The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in...The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in heterogeneous deployments.When multiple TSN networks interconnect over non-TSN networks,all devices in the network need to be syn-chronized by sharing a uniform time reference.How-ever,most non-TSN networks are best-effort.Path delay asymmetry and random noise accumulation can introduce unpredictable time errors during end-to-end time synchronization.These factors can degrade syn-chronization performance.Therefore,cross-domain time synchronization becomes a challenging issue for multiple TSN networks interconnected by non-TSN networks.This paper presents a cross-domain time synchronization scheme that follows the software-defined TSN(SD-TSN)paradigm.It utilizes a com-bined control plane constructed by a coordinate con-troller and a domain controller for centralized control and management of cross-domain time synchroniza-tion.The general operation flow of the cross-domain time synchronization process is designed.The mecha-nism of cross-domain time synchronization is revealed by introducing a synchronization model and an error compensation method.A TSN cross-domain proto-type testbed is constructed for verification.Results show that the scheme can achieve end-to-end high-precision time synchronization with accuracy and sta-bility.展开更多
Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid ...Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases.展开更多
The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic c...The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic complementarity of multiple bands are crucial for enhancing the spectrum efficiency,reducing network energy consumption,and ensuring a consistent user experience.This paper investigates the present researches and challenges associated with deployment of multi-band integrated networks in existing infrastructures.Then,an evolutionary path for integrated networking is proposed with the consideration of maturity of emerging technologies and practical network deployment.The proposed design principles for 6G multi-band integrated networking aim to achieve on-demand networking objectives,while the architecture supports full spectrum access and collaboration between high and low frequencies.In addition,the potential key air interface technologies and intelligent technologies for integrated networking are comprehensively discussed.It will be a crucial basis for the subsequent standards promotion of 6G multi-band integrated networking technology.展开更多
With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of hig...With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of high, medium, and low Earth orbit satellite networks with terrestrial networks has become a critical direction for future communication technologies. The objective is to develop a space-terrestrial integrated 6G network that ensures ubiquitous connectivity and seamless services, facilitating intelligent interconnection and collaborative symbiosis among humans, machines, and objects. This integration has become a central focus of global technological innovation.展开更多
From fifth-generation(5G)communication technology onward,non-terrestrial networks(NTNs)have emerged as a key component of future network architectures.Especially through the rise of low-Earth-orbit satellite constella...From fifth-generation(5G)communication technology onward,non-terrestrial networks(NTNs)have emerged as a key component of future network architectures.Especially through the rise of low-Earth-orbit satellite constellations,NTNs enable a space Internet and present a paradigm shift in delivering reliable services to even the most remote regions on Earth.However,the extensive coverage and rapid movement of satellites pose unique challenges in user equipment access and inter-satellite transmission,impacting the quality of service and service continuity.This paper offers an in-depth review of NTN networking technologies in the context of six-generation(6G)mobile networks evolution,focusing on access management,satellite mobility,and hetero-network slicing.Building on this foundation and considering the latest trends in NTN development,we then present innovative perspectives on emerging challenges,including satellite beamforming,handover mechanisms,and service delivery.Lastly,we identify key open research areas and propose future directions to improve NTN performance and accelerate satellite Internet deployment.展开更多
The rapid evolution of satellite constellation projects(e.g.,SpaceX)and the standardization of 3rd Generation Partnership Project(3GPP)non-terrestrial networks(NTNs)have positioned satellite Internet networking(SIN)as...The rapid evolution of satellite constellation projects(e.g.,SpaceX)and the standardization of 3rd Generation Partnership Project(3GPP)non-terrestrial networks(NTNs)have positioned satellite Internet networking(SIN)as a cornerstone of future communication systems.The demand for ubiquitous connectivity,resilient infrastructures,and intelligent network services has never been greater,driven by applications ranging from global broadband access to emergency response and space-air-ground integration.展开更多
With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.Howev...With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance.展开更多
Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently r...Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently realize load balancing.However,such a ubiquitous caching approach may cause problems including duplicate caching and low data diversity,thus reducing the caching efficiency of NDN routers.To mitigate these caching problems and improve the NDN caching efficiency,in this paper,a hierarchical-based sequential caching(HSC)scheme is proposed.In this scheme,the NDN routers in the data transmission path are divided into various levels and data with different request frequencies are cached in distinct router levels.The aim is to cache data with high request frequencies in the router that is closest to the content requester to increase the response probability of the nearby data,improve the data caching efficiency of named data networks,shorten the response time,and reduce cache redundancy.Simulation results show that this scheme can effectively improve the cache hit rate(CHR)and reduce the average request delay(ARD)and average route hop(ARH).展开更多
Time synchronization is a prerequisite for ensuring determinism in time-sensitive networking(TSN).While time synchronization errors cannot be overlooked,pursuing minimal time errors may incur unnecessary costs.Using c...Time synchronization is a prerequisite for ensuring determinism in time-sensitive networking(TSN).While time synchronization errors cannot be overlooked,pursuing minimal time errors may incur unnecessary costs.Using complex network theory,this study proposes a hierarchy for TSN and introduces the concept of bounded time error.A coupling model between traffic scheduling and time synchronization is established,deriving functional relationships among end-to-end delay,delay jitter,gate window,and time error.These relationships illustrate that time errors can trigger jumps in delay and delay jitter.To evaluate different time errors impact on traffic scheduling performance,an end-to-end transmission experiment scheme is designed,along with the construction of a TSN test platform implementing two representative cases.Case A is a closed TSN domain scenario with pure TSN switches emulating closed factory floor network.Case B depicts remote factory interconnection where TSN domains link via non-TSN domains composed of OpenFlow switches.Results from Case A show that delay and delay jitter on a single node are most significantly affected by time errors,up to one gating cycle.End-to-end delay jitter tends to increase with the number of hops.When the ratio of time error bound to window exceeds 10%,the number of schedulable traffic flows decreases rapidly.Case B reveals that when time error is below 1μs,the number of schedulable traffic flows begins to increase significantly,approaching full schedulability at errors below 0.6μs.展开更多
The rapid growth in available network bandwidth has directly contributed to an exponential increase in mobile data traffic,creating significant challenges for network energy consumption.Also,with the extraordinary gro...The rapid growth in available network bandwidth has directly contributed to an exponential increase in mobile data traffic,creating significant challenges for network energy consumption.Also,with the extraordinary growth of mobile communications,the data traffic has dramatically expanded,which has led to massive grid power consumption and incurred high operating expenditure(OPEX).However,the majority of current network designs struggle to efficientlymanage a massive amount of data using little power,which degrades energy efficiency performance.Thereby,it is necessary to have an efficient mechanism to reduce power consumption when processing large amounts of data in network data centers.Utilizing renewable energy sources to power the Cloud Radio Access Network(C-RAN)greatly reduces the need to purchase energy from the utility grid.In this paper,we propose a bandwidth-aware hybrid energypowered C-RAN that focuses on throughput and energy efficiency(EE)by lowering grid usage,aiming to enhance the EE.This paper examines the energy efficiency,spectral efficiency(SE),and average on-grid energy consumption,dealing with the major challenges of the temporal and spatial nature of traffic and renewable energy generation across various network setups.To assess the effectiveness of the suggested network by changing the transmission bandwidth,a comprehensive simulation has been conducted.The numerical findings support the efficacy of the suggested approach.展开更多
Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combinin...Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.展开更多
To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review a...To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review and SwissADME platform.Genes related to the inflammation were collected using Genecards and OMIM databases,and the intersection genes were submitted on STRING and DAVID websites.Then,the protein interaction network(PPI),gene ontology(GO)and pathway(KEGG)were analyzed.Cytoscape 3.7.2 software was used to construct the“Hibiscus mutabilis L.-active ingredient-target-inflammation”network diagram,and AutoDockTools-1.5.6 software was used for the molecular docking verification.The antiinflammatory effect of Hibiscus mutabilis L.active ingredient was verified by the RAW264.7 inflammatory cell model.The results showed that 11 active components and 94 potential targets,1029 inflammatory targets and 24 intersection targets were obtained from Hibiscus mutabilis L..The key anti-inflammatory active ingredients of Hibiscus mutabilis L.are quercetin,apigenin and luteolin.Its action pathway is mainly related to NF-κB,cancer pathway and TNF signaling pathway.Cell experiments showed that total flavonoids of Hibiscus mutabilis L.could effectively inhibit the expression of tumor necrosis factor(TNF-α),interleukin 8(IL-8)and epidermal growth factor receptor(EGFR)in LPS-induced RAW 264.7 inflammatory cells.It also downregulates the phosphorylation of human nuclear factor ĸB inhibitory protein α(IĸBα)and NF-κB p65 subunit protein(p65).Overall,the anti-inflammatory effect of Hibiscus mutabilis L.is related to many active components,many signal pathways and targets,which provides a theoretical basis for its further development and application.展开更多
The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children a...The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes.展开更多
Distributed Denial of Service(DDoS)attacks are one of the severe threats to network infrastructure,sometimes bypassing traditional diagnosis algorithms because of their evolving complexity.PresentMachine Learning(ML)t...Distributed Denial of Service(DDoS)attacks are one of the severe threats to network infrastructure,sometimes bypassing traditional diagnosis algorithms because of their evolving complexity.PresentMachine Learning(ML)techniques for DDoS attack diagnosis normally apply network traffic statistical features such as packet sizes and inter-arrival times.However,such techniques sometimes fail to capture complicated relations among various traffic flows.In this paper,we present a new multi-scale ensemble strategy given the Graph Neural Networks(GNNs)for improving DDoS detection.Our technique divides traffic into macro-and micro-level elements,letting various GNN models to get the two corase-scale anomalies and subtle,stealthy attack models.Through modeling network traffic as graph-structured data,GNNs efficiently learn intricate relations among network entities.The proposed ensemble learning algorithm combines the results of several GNNs to improve generalization,robustness,and scalability.Extensive experiments on three benchmark datasets—UNSW-NB15,CICIDS2017,and CICDDoS2019—show that our approach outperforms traditional machine learning and deep learning models in detecting both high-rate and low-rate(stealthy)DDoS attacks,with significant improvements in accuracy and recall.These findings demonstrate the suggested method’s applicability and robustness for real-world implementation in contexts where several DDoS patterns coexist.展开更多
1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring na...1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring nations and regions,including the United States,Europe,China,and Russia.Specifically,Space X’s Starlink project has deployed over 6750 satellites,2while One Web has completed its initial phase of satellite constellation deployment with more than 600 satellites.展开更多
(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified co...(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified compounds(5–7),were isolated from the crude extract of the mangrove-derived fungus Penicillium sp.,guided by heteronuclear single quantum correlation(HSQC)-based small molecule accurate recognition technology(SMART 2.0)and liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based molecular networking.The structural elucidation of new compounds was accomplished through comprehensive spectroscopic analysis,and their absolute configurations were determined using DP4+^(13)C nuclear magnetic resonance(NMR)calculations and electronic circular dichroism(ECD)calculations.Compounds 1a/1b–4a/4b demonstrated moderate cytotoxicity against three human cancer cell lines HeLa,HCT116 and MCF-7 with half maximal inhibitory concentration(IC50)values ranging from 15.95±1.64 to 28.56±2.59μmol·L–1.展开更多
With the growing complexity and decentralization of network systems,the attack surface has expanded,which has led to greater concerns over network threats.In this context,artificial intelligence(AI)-based network intr...With the growing complexity and decentralization of network systems,the attack surface has expanded,which has led to greater concerns over network threats.In this context,artificial intelligence(AI)-based network intrusion detection systems(NIDS)have been extensively studied,and recent efforts have shifted toward integrating distributed learning to enable intelligent and scalable detection mechanisms.However,most existing works focus on individual distributed learning frameworks,and there is a lack of systematic evaluations that compare different algorithms under consistent conditions.In this paper,we present a comprehensive evaluation of representative distributed learning frameworks—Federated Learning(FL),Split Learning(SL),hybrid collaborative learning(SFL),and fully distributed learning—in the context of AI-driven NIDS.Using recent benchmark intrusion detection datasets,a unified model backbone,and controlled distributed scenarios,we assess these frameworks across multiple criteria,including detection performance,communication cost,computational efficiency,and convergence behavior.Our findings highlight distinct trade-offs among the distributed learning frameworks,demonstrating that the optimal choice depends strongly on systemconstraints such as bandwidth availability,node resources,and data distribution.This work provides the first holistic analysis of distributed learning approaches for AI-driven NIDS and offers practical guidelines for designing secure and efficient intrusion detection systems in decentralized environments.展开更多
Identifying the community structure of complex networks is crucial to extracting insights and understanding network properties.Although several community detection methods have been proposed,many are unsuitable for so...Identifying the community structure of complex networks is crucial to extracting insights and understanding network properties.Although several community detection methods have been proposed,many are unsuitable for social networks due to significant limitations.Specifically,most approaches depend mainly on user-user structural links while overlooking service-centric,semantic,and multi-attribute drivers of community formation,and they also lack flexible filtering mechanisms for large-scale,service-oriented settings.Our proposed approach,called community discovery-based service(CDBS),leverages user profiles and their interactions with consulted web services.The method introduces a novel similarity measure,global similarity interaction profile(GSIP),which goes beyond typical similarity measures by unifying user and service profiles for all attributes types into a coherent representation,thereby clarifying its novelty and contribution.It applies multiple filtering criteria related to user attributes,accessed services,and interaction patterns.Experimental comparisons against Louvain,Hierarchical Agglomerative Clustering,Label Propagation and Infomap show that CDBS reveals the higher performance as it achieves 0.74 modularity,0.13 conductance,0.77 coverage,and significantly fast response time of 9.8 s,even with 10,000 users and 400 services.Moreover,community discoverybased service consistently detects a larger number of communities with distinct topics of interest,underscoring its capacity to generate detailed and efficient structures in complex networks.These results confirm both the efficiency and effectiveness of the proposed method.Beyond controlled evaluation,communities discovery based service is applicable to targeted recommendations,group-oriented marketing,access control,and service personalization,where communities are shaped not only by user links but also by service engagement.展开更多
With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a ...With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a promising Deep Learning(DL)approach,has proven to be highly effective in identifying intricate patterns in graph⁃structured data and has already found wide applications in the field of network security.In this paper,we propose a hybrid Graph Convolutional Network(GCN)⁃GraphSAGE model for Anomaly Traffic Detection,namely HGS⁃ATD,which aims to improve the accuracy of anomaly traffic detection by leveraging edge feature learning to better capture the relationships between network entities.We validate the HGS⁃ATD model on four publicly available datasets,including NF⁃UNSW⁃NB15⁃v2.The experimental results show that the enhanced hybrid model is 5.71%to 10.25%higher than the baseline model in terms of accuracy,and the F1⁃score is 5.53%to 11.63%higher than the baseline model,proving that the model can effectively distinguish normal traffic from attack traffic and accurately classify various types of attacks.展开更多
基金supported in part by National Key R&D Program of China(Grant No.2022YFC3803700)in part by the National Natural Science Foundation of China(Grant No.92067102)in part by the project of Beijing Laboratory of Advanced Information Networks.
文摘The rise of time-sensitive applications with broad geographical scope drives the development of time-sensitive networking(TSN)from intra-domain to inter-domain to ensure overall end-to-end connectivity requirements in heterogeneous deployments.When multiple TSN networks interconnect over non-TSN networks,all devices in the network need to be syn-chronized by sharing a uniform time reference.How-ever,most non-TSN networks are best-effort.Path delay asymmetry and random noise accumulation can introduce unpredictable time errors during end-to-end time synchronization.These factors can degrade syn-chronization performance.Therefore,cross-domain time synchronization becomes a challenging issue for multiple TSN networks interconnected by non-TSN networks.This paper presents a cross-domain time synchronization scheme that follows the software-defined TSN(SD-TSN)paradigm.It utilizes a com-bined control plane constructed by a coordinate con-troller and a domain controller for centralized control and management of cross-domain time synchroniza-tion.The general operation flow of the cross-domain time synchronization process is designed.The mecha-nism of cross-domain time synchronization is revealed by introducing a synchronization model and an error compensation method.A TSN cross-domain proto-type testbed is constructed for verification.Results show that the scheme can achieve end-to-end high-precision time synchronization with accuracy and sta-bility.
基金funded by the National Key Research and Development Program of China(No.2022YFC2804101)the Guangdong Provincial Key R&D Program(No.2023B1111050011)+2 种基金the Guangdong Basic and Applied Basic Research Foundation(No.2023A1515010432)the Guangzhou Basic and Applied Basic Research Foundation(No.202201010305)the High-Level Talents Special Program of Zhejiang(No.2022R52036)。
文摘Guided by molecular networking,nine novel curvularin derivatives(1-9)and 16 known analogs(10-25)were isolated from the hydrothermal vent sediment fungus Penicillium sp.HL-50.Notably,compounds 5-7 represented a hybrid of curvularin and purine.The structures and absolute configurations of compounds 1-9 were elucidated via nuclear magnetic resonance(NMR)spectroscopy,X-ray diffraction,electronic circular dichroism(ECD)calculations,^(13)C NMR calculation,modified Mosher's method,and chemical derivatization.Investigation of anti-inflammatory activities revealed that compounds 7-9,11,12,14,15,and 18 exhibited significant suppressive effects against lipopolysaccharide(LPS)-induced nitric oxide(NO)production in murine macrophage RAW264.7 cells,with IC_(50)values ranging from 0.44 to 4.40μmol·L^(-1).Furthermore,these bioactive compounds were found to suppress the expression of inflammation-related proteins,including inducible NO synthase(i NOS),cyclooxygenase-2(COX-2),NLR family pyrin domain-containing protein 3(NLRP3),and nuclear factor kappa-B(NF-κB).Additional studies demonstrated that the novel compound 7 possessed potent antiinflammatory activity by inhibiting the transcription of inflammation-related genes,downregulating the expression of inflammation-related proteins,and inhibiting the release of inflammatory cytokines,indicating its potential application in the treatment of inflammatory diseases.
基金supported by China’s National Key R&D Program(Project Number:2022YFB2902100)。
文摘The sixth-generation(6G)networks will consist of multiple bands such as low-frequency,midfrequency,millimeter wave,terahertz and other bands to meet various business requirements and networking scenarios.The dynamic complementarity of multiple bands are crucial for enhancing the spectrum efficiency,reducing network energy consumption,and ensuring a consistent user experience.This paper investigates the present researches and challenges associated with deployment of multi-band integrated networks in existing infrastructures.Then,an evolutionary path for integrated networking is proposed with the consideration of maturity of emerging technologies and practical network deployment.The proposed design principles for 6G multi-band integrated networking aim to achieve on-demand networking objectives,while the architecture supports full spectrum access and collaboration between high and low frequencies.In addition,the potential key air interface technologies and intelligent technologies for integrated networking are comprehensively discussed.It will be a crucial basis for the subsequent standards promotion of 6G multi-band integrated networking technology.
文摘With the large-scale deployment of satellite constellations such as Starlink and the rapid advancement of technologies including artificial intelligence (AI) and non-terrestrial networks (NTNs), the integration of high, medium, and low Earth orbit satellite networks with terrestrial networks has become a critical direction for future communication technologies. The objective is to develop a space-terrestrial integrated 6G network that ensures ubiquitous connectivity and seamless services, facilitating intelligent interconnection and collaborative symbiosis among humans, machines, and objects. This integration has become a central focus of global technological innovation.
基金supported by the National Research Foundation,Singapore and Infocomm Media Development Authority under its Future Communications Research&Development Programme.
文摘From fifth-generation(5G)communication technology onward,non-terrestrial networks(NTNs)have emerged as a key component of future network architectures.Especially through the rise of low-Earth-orbit satellite constellations,NTNs enable a space Internet and present a paradigm shift in delivering reliable services to even the most remote regions on Earth.However,the extensive coverage and rapid movement of satellites pose unique challenges in user equipment access and inter-satellite transmission,impacting the quality of service and service continuity.This paper offers an in-depth review of NTN networking technologies in the context of six-generation(6G)mobile networks evolution,focusing on access management,satellite mobility,and hetero-network slicing.Building on this foundation and considering the latest trends in NTN development,we then present innovative perspectives on emerging challenges,including satellite beamforming,handover mechanisms,and service delivery.Lastly,we identify key open research areas and propose future directions to improve NTN performance and accelerate satellite Internet deployment.
文摘The rapid evolution of satellite constellation projects(e.g.,SpaceX)and the standardization of 3rd Generation Partnership Project(3GPP)non-terrestrial networks(NTNs)have positioned satellite Internet networking(SIN)as a cornerstone of future communication systems.The demand for ubiquitous connectivity,resilient infrastructures,and intelligent network services has never been greater,driven by applications ranging from global broadband access to emergency response and space-air-ground integration.
基金supported by the Researchers Supporting Project of King Saud University,Riyadh,Saudi Arabia,under Project RSPD2025R681。
文摘With the continuous advancement of communication and unmanned aerial vehicle(UAV)technologies,the collaborative operations of diverse platforms,including UAVs and ground vehicles,have been significantly promoted.However,battlefield uncertainties,such as equipment failures and enemy attacks,can impact these collaborative operations'stability and communication efficiency.To this end,we design a highly destruction-resistant air-ground cooperative resilient networking platform that aims to enhance the robustness of network communications by integrating ground vehicle information for UAV network deployment.It then incorporates the concept of virtual guiding force,enabling the UAV swarm to adaptively configure its network layout based on ground vehicle information,thereby improving network destruction resistance.Simulation results demonstrate that the UAV swarm involved in the proposed platform exhibits balanced flight energy consumption and excellent performance in network destruction resistance.
基金supported in part by the National Natural Science Foundation of China under Grant 61972424 and 62372479in part by the High Value Intellectual Property Cultivation Project of Hubei Province,China,under grant D2021002094+1 种基金in part by JSPS KAKENHI under Grants JP16K00117 and JP19K20250in part by the Leading Initiative for Excellent Young Researchers(LEADER),MEXT,Japan,and KDDI Foundation.
文摘Named data networking(NDNs)is an idealized deployment of information-centric networking(ICN)that has attracted attention from scientists and scholars worldwide.A distributed in-network caching scheme can efficiently realize load balancing.However,such a ubiquitous caching approach may cause problems including duplicate caching and low data diversity,thus reducing the caching efficiency of NDN routers.To mitigate these caching problems and improve the NDN caching efficiency,in this paper,a hierarchical-based sequential caching(HSC)scheme is proposed.In this scheme,the NDN routers in the data transmission path are divided into various levels and data with different request frequencies are cached in distinct router levels.The aim is to cache data with high request frequencies in the router that is closest to the content requester to increase the response probability of the nearby data,improve the data caching efficiency of named data networks,shorten the response time,and reduce cache redundancy.Simulation results show that this scheme can effectively improve the cache hit rate(CHR)and reduce the average request delay(ARD)and average route hop(ARH).
基金supported in part by the Science and Technology Research and Development Foundation of China Academy of Railway Sciences Corporation Limited(Grant No.2023YJ364)in part by National Key R&D Program of China(Grant No.2022YFC3803700)in part by the project of Beijing Laboratory of Advanced Information Networks.
文摘Time synchronization is a prerequisite for ensuring determinism in time-sensitive networking(TSN).While time synchronization errors cannot be overlooked,pursuing minimal time errors may incur unnecessary costs.Using complex network theory,this study proposes a hierarchy for TSN and introduces the concept of bounded time error.A coupling model between traffic scheduling and time synchronization is established,deriving functional relationships among end-to-end delay,delay jitter,gate window,and time error.These relationships illustrate that time errors can trigger jumps in delay and delay jitter.To evaluate different time errors impact on traffic scheduling performance,an end-to-end transmission experiment scheme is designed,along with the construction of a TSN test platform implementing two representative cases.Case A is a closed TSN domain scenario with pure TSN switches emulating closed factory floor network.Case B depicts remote factory interconnection where TSN domains link via non-TSN domains composed of OpenFlow switches.Results from Case A show that delay and delay jitter on a single node are most significantly affected by time errors,up to one gating cycle.End-to-end delay jitter tends to increase with the number of hops.When the ratio of time error bound to window exceeds 10%,the number of schedulable traffic flows decreases rapidly.Case B reveals that when time error is below 1μs,the number of schedulable traffic flows begins to increase significantly,approaching full schedulability at errors below 0.6μs.
文摘The rapid growth in available network bandwidth has directly contributed to an exponential increase in mobile data traffic,creating significant challenges for network energy consumption.Also,with the extraordinary growth of mobile communications,the data traffic has dramatically expanded,which has led to massive grid power consumption and incurred high operating expenditure(OPEX).However,the majority of current network designs struggle to efficientlymanage a massive amount of data using little power,which degrades energy efficiency performance.Thereby,it is necessary to have an efficient mechanism to reduce power consumption when processing large amounts of data in network data centers.Utilizing renewable energy sources to power the Cloud Radio Access Network(C-RAN)greatly reduces the need to purchase energy from the utility grid.In this paper,we propose a bandwidth-aware hybrid energypowered C-RAN that focuses on throughput and energy efficiency(EE)by lowering grid usage,aiming to enhance the EE.This paper examines the energy efficiency,spectral efficiency(SE),and average on-grid energy consumption,dealing with the major challenges of the temporal and spatial nature of traffic and renewable energy generation across various network setups.To assess the effectiveness of the suggested network by changing the transmission bandwidth,a comprehensive simulation has been conducted.The numerical findings support the efficacy of the suggested approach.
文摘Optimizing routing and resource allocation in decentralized unmanned aerial vehicle(UAV)networks remains challenging due to interference and rapidly changing topologies.The authors introduce a novel framework combining double deep Q-networks(DDQNs)and graph neural networks(GNNs)for joint routing and resource allocation.The framework uses GNNs to model the network topology and DDQNs to adaptively control routing and resource allocation,addressing interference and improving network performance.Simulation results show that the proposed approach outperforms traditional methods such as Closest-to-Destination(c2Dst),Max-SINR(mSINR),and Multi-Layer Perceptron(MLP)-based models,achieving approximately 23.5% improvement in throughput,50% increase in connection probability,and 17.6% reduction in number of hops,demonstrating its effectiveness in dynamic UAV networks.
文摘To explore the material basis and mechanisms of the anti-inflammatory effects of Hibiscus mutabilis L..The active ingredients and potential targets of Hibiscus mutabilis L.were obtained through the literature review and SwissADME platform.Genes related to the inflammation were collected using Genecards and OMIM databases,and the intersection genes were submitted on STRING and DAVID websites.Then,the protein interaction network(PPI),gene ontology(GO)and pathway(KEGG)were analyzed.Cytoscape 3.7.2 software was used to construct the“Hibiscus mutabilis L.-active ingredient-target-inflammation”network diagram,and AutoDockTools-1.5.6 software was used for the molecular docking verification.The antiinflammatory effect of Hibiscus mutabilis L.active ingredient was verified by the RAW264.7 inflammatory cell model.The results showed that 11 active components and 94 potential targets,1029 inflammatory targets and 24 intersection targets were obtained from Hibiscus mutabilis L..The key anti-inflammatory active ingredients of Hibiscus mutabilis L.are quercetin,apigenin and luteolin.Its action pathway is mainly related to NF-κB,cancer pathway and TNF signaling pathway.Cell experiments showed that total flavonoids of Hibiscus mutabilis L.could effectively inhibit the expression of tumor necrosis factor(TNF-α),interleukin 8(IL-8)and epidermal growth factor receptor(EGFR)in LPS-induced RAW 264.7 inflammatory cells.It also downregulates the phosphorylation of human nuclear factor ĸB inhibitory protein α(IĸBα)and NF-κB p65 subunit protein(p65).Overall,the anti-inflammatory effect of Hibiscus mutabilis L.is related to many active components,many signal pathways and targets,which provides a theoretical basis for its further development and application.
基金supported by the IITP(Institute of Information&Communications Technology Planning&Evaluation)-ITRC(Information Technology Research Center)grant funded by the Korean government(Ministry of Science and ICT)(IITP-2025-RS-2024-00438056).
文摘The increased accessibility of social networking services(SNSs)has facilitated communication and information sharing among users.However,it has also heightened concerns about digital safety,particularly for children and adolescents who are increasingly exposed to online grooming crimes.Early and accurate identification of grooming conversations is crucial in preventing long-term harm to victims.However,research on grooming detection in South Korea remains limited,as existing models trained primarily on English text and fail to reflect the unique linguistic features of SNS conversations,leading to inaccurate classifications.To address these issues,this study proposes a novel framework that integrates optical character recognition(OCR)technology with KcELECTRA,a deep learning-based natural language processing(NLP)model that shows excellent performance in processing the colloquial Korean language.In the proposed framework,the KcELECTRA model is fine-tuned by an extensive dataset,including Korean social media conversations,Korean ethical verification data from AI-Hub,and Korean hate speech data from Hug-gingFace,to enable more accurate classification of text extracted from social media conversation images.Experimental results show that the proposed framework achieves an accuracy of 0.953,outperforming existing transformer-based models.Furthermore,OCR technology shows high accuracy in extracting text from images,demonstrating that the proposed framework is effective for online grooming detection.The proposed framework is expected to contribute to the more accurate detection of grooming text and the prevention of grooming-related crimes.
文摘Distributed Denial of Service(DDoS)attacks are one of the severe threats to network infrastructure,sometimes bypassing traditional diagnosis algorithms because of their evolving complexity.PresentMachine Learning(ML)techniques for DDoS attack diagnosis normally apply network traffic statistical features such as packet sizes and inter-arrival times.However,such techniques sometimes fail to capture complicated relations among various traffic flows.In this paper,we present a new multi-scale ensemble strategy given the Graph Neural Networks(GNNs)for improving DDoS detection.Our technique divides traffic into macro-and micro-level elements,letting various GNN models to get the two corase-scale anomalies and subtle,stealthy attack models.Through modeling network traffic as graph-structured data,GNNs efficiently learn intricate relations among network entities.The proposed ensemble learning algorithm combines the results of several GNNs to improve generalization,robustness,and scalability.Extensive experiments on three benchmark datasets—UNSW-NB15,CICIDS2017,and CICDDoS2019—show that our approach outperforms traditional machine learning and deep learning models in detecting both high-rate and low-rate(stealthy)DDoS attacks,with significant improvements in accuracy and recall.These findings demonstrate the suggested method’s applicability and robustness for real-world implementation in contexts where several DDoS patterns coexist.
基金co-supported by the National Natural Science Foundation of China(Nos.62225103,U2441227,U24A20211)the Fundamental Research Funds for the Central Universities of China(No.FRF-TP-22-002C2)。
文摘1.Introduction As a key development of the next-generation spatial information infrastructure,1the Satellite-Terrestrial Integrated Network(STIN)has become a strategic priority actively pursued by major spacefaring nations and regions,including the United States,Europe,China,and Russia.Specifically,Space X’s Starlink project has deployed over 6750 satellites,2while One Web has completed its initial phase of satellite constellation deployment with more than 600 satellites.
基金supported by the National Key Research and Development Program of China(No.2022YFC2303100)the National Natural Science Foundation of China(Nos.32022002 and 21977113).
文摘(±)-Penicithrones A–D(1a/1b–4a/4b),four novel pairs of anthrone–cyclopentenone heterodimers characterized by a distinctive bridged 6/6/6−5 tetracyclic core skeleton,together with three previously identified compounds(5–7),were isolated from the crude extract of the mangrove-derived fungus Penicillium sp.,guided by heteronuclear single quantum correlation(HSQC)-based small molecule accurate recognition technology(SMART 2.0)and liquid chromatography-tandem mass spectrometry(LC-MS/MS)-based molecular networking.The structural elucidation of new compounds was accomplished through comprehensive spectroscopic analysis,and their absolute configurations were determined using DP4+^(13)C nuclear magnetic resonance(NMR)calculations and electronic circular dichroism(ECD)calculations.Compounds 1a/1b–4a/4b demonstrated moderate cytotoxicity against three human cancer cell lines HeLa,HCT116 and MCF-7 with half maximal inhibitory concentration(IC50)values ranging from 15.95±1.64 to 28.56±2.59μmol·L–1.
基金supported by the Research year project of the KongjuNational University in 2025 and the Institute of Information&Communications Technology Planning&Evaluation(IITP)grant funded by the Korea government(MSIT)(No.RS-2024-00444170,Research and International Collaboration on Trust Model-Based Intelligent Incident Response Technologies in 6G Open Network Environment).
文摘With the growing complexity and decentralization of network systems,the attack surface has expanded,which has led to greater concerns over network threats.In this context,artificial intelligence(AI)-based network intrusion detection systems(NIDS)have been extensively studied,and recent efforts have shifted toward integrating distributed learning to enable intelligent and scalable detection mechanisms.However,most existing works focus on individual distributed learning frameworks,and there is a lack of systematic evaluations that compare different algorithms under consistent conditions.In this paper,we present a comprehensive evaluation of representative distributed learning frameworks—Federated Learning(FL),Split Learning(SL),hybrid collaborative learning(SFL),and fully distributed learning—in the context of AI-driven NIDS.Using recent benchmark intrusion detection datasets,a unified model backbone,and controlled distributed scenarios,we assess these frameworks across multiple criteria,including detection performance,communication cost,computational efficiency,and convergence behavior.Our findings highlight distinct trade-offs among the distributed learning frameworks,demonstrating that the optimal choice depends strongly on systemconstraints such as bandwidth availability,node resources,and data distribution.This work provides the first holistic analysis of distributed learning approaches for AI-driven NIDS and offers practical guidelines for designing secure and efficient intrusion detection systems in decentralized environments.
文摘Identifying the community structure of complex networks is crucial to extracting insights and understanding network properties.Although several community detection methods have been proposed,many are unsuitable for social networks due to significant limitations.Specifically,most approaches depend mainly on user-user structural links while overlooking service-centric,semantic,and multi-attribute drivers of community formation,and they also lack flexible filtering mechanisms for large-scale,service-oriented settings.Our proposed approach,called community discovery-based service(CDBS),leverages user profiles and their interactions with consulted web services.The method introduces a novel similarity measure,global similarity interaction profile(GSIP),which goes beyond typical similarity measures by unifying user and service profiles for all attributes types into a coherent representation,thereby clarifying its novelty and contribution.It applies multiple filtering criteria related to user attributes,accessed services,and interaction patterns.Experimental comparisons against Louvain,Hierarchical Agglomerative Clustering,Label Propagation and Infomap show that CDBS reveals the higher performance as it achieves 0.74 modularity,0.13 conductance,0.77 coverage,and significantly fast response time of 9.8 s,even with 10,000 users and 400 services.Moreover,community discoverybased service consistently detects a larger number of communities with distinct topics of interest,underscoring its capacity to generate detailed and efficient structures in complex networks.These results confirm both the efficiency and effectiveness of the proposed method.Beyond controlled evaluation,communities discovery based service is applicable to targeted recommendations,group-oriented marketing,access control,and service personalization,where communities are shaped not only by user links but also by service engagement.
基金National Natural Science Foundation of China(Grant No.62103434)National Science Fund for Distinguished Young Scholars(Grant No.62176263).
文摘With network attack technology continuing to develop,traditional anomaly traffic detection methods that rely on feature engineering are increasingly insufficient in efficiency and accuracy.Graph Neural Network(GNN),a promising Deep Learning(DL)approach,has proven to be highly effective in identifying intricate patterns in graph⁃structured data and has already found wide applications in the field of network security.In this paper,we propose a hybrid Graph Convolutional Network(GCN)⁃GraphSAGE model for Anomaly Traffic Detection,namely HGS⁃ATD,which aims to improve the accuracy of anomaly traffic detection by leveraging edge feature learning to better capture the relationships between network entities.We validate the HGS⁃ATD model on four publicly available datasets,including NF⁃UNSW⁃NB15⁃v2.The experimental results show that the enhanced hybrid model is 5.71%to 10.25%higher than the baseline model in terms of accuracy,and the F1⁃score is 5.53%to 11.63%higher than the baseline model,proving that the model can effectively distinguish normal traffic from attack traffic and accurately classify various types of attacks.
