria of the ternary Mg-Gd-Ag system in the region of 0-50 at.%Gd at 450℃and 500℃were investigated by combining the electron probe microanalysis and X-ray diffraction of totally 66 equilibrated alloys,with two isothermal sections at 450℃and 500℃established accordingly;and relatively high solid solubility of Ag in GdMg_(3)was characterized.Moreover,seven ternary compounds(denoted asτ_(1)toτ_(7))were found,and their crystal structures were refined by using Rietveld method.Theτ_(1)was identical to the previously reported X phase with a diamond-cubic structure,while the remaining six ternary compounds(τ_(2)toτ_(7))were newly found.The seven ternary compounds(τ_(1)toτ_(7))are among the space groups of Fd3m(τ_(1)),P4/nmm(τ_(2)),P63mc(τ_(3)),P63mc(τ_(4)),Pmn2_(1)(τ_(5)),P62m(τ_(6))and Pc(τ_(7)).Their homogeneity ranges and lattice parameters were carefully determined.The solubilities of the third elements in the binary compounds of the three subsystems were also well measured.It is anticipated that the presently obtained phase equilibria as well as the crystal structures of ternary compounds in the Mg-Gd-Ag system would serve as a foundation for developing thermodynamic database and alloy design in the near future.展开更多
基金funded by the Defense Acquisition Program Administration(DAPA)(Grant No.KRIT-CT-23-059)supported by the‘Human Resources Program in Energy Technology’of the Korea Institute of Energy Technology Evaluation and Planning(KETEP),which was funded by the Ministry of Trade,Industry,and Energy(MOTIE)(Grant No.RS-2024-00398425).
文摘A novel T-type specimen enabled the separation of the thermal and athermal contributions of electropulsing treatment(EPT)in pretwinned AZ31 Mg alloy.The combination of T-type geometry and carefully selected EPT conditions equalized the thermal contributions at two distinct locations(J70-C and J77-D)in a thermally stable regime,which isolated the athermal effect in J70-C.The results were verified using finite element analysis.Although the athermal EPT contribution did not alter the fundamental microstructural evolution mechanisms,the evolution rate increased significantly.As a result,the J70-C region exhibited faster grain growth,annihilation of twin boundaries,reduction of low-angle grain boundaries,dislocation annihilation,and static recrystallization compared to its counterpart,as further supported by the microhardness trends.These results were interpreted in light of the additional driving force by the athermal EPT contribution,which accelerated the strain-induced boundary migrations beyond Joule heating alone.The proposed T-type specimen methodology offers a robust framework for decoupling the thermal and athermal effects in macroscale EPT processes.
基金Supported by the Medical Education Research Project from Nanjing Drum Tower Hospital,No.2021-7the Clinical Trials Fund from Nanjing Drum Tower Hospital,No.2022-YXZX-XH-04National Natural Science Foundation of China,No.82203063.
文摘BACKGROUND Endoscopic submucosal dissection(ESD)is a standardized therapeutic approach for early carcinoma of the digestive tracts.In this regard,the process of histopathological diagnosis requires standardization.However,the uneven development of healthcare in China,especially in eastern and western China,creates challenges for sharing a standardized diagnostic process.AIM To optimize the process of ESD specimen sampling,embedding and slide production,and to provide complete and accurate pathological reports.METHODS We established a practical process of specimen sampling,created standardized reporting templates,and trained pathologists from neighboring hospitals and those in the western region.A training effectiveness survey was conducted,and the collected data were assessed by the corresponding percentages.RESULTS A total of 111 valid feedback forms have been received,among which 58%of the participants obtained photographs during specimen collection,whereas the percentage increased to 79%after training.Only 58%and 62%of the respondents ensured the mucosal tissue strips were flat and their order remained unchanged;after training,these two proportions increased to 95%and 92%,respectively.Approximately half the participants measured the depth of the submucosal infiltration,which significantly increased to 95%after training.The percentage of pathologists who did not evaluate lymphovascular invasion effectively reduced.Only 22%of the participants had fixed clinic-pathological meetings before training,which increased to 49%after training.The number of participants who had a thorough understanding of endoscopic diagnosis also significantly increased.CONCLUSION There have been significant improvements in the process of specimen collection,section quality,and pathology reporting in trained hospitals.Therefore,our study provides valuable insights for others facing similar challenges.
文摘The objective of this study is to evaluate the efficacy of laparoscopic surgery combined with the rectal inversion and specimen extraction(RIES)technique for rectal cancer,focusing on both short-term and long-term outcomes.A retrospective comparative analysis was performed on 120 patients who underwent laparoscopic radical excision for rectal cancer from June 2017 to June 2021.Patients were categorized into two groups:Group RIES(n=58),which received the novel RIES technique,and Group AIES(n=62),which underwent the conventional abdominal incision for specimen extraction.Short-term outcomes,such as postoperative pelvic sepsis,temporary ileus,anastomotic leakage,and anastomotic stricture,were meticulously recorded.Longterm efficacy was evaluated through the 3-year overall survival(OS),disease-free survival(DFS),and local recurrence rate(LRR).The RIES group demonstrated a 3-year OS,DFS,and LRR of 86.2%,77.6%,and 8.6%,respectively,with a low incidence of short-term complications.Comparatively,the AIES group showed a 3-year OS,DFS,and LRR of 83.9%,74.2%,and 19.4%,respectively,with slightly higher rates of postoperative complications.Statistical analysis using the Student's t-test,the chi-square(χ^(2))test revealed no significant differences in the primary outcomes between the two groups,and suggested the noninferiority of the RIES technique.The study suggests that the RIES technique is a safe,feasible,and potentially functional and oncological superior approach to rectal cancer treatment,without compromising clinical efficacy.Further research is warranted to validate thesefindings in a larger,multicenter,and randomized controlled trial.
基金co-supported by the National Natural Science Foundation of China(51805017)National Science and Technology Project(J2017-IV-0012-0049)+1 种基金National Science and Technology Project,China(J2019-IV-0007-0075)the Fundamental Research Funds for the Central Universities,China(JKF-20240036).
文摘The paper designs a novel material-level specimen and its dedicated fixture suitable for applying Combined high-and low-Cycle Fatigue(CCF)loads.Unlike full-scale or simulation specimens,the CCF specimen eliminates geometrically induced stress gradients in the test region.Experimental data on CCF life and strain responses of ZSGH4169 alloy are acquired under different CCF loads.The Maximum Strain within Each(MSE)CCF cycle is demonstrated to be independent of the Low-Cycle Fatigue(LCF)loads and High-Cycle Fatigue(HCF)stress amplitudes,but exhibits a correlation with the Cycle Ratio of HCF/LCF(Rf).The growth law of MSE changes from linear to logarithmic as Rfdecreases.Strain amplitudes in the dwell stage,observed unaffected by Rf,are quantified as a function of LCF nominal stresses and HCF stress amplitudes.However,under a defined CCF load,strain amplitudes in the dwell stage remain constant.Strain peaks in the dwell stage in a single CCF cycle decrease in a power function with increasing HCF cycles.
基金support from the Natural Science Foundation of Hunan Province for Distinguished Young Scholars(No.2021JJ10062)is acknowledged.
文摘Alloying with Gd and Ag can significantly enhance the comprehensive properties of magnesium alloys,and accurate phase equilibria are a necessity for advanced alloy design.However,literature review reveals limited information on the phase equilibria in the ternary Mg-Gd-Ag system.Thus,in this paper,the phase equilibria of the ternary Mg-Gd-Ag system in the region of 0-50 at.%Gd at 450℃and 500℃were investigated by combining the electron probe microanalysis and X-ray diffraction of totally 66 equilibrated alloys,with two isothermal sections at 450℃and 500℃established accordingly;and relatively high solid solubility of Ag in GdMg_(3)was characterized.Moreover,seven ternary compounds(denoted asτ_(1)toτ_(7))were found,and their crystal structures were refined by using Rietveld method.Theτ_(1)was identical to the previously reported X phase with a diamond-cubic structure,while the remaining six ternary compounds(τ_(2)toτ_(7))were newly found.The seven ternary compounds(τ_(1)toτ_(7))are among the space groups of Fd3m(τ_(1)),P4/nmm(τ_(2)),P63mc(τ_(3)),P63mc(τ_(4)),Pmn2_(1)(τ_(5)),P62m(τ_(6))and Pc(τ_(7)).Their homogeneity ranges and lattice parameters were carefully determined.The solubilities of the third elements in the binary compounds of the three subsystems were also well measured.It is anticipated that the presently obtained phase equilibria as well as the crystal structures of ternary compounds in the Mg-Gd-Ag system would serve as a foundation for developing thermodynamic database and alloy design in the near future.
