The Fifth-Generation(5G)cellular and wireless communication envisage to integrate multiple technologies to provide a wide range of applications.The rapid growth of Information and Communication Technology(ICT)needs a ...The Fifth-Generation(5G)cellular and wireless communication envisage to integrate multiple technologies to provide a wide range of applications.The rapid growth of Information and Communication Technology(ICT)needs a common cellular platform to increase the network’s extensibility and adaptability.The Cloud Radio Access Network(C-RAN)offers a scalable and flexible Base Station(BS)architecture for the next-generation wireless and mobile networks,where the BS functionality is split into a distributed radio unit known as Remote Radio Head(RRH)and a Centralized BaseBand Unit(C-BBU).To further make the C-BBU scalable and flexible,the baseband signal processing is carried out over a virtualized platform.The load at the RRH and C-BBU can vary from under-loaded to overloaded conditions which increase the power consumption and degrade the Quality-of-Service(QoS)of the C-RAN.In this paper,we formulate under-loaded and overloaded conditions at the RRH and the C-BBU,and propose a Co-operative Load Balancing(CLB)algorithm for handling the cellular traffic in real-time under different load conditions.The proposed CLB aims to maximize the utilization of hardware resources at the RRH and C-BBU.The CLB algorithm is compared with CDI,CZ,NDLB,DLB in the first phase for the RF load balancing.In the second phase of simulation,CLB is compared with the FCFS,IWRR,OLB,GP and TLB algorithms for server(C-BBU)load balancing.The parameters considered for comparison are:User Entity(UE)waiting time,blocking probability and processing time at the RRH and the C-BBU.Simulation results show that the use of co-operative load balancing technique improves the QoS in the C-RAN by reducing the blocking probability and UE waiting time.The CLB algorithm is validated with LTE TU-Vienna and cloudSim simulators for the RRH and the C-BBU,respectively.展开更多
Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the del...Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy.展开更多
From the perspective of Multimodal Metaphor Theory,the architectural scenes in Ne Zha 2 embody highly condensed cultural connotations.Through the synergy of vision,soundscape,and dialect,the film constructs a metaphor...From the perspective of Multimodal Metaphor Theory,the architectural scenes in Ne Zha 2 embody highly condensed cultural connotations.Through the synergy of vision,soundscape,and dialect,the film constructs a metaphorical chain of“human order-ethnic oppression-theocratic structure”via the three core architectural spaces.As core signifiers,buildings drive the plot,shape characters,and convey values.The study reveals that animation activates traditional architecture’s metaphorical potential through cross-modal mapping,endowing historical symbols with contemporary vitality and providing a paradigm for the creative transformation of traditional culture.展开更多
Deep learning has become integral to robotics,particularly in tasks such as robotic grasping,where objects often exhibit diverse shapes,textures,and physical properties.In robotic grasping tasks,due to the diverse cha...Deep learning has become integral to robotics,particularly in tasks such as robotic grasping,where objects often exhibit diverse shapes,textures,and physical properties.In robotic grasping tasks,due to the diverse characteristics of the targets,frequent adjustments to the network architecture and parameters are required to avoid a decrease in model accuracy,which presents a significant challenge for non-experts.Neural Architecture Search(NAS)provides a compelling method through the automated generation of network architectures,enabling the discovery of models that achieve high accuracy through efficient search algorithms.Compared to manually designed networks,NAS methods can significantly reduce design costs,time expenditure,and improve model performance.However,such methods often involve complex topological connections,and these redundant structures can severely reduce computational efficiency.To overcome this challenge,this work puts forward a robotic grasp detection framework founded on NAS.The method automatically designs a lightweight network with high accuracy and low topological complexity,effectively adapting to the target object to generate the optimal grasp pose,thereby significantly improving the success rate of robotic grasping.Additionally,we use Class Activation Mapping(CAM)as an interpretability tool,which captures sensitive information during the perception process through visualized results.The searched model achieved competitive,and in some cases superior,performance on the Cornell and Jacquard public datasets,achieving accuracies of 98.3%and 96.8%,respectively,while sustaining a detection speed of 89 frames per second with only 0.41 million parameters.To further validate its effectiveness beyond benchmark evaluations,we conducted real-world grasping experiments on a UR5 robotic arm,where the model demonstrated reliable performance across diverse objects and high grasp success rates,thereby confirming its practical applicability in robotic manipulation tasks.展开更多
With the rapid development of image-generative AI (artificial intelligence) technology, its application in undergraduate Landscape Architecture education has demonstrated significant potential. Based on this, the pres...With the rapid development of image-generative AI (artificial intelligence) technology, its application in undergraduate Landscape Architecture education has demonstrated significant potential. Based on this, the present study explores the implications of integrating image-generative AI into Landscape Architecture courses from three perspectives: stimulating students creative design potential, expanding approaches to form and concept generation, and enhancing the visualization of spatial scenes. Furthermore, it discusses application strategies from three dimensions: AI-assisted conceptual generation, human-machine collaboration for design refinement, and optimization of scheme presentation and evaluation. This paper aims to provide relevant educators with insights and references.展开更多
Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key componen...Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems.展开更多
Improved yield potential is the goal of barley domestication and cultivation.During this process,two-and six-rowed barley types emerged and have been utilised in breeding and production.The six-rowed type could produc...Improved yield potential is the goal of barley domestication and cultivation.During this process,two-and six-rowed barley types emerged and have been utilised in breeding and production.The six-rowed type could produce three times as many grains as its ancestral two-rowed forms,thus dominating barley cultivation for thousands of years.The deficiens form of the two-rowed type,characterised by extremely suppressed lateral spikelets,has gained dominance over the past few decades in barley-growing regions worldwide.We hypothesised that the absence of lateral spikelets in deficiens barley affects spike architecture and spike-related traits,contributing to its superior yield potential of deficiens barley cultivation.Currently,a deficiens barley variety,RGT Planet,is the most popular barley variety in the world.In this study,we used two F_(2) populations derived from crossing RGT Planet with two canonical two-rowed barley and identified the functional allele Vrs1.t1 associated with deficiens morphology.We observed that the Vrs1.t1 allele may contribute to high yield potential by optimising spike architecture through increased spikelet length,grain number,and grain size.Phylogenetic analysis suggests that the deficiens mutation was likely present from the early stages of barley cultivation in the Fertile Crescent and spread to Ethiopia and beyond with agricultural expansion.We conclude that the ancient deficiens allele Vrs1.t1 has been a critical driver for the recent success of modern barley improvement by optimising spike architecture.展开更多
Wheat(Triticum aestivum)faces significant threats from diseases such as powdery mildew(Blumeria graminis)and Fusarium head blight(FHB;caused by Fusarium graminearum),which cause severe yield losses.Moreover,the antago...Wheat(Triticum aestivum)faces significant threats from diseases such as powdery mildew(Blumeria graminis)and Fusarium head blight(FHB;caused by Fusarium graminearum),which cause severe yield losses.Moreover,the antagonism between yield-related traits and disease resistance makes yield resistance coordination a major challenge in wheat breeding.The lack of genetic resources combining both disease resistance and high yield constrains the elucidation of underlying resistance-yield trade-off mechanisms,thereby hindering the development of high-yield and disease-resistant wheat cultivars.Remarkably,Yangmai 33(YM33),a notable wheat cultivar with resistance to both powdery mildew and FHB as well as high-yield performance,was recently developed.It offers a unique opportunity to dissect the genomic architecture underlying the coordination between disease resistance and yield.展开更多
With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has surged.In this work,a novel gradient-layered architecture was design based on single-pore hollow lignin...With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has surged.In this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable supercapacitors.By depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene lamella.Moreover,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of lignin.All these strategies effectively enhanced the capacitive performance of the electrodes.In addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the electrodes.Flexible electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),respectively.Moreover,their capacitances were well preserved after 1000 times of 600%stretch-release cycling.This study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.展开更多
The key technologies involved in the evolution of the Cloud-based Radio Access Network(C-RAN) are discussed in this paper. Taking the Frameless Network Architecture(FNA) as a starting point, a cell-lessbased network t...The key technologies involved in the evolution of the Cloud-based Radio Access Network(C-RAN) are discussed in this paper. Taking the Frameless Network Architecture(FNA) as a starting point, a cell-lessbased network topology for a multi-tier Heterogeneous Network(Het Net) and ultra-dense network is proposed. The FNA network topology modeling is researched with centralized processing and distributed antenna deployments. The Antenna Element(AE) is released as a new dimensional radio resource that is included in the centralized Radio Resource Management(RRM) processes. This contributes to the on-demand user-centric serving-set associations with cell-edge effect elimination. The Control Plane(CP) and User Plane(UP) separation and adaptation are introduced for energy efficiency improvements. The centralized RRM and different optimization goals are discussed for fully exploring the merits from the centralized computing of C-RAN. Considering the complexity, near-optimal approaches for specific users' Quality-of-Service(Qo S) requirements are addressed. Finally, based on the research highlighted above, the way forward of C-RAN evolution is discussed.展开更多
High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V1...High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.展开更多
Modern aircraft tend to use fuel thermal management systems to cool onboard heat sources.However,the design of heat transfer architectures for fuel thermal management systems relies on the experience of the engineers ...Modern aircraft tend to use fuel thermal management systems to cool onboard heat sources.However,the design of heat transfer architectures for fuel thermal management systems relies on the experience of the engineers and lacks theoretical guidance.This paper proposes a concise graph representation method based on graph theory for fuel thermal management systems,which can represent all possible connections between subsystems.A generalized optimization algorithm is proposed for fuel thermal management system architecture to minimize the heat sink.This algorithm can autonomously arrange subsystems with heat production differences and efficiently utilize the architecture of the fuel heat sink.At the same time,two evaluation indices are proposed from the perspective of subsystems.These indices intuitively and clearly show that the reason for the high efficiency of heat sink utilization is the balanced and moderate cooling of each subsystem and verify the rationality of the architecture optimization method.A set of simulations are also conducted,which demonstrate that the fuel tank temperature has no effect on the performance of the architecture.This paper provides a reference for the architectural design of aircraft fuel thermal management systems.The metrics used in this paper can also be utilized to evaluate the existing architecture.展开更多
To address the discrepancies between well and seismic data in stratigraphic correlation of the Triassic Yanchang Formation in the Ordos Basin,NW China,traditional stratigraphic classification schemes,the latest 3D sei...To address the discrepancies between well and seismic data in stratigraphic correlation of the Triassic Yanchang Formation in the Ordos Basin,NW China,traditional stratigraphic classification schemes,the latest 3D seismic and drilling data,and reservoir sections are thoroughly investigated.Guided by the theory of sequence stratigraphy,the progradational sequence stratigraphic framework of the Yanchang Formation is systematically constructed to elucidate new deposition mechanisms in the depressed lacustrine basin,and it has been successfully applied to the exploration and development practices in the Qingcheng Oilfield.Key findings are obtained in three aspects.First,the seismic progradational reflections,marker tuff beds,and condensed sections of flooding surfaces in the Yanchang Formation are consistent and isochronous.Using flooding surface markers as a reference,a progradational sequence stratigraphic architecture is reconstructed for the middle-upper part of Yanchang Formation,and divided into seven clinoform units(CF1-CF7).Second,progradation predominantly occurs in semi-deep to deep lake environments,with the depositional center not always coinciding with the thickest strata.The lacustrine basin underwent an evolution of“oscillatory regression-progradational infilling-multi-phase superimposition”.Third,the case study of Qingcheng Oilfield reveals that the major pay zones consist of“isochronous but heterochronous”gravity-flow sandstone complexes.Guided by the progradational sequence stratigraphic architecture,horizontal well oil-layer penetration rates remain above 82%.The progradational sequence stratigraphic architecture and associated geological insights are more consistent with the sedimentary infilling mechanisms of large-scale continental depressed lacustrine basins and actual drilling results.The research results provide crucial theoretical and technical support for subsequent refined exploration and development of the Yanchang Formation,and are expected to offer a reference for research and production practice in similar continental lacustrine basins.展开更多
It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle acc...It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope.展开更多
Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in de...Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in defining places’architectural languages.Building from the local materials is an essential ingredient of the local distinctiveness,whilst forming the architectural grand gesture in its context.In Siwa oasis,salt architecture has formed that architectural grand gesture.The vernacular vocabularies adopted by old Bedouins using salt bricks generated Siwa’s unique spirit.In this paper,some examples are illustrated based on a series of site visits to three main sites in Siwa,namely:Old Shali,Abu Shuruf,and Aghourmy.This shows the evolution of Siwa’s vernacular architecture and the role of the architectural language or detrimental effect on the overall quality of architecture.From the site visits,it was observed that building with the traditional technique is now becoming abandoned in Siwa,explained by the local builders to be due to the huge costs required;forcing them to shifting to modern architecture.The influx to building using modern techniques has led to a significant transformation in the urban morphology and spirit of Siwa.Herein lies the scope of this paper:to discuss the impact of the evolution of vernacular architecture on the overall quality of architecture in Siwa and thus identifying the problems which will lead to policy formulation and guidelines for the redevelopment of Siwa in order to“revitalize/resuscitate”its vernacular style accordingly.展开更多
This paper adopts the Global Workspace Theory as a neuro-scientifically plausible theory for developing conscious cognitive architecture.The Global Workspace Theory’s compatibility with the working mechanisms underne...This paper adopts the Global Workspace Theory as a neuro-scientifically plausible theory for developing conscious cognitive architecture.The Global Workspace Theory’s compatibility with the working mechanisms underneath human brains is enhanced by the implementation of different cognitive features based on this framework.Amongst the topics in the literature for intelligent systems,we start with attention,memory and learning mechanisms,and corresponding experiments are summarized here.We also discuss how other topics of cognitive robotics could be developed based on these three basic components,and their correlations.This provides a foundation for future long-term development of cognitive architectures of cognitive robots.The research in this paper follows the incremental research pathway for the architecture implementation,which is consistent with the Biologically Inspired Cognitive Architecture roadmap.展开更多
Henry Killam Murphy,an American architect in the 20th century(1877—1954),advocated the idea of adaptive architecture and the traditional renaissance design method,and believed that different countries and regions sho...Henry Killam Murphy,an American architect in the 20th century(1877—1954),advocated the idea of adaptive architecture and the traditional renaissance design method,and believed that different countries and regions should have their own architectural art.He recognized and appreciated traditional Chinese architecture and used it in Chinese architectural design.Based on Henry Killam Murphy’s design of Tsinghua University,Ginling College and Beijing Yenching University in China from 1914 to 1935,this paper discussed and probed into the construction of Murphy’s creation concept and technique,and the selection of the Architectural History of China and Yang Bingde’s Blend of Chinese&Western Architectural Culture in Chinese Modern History,and also compared to Murphy and Chinese architects of the 20th century,so as to demonstrate different design attitudes of Chinese traditional architectural culture and the western architectural culture during the fusion,and Henry Killam Murphy’s impact and far-reaching significance on China’s modern campus planning.展开更多
A restoration concept has been developed based on the Baiyun Taoist Temple Map found in the Continuation of the Gaolan County Annals.This study systematically analyzes the architectural features of Baiyun Taoist Templ...A restoration concept has been developed based on the Baiyun Taoist Temple Map found in the Continuation of the Gaolan County Annals.This study systematically analyzes the architectural features of Baiyun Taoist Temple in Lanzhou during the Daoguang period of the Qing Dynasty from three perspectives:overall layout,spatial design,and garden artistic conception.The analysis offers a representative case for understanding the spatial organization principles and cultural connotation of Taoist architecture in the Lanzhou region during the Qing Dynasty.展开更多
The aim of this article is to present my interpretation of the holistic-phenomenological worldview in practice.This study demonstrates how this approach,as well as the planning process that I followed(a process fundam...The aim of this article is to present my interpretation of the holistic-phenomenological worldview in practice.This study demonstrates how this approach,as well as the planning process that I followed(a process fundamentally different from conventional ones)was implemented in a residential neighborhood I designed and built in the social,economic,and physical structure of the collective known in Israel as a‘kibbutz’.The intention is to raise a broad public discussion and pose a challenge to 21st-century architecture regarding how to intervene in a moral and human way within an existing environment,urban or natural,which must be respected and preserved,when integrating within it a new contemporary architecture.展开更多
文摘The Fifth-Generation(5G)cellular and wireless communication envisage to integrate multiple technologies to provide a wide range of applications.The rapid growth of Information and Communication Technology(ICT)needs a common cellular platform to increase the network’s extensibility and adaptability.The Cloud Radio Access Network(C-RAN)offers a scalable and flexible Base Station(BS)architecture for the next-generation wireless and mobile networks,where the BS functionality is split into a distributed radio unit known as Remote Radio Head(RRH)and a Centralized BaseBand Unit(C-BBU).To further make the C-BBU scalable and flexible,the baseband signal processing is carried out over a virtualized platform.The load at the RRH and C-BBU can vary from under-loaded to overloaded conditions which increase the power consumption and degrade the Quality-of-Service(QoS)of the C-RAN.In this paper,we formulate under-loaded and overloaded conditions at the RRH and the C-BBU,and propose a Co-operative Load Balancing(CLB)algorithm for handling the cellular traffic in real-time under different load conditions.The proposed CLB aims to maximize the utilization of hardware resources at the RRH and C-BBU.The CLB algorithm is compared with CDI,CZ,NDLB,DLB in the first phase for the RF load balancing.In the second phase of simulation,CLB is compared with the FCFS,IWRR,OLB,GP and TLB algorithms for server(C-BBU)load balancing.The parameters considered for comparison are:User Entity(UE)waiting time,blocking probability and processing time at the RRH and the C-BBU.Simulation results show that the use of co-operative load balancing technique improves the QoS in the C-RAN by reducing the blocking probability and UE waiting time.The CLB algorithm is validated with LTE TU-Vienna and cloudSim simulators for the RRH and the C-BBU,respectively.
基金financially supported by the Liaoning Revitalization Talents Program (No.XLYC2403107)the Excellent Youth Science Foundation of Liaoning Province (No.2024JH3/10200046)the Basic Scientific Research Project of Liaoning Provincial Department of Education (No.LJ212410163015)。
文摘Despite demonstrating significant anti-tumor potential as an artemisinin derivative,artesunate faces delivery efficiency challenges due to low water solubility and insufficient targeting specificity.To improve the delivery efficiency,we engineered three artesunate(ART) derivatives,AC_(15)-L(linear),AC_(15)-B(branched),and AC_(15)-C(cyclic) with distinct aliphatic chain architectures.Unexpectedly,we observed that AC_(15)-C exhibited superior cytotoxicity against 4T1 breast cancer cells,and had the highest binding affinity for Lon protease 1(LONP1)(-72.6 kcal/mol).Subsequently,disulfide bond-containing lipid-PEG(DSPESS-PEG2K) modified chain architecture-engineered ART derivatives nanoassemblies(NAs) were developed to mitigate solubility-related limitations while enhancing targeting precision.Molecular docking and experimental validation demonstrated that ART derivatives inhibited LONP1 through hydrophobic interactions while preserved Fe^(2+)-mediated Fenton-like reaction activity.In vitro and in vivo evaluations demonstrated that AC_(15)-C NAs outperformed free ART and other NAs,suppressing 4T1 tumor growth via dual action:LONP1-directed mitochondrial proteostasis collapse and reactive oxygen species(ROS) amplification through Fe^(2+)-ART interactions.This study elucidated a novel anti-tumor mechanism of ART through the rational design of derivatives with spatially configured aliphatic chains,and developed reductionresponsive NAs to provide an advanced delivery strategy.
文摘From the perspective of Multimodal Metaphor Theory,the architectural scenes in Ne Zha 2 embody highly condensed cultural connotations.Through the synergy of vision,soundscape,and dialect,the film constructs a metaphorical chain of“human order-ethnic oppression-theocratic structure”via the three core architectural spaces.As core signifiers,buildings drive the plot,shape characters,and convey values.The study reveals that animation activates traditional architecture’s metaphorical potential through cross-modal mapping,endowing historical symbols with contemporary vitality and providing a paradigm for the creative transformation of traditional culture.
基金funded by Guangdong Basic and Applied Basic Research Foundation(2023B1515120064)National Natural Science Foundation of China(62273097).
文摘Deep learning has become integral to robotics,particularly in tasks such as robotic grasping,where objects often exhibit diverse shapes,textures,and physical properties.In robotic grasping tasks,due to the diverse characteristics of the targets,frequent adjustments to the network architecture and parameters are required to avoid a decrease in model accuracy,which presents a significant challenge for non-experts.Neural Architecture Search(NAS)provides a compelling method through the automated generation of network architectures,enabling the discovery of models that achieve high accuracy through efficient search algorithms.Compared to manually designed networks,NAS methods can significantly reduce design costs,time expenditure,and improve model performance.However,such methods often involve complex topological connections,and these redundant structures can severely reduce computational efficiency.To overcome this challenge,this work puts forward a robotic grasp detection framework founded on NAS.The method automatically designs a lightweight network with high accuracy and low topological complexity,effectively adapting to the target object to generate the optimal grasp pose,thereby significantly improving the success rate of robotic grasping.Additionally,we use Class Activation Mapping(CAM)as an interpretability tool,which captures sensitive information during the perception process through visualized results.The searched model achieved competitive,and in some cases superior,performance on the Cornell and Jacquard public datasets,achieving accuracies of 98.3%and 96.8%,respectively,while sustaining a detection speed of 89 frames per second with only 0.41 million parameters.To further validate its effectiveness beyond benchmark evaluations,we conducted real-world grasping experiments on a UR5 robotic arm,where the model demonstrated reliable performance across diverse objects and high grasp success rates,thereby confirming its practical applicability in robotic manipulation tasks.
基金Supported by Applied Brand Course of Mianyang Teacher's College(Investigation and Monitoring of Natural Resources).
文摘With the rapid development of image-generative AI (artificial intelligence) technology, its application in undergraduate Landscape Architecture education has demonstrated significant potential. Based on this, the present study explores the implications of integrating image-generative AI into Landscape Architecture courses from three perspectives: stimulating students creative design potential, expanding approaches to form and concept generation, and enhancing the visualization of spatial scenes. Furthermore, it discusses application strategies from three dimensions: AI-assisted conceptual generation, human-machine collaboration for design refinement, and optimization of scheme presentation and evaluation. This paper aims to provide relevant educators with insights and references.
基金supported by National Key Research and Development Program of China(No.2023YFB 4404200).
文摘Fault-tolerant systems are crucial for ensuring the reliability and availability of missioncritical applications in modern computing environments.The dynamic heterogeneous redundancy(DHR)architecture is a key component in constructing fault-tolerant systems,particularly in areas such as national security,power networks,and banking private networks.DHR is transforming the cyberspace security industry chain by accommodating a broader range of applications and increasingly capturing the market.However,the development of applications for DHR architecture encounters challenges due to the complexities of handling heterogeneity,managing dynamism,and maintaining usability.To address these issues,we introduce MimicStudio,a comprehensive development framework with a standardized workflow.To our knowledge,MimicStudio is the first effective solution for DHR software development.We present a detailed implementation of MimicStudio with a heterogeneous microcontroller unit project,encompassing three CPUs with different instruction set architectures.The paper evaluates MimicStudio’s support for essential features,including zero-copy synchronization,parallelized build,multi-core collaborative debugging,and dynamic adjustment of the software system’s structure.Our results show that MimicStudio provides a flexible and efficient solution for supporting the dynamic,heterogeneous,and redundant features of fault-tolerant systems.
基金Funding for this research was provided by the Australia Grain Research and Development Corporation(9176507)the Western Crop Genetics Alliance.Jingye Cheng thanks The University of Tasmania,Australia for the scholarship(495802)。
文摘Improved yield potential is the goal of barley domestication and cultivation.During this process,two-and six-rowed barley types emerged and have been utilised in breeding and production.The six-rowed type could produce three times as many grains as its ancestral two-rowed forms,thus dominating barley cultivation for thousands of years.The deficiens form of the two-rowed type,characterised by extremely suppressed lateral spikelets,has gained dominance over the past few decades in barley-growing regions worldwide.We hypothesised that the absence of lateral spikelets in deficiens barley affects spike architecture and spike-related traits,contributing to its superior yield potential of deficiens barley cultivation.Currently,a deficiens barley variety,RGT Planet,is the most popular barley variety in the world.In this study,we used two F_(2) populations derived from crossing RGT Planet with two canonical two-rowed barley and identified the functional allele Vrs1.t1 associated with deficiens morphology.We observed that the Vrs1.t1 allele may contribute to high yield potential by optimising spike architecture through increased spikelet length,grain number,and grain size.Phylogenetic analysis suggests that the deficiens mutation was likely present from the early stages of barley cultivation in the Fertile Crescent and spread to Ethiopia and beyond with agricultural expansion.We conclude that the ancient deficiens allele Vrs1.t1 has been a critical driver for the recent success of modern barley improvement by optimising spike architecture.
基金supported by the National Key R&D Program of China(2024YFD1201100)the research program from the Zhongshan Biological Breeding Laboratory(ZSBBL-KY2023-02)the National Natural Science Foundation of China(32341037).
文摘Wheat(Triticum aestivum)faces significant threats from diseases such as powdery mildew(Blumeria graminis)and Fusarium head blight(FHB;caused by Fusarium graminearum),which cause severe yield losses.Moreover,the antagonism between yield-related traits and disease resistance makes yield resistance coordination a major challenge in wheat breeding.The lack of genetic resources combining both disease resistance and high yield constrains the elucidation of underlying resistance-yield trade-off mechanisms,thereby hindering the development of high-yield and disease-resistant wheat cultivars.Remarkably,Yangmai 33(YM33),a notable wheat cultivar with resistance to both powdery mildew and FHB as well as high-yield performance,was recently developed.It offers a unique opportunity to dissect the genomic architecture underlying the coordination between disease resistance and yield.
基金supported by Natural Science and Engineering Research Council of Canada(RGPIN-2017-06737)Canada Research Chairs program,the National Key Research and Development Program of China(2017YFD0601005,2022YFD0904201)+1 种基金the National Natural Science Foundation of China(51203075)the China Scholarship Council(Grant No.CSC202208320361).
文摘With the rapid development of flexible wearable electronics,the demand for stretchable energy storage devices has surged.In this work,a novel gradient-layered architecture was design based on single-pore hollow lignin nanospheres(HLNPs)-intercalated two-dimensional transition metal carbide(Ti_(3)C_(2)T_(x) MXene)for fabricating highly stretchable and durable supercapacitors.By depositing and inserting HLNPs in the MXene layers with a bottom-up decreasing gradient,a multilayered porous MXene structure with smooth ion channels was constructed by reducing the overstacking of MXene lamella.Moreover,the micro-chamber architecture of thin-walled lignin nanospheres effectively extended the contact area between lignin and MXene to improve ion and electron accessibility,thus better utilizing the pseudocapacitive property of lignin.All these strategies effectively enhanced the capacitive performance of the electrodes.In addition,HLNPs,which acted as a protective phase for MXene layer,enhanced mechanical properties of the wrinkled stretchable electrodes by releasing stress through slip and deformation during the stretch-release cycling and greatly improved the structural integrity and capacitive stability of the electrodes.Flexible electrodes and symmetric flexible all-solid-state supercapacitors capable of enduring 600%uniaxial tensile strain were developed with high specific capacitances of 1273 mF cm^(−2)(241 F g^(−1))and 514 mF cm^(−2)(95 F g^(−1)),respectively.Moreover,their capacitances were well preserved after 1000 times of 600%stretch-release cycling.This study showcased new possibilities of incorporating biobased lignin nanospheres in energy storage devices to fabricate stretchable devices leveraging synergies among various two-dimensional nanomaterials.
基金supported by the National High Technology Research and Development Program of China No.2014AA01A701Nature and Science Foundation of China under Grants No.61471068,61421061+2 种基金Beijing Nova Programme No.Z131101000413030International Collaboration Project No.2015DFT10160National Major Project No.2016ZX03001009-003
文摘The key technologies involved in the evolution of the Cloud-based Radio Access Network(C-RAN) are discussed in this paper. Taking the Frameless Network Architecture(FNA) as a starting point, a cell-lessbased network topology for a multi-tier Heterogeneous Network(Het Net) and ultra-dense network is proposed. The FNA network topology modeling is researched with centralized processing and distributed antenna deployments. The Antenna Element(AE) is released as a new dimensional radio resource that is included in the centralized Radio Resource Management(RRM) processes. This contributes to the on-demand user-centric serving-set associations with cell-edge effect elimination. The Control Plane(CP) and User Plane(UP) separation and adaptation are introduced for energy efficiency improvements. The centralized RRM and different optimization goals are discussed for fully exploring the merits from the centralized computing of C-RAN. Considering the complexity, near-optimal approaches for specific users' Quality-of-Service(Qo S) requirements are addressed. Finally, based on the research highlighted above, the way forward of C-RAN evolution is discussed.
基金supported by the National Key Research and Development Program of China(2023YFD2303302,2022YFD2300803)the National Natural Science Foundation of China(32160445)the China Agriculture Research System of MOF and MARA(CARS-02-16).
文摘High-density planting increases maize yield but also canopy crowding and stalk lodging.Aiming this contradiction,a wavy canopy was created using interlaced chemical application(IC)of a plant growth retardant at the V14 stage with three densities(60,000,75,000,and 90,000 plants ha-1,indicated by D1,D2,and D3,respectively)for two seasons.The results showed that the IC-treated wavy canopy featuring both natural height(IC-H)and dwarfed(IC-L)plants,improved light transmission by 8.54%,8.49%,and 16.49%on average than the corresponding controls(CK)at D1,D2,and D3,respectively.The alleviation of canopy crowding stimulated leaf photosynthesis,sugar availability,basal-internode strength,and decreased plant lodging ratios in both IC-H and IC-L,particularly under higher densities.Meanwhile,the IC populations produced significantly higher yield than CK,with an average increase of 3.38%,16.70%,and 15.28%at D1,D2,and D3,respectively.Collectively,this study proposed a new wavy canopy strategy using plant growth retardant to simultaneously increase yield performance and lodging resistance,thus offering a sustainable solution for further development of high-density maize production.
文摘Modern aircraft tend to use fuel thermal management systems to cool onboard heat sources.However,the design of heat transfer architectures for fuel thermal management systems relies on the experience of the engineers and lacks theoretical guidance.This paper proposes a concise graph representation method based on graph theory for fuel thermal management systems,which can represent all possible connections between subsystems.A generalized optimization algorithm is proposed for fuel thermal management system architecture to minimize the heat sink.This algorithm can autonomously arrange subsystems with heat production differences and efficiently utilize the architecture of the fuel heat sink.At the same time,two evaluation indices are proposed from the perspective of subsystems.These indices intuitively and clearly show that the reason for the high efficiency of heat sink utilization is the balanced and moderate cooling of each subsystem and verify the rationality of the architecture optimization method.A set of simulations are also conducted,which demonstrate that the fuel tank temperature has no effect on the performance of the architecture.This paper provides a reference for the architectural design of aircraft fuel thermal management systems.The metrics used in this paper can also be utilized to evaluate the existing architecture.
基金Supported by the National Science and Technology Major Project(2017ZX05001)CNPC Technology Project(2023YQX20111).
文摘To address the discrepancies between well and seismic data in stratigraphic correlation of the Triassic Yanchang Formation in the Ordos Basin,NW China,traditional stratigraphic classification schemes,the latest 3D seismic and drilling data,and reservoir sections are thoroughly investigated.Guided by the theory of sequence stratigraphy,the progradational sequence stratigraphic framework of the Yanchang Formation is systematically constructed to elucidate new deposition mechanisms in the depressed lacustrine basin,and it has been successfully applied to the exploration and development practices in the Qingcheng Oilfield.Key findings are obtained in three aspects.First,the seismic progradational reflections,marker tuff beds,and condensed sections of flooding surfaces in the Yanchang Formation are consistent and isochronous.Using flooding surface markers as a reference,a progradational sequence stratigraphic architecture is reconstructed for the middle-upper part of Yanchang Formation,and divided into seven clinoform units(CF1-CF7).Second,progradation predominantly occurs in semi-deep to deep lake environments,with the depositional center not always coinciding with the thickest strata.The lacustrine basin underwent an evolution of“oscillatory regression-progradational infilling-multi-phase superimposition”.Third,the case study of Qingcheng Oilfield reveals that the major pay zones consist of“isochronous but heterochronous”gravity-flow sandstone complexes.Guided by the progradational sequence stratigraphic architecture,horizontal well oil-layer penetration rates remain above 82%.The progradational sequence stratigraphic architecture and associated geological insights are more consistent with the sedimentary infilling mechanisms of large-scale continental depressed lacustrine basins and actual drilling results.The research results provide crucial theoretical and technical support for subsequent refined exploration and development of the Yanchang Formation,and are expected to offer a reference for research and production practice in similar continental lacustrine basins.
文摘It’s possible for malicious operators to seize hold of electrical control systems, for instance, the engine control unit of driverless vehicles, from various vectors, e.g. autonomic control system, remote vehicle access, or human drivers. To mitigate potential risks, this paper provides the inauguration study by proposing a theoretical framework in the physical, human and cyber triad. Its goal is to, at each time point, detect adversary control behaviors and protect control systems against malicious operations via integrating a variety of methods. This paper only proposes a theoretical framework which tries to indicate possible threats. With the support of the framework, the security system can lightly reduce the risk. The development and implementation of the system are out of scope.
文摘Not always climate and cultural contexts are discussed at the forefront of architectural discussions on traditional or vernacular architecture,nevertheless,the construction material also plays a significant part in defining places’architectural languages.Building from the local materials is an essential ingredient of the local distinctiveness,whilst forming the architectural grand gesture in its context.In Siwa oasis,salt architecture has formed that architectural grand gesture.The vernacular vocabularies adopted by old Bedouins using salt bricks generated Siwa’s unique spirit.In this paper,some examples are illustrated based on a series of site visits to three main sites in Siwa,namely:Old Shali,Abu Shuruf,and Aghourmy.This shows the evolution of Siwa’s vernacular architecture and the role of the architectural language or detrimental effect on the overall quality of architecture.From the site visits,it was observed that building with the traditional technique is now becoming abandoned in Siwa,explained by the local builders to be due to the huge costs required;forcing them to shifting to modern architecture.The influx to building using modern techniques has led to a significant transformation in the urban morphology and spirit of Siwa.Herein lies the scope of this paper:to discuss the impact of the evolution of vernacular architecture on the overall quality of architecture in Siwa and thus identifying the problems which will lead to policy formulation and guidelines for the redevelopment of Siwa in order to“revitalize/resuscitate”its vernacular style accordingly.
基金Supported by the European Union’s Horizon Europe research and innovation program(101120727-PRIMI).
文摘This paper adopts the Global Workspace Theory as a neuro-scientifically plausible theory for developing conscious cognitive architecture.The Global Workspace Theory’s compatibility with the working mechanisms underneath human brains is enhanced by the implementation of different cognitive features based on this framework.Amongst the topics in the literature for intelligent systems,we start with attention,memory and learning mechanisms,and corresponding experiments are summarized here.We also discuss how other topics of cognitive robotics could be developed based on these three basic components,and their correlations.This provides a foundation for future long-term development of cognitive architectures of cognitive robots.The research in this paper follows the incremental research pathway for the architecture implementation,which is consistent with the Biologically Inspired Cognitive Architecture roadmap.
文摘Henry Killam Murphy,an American architect in the 20th century(1877—1954),advocated the idea of adaptive architecture and the traditional renaissance design method,and believed that different countries and regions should have their own architectural art.He recognized and appreciated traditional Chinese architecture and used it in Chinese architectural design.Based on Henry Killam Murphy’s design of Tsinghua University,Ginling College and Beijing Yenching University in China from 1914 to 1935,this paper discussed and probed into the construction of Murphy’s creation concept and technique,and the selection of the Architectural History of China and Yang Bingde’s Blend of Chinese&Western Architectural Culture in Chinese Modern History,and also compared to Murphy and Chinese architects of the 20th century,so as to demonstrate different design attitudes of Chinese traditional architectural culture and the western architectural culture during the fusion,and Henry Killam Murphy’s impact and far-reaching significance on China’s modern campus planning.
文摘A restoration concept has been developed based on the Baiyun Taoist Temple Map found in the Continuation of the Gaolan County Annals.This study systematically analyzes the architectural features of Baiyun Taoist Temple in Lanzhou during the Daoguang period of the Qing Dynasty from three perspectives:overall layout,spatial design,and garden artistic conception.The analysis offers a representative case for understanding the spatial organization principles and cultural connotation of Taoist architecture in the Lanzhou region during the Qing Dynasty.
文摘The aim of this article is to present my interpretation of the holistic-phenomenological worldview in practice.This study demonstrates how this approach,as well as the planning process that I followed(a process fundamentally different from conventional ones)was implemented in a residential neighborhood I designed and built in the social,economic,and physical structure of the collective known in Israel as a‘kibbutz’.The intention is to raise a broad public discussion and pose a challenge to 21st-century architecture regarding how to intervene in a moral and human way within an existing environment,urban or natural,which must be respected and preserved,when integrating within it a new contemporary architecture.
