In this paper, the eigenfunction method established by Chen Jin-quan is used to compute the C-G coefficients in regard to the coupling between symmetry points and lines in the first Brillouin zone of the structure D6h...In this paper, the eigenfunction method established by Chen Jin-quan is used to compute the C-G coefficients in regard to the coupling between symmetry points and lines in the first Brillouin zone of the structure D6h^1, space group. Therewith, the wave vector selection rule and the C-G series, are also given as the middle result of computing the C-G coefficients.展开更多
The eigenfunction method put forward by Chen Jin-quan is illustrated. We apply this theory to the space group D1_ 6h. The selection rules of this space are worked out in the points of higher symmetry A,K,H in the firs...The eigenfunction method put forward by Chen Jin-quan is illustrated. We apply this theory to the space group D1_ 6h. The selection rules of this space are worked out in the points of higher symmetry A,K,H in the first Brillion Zone. The C-G coefficients are calculated for K.HA.展开更多
多发性骨髓瘤(multiple myeloma,MM)是一种不可治愈的血液系统恶性肿瘤,尽管新型蛋白酶体抑制剂、免疫调节剂及CD38单抗等药物的应用显著延长了患者的生存时间,但复发耐药仍难以避免。细胞免疫治疗,特别是嵌合抗原受体(chimeric antigen...多发性骨髓瘤(multiple myeloma,MM)是一种不可治愈的血液系统恶性肿瘤,尽管新型蛋白酶体抑制剂、免疫调节剂及CD38单抗等药物的应用显著延长了患者的生存时间,但复发耐药仍难以避免。细胞免疫治疗,特别是嵌合抗原受体(chimeric antigen receptor,CAR)T细胞疗法的快速发展,极大程度的改变了复发/难治性(relapsed/refractory,R/R)MM患者的治疗现状。FDA目前已批准了2款靶向B细胞成熟抗原(B cell maturation antigen,BCMA)的CAR-T细胞产品,使其用于既往接受过4线及以上治疗的R/R MM患者。随着临床研究的不断深入,靶向GPRC5D(G protein-coupled receptor C class Group 5 member D,G蛋白偶联受体C类第5组成员D)的CAR-T细胞治疗也显示出其独特的优势。除了应用于难治复发的患者,多项临床试验支持CAR-T在MM中治疗线数的前移。本文就CAR-T细胞治疗在MM中开展的关键性临床研究展开综述,旨在为临床应用提供参考。展开更多
文摘In this paper, the eigenfunction method established by Chen Jin-quan is used to compute the C-G coefficients in regard to the coupling between symmetry points and lines in the first Brillouin zone of the structure D6h^1, space group. Therewith, the wave vector selection rule and the C-G series, are also given as the middle result of computing the C-G coefficients.
文摘The eigenfunction method put forward by Chen Jin-quan is illustrated. We apply this theory to the space group D1_ 6h. The selection rules of this space are worked out in the points of higher symmetry A,K,H in the first Brillion Zone. The C-G coefficients are calculated for K.HA.
文摘多发性骨髓瘤(multiple myeloma,MM)是一种不可治愈的血液系统恶性肿瘤,尽管新型蛋白酶体抑制剂、免疫调节剂及CD38单抗等药物的应用显著延长了患者的生存时间,但复发耐药仍难以避免。细胞免疫治疗,特别是嵌合抗原受体(chimeric antigen receptor,CAR)T细胞疗法的快速发展,极大程度的改变了复发/难治性(relapsed/refractory,R/R)MM患者的治疗现状。FDA目前已批准了2款靶向B细胞成熟抗原(B cell maturation antigen,BCMA)的CAR-T细胞产品,使其用于既往接受过4线及以上治疗的R/R MM患者。随着临床研究的不断深入,靶向GPRC5D(G protein-coupled receptor C class Group 5 member D,G蛋白偶联受体C类第5组成员D)的CAR-T细胞治疗也显示出其独特的优势。除了应用于难治复发的患者,多项临床试验支持CAR-T在MM中治疗线数的前移。本文就CAR-T细胞治疗在MM中开展的关键性临床研究展开综述,旨在为临床应用提供参考。
